KEGG   PATHWAY: nlo03040
Entry
nlo03040                    Pathway                                
Name
Spliceosome - Neodiprion lecontei (redheaded pine sawfly)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
nlo03040  Spliceosome
nlo03040

Other DBs
GO: 0005681
Organism
Neodiprion lecontei (redheaded pine sawfly) [GN:nlo]
Gene
124293186  U1 spliceosomal RNA [KO:K14276]
124294859  U1 spliceosomal RNA [KO:K14276]
124293772  U2 spliceosomal RNA [KO:K14277]
124295619  U2 spliceosomal RNA [KO:K14277]
124293177  U2 spliceosomal RNA [KO:K14277]
124294354  U4 spliceosomal RNA [KO:K14278]
124294278  U5 spliceosomal RNA [KO:K14279]
124293773  U6 spliceosomal RNA [KO:K14280]
124293770  U6 spliceosomal RNA [KO:K14280]
124295223  U6 spliceosomal RNA [KO:K14280]
124293769  U6 spliceosomal RNA [KO:K14280]
107222388  probable ATP-dependent RNA helicase DDX46 [KO:K12811] [EC:5.6.2.7]
107224782  ATP-dependent RNA helicase WM6 [KO:K12812] [EC:5.6.2.7]
107226198  probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-4 [KO:K12813] [EC:5.6.2.6]
107223817  pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 isoform X1 [KO:K12815] [EC:5.6.2.6]
107221344  pre-mRNA-processing factor 17 [KO:K12816]
107226329  pre-mRNA-splicing factor 18 [KO:K12817]
107216600  ATP-dependent RNA helicase DHX8 [KO:K12818] [EC:5.6.2.6]
107217128  pre-mRNA-splicing factor Slu7 [KO:K12819]
107224957  putative pre-mRNA-splicing factor ATP-dependent RNA helicase PRP1 isoform X1 [KO:K12820] [EC:5.6.2.6]
107216539  small nuclear ribonucleoprotein-associated protein B [KO:K11086]
107220773  probable small nuclear ribonucleoprotein Sm D1 isoform X1 [KO:K11087]
107219071  probable small nuclear ribonucleoprotein Sm D2 [KO:K11096]
107223326  small nuclear ribonucleoprotein Sm D3 [KO:K11088]
107220234  probable small nuclear ribonucleoprotein E [KO:K11097]
107221314  small nuclear ribonucleoprotein F [KO:K11098]
107222266  probable small nuclear ribonucleoprotein G [KO:K11099]
107227892  LOW QUALITY PROTEIN: U1 small nuclear ribonucleoprotein 70 kDa [KO:K11093]
107226648  U1 small nuclear ribonucleoprotein C [KO:K11095]
107217646  pre-mRNA-processing factor 40 homolog A [KO:K12821]
107222888  ATP-dependent RNA helicase p62 [KO:K12823] [EC:5.6.2.7]
107222890  ATP-dependent RNA helicase dbp2 [KO:K12823] [EC:5.6.2.7]
107225873  ATP-dependent RNA helicase dbp2 isoform X1 [KO:K12823] [EC:5.6.2.7]
107218180  ATP-dependent RNA helicase p62 isoform X1 [KO:K12823] [EC:5.6.2.7]
107227697  transcription elongation regulator 1 isoform X3 [KO:K12824]
107226080  probable U2 small nuclear ribonucleoprotein A' [KO:K11092]
107222263  U1 small nuclear ribonucleoprotein A [KO:K11094]
107217111  splicing factor 3A subunit 1 [KO:K12825]
107221492  splicing factor 3A subunit 2 [KO:K12826]
107225523  splicing factor 3A subunit 3 [KO:K12827]
107219508  splicing factor 3B subunit 1 isoform X1 [KO:K12828]
107223539  splicing factor 3B subunit 2 isoform X1 [KO:K12829]
107222889  splicing factor 3B subunit 3 [KO:K12830]
107218132  splicing factor 3B subunit 4 [KO:K12831]
107227851  splicing factor 3B subunit 5 [KO:K12832]
107219776  splicing factor 3B subunit 6 [KO:K12833]
107221626  PHD finger-like domain-containing protein 5A [KO:K12834]
107223430  ATP-dependent RNA helicase DDX42 isoform X1 [KO:K12835] [EC:5.6.2.7]
107218126  splicing factor U2af 38 kDa subunit isoform X1 [KO:K12836]
107224612  splicing factor U2AF 50 kDa subunit isoform X3 [KO:K12837]
107217922  poly(U)-binding-splicing factor half pint isoform X3 [KO:K12838]
107224643  survival of motor neuron-related-splicing factor 30 [KO:K12839]
107220120  splicing factor 45 [KO:K12840]
107227996  U2 snRNP-associated SURP motif-containing protein isoform X1 [KO:K12842]
107216465  U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
107223841  U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
107220757  U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
107226642  U6 snRNA-associated Sm-like protein LSm5 isoform X1 [KO:K12624]
107222903  U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
107218627  U6 snRNA-associated Sm-like protein LSm7 isoform X1 [KO:K12626]
107224806  U6 snRNA-associated Sm-like protein LSm8 [KO:K12627]
107225387  U4/U6 small nuclear ribonucleoprotein Prp3 [KO:K12843]
107225310  U4/U6 small nuclear ribonucleoprotein Prp4 [KO:K12662]
107221192  peptidyl-prolyl cis-trans isomerase H [KO:K09567] [EC:5.2.1.8]
107218740  U4/U6 small nuclear ribonucleoprotein Prp31 [KO:K12844]
107217820  NHP2-like protein 1 homolog [KO:K12845]
107224445  U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein isoform X1 [KO:K12846]
107227735  U4/U6.U5 tri-snRNP-associated protein 2 isoform X1 [KO:K12847]
107222185  U4/U6.U5 tri-snRNP-associated protein 1 [KO:K11984]
107219953  zinc finger matrin-type protein 2 [KO:K12848]
107228099  pre-mRNA-splicing factor 38A [KO:K12849]
107225205  pre-mRNA-splicing factor 38B isoform X1 [KO:K12850]
107221384  116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
107219044  putative U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:5.6.2.6]
107221764  pre-mRNA-processing factor 6 [KO:K12855]
107220273  pre-mRNA-processing-splicing factor 8 [KO:K12856]
107221736  U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
107221400  probable ATP-dependent RNA helicase DDX23 isoform X1 [KO:K12858] [EC:5.6.2.7]
107222741  thioredoxin-like protein 4A isoform X2 [KO:K12859]
107221611  pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
107226334  cell division cycle 5-like protein [KO:K12860]
107220005  pre-mRNA-splicing factor SPF27 [KO:K12861]
107228115  pleiotropic regulator 1 isoform X1 [KO:K12862]
107222376  protein CWC15 homolog [KO:K12863]
107222239  beta-catenin-like protein 1 [KO:K12864]
107220505  heat shock protein 70 B2 [KO:K03283]
107222059  heat shock protein 70 B2-like [KO:K03283]
107223301  heat shock 70 kDa protein cognate 4-like [KO:K03283]
107217221  heat shock 70 kDa protein cognate 4 [KO:K03283]
107218651  major heat shock 70 kDa protein Ab [KO:K03283]
124293854  heat shock protein 70 B2-like [KO:K03283]
107227401  polyglutamine-binding protein 1 isoform X2 [KO:K12865]
107217441  puff-specific protein Bx42 [KO:K06063]
107224136  pre-mRNA-splicing factor syf1 homolog [KO:K12867]
107217163  pre-mRNA-splicing factor syf2 [KO:K12868]
107218286  protein crooked neck [KO:K12869]
107223555  pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
107223745  peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
107227753  peptidyl-prolyl cis-trans isomerase E [KO:K09564] [EC:5.2.1.8]
107220467  coiled-coil domain-containing protein 12 [KO:K12871]
107224929  pre-mRNA-splicing factor RBM22 [KO:K12872]
107216488  protein BUD31 homolog [KO:K12873]
107223534  RNA helicase aquarius isoform X1 [KO:K12874]
107216911  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
107218338  RNA-binding protein 8A [KO:K12876]
107224705  protein mago nashi homolog [KO:K12877]
107222960  THO complex subunit 1 isoform X1 [KO:K12878]
107224555  THO complex subunit 2 isoform X1 [KO:K12879]
107225782  THO complex subunit 3 [KO:K12880]
107216607  THO complex subunit 4 [KO:K12881]
107217935  nuclear cap-binding protein subunit 1 [KO:K12882]
107220746  nuclear cap-binding protein subunit 2 [KO:K12883]
107219500  heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog isoform X1 [KO:K12741]
107224383  heterogeneous nuclear ribonucleoprotein K homolog [KO:K12886]
107223174  serine/arginine-rich splicing factor 1A [KO:K12890]
107225262  serine/arginine-rich splicing factor 2 isoform X1 [KO:K12891]
107218660  serine-arginine protein 55 isoform X5 [KO:K12893]
107227152  serine/arginine-rich splicing factor 7 isoform X3 [KO:K12896]
107226058  transformer-2 protein homolog alpha isoform X1 [KO:K12897]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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