KEGG   PATHWAY: oda04110
Entry
oda04110                    Pathway                                
Name
Cell cycle - Oryx dammah (scimitar-horned oryx)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
oda04110  Cell cycle
oda04110

Other DBs
GO: 0000278
Organism
Oryx dammah (scimitar-horned oryx) [GN:oda]
Gene
120874144  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
120857878  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
120870130  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
120857506  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
120877860  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
120883039  RB1; retinoblastoma-associated protein [KO:K06618]
120868639  RBL1; retinoblastoma-like protein 1 [KO:K04681]
120873101  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
120852101  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
120862479  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
120854213  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
120871857  histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
120868702  E2F1; transcription factor E2F1 [KO:K17454]
120855099  E2F2; transcription factor E2F2 [KO:K09389]
120870281  E2F3; transcription factor E2F3 [KO:K06620]
120878530  E2F5; transcription factor E2F5 isoform X1 [KO:K04682]
120872765  E2F4; transcription factor E2F4 isoform X1 [KO:K04682]
120883387  TFDP1; transcription factor Dp-1 [KO:K04683]
120858141  TFDP2; transcription factor Dp-2 isoform X1 [KO:K09392]
120871233  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
120872413  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
120880130  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
120852691  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
120881010  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
120852520  mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
120860896  mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
120880976  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
120878883  MYC; myc proto-oncogene protein [KO:K04377]
120880596  ZBTB17; zinc finger and BTB domain-containing protein 17 [KO:K10500]
120862141  cyclin-dependent kinase inhibitor 2A-like isoform X1 [KO:K06621]
120862151  CDKN2B; LOW QUALITY PROTEIN: cyclin-dependent kinase 4 inhibitor B [KO:K04685]
120856165  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
120863969  CDKN2D; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
120858866  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
120874161  CDKN1C; cyclin-dependent kinase inhibitor 1C isoform X1 [KO:K09993]
120870199  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
120878476  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
120873257  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
120857423  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
120878517  S-phase kinase-associated protein 1 [KO:K03094]
120879643  S-phase kinase-associated protein 1-like [KO:K03094]
120870469  S-phase kinase-associated protein 1-like [KO:K03094]
120863662  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
120877870  CUL1; cullin-1 [KO:K03347]
120878126  cullin-1-like [KO:K03347]
120857602  RBX1; E3 ubiquitin-protein ligase RBX1 isoform X1 [KO:K03868] [EC:2.3.2.32]
120879342  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
120883114  CCNA1; cyclin-A1 [KO:K06627]
120861664  CCNA2; cyclin-A2 [KO:K06627]
120867196  CDC6; cell division control protein 6 homolog [KO:K02213]
120872953  CDT1; DNA replication factor Cdt1 [KO:K10727]
120856124  ORC1; origin recognition complex subunit 1 [KO:K02603]
120854632  ORC2; origin recognition complex subunit 2 [KO:K02604]
120862741  ORC3; origin recognition complex subunit 3 isoform X1 [KO:K02605]
120854771  ORC4; origin recognition complex subunit 4 isoform X1 [KO:K02606]
120878155  ORC5; origin recognition complex subunit 5 [KO:K02607]
120872920  ORC6; origin recognition complex subunit 6 isoform X1 [KO:K02608]
120868048  MCM2; DNA replication licensing factor MCM2 [KO:K02540] [EC:5.6.2.3]
120855458  LOW QUALITY PROTEIN: DNA replication licensing factor MCM2-like [KO:K02540] [EC:5.6.2.3]
120870003  MCM3; DNA replication licensing factor MCM3 isoform X1 [KO:K02541] [EC:5.6.2.3]
120878554  MCM4; DNA replication licensing factor MCM4 [KO:K02212] [EC:5.6.2.3]
120858593  MCM5; DNA replication licensing factor MCM5 [KO:K02209] [EC:5.6.2.3]
120854491  MCM6; DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
120879628  MCM7; DNA replication licensing factor MCM7 isoform X1 [KO:K02210] [EC:5.6.2.3]
120871361  CDC45; cell division control protein 45 homolog [KO:K06628]
120875635  TICRR; treslin [KO:K26117]
120878888  mdm2-binding protein [KO:K26116]
120856870  CDC7; cell division cycle 7-related protein kinase [KO:K02214] [EC:2.7.11.1]
120878090  DBF4; protein DBF4 homolog A isoform X1 [KO:K06629]
120867016  DBF4B; protein DBF4 homolog B [KO:K06629]
120865245  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
120879607  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
120853048  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
120882140  CCNB3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
120868903  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
120863610  CDC25C; M-phase inducer phosphatase 3 [KO:K05867] [EC:3.1.3.48]
120878419  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
120851886  YWHAQ; 14-3-3 protein theta [KO:K16197]
120869555  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
120866234  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
120878832  YWHAG; 14-3-3 protein gamma [KO:K16198]
120871275  YWHAH; 14-3-3 protein eta isoform X1 [KO:K16198]
120876160  PLK1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
120868434  serine/threonine-protein kinase PLK1-like [KO:K06631] [EC:2.7.11.21]
120876473  WEE1; wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
120877664  WEE2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
120873903  PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
120863291  CCNH; cyclin-H isoform X1 [KO:K06634]
120879617  CDK7; cyclin-dependent kinase 7 isoform X1 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
120883510  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
120852167  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
120866973  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
120861995  ANAPC4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
120871035  ANAPC5; anaphase-promoting complex subunit 5 [KO:K03352]
120883397  CDC16; cell division cycle protein 16 homolog [KO:K03353]
120871043  ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
120863615  CDC23; cell division cycle protein 23 homolog isoform X1 [KO:K03355]
120881448  anaphase-promoting complex subunit 10-like [KO:K03357]
120870886  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
120866891  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
120876207  anaphase-promoting complex subunit CDC26-like [KO:K03359]
120863368  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
120857456  ANAPC13; anaphase-promoting complex subunit 13 isoform X1 [KO:K12456]
120876725  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
120865322  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
120856283  CDC20; cell division cycle protein 20 homolog [KO:K03363]
120863346  PTTG1; securin isoform X1 [KO:K06635]
120858293  ESPL1; separin [KO:K02365] [EC:3.4.22.49]
120882158  SMC1A; structural maintenance of chromosomes protein 1A isoform X1 [KO:K06636]
120858475  SMC1B; structural maintenance of chromosomes protein 1B isoform X1 [KO:K06636]
120873623  SMC3; structural maintenance of chromosomes protein 3 [KO:K06669]
120878892  RAD21; double-strand-break repair protein rad21 homolog [KO:K06670]
120860714  double-strand-break repair protein rad21 homolog [KO:K06670]
120881496  STAG2; cohesin subunit SA-2 isoform X1 [KO:K06671]
120857552  STAG1; cohesin subunit SA-1 isoform X1 [KO:K06671]
120881927  ATRX; transcriptional regulator ATRX isoform X1 [KO:K10779]
120857869  DDX11; ATP-dependent DNA helicase DDX11 [KO:K11273] [EC:5.6.2.7]
120879349  NIPBL; nipped-B-like protein isoform X1 [KO:K06672]
120864301  MAU2; MAU2 chromatid cohesion factor homolog isoform X1 [KO:K11266]
120881979  HDAC8; histone deacetylase 8 isoform X1 [KO:K11405] [EC:3.5.1.98]
120881125  ESCO1; N-acetyltransferase ESCO1 [KO:K11268] [EC:2.3.1.-]
120861442  ESCO2; N-acetyltransferase ESCO2 [KO:K11268] [EC:2.3.1.-]
120883130  PDS5B; sister chromatid cohesion protein PDS5 homolog B isoform X1 [KO:K11267]
120862051  PDS5A; sister chromatid cohesion protein PDS5 homolog A [KO:K11267]
120865168  WAPL; wings apart-like protein homolog isoform X1 [KO:K25163]
120874680  sororin-like isoform X1 [KO:K17390]
120866011  AURKB; aurora kinase B isoform X1 [KO:K11479] [EC:2.7.11.1]
120880168  SGO1; shugoshin 1 [KO:K11580]
120863659  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
120865628  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
120876226  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
120859757  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
120871966  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
120880045  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
120874655  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
120875176  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
120852839  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
120870107  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
120881104  NDC80; kinetochore protein NDC80 homolog [KO:K11547]
120853204  KNL1; kinetochore scaffold 1 [KO:K11542]
120862915  TTK; dual specificity protein kinase TTK isoform X1 [KO:K08866] [EC:2.7.12.1]
120883331  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
120859915  mitotic spindle assembly checkpoint protein MAD2A-like [KO:K02537]
120860394  LOW QUALITY PROTEIN: mitotic spindle assembly checkpoint protein MAD2A-like [KO:K02537]
120861676  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
120880224  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
120853220  BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
120873895  BUB3; mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
120883515  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
120879281  TRIP13; pachytene checkpoint protein 2 homolog isoform X1 [KO:K22399]
120870088  MAD2L1-binding protein [KO:K26093]
120864800  FZR1; fizzy-related protein homolog isoform X1 [KO:K03364]
120862630  FBXO5; F-box only protein 5 [KO:K10292]
120867115  CDC14B; dual specificity protein phosphatase CDC14B isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
120856799  CDC14A; dual specificity protein phosphatase CDC14A isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
120857601  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
120874330  CREB-binding protein [KO:K04498] [EC:2.3.1.48]
120878553  PRKDC; DNA-dependent protein kinase catalytic subunit [KO:K06642] [EC:2.7.11.1]
120858185  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
120876210  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
120857720  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
120866037  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
120864775  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
120864843  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
120857017  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
120868931  PCNA; proliferating cell nuclear antigen [KO:K04802]
120855107  SFN; 14-3-3 protein sigma [KO:K06644]
120874428  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
120871465  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
120868201  CDC25A; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
Reference
PMID:7908906
  Authors
Matsuoka S, Yamaguchi M, Matsukage A
  Title
D-type cyclin-binding regions of proliferating cell nuclear antigen.
  Journal
J Biol Chem 269:11030-6 (1994)
Reference
PMID:8242749
  Authors
Welch PJ, Wang JY
  Title
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.
  Journal
Cell 75:779-90 (1993)
DOI:10.1016/0092-8674(93)90497-E
Reference
PMID:16936746
  Authors
Macaluso M, Montanari M, Giordano A
  Title
Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes.
  Journal
Oncogene 25:5263-7 (2006)
DOI:10.1038/sj.onc.1209680
Reference
PMID:15838516
  Authors
Cobrinik D
  Title
Pocket proteins and cell cycle control.
  Journal
Oncogene 24:2796-809 (2005)
DOI:10.1038/sj.onc.1208619
Reference
PMID:17568790
  Authors
Boutros R, Lobjois V, Ducommun B
  Title
CDC25 phosphatases in cancer cells: key players? Good targets?
  Journal
Nat Rev Cancer 7:495-507 (2007)
DOI:10.1038/nrc2169
Reference
PMID:9832503
  Authors
Diehl JA, Cheng M, Roussel MF, Sherr CJ
  Title
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
  Journal
Genes Dev 12:3499-511 (1998)
DOI:10.1101/gad.12.22.3499
Reference
PMID:19020303
  Authors
Klein EA, Assoian RK
  Title
Transcriptional regulation of the cyclin D1 gene at a glance.
  Journal
J Cell Sci 121:3853-7 (2008)
DOI:10.1242/jcs.039131
Reference
PMID:10385618
  Authors
Sherr CJ, Roberts JM
  Title
CDK inhibitors: positive and negative regulators of G1-phase progression.
  Journal
Genes Dev 13:1501-12 (1999)
DOI:10.1101/gad.13.12.1501
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:12925736
  Authors
Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K, Nakayama KI
  Title
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
  Journal
Proc Natl Acad Sci U S A 100:10231-6 (2003)
DOI:10.1073/pnas.1831009100
Reference
PMID:16212951
  Authors
Bond M, Sala-Newby GB, Wu YJ, Newby AC
  Title
Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
  Journal
Cardiovasc Res 69:198-206 (2006)
DOI:10.1016/j.cardiores.2005.08.020
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11099028
  Authors
Vogelstein B, Lane D, Levine AJ
  Title
Surfing the p53 network.
  Journal
Nature 408:307-10 (2000)
DOI:10.1038/35042675
Reference
PMID:7973727
  Authors
Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr
  Title
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
  Journal
Science 266:1376-80 (1994)
DOI:10.1126/science.7973727
Reference
PMID:9889196
  Authors
Petersen BO, Lukas J, Sorensen CS, Bartek J, Helin K
  Title
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
  Journal
EMBO J 18:396-410 (1999)
DOI:10.1093/emboj/18.2.396
Reference
PMID:17018296
  Authors
Sheu YJ, Stillman B
  Title
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
  Journal
Mol Cell 24:101-13 (2006)
DOI:10.1016/j.molcel.2006.07.033
Reference
PMID:9029154
  Authors
Martinez AM, Afshar M, Martin F, Cavadore JC, Labbe JC, Doree M
  Title
Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
  Journal
EMBO J 16:343-54 (1997)
DOI:10.1093/emboj/16.2.343
Reference
PMID:15876871
  Authors
Lolli G, Johnson LN
  Title
CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
  Journal
Cell Cycle 4:572-7 (2005)
DOI:10.4161/cc.4.4.1607
Reference
PMID:17426725
  Authors
Musacchio A, Salmon ED
  Title
The spindle-assembly checkpoint in space and time.
  Journal
Nat Rev Mol Cell Biol 8:379-93 (2007)
DOI:10.1038/nrm2163
Reference
PMID:12573239
  Authors
Uhlmann F
  Title
Chromosome cohesion and separation: from men and molecules.
  Journal
Curr Biol 13:R104-14 (2003)
DOI:10.1016/S0960-9822(03)00039-3
Reference
PMID:15568976
  Authors
Stegmeier F, Amon A
  Title
Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
  Journal
Annu Rev Genet 38:203-32 (2004)
DOI:10.1146/annurev.genet.38.072902.093051
Reference
PMID:9618481
  Authors
Moustakas A, Kardassis D
  Title
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
  Journal
Proc Natl Acad Sci U S A 95:6733-8 (1998)
DOI:10.1073/pnas.95.12.6733
Reference
PMID:26650195
  Authors
de Boer HR, Guerrero Llobet S, van Vugt MA
  Title
Controlling the response to DNA damage by the APC/C-Cdh1.
  Journal
Cell Mol Life Sci 73:949-60 (2016)
DOI:10.1007/s00018-015-2096-7
Reference
PMID:20935501
  Authors
Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
  Title
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
  Journal
Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
oda03030  DNA replication
oda04010  MAPK signaling pathway
oda04120  Ubiquitin mediated proteolysis
oda04210  Apoptosis
KO pathway
ko04110   
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