KEGG   PATHWAY: oda04152
Entry
oda04152                    Pathway                                
Name
AMPK signaling pathway - Oryx dammah (scimitar-horned oryx)
Description
AMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in the cellular AMP:ATP ratio caused by metabolic stresses that either interfere with ATP production (eg, deprivation for glucose or oxygen) or that accelerate ATP consumption (eg, muscle contraction). Several upstream kinases, including liver kinase B1 (LKB1), calcium/calmodulin kinase kinase-beta (CaMKK beta), and TGF-beta-activated kinase-1 (TAK-1), can activate AMPK by phosphorylating a threonine residue on its catalytic alpha-subunit. Once activated, AMPK leads to a concomitant inhibition of energy-consuming biosynthetic pathways, such as protein, fatty acid and glycogen synthesis, and activation of ATP-producing catabolic pathways, such as fatty acid oxidation and glycolysis.
Class
Environmental Information Processing; Signal transduction
Pathway map
oda04152  AMPK signaling pathway
oda04152

Other DBs
GO: 2000479
Organism
Oryx dammah (scimitar-horned oryx) [GN:oda]
Gene
120862713  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
120863710  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
120883058  CAB39L; calcium-binding protein 39-like isoform X1 [KO:K08272]
120854272  CAB39; calcium-binding protein 39 [KO:K08272]
120866947  STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
120854618  STRADB; STE20-related kinase adapter protein beta [KO:K17532]
120877318  leptin [KO:K05424]
120857031  LEPR; leptin receptor isoform X1 [KO:K05062]
120871048  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
120860293  alpha-1A adrenergic receptor isoform X1 [KO:K04135]
120866027  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
120872466  ADIPOQ; adiponectin isoform X1 [KO:K07296]
120880093  ADIPOR1; adiponectin receptor protein 1 isoform X1 [KO:K07297]
120857843  ADIPOR2; adiponectin receptor protein 2 isoform X1 [KO:K07297]
120879416  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
120856086  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
120871110  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
120855986  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
120877947  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
120861280  5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
120854364  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
120858195  5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
120882186  PFKFB1; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 1 isoform X1 [KO:K19028] [EC:2.7.1.105 3.1.3.46]
120879930  PFKFB2; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 isoform X1 [KO:K19029] [EC:2.7.1.105 3.1.3.46]
120869143  PFKFB3; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform X1 [KO:K01103] [EC:2.7.1.105 3.1.3.46]
120868247  PFKFB4; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 4 isoform X1 [KO:K19030] [EC:2.7.1.105 3.1.3.46]
120866996  FBP2; fructose-1,6-bisphosphatase isozyme 2 [KO:K03841] [EC:3.1.3.11]
120867004  fructose-1,6-bisphosphatase 1 [KO:K03841] [EC:3.1.3.11]
120861312  ATP-dependent 6-phosphofructokinase, muscle type isoform X1 [KO:K00850] [EC:2.7.1.11]
120869458  ATP-dependent 6-phosphofructokinase, platelet type [KO:K00850] [EC:2.7.1.11]
120856433  PFKL; ATP-dependent 6-phosphofructokinase, liver type [KO:K00850] [EC:2.7.1.11]
120858140  ATP-dependent 6-phosphofructokinase, muscle type isoform X1 [KO:K00850] [EC:2.7.1.11]
120869566  HNF4A; hepatocyte nuclear factor 4-alpha isoform X1 [KO:K07292]
120867120  G6PC1; glucose-6-phosphatase isoform X1 [KO:K01084] [EC:3.1.3.9]
120854888  G6PC2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
120867042  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
120853458  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
120869363  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X1 [KO:K01596] [EC:4.1.1.32]
120869894  LOW QUALITY PROTEIN: CREB-regulated transcription coactivator 2-like [KO:K16333]
120855778  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
120854564  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
120876928  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
120877626  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
120880365  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
120855782  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
120864822  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
120877414  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
120861984  PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
120863892  ELAVL1; ELAV-like protein 1 [KO:K13088]
120874144  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
120883114  CCNA1; cyclin-A1 [KO:K06627]
120861664  CCNA2; cyclin-A2 [KO:K06627]
120875931  EEF2K; eukaryotic elongation factor 2 kinase isoform X1 [KO:K08292] [EC:2.7.11.20]
120883280  elongation factor 2 [KO:K03234]
120883308  elongation factor 2-like [KO:K03234]
120878804  LOW QUALITY PROTEIN: elongation factor 2-like [KO:K03234]
120864552  EEF2; elongation factor 2 [KO:K03234]
120883089  FOXO1; forkhead box protein O1 [KO:K07201]
120862529  FOXO3; forkhead box protein O3 [KO:K09408]
120865204  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
120866070  SLC2A4; solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
120858929  GYS2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
120872161  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
120872376  LIPE; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
120852611  3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform X1 [KO:K00021] [EC:1.1.1.34]
120860962  3-hydroxy-3-methylglutaryl-coenzyme A reductase [KO:K00021] [EC:1.1.1.34]
120867381  SREBF1; sterol regulatory element-binding protein 1 isoform X1 [KO:K07197]
120866858  FASN; fatty acid synthase [KO:K00665] [EC:2.3.1.85]
120866406  ACACA; acetyl-CoA carboxylase 1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
120861510  SCD5; stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
120873536  SCD; stearoyl-CoA desaturase [KO:K00507] [EC:1.14.19.1]
120871398  ACACB; acetyl-CoA carboxylase 2 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
120873237  MLYCD; malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
120874135  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
120857792  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
120872120  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform isoform X1 [KO:K19524] [EC:2.3.1.21]
120881052  CIDEA; cell death activator CIDE-A isoform X1 [KO:K25893]
120863659  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
120865628  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
120876226  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
120859757  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
120871966  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
120861553  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
120863494  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
120865981  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
120882431  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
120875088  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
120857518  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
120880045  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
120874655  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
120875176  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
120852839  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
120870107  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
120862028  TBC1D1; TBC1 domain family member 1 isoform X1 [KO:K18341]
120878605  RAB2A; ras-related protein Rab-2A isoform X1 [KO:K07877]
120864186  RAB8A; ras-related protein Rab-8A [KO:K07901]
120851591  RAB10; ras-related protein Rab-10 [KO:K07903]
120863371  RAB11B; ras-related protein Rab-11B [KO:K07905]
120864289  RAB14; ras-related protein Rab-14 [KO:K07881]
120877516  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
120878121  platelet glycoprotein 4-like [KO:K06259]
120878122  LOW QUALITY PROTEIN: platelet glycoprotein 4-like [KO:K06259]
120878123  platelet glycoprotein 4 [KO:K06259]
120858659  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
120875257  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
120874170  INS; insulin [KO:K04526]
120863920  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
120854447  IRS1; insulin receptor substrate 1 [KO:K16172]
120883252  IRS2; insulin receptor substrate 2 [KO:K07187]
120879389  insulin receptor substrate 1-like [KO:K17445]
120881381  IRS4; insulin receptor substrate 4 [KO:K17446]
120880186  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
120871400  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
120857849  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
120879604  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
120864210  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
120856226  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
120873714  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
120880303  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
120875130  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120872394  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
120873306  TSC2; tuberin isoform X1 [KO:K07207]
120852124  TSC1; hamartin isoform X1 [KO:K07206]
120877946  RHEB; GTP-binding protein Rheb [KO:K07208]
120880214  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
120866846  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
120872112  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
120874776  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
120866437  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
120865656  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
120868104  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
120871548  ULK1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
Compound
C00003  NAD+
C00008  ADP
C00020  AMP
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00040  Acyl-CoA
C00076  Calcium cation
C00083  Malonyl-CoA
C00085  D-Fructose 6-phosphate
C00162  Fatty acid
C00354  D-Fructose 1,6-bisphosphate
C00389  Quercetin
C00665  beta-D-Fructose 2,6-bisphosphate
C00668  alpha-D-Glucose 6-phosphate
C00698  Cl-
C00757  Berberine
C01172  beta-D-Glucose 6-phosphate
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07151  Metformin
C09731  Epigallocatechin gallate
D08351  Phenformin (BAN)
Reference
PMID:19584320
  Authors
Steinberg GR, Kemp BE
  Title
AMPK in Health and Disease.
  Journal
Physiol Rev 89:1025-78 (2009)
DOI:10.1152/physrev.00011.2008
Reference
PMID:15509864
  Authors
Hardie DG.
  Title
The AMP-activated protein kinase pathway--new players upstream and downstream.
  Journal
J Cell Sci 117:5479-87 (2004)
DOI:10.1242/jcs.01540
Reference
PMID:23747347
  Authors
Russo GL, Russo M, Ungaro P
  Title
AMP-activated protein kinase: a target for old drugs against diabetes and cancer.
  Journal
Biochem Pharmacol 86:339-50 (2013)
DOI:10.1016/j.bcp.2013.05.023
Reference
PMID:19393004
  Authors
Ronnett GV, Ramamurthy S, Kleman AM, Landree LE, Aja S
  Title
AMPK in the brain: its roles in energy balance and neuroprotection.
  Journal
J Neurochem 109 Suppl 1:17-23 (2009)
DOI:10.1111/j.1471-4159.2009.05916.x
Reference
PMID:20010958
  Authors
Li J, McCullough LD
  Title
Effects of AMP-activated protein kinase in cerebral ischemia.
  Journal
J Cereb Blood Flow Metab 30:480-92 (2010)
DOI:10.1038/jcbfm.2009.255
Reference
PMID:22700795
  Authors
Sanchez AM, Candau RB, Csibi A, Pagano AF, Raibon A, Bernardi H
  Title
The role of AMP-activated protein kinase in the coordination of skeletal muscle turnover and energy homeostasis.
  Journal
Am J Physiol Cell Physiol 303:C475-85 (2012)
DOI:10.1152/ajpcell.00125.2012
Reference
PMID:16644802
  Authors
Viollet B, Foretz M, Guigas B, Horman S, Dentin R, Bertrand L, Hue L, Andreelli F
  Title
Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders.
  Journal
J Physiol 574:41-53 (2006)
DOI:10.1113/jphysiol.2006.108506
Reference
PMID:19629071
  Authors
Shackelford DB, Shaw RJ
  Title
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression.
  Journal
Nat Rev Cancer 9:563-75 (2009)
DOI:10.1038/nrc2676
Reference
PMID:22885100
  Authors
Chung JH, Manganiello V, Dyck JR
  Title
Resveratrol as a calorie restriction mimetic: therapeutic implications.
  Journal
Trends Cell Biol 22:546-54 (2012)
DOI:10.1016/j.tcb.2012.07.004
Reference
PMID:20357764
  Authors
Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T
  Title
Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.
  Journal
Nature 464:1313-9 (2010)
DOI:10.1038/nature08991
Reference
PMID:17307971
  Authors
Towler MC, Hardie DG
  Title
AMP-activated protein kinase in metabolic control and insulin signaling.
  Journal
Circ Res 100:328-41 (2007)
DOI:10.1161/01.RES.0000256090.42690.05
Reference
PMID:23899560
  Authors
Richter EA, Hargreaves M
  Title
Exercise, GLUT4, and skeletal muscle glucose uptake.
  Journal
Physiol Rev 93:993-1017 (2013)
DOI:10.1152/physrev.00038.2012
Reference
PMID:16054041
  Authors
Kahn BB, Alquier T, Carling D, Hardie DG
  Title
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.
  Journal
Cell Metab 1:15-25 (2005)
DOI:10.1016/j.cmet.2004.12.003
Reference
PMID:23565491
  Authors
Minokoshi Y, Toda C, Okamoto S
  Title
Regulatory role of leptin in glucose and lipid metabolism in skeletal muscle.
  Journal
Indian J Endocrinol Metab 16:S562-8 (2012)
DOI:10.4103/2230-8210.105573
Reference
PMID:16723978
  Authors
Guggino WB, Stanton BA
  Title
New insights into cystic fibrosis: molecular switches that regulate CFTR.
  Journal
Nat Rev Mol Cell Biol 7:426-36 (2006)
DOI:10.1038/nrm1949
Reference
PMID:16479585
  Authors
Cheng A, Saltiel AR
  Title
More TORC for the gluconeogenic engine.
  Journal
Bioessays 28:231-4 (2006)
DOI:10.1002/bies.20375
Reference
PMID:19197243
  Authors
Herrero-Martin G, Hoyer-Hansen M, Garcia-Garcia C, Fumarola C, Farkas T, Lopez-Rivas A, Jaattela M
  Title
TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells.
  Journal
EMBO J 28:677-85 (2009)
DOI:10.1038/emboj.2009.8
Reference
PMID:19724019
  Authors
Morris DL, Rui L
  Title
Recent advances in understanding leptin signaling and leptin resistance.
  Journal
Am J Physiol Endocrinol Metab 297:E1247-59 (2009)
DOI:10.1152/ajpendo.00274.2009
Reference
PMID:18725075
  Authors
Minokoshi Y, Shiuchi T, Lee S, Suzuki A, Okamoto S
  Title
Role of hypothalamic AMP-kinase in food intake regulation.
  Journal
Nutrition 24:786-90 (2008)
DOI:10.1016/j.nut.2008.06.002
Reference
PMID:23024365
  Authors
Miyamoto L, Ebihara K, Kusakabe T, Aotani D, Yamamoto-Kataoka S, Sakai T, Aizawa-Abe M, Yamamoto Y, Fujikura J, Hayashi T, Hosoda K, Nakao K
  Title
Leptin activates hepatic 5'-AMP-activated protein kinase through sympathetic nervous system and alpha1-adrenergic receptor: a potential mechanism for improvement of fatty liver in lipodystrophy by leptin.
  Journal
J Biol Chem 287:40441-7 (2012)
DOI:10.1074/jbc.M112.384545
Related
pathway
oda00010  Glycolysis / Gluconeogenesis
oda00061  Fatty acid biosynthesis
oda00500  Starch and sucrose metabolism
oda01040  Biosynthesis of unsaturated fatty acids
oda04110  Cell cycle
oda04140  Autophagy - animal
oda04150  mTOR signaling pathway
oda04151  PI3K-Akt signaling pathway
oda04910  Insulin signaling pathway
oda04920  Adipocytokine signaling pathway
KO pathway
ko04152   
LinkDB

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