KEGG   PATHWAY: nvs04530
Entry
nvs04530                    Pathway                                
Name
Tight junction - Neogale vison (American mink)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
nvs04530  Tight junction
nvs04530

Other DBs
GO: 0005923
Organism
Neogale vison (American mink) [GN:nvs]
Gene
122909819  CRB3; protein crumbs homolog 3 [KO:K06090]
122904797  CLDN12; claudin-12 [KO:K06087]
122889126  CLDN23; claudin-23 [KO:K06087]
122889145  putative claudin-24 [KO:K06087]
122889146  claudin-22-like [KO:K06087]
122896405  CLDN2; claudin-2 [KO:K06087]
122896718  CLDN34; claudin-34 [KO:K06087]
122898676  CLDN19; claudin-19 [KO:K06087]
122906691  CLDN7; claudin-7 [KO:K06087]
122907190  CLDN10; claudin-10 isoform X1 [KO:K06087]
122913973  CLDN25; putative claudin-25 [KO:K06087]
122901196  LOW QUALITY PROTEIN: claudin-10-like [KO:K06087]
122908805  CLDN1; claudin-1 [KO:K06087]
122908913  CLDN18; claudin-18 isoform X1 [KO:K06087]
122901998  CLDN5; claudin-5 [KO:K06087]
122895283  CLDN6; claudin-6 [KO:K06087]
122895325  CLDN15; claudin-15 isoform X1 [KO:K06087]
122895521  CLDN9; claudin-9 [KO:K06087]
122903082  CLDN20; claudin-20 [KO:K06087]
122910298  CLDN14; claudin-14 [KO:K06087]
122910335  CLDN8; claudin-8 [KO:K06087]
122910336  CLDN17; claudin-17 [KO:K06087]
122910481  CLDN11; claudin-11 [KO:K06087]
122910516  CLDN16; LOW QUALITY PROTEIN: claudin-16 [KO:K06087]
122895571  CLDN4; claudin-4 [KO:K06087]
122895583  CLDN3; claudin-3 [KO:K06087]
122918780  OCLN; occludin [KO:K06088]
122918358  F11R; junctional adhesion molecule A isoform X1 [KO:K06089]
122908366  JAM2; junctional adhesion molecule B [KO:K06735]
122912449  JAM3; junctional adhesion molecule C [KO:K06785]
122904260  BVES; blood vessel epicardial substance [KO:K21108]
122899548  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
122901810  cell division control protein 42 homolog [KO:K04393]
122915972  PARD6B; partitioning defective 6 homolog beta isoform X1 [KO:K06093]
122902788  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
122911337  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
122893966  PALS1; protein PALS1 isoform X1 [KO:K06091]
122902196  MPP4; MAGUK p55 subfamily member 4 [KO:K21109]
122909879  TJP3; tight junction protein ZO-3 isoform X1 [KO:K06097]
122900033  PATJ; inaD-like protein isoform X1 [KO:K06092]
122917599  MPDZ; multiple PDZ domain protein isoform X1 [KO:K06095]
122899350  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
122908688  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
122896439  AMOT; angiomotin isoform X1 [KO:K16819]
122912475  AMOTL1; angiomotin-like protein 1 isoform X1 [KO:K06104]
122908926  AMOTL2; angiomotin-like protein 2 [KO:K06104]
122889845  LOW QUALITY PROTEIN: rho GTPase-activating protein 17-like [KO:K20638]
122895830  ARHGAP17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
122895963  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
122903276  NF2; merlin isoform X1 [KO:K16684]
122905987  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
122906866  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
122908825  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
122904243  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
122889911  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
122891679  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
122911710  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
122912265  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
122889649  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
122889741  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
122890558  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
122901225  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
122892009  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
122908346  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
122893355  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
122908539  TJAP1; tight junction-associated protein 1 isoform X1 [KO:K06105]
122912526  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
122896321  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
122894156  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
122906928  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase NEDD4-like [KO:K13305] [EC:2.3.2.26]
122906929  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase NEDD4-like [KO:K13305] [EC:2.3.2.26]
122906930  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase NEDD4-like [KO:K13305] [EC:2.3.2.26]
122902852  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
122900510  CGN; cingulin isoform X1 [KO:K06102]
122894160  CGNL1; cingulin-like protein 1 isoform X1 [KO:K21110]
122918282  ARHGEF2; rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
122909429  RHOA; transforming protein RhoA [KO:K04513]
122889703  GATA4; transcription factor GATA-4 isoform X1 [KO:K09183]
122911270  MARVELD3; MARVEL domain-containing protein 3 isoform X1 [KO:K21099]
122889387  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
122889452  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
122900866  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
122915651  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
122900023  JUN; transcription factor AP-1 [KO:K04448]
122918851  CD1D; antigen-presenting glycoprotein CD1d [KO:K06448]
122918868  T-cell surface glycoprotein CD1b-like [KO:K06448]
122918028  T-cell surface glycoprotein CD1a-like isoform X1 [KO:K06448]
122918029  T-cell surface glycoprotein CD1a-like isoform X1 [KO:K06448]
122918031  T-cell surface glycoprotein CD1a-like isoform X1 [KO:K06448]
122918032  T-cell surface glycoprotein CD1a-like [KO:K06448]
122918033  T-cell surface glycoprotein CD1a-like isoform X1 [KO:K06448]
122918034  T-cell surface glycoprotein CD1c-like [KO:K06448]
122918035  T-cell surface glycoprotein CD1e, membrane-associated-like isoform X1 [KO:K06448]
122905012  CFTR; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
122892356  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
122896632  Y-box-binding protein 3-like [KO:K06099]
122896633  Y-box-binding protein 3-like [KO:K06099]
122892486  YBX3; Y-box-binding protein 3 isoform X1 [KO:K06099]
122911927  SYMPK; symplekin [KO:K06100]
122916241  PCNA; proliferating cell nuclear antigen [KO:K04802]
122913270  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
122906299  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
122908311  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
122891763  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
122906012  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
122902884  EZR; ezrin isoform X1 [KO:K08007]
122912215  RDX; radixin isoform X1 [KO:K05762]
122897680  MSN; moesin [KO:K05763]
122916358  PRKCE; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
122905894  ACTG1; actin, cytoplasmic 2 [KO:K05692]
122895995  ACTB; actin, cytoplasmic 1 [KO:K05692]
122909338  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
122906270  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
122909795  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
122916091  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
122913262  CTTN; src substrate cortactin isoform X1 [KO:K06106]
122908892  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
122916541  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
122905225  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
122902719  ACTR3; actin-related protein 3 [KO:K18584]
122918582  actin-related protein 2/3 complex subunit 1A-like [KO:K05757]
122895772  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
122895775  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
122902297  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
122910643  LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 3-like [KO:K05756]
122903441  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
122909226  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
122918610  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
122917255  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
122894693  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
122896409  WAS; wiskott-Aldrich syndrome protein [KO:K05747]
122911938  vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
122900129  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
122909651  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
122918225  RAB13; ras-related protein Rab-13 isoform X1 [KO:K06109]
122909779  ARHGEF18; rho guanine nucleotide exchange factor 18 isoform X1 [KO:K21066]
122902995  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
122915310  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
122902064  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
122917365  EPB41L4B; band 4.1-like protein 4B isoform X1 [KO:K21111]
122909957  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
122900018  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
122894750  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
122900404  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
122903371  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
122905216  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
122891254  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
122901740  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
122911790  MYH14; myosin-14 isoform X1 [KO:K10352]
122891157  MYH9; myosin-9 [KO:K10352]
122906748  MYH10; myosin-10 isoform X1 [KO:K10352]
122895602  MYH11; myosin-11 isoform X1 [KO:K10352]
122891826  MYL6B; myosin light chain 6B isoform X1 [KO:K12751]
122891827  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
122916104  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
122903010  myosin regulatory light polypeptide 9 [KO:K12757]
122903011  myosin regulatory light chain 12B [KO:K12757]
122910294  IGSF5; immunoglobulin superfamily member 5 [KO:K06786]
122909286  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
122893974  SYNPO; synaptopodin isoform X1 [KO:K21112]
122893645  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
122911641  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
122895618  MICALL2; MICAL-like protein 2 isoform X1 [KO:K21068]
122909639  RAB8A; ras-related protein Rab-8A [KO:K07901]
122894455  RAB8B; ras-related protein Rab-8B [KO:K07902]
122892028  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
122900324  RAP1A; ras-related protein Rap-1A [KO:K04353]
122892401  ITGB1; integrin beta-1 [KO:K05719]
122902557  AFDN; afadin isoform X1 [KO:K05702]
122917717  TJP2; tight junction protein ZO-2 isoform X1 [KO:K06098]
122889517  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
122896431  RAP2C; ras-related protein Rap-2c isoform X1 [KO:K07839]
122918802  MARVELD2; MARVEL domain-containing protein 2 [KO:K17291]
122918800  tubulin alpha-8 chain [KO:K07374]
122897974  tubulin alpha-4A chain [KO:K07374]
122891693  TUBAL3; LOW QUALITY PROTEIN: tubulin alpha chain-like 3 [KO:K07374]
122892569  TUBA1A; tubulin alpha-1A chain [KO:K07374]
122892570  tubulin alpha-1C chain [KO:K07374]
122892581  TUBA1B; tubulin alpha-1B chain [KO:K07374]
122892638  TUBA8; tubulin alpha-8 chain [KO:K07374]
122902333  tubulin alpha-4A chain [KO:K07374]
122903183  tubulin alpha-3 chain isoform X1 [KO:K07374]
122903185  tubulin alpha-3 chain isoform X1 [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
nvs04520  Adherens junction
nvs04810  Regulation of actin cytoskeleton
KO pathway
ko04530   
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