KEGG   PATHWAY: pdic04152
Entry
pdic04152                   Pathway                                
Name
AMPK signaling pathway - Phyllostomus discolor (pale spear-nosed bat)
Description
AMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in the cellular AMP:ATP ratio caused by metabolic stresses that either interfere with ATP production (eg, deprivation for glucose or oxygen) or that accelerate ATP consumption (eg, muscle contraction). Several upstream kinases, including liver kinase B1 (LKB1), calcium/calmodulin kinase kinase-beta (CaMKK beta), and TGF-beta-activated kinase-1 (TAK-1), can activate AMPK by phosphorylating a threonine residue on its catalytic alpha-subunit. Once activated, AMPK leads to a concomitant inhibition of energy-consuming biosynthetic pathways, such as protein, fatty acid and glycogen synthesis, and activation of ATP-producing catabolic pathways, such as fatty acid oxidation and glycolysis.
Class
Environmental Information Processing; Signal transduction
Pathway map
pdic04152  AMPK signaling pathway
pdic04152

Other DBs
GO: 2000479
Organism
Phyllostomus discolor (pale spear-nosed bat) [GN:pdic]
Gene
114493958  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
114504186  STK11; serine/threonine-protein kinase STK11 isoform X2 [KO:K07298] [EC:2.7.11.1]
114494472  CAB39; calcium-binding protein 39 [KO:K08272]
114508420  CAB39L; LOW QUALITY PROTEIN: calcium-binding protein 39-like [KO:K08272]
114502698  STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
114494294  STRADB; STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
114508146  leptin isoform X1 [KO:K05424]
114497664  LEPR; leptin receptor isoform X2 [KO:K05062]
114509708  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X4 [KO:K07359] [EC:2.7.11.17]
114503100  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
114490762  ADIPOQ; adiponectin isoform X3 [KO:K07296]
114512381  ADIPOR1; adiponectin receptor protein 1 [KO:K07297]
114512663  ADIPOR2; adiponectin receptor protein 2 [KO:K07297]
114497366  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
114500636  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
114509377  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
114488792  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
114495136  PRKAG3; LOW QUALITY PROTEIN: 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
114512770  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X2 [KO:K07200]
114507622  PRKAG2; LOW QUALITY PROTEIN: 5'-AMP-activated protein kinase subunit gamma-2 [KO:K07200]
114504846  PFKFB1; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 1 isoform X1 [KO:K19028] [EC:2.7.1.105 3.1.3.46]
114511831  PFKFB2; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 isoform X2 [KO:K19029] [EC:2.7.1.105 3.1.3.46]
114492260  PFKFB3; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform X1 [KO:K01103] [EC:2.7.1.105 3.1.3.46]
114501538  PFKFB4; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 4 isoform X4 [KO:K19030] [EC:2.7.1.105 3.1.3.46]
114512571  FBP1; fructose-1,6-bisphosphatase 1 [KO:K03841] [EC:3.1.3.11]
114512582  FBP2; fructose-1,6-bisphosphatase isozyme 2 [KO:K03841] [EC:3.1.3.11]
114490783  PFKL; ATP-dependent 6-phosphofructokinase, liver type [KO:K00850] [EC:2.7.1.11]
114512726  PFKM; ATP-dependent 6-phosphofructokinase, muscle type isoform X1 [KO:K00850] [EC:2.7.1.11]
114492584  ATP-dependent 6-phosphofructokinase, platelet type [KO:K00850] [EC:2.7.1.11]
114506450  HNF4A; hepatocyte nuclear factor 4-alpha isoform X2 [KO:K07292]
114495657  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
114503171  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
114503377  G6PC; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
114492345  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
114506378  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
114488806  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
114490749  LOW QUALITY PROTEIN: CREB-regulated transcription coactivator 2-like [KO:K16333]
114495167  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
114509629  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X3 [KO:K09048]
114488748  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
114503508  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
114499717  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X2 [KO:K09048]
114508155  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
114508223  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X2 [KO:K09047]
114491582  PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
114514987  ELAVL1; ELAV-like protein 1 isoform X1 [KO:K13088]
114500683  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
114502550  CCNA2; cyclin-A2 isoform X2 [KO:K06627]
114508811  CCNA1; cyclin-A1 [KO:K06627]
114501835  EEF2K; LOW QUALITY PROTEIN: eukaryotic elongation factor 2 kinase [KO:K08292] [EC:2.7.11.20]
114503262  EEF2; elongation factor 2 [KO:K03234]
114508586  FOXO1; forkhead box protein O1 [KO:K07201]
114495287  FOXO3; forkhead box protein O3 [KO:K09408]
114495975  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
114514995  SLC2A4; solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
114511006  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
114513100  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
114511611  LIPE; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
114494235  HMGCR; 3-hydroxy-3-methylglutaryl-Coenzyme A reductase [KO:K00021] [EC:1.1.1.34]
114515129  SREBF1; sterol regulatory element-binding protein 1 isoform X8 [KO:K07197]
114502687  FASN; fatty acid synthase isoform X1 [KO:K00665] [EC:2.3.1.85]
114502852  ACACA; acetyl-CoA carboxylase 1 isoform X3 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
114496271  SCD; acyl-CoA desaturase [KO:K00507] [EC:1.14.19.1]
114492317  SCD5; stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
114509274  ACACB; acetyl-CoA carboxylase 2 isoform X1 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
114488311  MLYCD; malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
114499316  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
114513428  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
114511156  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform isoform X2 [KO:K19524] [EC:2.3.1.21]
114506648  CIDEA; cell death activator CIDE-A isoform X1 [KO:K25893]
114508871  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
114509174  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
114511113  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
114499532  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
114502259  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
114509286  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
114496579  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
114492852  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform-like [KO:K04354]
114492681  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
114502139  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
114489878  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
114492604  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
114495708  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
114511826  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
114492375  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
114493014  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
114500382  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
114492690  TBC1D1; TBC1 domain family member 1 isoform X1 [KO:K18341]
114514470  RAB2A; ras-related protein Rab-2A [KO:K07877]
114503502  RAB8A; ras-related protein Rab-8A [KO:K07901]
114498591  RAB10; ras-related protein Rab-10 [KO:K07903]
114502741  RAB11B; ras-related protein Rab-11B [KO:K07905]
114515056  LOW QUALITY PROTEIN: ras-related protein Rab-11B-like [KO:K07905]
114514236  LOW QUALITY PROTEIN: ras-related protein Rab-11B-like [KO:K07905]
114514622  ras-related protein Rab-11B-like [KO:K07905]
114514449  LOW QUALITY PROTEIN: ras-related protein Rab-11B-like [KO:K07905]
114511155  RAB14; ras-related protein Rab-14 [KO:K07881]
114507755  CFTR; cystic fibrosis transmembrane conductance regulator isoform X4 [KO:K05031] [EC:5.6.1.6]
114507608  CD36; platelet glycoprotein 4 [KO:K06259]
114513472  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
114488551  IGF1R; insulin-like growth factor 1 receptor isoform X2 [KO:K05087] [EC:2.7.10.1]
114500824  INS; insulin [KO:K04526]
114509225  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
114494358  IRS1; insulin receptor substrate 1 [KO:K16172]
114508468  IRS2; insulin receptor substrate 2 isoform X2 [KO:K07187]
114505548  IRS4; LOW QUALITY PROTEIN: insulin receptor substrate 4 [KO:K17446]
114497407  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
114490993  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
114501452  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
114496100  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
114502559  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
114501063  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
114495251  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
114510957  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114512350  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114492688  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114509258  TSC2; tuberin isoform X7 [KO:K07207]
114502990  TSC1; LOW QUALITY PROTEIN: hamartin [KO:K07206]
114507715  RHEB; GTP-binding protein Rheb [KO:K07208]
114496034  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
114502272  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
114511038  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
114502684  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
114499422  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
114508926  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
114501975  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
114489729  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
Compound
C00003  NAD+
C00008  ADP
C00020  AMP
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00040  Acyl-CoA
C00076  Calcium cation
C00083  Malonyl-CoA
C00085  D-Fructose 6-phosphate
C00162  Fatty acid
C00354  D-Fructose 1,6-bisphosphate
C00389  Quercetin
C00665  beta-D-Fructose 2,6-bisphosphate
C00668  alpha-D-Glucose 6-phosphate
C00698  Cl-
C00757  Berberine
C01172  beta-D-Glucose 6-phosphate
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07151  Metformin
C09731  Epigallocatechin gallate
D08351  Phenformin (BAN)
Reference
PMID:19584320
  Authors
Steinberg GR, Kemp BE
  Title
AMPK in Health and Disease.
  Journal
Physiol Rev 89:1025-78 (2009)
DOI:10.1152/physrev.00011.2008
Reference
PMID:15509864
  Authors
Hardie DG.
  Title
The AMP-activated protein kinase pathway--new players upstream and downstream.
  Journal
J Cell Sci 117:5479-87 (2004)
DOI:10.1242/jcs.01540
Reference
PMID:23747347
  Authors
Russo GL, Russo M, Ungaro P
  Title
AMP-activated protein kinase: a target for old drugs against diabetes and cancer.
  Journal
Biochem Pharmacol 86:339-50 (2013)
DOI:10.1016/j.bcp.2013.05.023
Reference
PMID:19393004
  Authors
Ronnett GV, Ramamurthy S, Kleman AM, Landree LE, Aja S
  Title
AMPK in the brain: its roles in energy balance and neuroprotection.
  Journal
J Neurochem 109 Suppl 1:17-23 (2009)
DOI:10.1111/j.1471-4159.2009.05916.x
Reference
PMID:20010958
  Authors
Li J, McCullough LD
  Title
Effects of AMP-activated protein kinase in cerebral ischemia.
  Journal
J Cereb Blood Flow Metab 30:480-92 (2010)
DOI:10.1038/jcbfm.2009.255
Reference
PMID:22700795
  Authors
Sanchez AM, Candau RB, Csibi A, Pagano AF, Raibon A, Bernardi H
  Title
The role of AMP-activated protein kinase in the coordination of skeletal muscle turnover and energy homeostasis.
  Journal
Am J Physiol Cell Physiol 303:C475-85 (2012)
DOI:10.1152/ajpcell.00125.2012
Reference
PMID:16644802
  Authors
Viollet B, Foretz M, Guigas B, Horman S, Dentin R, Bertrand L, Hue L, Andreelli F
  Title
Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders.
  Journal
J Physiol 574:41-53 (2006)
DOI:10.1113/jphysiol.2006.108506
Reference
PMID:19629071
  Authors
Shackelford DB, Shaw RJ
  Title
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression.
  Journal
Nat Rev Cancer 9:563-75 (2009)
DOI:10.1038/nrc2676
Reference
PMID:22885100
  Authors
Chung JH, Manganiello V, Dyck JR
  Title
Resveratrol as a calorie restriction mimetic: therapeutic implications.
  Journal
Trends Cell Biol 22:546-54 (2012)
DOI:10.1016/j.tcb.2012.07.004
Reference
PMID:20357764
  Authors
Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T
  Title
Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.
  Journal
Nature 464:1313-9 (2010)
DOI:10.1038/nature08991
Reference
PMID:17307971
  Authors
Towler MC, Hardie DG
  Title
AMP-activated protein kinase in metabolic control and insulin signaling.
  Journal
Circ Res 100:328-41 (2007)
DOI:10.1161/01.RES.0000256090.42690.05
Reference
PMID:23899560
  Authors
Richter EA, Hargreaves M
  Title
Exercise, GLUT4, and skeletal muscle glucose uptake.
  Journal
Physiol Rev 93:993-1017 (2013)
DOI:10.1152/physrev.00038.2012
Reference
PMID:16054041
  Authors
Kahn BB, Alquier T, Carling D, Hardie DG
  Title
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.
  Journal
Cell Metab 1:15-25 (2005)
DOI:10.1016/j.cmet.2004.12.003
Reference
PMID:23565491
  Authors
Minokoshi Y, Toda C, Okamoto S
  Title
Regulatory role of leptin in glucose and lipid metabolism in skeletal muscle.
  Journal
Indian J Endocrinol Metab 16:S562-8 (2012)
DOI:10.4103/2230-8210.105573
Reference
PMID:16723978
  Authors
Guggino WB, Stanton BA
  Title
New insights into cystic fibrosis: molecular switches that regulate CFTR.
  Journal
Nat Rev Mol Cell Biol 7:426-36 (2006)
DOI:10.1038/nrm1949
Reference
PMID:16479585
  Authors
Cheng A, Saltiel AR
  Title
More TORC for the gluconeogenic engine.
  Journal
Bioessays 28:231-4 (2006)
DOI:10.1002/bies.20375
Reference
PMID:19197243
  Authors
Herrero-Martin G, Hoyer-Hansen M, Garcia-Garcia C, Fumarola C, Farkas T, Lopez-Rivas A, Jaattela M
  Title
TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells.
  Journal
EMBO J 28:677-85 (2009)
DOI:10.1038/emboj.2009.8
Reference
PMID:19724019
  Authors
Morris DL, Rui L
  Title
Recent advances in understanding leptin signaling and leptin resistance.
  Journal
Am J Physiol Endocrinol Metab 297:E1247-59 (2009)
DOI:10.1152/ajpendo.00274.2009
Reference
PMID:18725075
  Authors
Minokoshi Y, Shiuchi T, Lee S, Suzuki A, Okamoto S
  Title
Role of hypothalamic AMP-kinase in food intake regulation.
  Journal
Nutrition 24:786-90 (2008)
DOI:10.1016/j.nut.2008.06.002
Reference
PMID:23024365
  Authors
Miyamoto L, Ebihara K, Kusakabe T, Aotani D, Yamamoto-Kataoka S, Sakai T, Aizawa-Abe M, Yamamoto Y, Fujikura J, Hayashi T, Hosoda K, Nakao K
  Title
Leptin activates hepatic 5'-AMP-activated protein kinase through sympathetic nervous system and alpha1-adrenergic receptor: a potential mechanism for improvement of fatty liver in lipodystrophy by leptin.
  Journal
J Biol Chem 287:40441-7 (2012)
DOI:10.1074/jbc.M112.384545
Related
pathway
pdic00010  Glycolysis / Gluconeogenesis
pdic00061  Fatty acid biosynthesis
pdic00500  Starch and sucrose metabolism
pdic01040  Biosynthesis of unsaturated fatty acids
pdic04110  Cell cycle
pdic04140  Autophagy - animal
pdic04150  mTOR signaling pathway
pdic04151  PI3K-Akt signaling pathway
pdic04910  Insulin signaling pathway
pdic04920  Adipocytokine signaling pathway
KO pathway
ko04152   
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