KEGG   PATHWAY: nwh04261
Entry
nwh04261                    Pathway                                
Name
Adrenergic signaling in cardiomyocytes - Nematolebias whitei (Rio pearlfish)
Description
Cardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, and alpha-1C). In the human heart the beta-1-AR is the pre- dominate receptor. Acute sympathetic stimulation of cardiac beta-1-ARs induces positive inotropic and chronotropic effects, the most effective mechanism to acutely increase output of the heart, by coupling to Gs, formation of cAMP by adenylyl cyclase (AC), and PKA- dependent phosphorylation of various target proteins (e.g., ryanodine receptor [RyR]; phospholamban [PLB], troponin I [TnI], and the L-type Ca2+ channel [LTCC]). Chronic beta-1-AR stimulation is detrimental and induces cardiomyocyte hypertrophy and apoptosis. beta-2-AR coupled to Gs exerts a proapoptotic action as well as beta-1-AR, while beta-2-AR coupled to Gi exerts an antiapoptotic action.
Class
Organismal Systems; Circulatory system
Pathway map
nwh04261  Adrenergic signaling in cardiomyocytes
nwh04261

Other DBs
GO: 0001997
Organism
Nematolebias whitei (Rio pearlfish) [GN:nwh]
Gene
119423646  adrb1; beta-1 adrenergic receptor [KO:K04141]
119409101  adrb2a; adrenoceptor beta 2, surface a [KO:K04142]
119420853  beta-2 adrenergic receptor [KO:K04142]
119411849  guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
119417683  gnas; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
119407638  adcy1a; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
119415057  LOW QUALITY PROTEIN: adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
119410353  adcy2a; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
119425622  adcy2b; adenylate cyclase type 2b [KO:K08042] [EC:4.6.1.1]
119418144  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
119410425  adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
119419477  adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
119417525  adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
119417632  adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
119426404  adcy7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
119428743  si:ch211-132f19.7; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
119415271  adcy8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
119420989  adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
119423075  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
119419361  popdc2; popeye domain-containing 2 [KO:K26206]
119410433  popdc3; popeye domain-containing protein 3 [KO:K26207]
119418196  potassium channel subfamily K member 2-like [KO:K04913]
119426018  kcnk2a; potassium channel subfamily K member 2 [KO:K04913]
119421717  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a [KO:K04345] [EC:2.7.11.11]
119407776  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
119422780  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
119415051  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
119409315  atp1a3b; sodium/potassium-transporting ATPase subunit alpha-3b [KO:K01539] [EC:7.2.2.13]
119428748  sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
119428755  atp1a1a.4; sodium/potassium-transporting ATPase subunit alpha-1a.4 [KO:K01539] [EC:7.2.2.13]
119415241  atp1a2a; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
119425815  atp1a3a; sodium/potassium-transporting ATPase subunit alpha-3a [KO:K01539] [EC:7.2.2.13]
119430811  atp1b1a; sodium/potassium-transporting ATPase subunit beta-1a [KO:K01540]
119408866  atp1b4; protein ATP1B4 [KO:K01540]
119415041  atp1b3a; sodium/potassium-transporting ATPase subunit beta-3a [KO:K01540]
119420164  atp1b2b; sodium/potassium-transporting ATPase subunit beta-2b isoform X1 [KO:K01540]
119429163  atp1b1b; sodium/potassium-transporting ATPase subunit beta-1b [KO:K01540]
119410422  atp1b2a; sodium/potassium-transporting ATPase subunit beta-2a [KO:K01540]
119410819  sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
119409909  slc9a1a; Na(+)/H(+) exchanger beta [KO:K05742]
119425950  Na(+)/H(+) exchanger beta [KO:K05742]
119426912  kcnq1.1; potassium voltage-gated channel subfamily KQT member 1.1 [KO:K04926]
119409838  potassium voltage-gated channel subfamily E member 1 [KO:K04894]
119416045  plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
119411836  atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
119412049  plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
119417770  atp2b3b; plasma membrane calcium-transporting ATPase 3b [KO:K05850] [EC:7.2.2.10]
119428106  atp2b1a; plasma membrane calcium-transporting ATPase 1a [KO:K05850] [EC:7.2.2.10]
119422304  sodium/calcium exchanger 1 isoform X1 [KO:K05849]
119427036  slc8a3; sodium/calcium exchanger 3 [KO:K05849]
119413248  slc8a1b; sodium/calcium exchanger 1b isoform X1 [KO:K05849]
119409752  slc8a4b; solute carrier family 8 member 4b [KO:K05849]
119420242  slc8a2a; sodium/calcium exchanger 2a isoform X1 [KO:K05849]
119410776  slc8a2b; sodium/calcium exchanger 2b [KO:K05849]
119420624  slc8a4a; solute carrier family 8 member 4a [KO:K05849]
119426451  sodium channel protein type 2 subunit alpha-like [KO:K04838]
119414954  sodium channel protein type 4 subunit alpha B-like [KO:K04838]
119409839  si:ch211-225p5.8; sodium channel subunit beta-1 [KO:K04845]
119425832  scn1bb; sodium channel, voltage-gated, type I, beta b [KO:K04845]
119409256  scn1ba; sodium channel, voltage-gated, type I, beta a [KO:K04845]
119411117  sodium channel subunit beta-4-like [KO:K04848]
119420666  scn4bb; sodium channel, voltage-gated, type IV, beta b [KO:K04848]
119428184  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
119411902  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a [KO:K04851]
119417689  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
119417562  voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
119417628  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1 [KO:K04857]
119421878  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
119426756  cacnb2a; voltage-dependent L-type calcium channel subunit beta-2a [KO:K04863]
119417281  cacnb3b; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04864]
119417523  cacnb3a; voltage-dependent L-type calcium channel subunit beta-3a [KO:K04864]
119428723  voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
119416037  voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
119428490  cacna2d1a; voltage-dependent calcium channel subunit alpha-2/delta-1a [KO:K04858]
119411804  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a [KO:K04859]
119412468  LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859]
119417259  voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
119412820  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
119416071  voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
119428230  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
119421609  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
119422923  voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
119421318  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
119422421  voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
119422161  cacng3b; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
119422890  voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
119421137  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
119422403  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
119422404  cacng5a; calcium channel, voltage-dependent, gamma subunit 5a isoform X1 [KO:K04870]
119426181  voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
119409974  cacng6b; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
119409976  cacng7b; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
119425289  cacng7a; calcium channel, voltage-dependent, gamma subunit 7a [KO:K04872]
119425521  voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
119429476  voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
119426841  calmodulin-like protein 4 [KO:K02183]
119427283  calmodulin-1 [KO:K02183]
119418447  calm1b; calmodulin-1b [KO:K02183]
119410622  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
119430807  camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain [KO:K04515] [EC:2.7.11.17]
119407951  camk2d1; calcium/calmodulin-dependent protein kinase type II delta 1 chain [KO:K04515] [EC:2.7.11.17]
119413111  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
119413809  camk2b1; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
119424051  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
119425070  calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
119420360  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
119424109  ryr2a; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
119430102  ryr2b; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
119408500  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
119413777  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
119420453  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
119411232  ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
119408150  ppp2r2ca; protein phosphatase 2, regulatory subunit B, gamma a [KO:K04354]
119408454  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform X1 [KO:K04354]
119408543  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
119413490  ppp2r2aa; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
119424638  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
119430220  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
119427640  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
119427908  ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
119419692  ppp2r3b; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
119418493  ppp2r5cb; protein phosphatase 2, regulatory subunit B', gamma b isoform X1 [KO:K11584]
119418578  ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
119427486  ppp2r5eb; protein phosphatase 2, regulatory subunit B', epsilon [KO:K11584]
119427509  ppp2r5ca; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
119413653  ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
119409591  ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
119421853  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
119408360  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
119427307  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
119418592  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
119423989  ppp1cab; protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
119414132  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
119416786  tnnc1a; troponin C type 1a (slow) [KO:K05865]
119417564  troponin C, slow skeletal and cardiac muscles-like [KO:K05865]
119416395  tnnt2d; troponin T2d, cardiac [KO:K12045]
119416931  tnnt2a; troponin T type 2a (cardiac) [KO:K12045]
119412459  tnnt2b; troponin T, cardiac muscle isoforms isoform X1 [KO:K12045]
119428219  tnnt2c; troponin T2c, cardiac [KO:K12045]
119428469  tnnt2e; troponin T2e, cardiac [KO:K12045]
119416294  tpm1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
119423329  tropomyosin alpha-1 chain isoform X1 [KO:K10373]
119424715  tpm2; tropomyosin beta chain [KO:K10373]
119409210  tropomyosin alpha-4 chain [KO:K09290]
119429325  tropomyosin alpha-3 chain [KO:K09290]
119429554  tropomyosin alpha-3 chain [KO:K09290]
119429557  tropomyosin alpha-3 chain [KO:K09290]
119430660  tpm4a; tropomyosin 4a isoform X1 [KO:K10375]
119415210  tropomyosin alpha-1 chain isoform X1 [KO:K10375]
119422625  acta1a; actin alpha 1, skeletal muscle a isoform X1 [KO:K12314]
119423215  acta1b; actin alpha 1, skeletal muscle b [KO:K12314]
119427281  actin, alpha cardiac muscle [KO:K12314]
119427288  actin, alpha cardiac muscle 1 [KO:K12314]
119418606  actc1a; actin, alpha cardiac muscle 1a [KO:K12314]
119418656  myh6; myosin-6 [KO:K17751]
119414997  myosin-7 [KO:K17751]
119415000  myosin-7 [KO:K17751]
119412224  myl2a; myosin regulatory light chain 2a [KO:K10351]
119414137  myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
119414677  myl13; myosin, light chain 13 [KO:K12749]
119424670  myosin light chain 4 [KO:K12750]
119428680  pln; cardiac phospholamban [KO:K05852]
119421576  atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
119423990  atp2a1l; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like isoform X1 [KO:K05853] [EC:7.2.2.10]
119414139  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
119424447  atp2a2b; sarcoplasmic/endoplasmic reticulum calcium ATPase 2b [KO:K05853] [EC:7.2.2.10]
119420323  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
119418955  agt; angiotensinogen [KO:K09821]
119426883  type-1A angiotensin II receptor-like [KO:K04166]
119409124  agtr2; type-2 angiotensin II receptor [KO:K04167]
119413493  adra1aa; adrenoceptor alpha 1Aa [KO:K04135]
119425145  adra1ab; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
119409024  alpha-1A adrenergic receptor-like [KO:K04136]
119408096  adra1d; alpha-1D adrenergic receptor [KO:K04137]
119413945  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
119424498  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
119427438  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
119413479  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
119418479  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
119409287  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
119421632  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
119422396  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
119412779  protein phosphatase 1 regulatory subunit 1A-like [KO:K08050]
119421578  mapk3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
119413751  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
119427368  rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
119418938  creb1b; cyclic AMP-responsive element-binding protein 1b [KO:K05870]
119428635  cyclic AMP-responsive element-binding protein 1 [KO:K05870]
119419612  atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
119422100  atf4b; activating transcription factor 4b [KO:K04374]
119422427  atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
119430713  creb3l3a; cyclic AMP-responsive element-binding protein 3-like protein 3-A [KO:K09048]
119413291  creb3l3l; cAMP responsive element binding protein 3-like 3 like [KO:K09048]
119428369  creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
119414622  cyclic AMP-responsive element-binding protein 3-like protein 3-B [KO:K09048]
119428866  creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
119410110  creb5b; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
119426107  cyclic AMP-responsive element-binding protein 5 [KO:K09047]
119425887  atf6b; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
119414809  crema; cAMP-responsive element modulator isoform X1 [KO:K09052]
119415072  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
119416619  rapgef3; rap guanine nucleotide exchange factor 3 [KO:K08014]
119419154  rapgef4a; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
119414635  rap guanine nucleotide exchange factor 4 [KO:K04351]
119411666  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
119417639  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
119417725  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
119417736  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
119428581  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
119428582  mapk12b; mitogen-activated protein kinase 12b [KO:K04441] [EC:2.7.11.24]
119415605  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
119411793  gnai2b; guanine nucleotide-binding protein G(i) subunit alpha-2b [KO:K04630]
119416252  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
119412835  guanine nucleotide-binding protein G(i) subunit alpha-2-like [KO:K04630]
119417645  gnai3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
119428247  gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
119417338  si:rp71-17i16.5; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
119428023  pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
119421506  phosphoinositide 3-kinase regulatory subunit 5-like [KO:K21290]
119422493  phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
119423177  pik3r5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
119422614  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119418640  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119427445  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119410556  akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
Compound
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00238  Potassium cation
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00788  L-Adrenaline
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C07056  Isoproterenol
Reference
PMID:19883653
  Authors
Grimm M, Brown JH
  Title
Beta-adrenergic receptor signaling in the heart: role of CaMKII.
  Journal
J Mol Cell Cardiol 48:322-30 (2010)
DOI:10.1016/j.yjmcc.2009.10.016
Reference
PMID:21212391
  Authors
Yang JH, Saucerman JJ
  Title
Computational models reduce complexity and accelerate insight into cardiac signaling networks.
  Journal
Circ Res 108:85-97 (2011)
DOI:10.1161/CIRCRESAHA.110.223602
Reference
PMID:16765984
  Authors
Schaub MC, Hefti MA, Zaugg M
  Title
Integration of calcium with the signaling network in cardiac myocytes.
  Journal
J Mol Cell Cardiol 41:183-214 (2006)
DOI:10.1016/j.yjmcc.2006.04.005
Reference
PMID:22022314
  Authors
Taggart P, Boyett MR, Logantha S, Lambiase PD
  Title
Anger, emotion, and arrhythmias: from brain to heart.
  Journal
Front Physiol 2:67 (2011)
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Annu Rev Physiol 70:23-49 (2008)
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Synergy between CaMKII substrates and beta-adrenergic signaling in regulation of cardiac myocyte Ca(2+) handling.
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Biophys J 99:2038-47 (2010)
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The beta-adrenergic receptors.
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Xiao RP
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Beta-adrenergic signaling in the heart: dual coupling of the beta2-adrenergic receptor to G(s) and G(i) proteins.
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Sci STKE 2001:re15 (2001)
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Recent advances in cardiac beta(2)-adrenergic signal transduction.
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Emerging concepts and therapeutic implications of beta-adrenergic receptor subtype signaling.
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Pharmacol Ther 108:257-68 (2005)
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PMID:17826821
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Kuzumoto M, Takeuchi A, Nakai H, Oka C, Noma A, Matsuoka S
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Simulation analysis of intracellular Na+ and Cl- homeostasis during beta 1-adrenergic stimulation of cardiac myocyte.
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Prog Biophys Mol Biol 96:171-86 (2008)
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PMID:11805843
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Bers DM
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Cardiac excitation-contraction coupling.
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Nature 415:198-205 (2002)
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Ho D, Yan L, Iwatsubo K, Vatner DE, Vatner SF
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Modulation of beta-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5.
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Heart Fail Rev 15:495-512 (2010)
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PMID:15142747
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Saucerman JJ, McCulloch AD
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Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation.
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Prog Biophys Mol Biol 85:261-78 (2004)
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Yano M, Ikeda Y, Matsuzaki M
  Title
Altered intracellular Ca2+ handling in heart failure.
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J Clin Invest 115:556-64 (2005)
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Wehrens XH, Marks AR
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Novel therapeutic approaches for heart failure by normalizing calcium cycling.
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Nat Rev Drug Discov 3:565-73 (2004)
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The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications.
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J Am Coll Cardiol 54:1747-62 (2009)
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Molecular regulation of cardiac hypertrophy.
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Int J Biochem Cell Biol 40:2023-39 (2008)
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Related
pathway
nwh04020  Calcium signaling pathway
nwh04260  Cardiac muscle contraction
KO pathway
ko04261   
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