KEGG   PATHWAY: onl04115
Entry
onl04115                    Pathway                                
Name
p53 signaling pathway - Oreochromis niloticus (Nile tilapia)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
onl04115  p53 signaling pathway
onl04115

Organism
Oreochromis niloticus (Nile tilapia) [GN:onl]
Gene
100694314  atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
100708289  chek2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
100712269  atr; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
100707719  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
100689939  gorab; RAB6-interacting golgin [KO:K19748]
100697160  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
100690265  mdm4; protein Mdm4 isoform X1 [KO:K10127]
100702587  p53; cellular tumor antigen p53 isoform X1 [KO:K04451]
100709841  ppp1r13l; relA-associated inhibitor [KO:K27356]
102082412  cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
100698501  cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
100691373  G1/S-specific cyclin-D1 [KO:K04503]
100691051  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
100707642  G1/S-specific cyclin-D2 [KO:K10151]
100712090  G1/S-specific cyclin-D2 [KO:K10151]
100698323  G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
100690263  G1/S-specific cyclin-D2 isoform X1 [KO:K10152]
100710125  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100711614  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
100695113  cyclin-dependent kinase 4 isoform X1 [KO:K02091] [EC:2.7.11.22]
100692568  G1/S-specific cyclin-E2 isoform X2 [KO:K06626]
100696937  ccne1; LOW QUALITY PROTEIN: G1/S-specific cyclin-E1 [KO:K06626]
102075526  G1/S-specific cyclin-E3 isoform X2 [KO:K06626]
100706903  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
100711640  reprimo-like protein [KO:K10128]
100708896  rprm; protein reprimo [KO:K10128]
100708411  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
100692470  G2/mitotic-specific cyclin-B2 isoform X2 [KO:K21770]
100702661  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
100703831  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
100705173  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
100695767  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
100707977  growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
100706093  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
100706356  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
100698715  growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
100707083  gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
100700462  growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
100698065  gtse1; G2 and S phase-expressed protein 1 isoform X1 [KO:K10129]
100704885  LOW QUALITY PROTEIN: zinc finger protein 385A [KO:K26543]
100702076  zinc finger protein 385A isoform X1 [KO:K26543]
102083126  tumor necrosis factor receptor superfamily member 6 [KO:K04390]
100690631  p53-induced death domain-containing protein 1 [KO:K10130]
100706660  tumor necrosis factor receptor superfamily member 26 isoform X3 [KO:K04722]
100697530  tumor necrosis factor receptor superfamily member 10A [KO:K04722]
100702676  caspase-8 [KO:K04398] [EC:3.4.22.61]
100702139  caspase-8 [KO:K04398] [EC:3.4.22.61]
102079913  caspase-8 [KO:K04398] [EC:3.4.22.61]
109194206  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
100699927  uncharacterized protein LOC100699927 [KO:K04726]
106097998  apoptosis regulator BAX [KO:K02159]
109201890  apoptosis regulator BAX [KO:K02159]
100706164  apoptosis regulator BAX [KO:K02159]
100708355  siva1; LOW QUALITY PROTEIN: apoptosis regulatory protein Siva [KO:K22744]
100704382  bcl2l1; bcl-2-like protein 1 [KO:K04570]
100700270  bcl-2-like protein 1 [KO:K04570]
100710191  bcl2; apoptosis regulator Bcl-2 [KO:K02161]
102079353  apoptosis regulator Bcl-2 [KO:K02161]
100704508  tp53i3; quinone oxidoreductase PIG3 [KO:K10133] [EC:1.-.-.-]
100710106  ei24; etoposide-induced protein 2.4 homolog [KO:K10134]
100692477  metacaspase-1 [KO:K10135]
102082295  protein shisa-5 [KO:K10135]
102082447  protein shisa-5 isoform X1 [KO:K10135]
112846911  protein shisa-4-like [KO:K10135]
100692399  perp; p53 apoptosis effector related to PMP-22 [KO:K10136]
100706078  zmat3; zinc finger matrin-type protein 3 [KO:K10137]
100696229  siah1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
100692041  cytochrome c isoform X3 [KO:K08738]
100693973  LOW QUALITY PROTEIN: cytochrome c-a-like [KO:K08738]
100696271  cytochrome c-b [KO:K08738]
100701636  apaf1; apoptotic protease-activating factor 1 [KO:K02084]
100700134  casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
100695417  caspase-3 [KO:K02187] [EC:3.4.22.56]
100695678  caspase-3 [KO:K02187] [EC:3.4.22.56]
100534438  casp3a; caspase 3, apoptosis-related cysteine peptidase a [KO:K02187] [EC:3.4.22.56]
100704027  aifm2; apoptosis-inducing factor 2 [KO:K22745]
100702310  insulin-like growth factor-binding protein 3 isoform X2 [KO:K10138]
102082028  insulin-like growth factor-binding protein 3 [KO:K10138]
100534565  igf1; insulin-like growth factor I precursor [KO:K05459]
100534428  insulin-like growth factor 3 [KO:K05459]
100703589  serpine1; plasminogen activator inhibitor 1 [KO:K03982]
100692892  adgrb1; adhesion G protein-coupled receptor B1 isoform X1 [KO:K04596]
100698212  cd82; CD82 antigen [KO:K06509]
100701053  CD82 antigen [KO:K06509]
100533981  thbs1b; thrombospondin-1 precursor [KO:K16857]
100533982  thrombospondin-1b precursor [KO:K16857]
100709229  ddb2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
100710041  ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
100698853  ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:1.17.4.1]
100699570  ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:1.17.4.1]
100696900  sesn1; sestrin-1 isoform X1 [KO:K10141]
100706543  sestrin-3 isoform X1 [KO:K10141]
100697678  sestrin-2 isoform X1 [KO:K20394]
100695712  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100707201  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100696216  tsc2; tuberin isoform X2 [KO:K07207]
100711547  steap3; metalloreductase STEAP3 [KO:K10142] [EC:1.16.1.-]
100691129  cop1; E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:2.3.2.27]
100709792  rchy1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
100704645  ccng1; cyclin-G1 [KO:K10145]
100696397  cyclin-G2 isoform X1 [KO:K10146]
100691064  cyclin-G2 [KO:K10146]
100702285  protein phosphatase 1D isoform X1 [KO:K10147] [EC:3.1.3.16]
100696917  ppm1d; protein phosphatase 1D [KO:K10147] [EC:3.1.3.16]
100694943  tp73; tumor protein p73 isoform X1 [KO:K10148]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
onl04110  Cell cycle
onl04210  Apoptosis
onl04218  Cellular senescence
KO pathway
ko04115   
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