KEGG   PATHWAY: nvs04810
Entry
nvs04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Neogale vison (American mink)
Class
Cellular Processes; Cell motility
Pathway map
nvs04810  Regulation of actin cytoskeleton
nvs04810

Other DBs
GO: 0030036
Organism
Neogale vison (American mink) [GN:nvs]
Gene
122889097  FGF20; fibroblast growth factor 20 [KO:K04358]
122889210  FGF5; fibroblast growth factor 5 [KO:K04358]
122889261  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
122889497  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
122889792  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
122889876  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
122889883  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
122890061  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
122890243  MYL5; myosin light chain 5 [KO:K12753]
122890262  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
122891157  MYH9; myosin-9 [KO:K10352]
122891465  ITGA8; integrin alpha-8 [KO:K06584]
122891553  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
122891646  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
122891698  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
122891700  NCKAP1L; nck-associated protein 1-like [KO:K05750]
122891954  FGF6; fibroblast growth factor 6 [KO:K04358]
122892012  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
122892137  ITGB7; integrin beta-7 [KO:K06590]
122892167  FGF23; fibroblast growth factor 23 [KO:K22428]
122892168  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
122892381  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
122892401  ITGB1; integrin beta-1 [KO:K05719]
122892446  KRAS; GTPase KRas isoform X1 [KO:K07827]
122892561  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
122892628  ITGA5; integrin alpha-5 [KO:K06484]
122892668  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
122892906  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
122892965  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
122893075  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
122893102  BDKRB2; B2 bradykinin receptor isoform X1 [KO:K03916]
122893287  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
122893363  ITGA11; integrin alpha-11 [KO:K06587]
122893445  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
122893512  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
122893538  CFL2; cofilin-2 [KO:K05765]
122893645  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
122893729  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
122893951  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
122894113  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
122894172  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122894274  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
122894367  ITGA2; integrin alpha-2 [KO:K06481]
122894384  ITGA1; integrin alpha-1 [KO:K06480]
122894712  C7; complement component C7 [KO:K03996]
122895267  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
122895287  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
122895342  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
122895602  MYH11; myosin-11 isoform X1 [KO:K10352]
122895632  [KO:K05718]
122895665  [KO:K05718]
122895695  ITGAX; integrin alpha-X [KO:K06462]
122895701  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
122895722  ITGAD; integrin alpha-D [KO:K06594]
122895772  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
122895775  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
122895963  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
122895995  ACTB; actin, cytoplasmic 1 [KO:K05692]
122896056  MYL10; myosin regulatory light chain 10 [KO:K12756]
122896063  LIMK1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
122896083  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
122896452  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
122896634  [KO:K05759]
122897137  FGF16; fibroblast growth factor 16 [KO:K04358]
122897234  TMSB4X; thymosin beta-4 [KO:K05764]
122897334  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
122897574  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
122897579  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
122897598  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
122897626  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
122897680  MSN; moesin [KO:K05763]
122898712  C8A; complement component C8 alpha chain [KO:K03997]
122898714  C8B; complement component C8 beta chain [KO:K03998]
122898888  [KO:K05752]
122898999  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
122899136  [KO:K07828]
122899425  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
122899548  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
122899627  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
122899633  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
122899916  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
122900073  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
122900262  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
122900359  NRAS; GTPase NRas [KO:K07828]
122900421  ITGA10; LOW QUALITY PROTEIN: integrin alpha-10 [KO:K06586]
122900499  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
122900636  CHRM3; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
122900811  VCL; vinculin isoform X1 [KO:K05700]
122900892  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
122901170  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
122901212  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
122901781  PFN3; profilin-3 [KO:K05759]
122901810  [KO:K04393]
122902064  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
122902211  FGF10; fibroblast growth factor 10 [KO:K04358]
122902217  ABI2; abl interactor 2 isoform X1 [KO:K05751]
122902234  C6; complement component C6 [KO:K03995]
122902240  C9; complement component C9 [KO:K04000]
122902254  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
122902278  FN1; fibronectin isoform X1 [KO:K05717]
122902297  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
122902527  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
122902595  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
122902649  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
122902659  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
122902666  ITGAV; integrin alpha-V [KO:K06487]
122902697  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
122902719  ACTR3; actin-related protein 3 [KO:K18584]
122902777  ARHGEF4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
122902884  EZR; ezrin isoform X1 [KO:K08007]
122902995  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
122903010  [KO:K12757]
122903011  [KO:K12757]
122903191  CRKL; crk-like protein [KO:K04438]
122903200  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122903242  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
122903333  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
122903363  PXN; paxillin isoform X1 [KO:K05760]
122903431  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
122903441  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
122903649  WASF1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
122904006  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
122904050  [KO:K05752]
122904168  [KO:K05759]
122904271  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
122904647  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
122904866  SCIN; adseverin [KO:K05768]
122904886  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
122905033  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
122905107  CHRM2; muscarinic acetylcholine receptor M2 isoform X1 [KO:K04130]
122905138  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
122905225  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
122905349  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
122905874  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
122905894  ACTG1; actin, cytoplasmic 2 [KO:K05692]
122905898  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
122905982  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
122906056  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
122906101  ITGB3; integrin beta-3 [KO:K06493]
122906138  ITGA2B; integrin alpha-IIb [KO:K06476]
122906314  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
122906356  CRK; adapter molecule crk isoform X1 [KO:K04438]
122906378  SSH2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
122906383  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
122906591  ITGA3; integrin alpha-3 [KO:K06482]
122906670  PFN1; profilin-1 [KO:K05759]
122906748  MYH10; myosin-10 isoform X1 [KO:K10352]
122906823  ITGAE; integrin alpha-E [KO:K06524]
122906918  FGF9; fibroblast growth factor 9 [KO:K04358]
122906925  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
122907122  RGCC; regulator of cell cycle RGCC [KO:K26108]
122907135  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
122907250  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
122907298  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
122908229  ITGB2; integrin beta-2 [KO:K06464]
122908346  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
122908596  PFN2; profilin-2 isoform X1 [KO:K05759]
122908712  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
122908785  KNG1; kininogen-1 isoform X1 [KO:K03898]
122908833  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
122908860  ITGB5; integrin beta-5 [KO:K06588]
122908866  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
122908899  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
122908906  MRAS; ras-related protein M-Ras [KO:K07831]
122909085  ITGA9; integrin alpha-9 [KO:K06585]
122909192  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
122909214  BRK1; protein BRICK1 [KO:K05752]
122909226  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
122909429  RHOA; transforming protein RhoA [KO:K04513]
122909513  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
122909588  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
122909693  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
122909813  VAV1; proto-oncogene vav [KO:K05730]
122909871  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
122909883  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
122909947  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
122909984  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
122910419  [KO:K05752]
122910643  [KO:K05756]
122911232  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
122911482  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
122911641  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
122911657  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
122911790  MYH14; myosin-14 isoform X1 [KO:K10352]
122911814  RRAS; ras-related protein R-Ras [KO:K07829]
122911908  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
122912005  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
122912036  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122912186  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
122912215  RDX; radixin isoform X1 [KO:K05762]
122912247  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
122912266  [KO:K05765]
122912374  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
122912557  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
122912742  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
122912880  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
122912887  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
122913029  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
122913177  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
122913185  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
122913220  HRAS; GTPase HRas isoform X1 [KO:K02833]
122913696  CFL1; cofilin-1 [KO:K05765]
122913721  FGF3; fibroblast growth factor 3 [KO:K04358]
122913879  FGF21; fibroblast growth factor 21 [KO:K22429]
122914590  INS; insulin [KO:K04526]
122914602  FGF4; fibroblast growth factor 4 [KO:K04358]
122914603  FGF19; fibroblast growth factor 19 [KO:K22603]
122915138  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
122915195  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
122915299  CYRIA; CYFIP-related Rac1 interactor A [KO:K27976]
122915310  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
122915597  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
122915800  PFN4; profilin-4 [KO:K05759]
122916091  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
122916104  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
122916259  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
122916541  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
122916772  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
122917082  C8G; complement component C8 gamma chain [KO:K03999]
122917100  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
122917255  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
122917299  GSN; gelsolin isoform X1 [KO:K05768]
122917302  C5; complement C5 [KO:K03994]
122917357  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
122917723  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
122917777  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 [KO:K05722]
122918302  IQGAP3; ras GTPase-activating-like protein IQGAP3 isoform X1 [KO:K05767]
122918315  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
122918388  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
122918399  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
122918524  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122918582  [KO:K05757]
122918610  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
122918691  ENAH; protein enabled homolog isoform X1 [KO:K05746]
122918797  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
122918946  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
122919116  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
122919222  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
nvs04010  MAPK signaling pathway
nvs04510  Focal adhesion
nvs04520  Adherens junction
KO pathway
ko04810   

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