KEGG   PATHWAY: pmrn00310
Entry
pmrn00310                   Pathway                                
Name
Lysine degradation - Petromyzon marinus (sea lamprey)
Class
Metabolism; Amino acid metabolism
Pathway map
pmrn00310  Lysine degradation
pmrn00310

Module
pmrn_M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA [PATH:pmrn00310]
Other DBs
GO: 0006554
Organism
Petromyzon marinus (sea lamprey) [GN:pmrn]
Gene
116942293  AASS; alpha-aminoadipic semialdehyde synthase, mitochondrial [KO:K14157] [EC:1.5.1.8 1.5.1.9]
116942294  alpha-aminoadipic semialdehyde synthase, mitochondrial-like isoform X1 [KO:K14157] [EC:1.5.1.8 1.5.1.9]
116941999  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
116954598  AADAT; kynurenine/alpha-aminoadipate aminotransferase, mitochondrial [KO:K00825] [EC:2.6.1.7 2.6.1.39]
116942487  DHTKD1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial [KO:K15791] [EC:1.2.4.-]
116953965  DLST; dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial [KO:K00658] [EC:2.3.1.61]
116947485  DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
116951945  GCDH; glutaryl-CoA dehydrogenase, mitochondrial [KO:K00252] [EC:1.3.8.6]
116945153  HADHA; trifunctional enzyme subunit alpha, mitochondrial [KO:K07515] [EC:4.2.1.17 1.1.1.211]
116947469  ECHS1; enoyl-CoA hydratase, mitochondrial isoform X1 [KO:K07511] [EC:4.2.1.17]
116950984  HADH; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial [KO:K00022] [EC:1.1.1.35]
116942021  ACAT1; acetyl-CoA acetyltransferase, mitochondrial [KO:K00626] [EC:2.3.1.9]
116956086  hydroxylysine kinase-like [KO:K18201] [EC:2.7.1.81]
116957684  hydroxylysine kinase-like [KO:K18201] [EC:2.7.1.81]
116957686  hydroxylysine kinase-like [KO:K18201] [EC:2.7.1.81]
116957688  LOW QUALITY PROTEIN: hydroxylysine kinase-like [KO:K18201] [EC:2.7.1.81]
116957689  hydroxylysine kinase-like [KO:K18201] [EC:2.7.1.81]
116950669  hydroxylysine kinase-like [KO:K18201] [EC:2.7.1.81]
116950823  hydroxylysine kinase-like [KO:K18201] [EC:2.7.1.81]
116950824  hydroxylysine kinase-like isoform X1 [KO:K18201] [EC:2.7.1.81]
116937932  hydroxylysine kinase-like [KO:K18201] [EC:2.7.1.81]
116939198  PIPOX; peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
116947693  CAMKMT; calmodulin-lysine N-methyltransferase [KO:K18826] [EC:2.1.1.60]
116942478  KMT2E; inactive histone-lysine N-methyltransferase 2E isoform X1 [KO:K09189] [EC:2.1.1.354]
116942974  SETD7; histone-lysine N-methyltransferase SETD7 [KO:K11431] [EC:2.1.1.364]
116956621  oocyte zinc finger protein XlCOF6-like isoform X1 [KO:K20796] [EC:2.1.1.354]
116937520  histone-lysine N-methyltransferase PRDM9-like [KO:K20796] [EC:2.1.1.354]
116937522  histone-lysine N-methyltransferase PRDM9-like [KO:K20796] [EC:2.1.1.354]
116937523  probable histone-lysine N-methyltransferase PRDM7 [KO:K20796] [EC:2.1.1.354]
116954923  ASH1L; histone-lysine N-methyltransferase ASH1L [KO:K06101] [EC:2.1.1.354]
116942143  histone-lysine N-methyltransferase ASH1L-like [KO:K06101] [EC:2.1.1.354]
116947374  histone-lysine N-methyltransferase SMYD3-like isoform X1 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
116947389  SMYD2; N-lysine methyltransferase SMYD2 isoform X1 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
116941256  histone-lysine N-methyltransferase Smyd1-like [KO:K11426] [EC:2.1.1.354 2.1.1.357]
116958796  SMYD1; histone-lysine N-methyltransferase SMYD1 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
116942370  SUV39H2; histone-lysine N-methyltransferase SUV39H2 [KO:K11419] [EC:2.1.1.355]
116944821  histone-lysine N-methyltransferase EHMT2-like isoform X1 [KO:K11420] [EC:2.1.1.355]
116939538  histone-lysine N-methyltransferase SETDB1-like isoform X1 [KO:K11421] [EC:2.1.1.366]
116941022  EZH2; histone-lysine N-methyltransferase EZH2 isoform X1 [KO:K11430] [EC:2.1.1.356]
116952266  histone-lysine N-methyltransferase SETMAR-like isoform X1 [KO:K11433] [EC:2.1.1.357]
116940694  histone-lysine N-methyltransferase NSD2-like isoform X1 [KO:K11424] [EC:2.1.1.357]
116941181  histone-lysine N-methyltransferase NSD2-like [KO:K11424] [EC:2.1.1.357]
116940988  SETD2; histone-lysine N-methyltransferase SETD2 isoform X1 [KO:K11423] [EC:2.1.1.359]
116943593  DOT1L; histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 [KO:K11427] [EC:2.1.1.360]
116944662  KMT5A; N-lysine methyltransferase KMT5A isoform X1 [KO:K11428] [EC:2.1.1.361]
116942008  PRDM6; putative histone-lysine N-methyltransferase PRDM6 [KO:K20795] [EC:2.1.1.361]
116939989  histone-lysine N-methyltransferase KMT5B-like isoform X1 [KO:K11429] [EC:2.1.1.362]
116945526  uncharacterized protein LOC116945526 isoform X1 [KO:K11429] [EC:2.1.1.362]
116950399  MDS1 and EVI1 complex locus protein EVI1-A-like [KO:K04462] [EC:2.1.1.367]
116946935  histone-lysine N-methyltransferase MECOM-like isoform X1 [KO:K22410] [EC:2.1.1.367]
116957152  TMLHE; trimethyllysine dioxygenase, mitochondrial [KO:K00474] [EC:1.14.11.8]
116936860  aldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
116958558  LOW QUALITY PROTEIN: aldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
116937977  aldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
116944424  ALDH16A1; LOW QUALITY PROTEIN: aldehyde dehydrogenase family 16 member A1 [KO:K00128] [EC:1.2.1.3]
116939079  aldehyde dehydrogenase family 3 member A2-like isoform X1 [KO:K00128] [EC:1.2.1.3]
116944976  ALDH9A1; 4-trimethylaminobutyraldehyde dehydrogenase isoform X1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
116950548  procollagen-lysine,2-oxoglutarate 5-dioxygenase 1-like [KO:K00473] [EC:1.14.11.4]
116946915  procollagen-lysine,2-oxoglutarate 5-dioxygenase 2-like isoform X1 [KO:K13645] [EC:1.14.11.4]
116939825  procollagen-lysine,2-oxoglutarate 5-dioxygenase 1-like [KO:K13646] [EC:1.14.11.4 2.4.1.50 2.4.1.66]
116953107  inactive glycosyltransferase 25 family member 3-like [KO:K11703] [EC:2.4.1.50]
116947119  procollagen galactosyltransferase 1-like [KO:K11703] [EC:2.4.1.50]
116944981  procollagen galactosyltransferase 1-like [KO:K11703] [EC:2.4.1.50]
Compound
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00037  Glycine
C00042  Succinate
C00047  L-Lysine
C00068  Thiamin diphosphate
C00136  Butanoyl-CoA
C00164  Acetoacetate
C00322  2-Oxoadipate
C00332  Acetoacetyl-CoA
C00408  L-Pipecolate
C00431  5-Aminopentanoate
C00449  N6-(L-1,3-Dicarboxypropyl)-L-lysine
C00450  (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate
C00487  Carnitine
C00489  Glutarate
C00527  Glutaryl-CoA
C00739  D-Lysine
C00877  Crotonoyl-CoA
C00956  L-2-Aminoadipate
C00990  5-Aminopentanamide
C01087  (R)-2-Hydroxyglutarate
C01142  (3S)-3,6-Diaminohexanoate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01149  4-Trimethylammoniobutanal
C01181  4-Trimethylammoniobutanoate
C01186  (3S,5S)-3,5-Diaminohexanoate
C01211  Procollagen 5-hydroxy-L-lysine
C01259  (3S)-3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
C01672  Cadaverine
C02188  Protein lysine
C02727  N6-Acetyl-L-lysine
C03087  5-Acetamidopentanoate
C03196  (S)-2-Hydroxyglutarate
C03239  6-Amino-2-oxohexanoate
C03273  5-Oxopentanoate
C03366  5-Phosphooxy-L-lysine
C03656  (S)-5-Amino-3-oxohexanoic acid
C03793  N6,N6,N6-Trimethyl-L-lysine
C04020  D-Lysopine
C04076  L-2-Aminoadipate 6-semialdehyde
C04092  Delta1-Piperideine-2-carboxylate
C04487  5-(D-Galactosyloxy)-L-lysine-procollagen
C05161  (2R,5S)-2,5-Diaminohexanoate
C05231  L-3-Aminobutyryl-CoA
C05544  Protein N6-methyl-L-lysine
C05545  Protein N6,N6-dimethyl-L-lysine
C05546  Protein N6,N6,N6-trimethyl-L-lysine
C05548  6-Acetamido-2-oxohexanoate
C05825  2-Amino-5-oxohexanoate
C06157  [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine
C12455  5-Aminopentanal
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16741  L-Hydroxylysine
C22667  4-Carboxy-1-hydroxybutyryl-ThPP
Reference
PMID:11802770
  Authors
Vaz FM, Wanders RJ.
  Title
Carnitine biosynthesis in mammals.
  Journal
Biochem J 361:417-29 (2002)
DOI:10.1042/bj3610417
Reference
PMID:1682209
  Authors
Large PJ, Robertson A.
  Title
The route of lysine breakdown in Candida tropicalis.
  Journal
FEMS Microbiol Lett 66:209-13 (1991)
DOI:10.1111/j.1574-6968.1990.tb03998.x
Related
pathway
pmrn00020  Citrate cycle (TCA cycle)
pmrn00300  Lysine biosynthesis
pmrn00780  Biotin metabolism
KO pathway
ko00310   
LinkDB

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