KEGG   PATHWAY: pchn04120
Entry
pchn04120                   Pathway                                
Name
Ubiquitin mediated proteolysis - Penaeus chinensis (fleshy prawn)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
pchn04120  Ubiquitin mediated proteolysis
pchn04120

Other DBs
GO: 0016567
Organism
Penaeus chinensis (fleshy prawn) [GN:pchn]
Gene
125029641  polyubiquitin-like [KO:K04551]
125027107  polyubiquitin-C [KO:K08770]
125044444  ubiquitin [KO:K02927]
125034162  ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
125031096  ubiquitin-like modifier-activating enzyme 1 isoform X1 [KO:K03178] [EC:6.2.1.45]
125044427  SUMO-activating enzyme subunit 1-like isoform X1 [KO:K10684] [EC:6.2.1.45]
125042615  SUMO-activating enzyme subunit 2-like [KO:K10685] [EC:6.2.1.45]
125027017  NEDD8-activating enzyme E1 catalytic subunit-like [KO:K10686] [EC:6.2.1.64]
125044654  ubiquitin-conjugating enzyme E2 A [KO:K10573] [EC:2.3.2.23]
125046818  ubiquitin-conjugating enzyme E2 C-like [KO:K06688] [EC:2.3.2.23]
125034159  ubiquitin-conjugating enzyme E2 4-like [KO:K06689] [EC:2.3.2.23]
125034180  ubiquitin-conjugating enzyme E2 D2B-like [KO:K06689] [EC:2.3.2.23]
125034202  ubiquitin-conjugating enzyme E2 D2B-like [KO:K06689] [EC:2.3.2.23]
125045510  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
125038876  ubiquitin-conjugating enzyme E2-17 kDa-like [KO:K06689] [EC:2.3.2.23]
125038883  ubiquitin-conjugating enzyme E2-17 kDa-like [KO:K06689] [EC:2.3.2.23]
125024834  ubiquitin-conjugating enzyme E2 E2-like [KO:K20217] [EC:2.3.2.23]
125031444  ubiquitin-conjugating enzyme E2 E1-like [KO:K20217] [EC:2.3.2.23]
125037030  NEDD8-conjugating enzyme UBE2F-like [KO:K10687] [EC:2.3.2.34]
125034442  ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
125027397  ubiquitin-conjugating enzyme E2 H [KO:K10576] [EC:2.3.2.23]
125034503  SUMO-conjugating enzyme UBC9-B [KO:K10577]
125040141  ubiquitin-conjugating enzyme E2 J1-like [KO:K10578] [EC:2.3.2.23]
125044689  ubiquitin-conjugating enzyme E2 J2-like [KO:K04554] [EC:2.3.2.23]
125043239  ubiquitin-conjugating enzyme E2 K-like [KO:K04649] [EC:2.3.2.23]
125030936  ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
125041378  NEDD8-conjugating enzyme Ubc12-like [KO:K10579] [EC:2.3.2.34]
125035329  ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
125031193  ubiquitin-conjugating enzyme E2 Q2-like isoform X1 [KO:K10582] [EC:2.3.2.23]
125044590  ubiquitin-conjugating enzyme E2 R2-like [KO:K02207] [EC:2.3.2.23]
125047692  ubiquitin-conjugating enzyme E2 S-like [KO:K10583] [EC:2.3.2.23]
125033425  ubiquitin-conjugating enzyme E2 W-like isoform X1 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
125043751  ubiquitin-conjugating enzyme E2 Z-like isoform X1 [KO:K10585] [EC:2.3.2.23]
125042121  baculoviral IAP repeat-containing protein 6-like isoform X1 [KO:K10586] [EC:2.3.2.23]
125037827  ubiquitin-protein ligase E3A-like isoform X1 [KO:K10587] [EC:2.3.2.26]
125034565  ubiquitin-protein ligase E3B-like [KO:K10588] [EC:2.3.2.26]
125038891  ubiquitin-protein ligase E3C-like [KO:K10589] [EC:2.3.2.26]
125029165  E3 ubiquitin-protein ligase SMURF1-like isoform X1 [KO:K04678] [EC:2.3.2.26]
125025650  E3 ubiquitin-protein ligase wwp-1-like isoform X1 [KO:K05633] [EC:2.3.2.26]
125035409  E3 ubiquitin-protein ligase TRIP12-like isoform X1 [KO:K10590] [EC:2.3.2.26]
125040596  E3 ubiquitin-protein ligase Nedd-4-like isoform X1 [KO:K10591] [EC:2.3.2.26]
125048286  E3 ubiquitin-protein ligase HUWE1-like isoform X1 [KO:K10592] [EC:2.3.2.26]
125034787  E3 ubiquitin-protein ligase hyd-like isoform X1 [KO:K10593] [EC:2.3.2.26]
125032043  LOW QUALITY PROTEIN: probable E3 ubiquitin-protein ligase HERC1 [KO:K10594] [EC:2.3.2.26]
125029164  E3 ubiquitin-protein ligase HERC2-like isoform X1 [KO:K10595] [EC:2.3.2.26]
125037172  probable E3 ubiquitin-protein ligase HERC4 isoform X1 [KO:K10615] [EC:2.3.2.26]
125026575  ubiquitin conjugation factor E4 A-like [KO:K10596] [EC:2.3.2.27]
125032299  ubiquitin conjugation factor E4 B-like [KO:K10597] [EC:2.3.2.27]
125044767  E3 ubiquitin-protein ligase CHIP-like [KO:K09561] [EC:2.3.2.27]
125033597  RING-type E3 ubiquitin-protein ligase PPIL2-like [KO:K10598] [EC:5.2.1.8]
125033573  pre-mRNA-processing factor 19-like [KO:K10599] [EC:2.3.2.27]
125031536  RING finger protein 37-like [KO:K10600]
125042360  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
125037205  E3 ubiquitin-protein ligase CBL-like [KO:K04707] [EC:2.3.2.27]
125043280  E3 ubiquitin-protein ligase parkin-like [KO:K04556] [EC:2.3.2.31]
125036729  E3 ubiquitin-protein ligase Siah1-like isoform X1 [KO:K04506] [EC:2.3.2.27]
125035846  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
125032140  mitogen-activated protein kinase kinase kinase 1-like isoform X1 [KO:K04416] [EC:2.7.11.25]
125046385  E3 ubiquitin-protein ligase COP1-like isoform X1 [KO:K10143] [EC:2.3.2.27]
125043742  RING finger and CHY zinc finger domain-containing protein 1-like [KO:K10144] [EC:2.3.2.27]
125024666  baculoviral IAP repeat-containing protein 3-like [KO:K16060]
125024832  baculoviral IAP repeat-containing protein 3-like [KO:K16060]
125024867  baculoviral IAP repeat-containing protein 3-like [KO:K16060]
125045792  baculoviral IAP repeat-containing protein 3-like [KO:K16060]
125028178  LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 7-B-like [KO:K04725] [EC:2.3.2.27]
125024828  putative inhibitor of apoptosis [KO:K16061]
125024830  putative inhibitor of apoptosis [KO:K16061]
125047223  death-associated inhibitor of apoptosis 2-like [KO:K16061]
125040715  putative inhibitor of apoptosis [KO:K16061]
125040831  death-associated inhibitor of apoptosis 1-like [KO:K16061]
125037289  E3 SUMO-protein ligase PIAS2-like isoform X1 [KO:K04706] [EC:2.3.2.-]
125041242  uncharacterized protein LOC125041242 [KO:K16063] [EC:2.3.2.-]
125041743  E3 ubiquitin-protein ligase synoviolin B-like [KO:K10601] [EC:2.3.2.27]
125035867  breast cancer type 1 susceptibility protein homolog [KO:K10605] [EC:2.3.2.27]
125034261  E3 ubiquitin-protein ligase FANCL-like isoform X1 [KO:K10606] [EC:2.3.2.27]
125039650  uncharacterized protein LOC125039650 [KO:K10607] [EC:2.3.2.27]
125040500  uncharacterized protein LOC125040500 [KO:K10608] [EC:2.3.2.27]
125046917  RING-box protein 1A [KO:K03868] [EC:2.3.2.32]
125040226  cullin-1-like [KO:K03347]
125043588  S-phase kinase-associated protein 1 isoform X1 [KO:K03094]
125025616  beta-TrCP-like isoform X1 [KO:K03362]
125040493  S-phase kinase-associated protein 2-like isoform X1 [KO:K03875]
125032986  F-box/WD repeat-containing protein 7-like [KO:K10260]
125034334  LOW QUALITY PROTEIN: beta-TrCP-like [KO:K10260]
125046814  cullin-2-like [KO:K03870]
125046786  elongin-C [KO:K03872]
125027935  elongin-B-like [KO:K03873]
125041087  cullin-3-like [KO:K03869]
125046571  LOW QUALITY PROTEIN: kelch-like ECH-associated protein 1B [KO:K10456]
125046785  rho-related BTB domain-containing protein 1-like isoform X1 [KO:K07868]
125048031  cullin-4A-like [KO:K10609]
125043732  DNA damage-binding protein 1-like [KO:K10610]
125046658  DNA damage-binding protein 2-like isoform X1 [KO:K10140]
125034883  DNA excision repair protein ERCC-8-like [KO:K10570]
125044771  DET1 homolog isoform X1 [KO:K10571]
125032735  RING-box protein 2-like [KO:K10611]
125034315  cullin-5-like isoform X1 [KO:K10612]
125035308  anaphase-promoting complex subunit 2-like [KO:K03349]
125031122  cell division cycle protein 20 homolog isoform X1 [KO:K03363]
125040640  fizzy-related protein homolog [KO:K03364]
125048213  anaphase-promoting complex subunit 1-like [KO:K03348]
125033920  cell division cycle protein 27 homolog isoform X1 [KO:K03350]
125030715  anaphase-promoting complex subunit 4-like [KO:K03351]
125034762  anaphase-promoting complex subunit 5-like isoform X1 [KO:K03352]
125043514  cell division cycle protein 16 homolog [KO:K03353]
125044480  anaphase-promoting complex subunit 7-like [KO:K03354]
125027050  cell division cycle protein 23 homolog [KO:K03355]
125029548  LOW QUALITY PROTEIN: anaphase-promoting complex subunit 10-like [KO:K03357]
125041692  anaphase-promoting complex subunit 15B-like [KO:K25228]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
pchn03050  Proteasome
KO pathway
ko04120   
LinkDB

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