KEGG   PATHWAY: pprm04150
Entry
pprm04150                   Pathway                                
Name
mTOR signaling pathway - Pimephales promelas (fathead minnow)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
pprm04150  mTOR signaling pathway
pprm04150

Organism
Pimephales promelas (fathead minnow) [GN:pprm]
Gene
120460327  slc7a5; large neutral amino acids transporter small subunit 1 [KO:K13780]
120470108  4F2 cell-surface antigen heavy chain-like [KO:K06519]
120470356  zgc:158423; 4F2 cell-surface antigen heavy chain [KO:K06519]
120494695  slc3a2b; solute carrier family 3 member 2b [KO:K06519]
120482355  slc38a9; sodium-coupled neutral amino acid transporter 9 [KO:K14995]
120476058  atp6v1ab; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
120470431  atp6v1aa; ATPase H+ transporting V1 subunit Aa [KO:K02145] [EC:7.1.2.2]
120483202  atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
120478169  atp6v1ba; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
120466755  atp6v1c2; V-type proton ATPase subunit C 1-B [KO:K02148]
120485409  atp6v1c1b; V-type proton ATPase subunit C 1-B [KO:K02148]
120471186  atp6v1c1a; V-type proton ATPase subunit C 1-A [KO:K02148]
120491952  atp6v1d; V-type proton ATPase subunit D [KO:K02149]
120476659  atp6v1e1b; V-type proton ATPase subunit E 1 [KO:K02150]
120458997  atp6v1e1a; V-type proton ATPase subunit E 1a [KO:K02150]
120476964  atp6v1f; V-type proton ATPase subunit F [KO:K02151]
120471938  atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
120482298  atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
120470790  lamtor1; ragulator complex protein LAMTOR1 isoform X1 [KO:K20397]
120481453  lamtor2; ragulator complex protein LAMTOR2 [KO:K20398]
120479781  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
120476967  lamtor4; ragulator complex protein LAMTOR4 [KO:K20399]
120469184  lamtor5; ragulator complex protein LAMTOR5 [KO:K16344]
120469860  flcn; folliculin [KO:K09594]
120473626  fnip1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
120493632  fnip2; folliculin-interacting protein 2 isoform X1 [KO:K20401]
120494862  rraga; ras-related GTP-binding protein A [KO:K16185]
120483696  rragcb; ras-related GTP binding Cb [KO:K16186]
120484463  rragca; ras-related GTP binding Ca [KO:K16186]
120479231  rragd; ras-related GTP-binding protein D [KO:K16186]
120485231  sesn2; sestrin-2 [KO:K20394]
120470252  castor1; cytosolic arginine sensor for mTORC1 subunit 1 [KO:K23080]
120472077  castor2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
120471132  mios; GATOR complex protein MIOS [KO:K20407]
120485347  seh1l; nucleoporin SEH1 isoform X1 [KO:K14299]
120495129  nucleoporin SEH1-like [KO:K14299]
120479386  wdr24; GATOR complex protein WDR24 [KO:K20408]
120464875  wdr59; GATOR complex protein WDR59 isoform X1 [KO:K20409]
120495403  sec13; protein SEC13 homolog [KO:K14004]
120482410  depdc5; LOW QUALITY PROTEIN: GATOR complex protein DEPDC5 [KO:K20404]
120466948  nprl2; GATOR complex protein NPRL2 [KO:K20405]
120489253  nprl3; GATOR complex protein NPRL3 isoform X1 [KO:K20406]
120494628  skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
120482786  rnf152; E3 ubiquitin-protein ligase rnf152 [KO:K15705] [EC:2.3.2.27]
120467212  rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
120489305  akt1s1; histone H3.v1 [KO:K16184]
120483559  mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
120484798  deptor; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
120480704  si:dkeyp-97e7.9; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
120487959  mlst8; target of rapamycin complex subunit lst8 [KO:K08266]
120479832  telo2; telomere length regulation protein TEL2 homolog [KO:K11137]
120481011  tti1; TELO2-interacting protein 1 homolog isoform X1 [KO:K20403]
120482726  clip1b; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
120471879  clip1a; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
120483549  grb10a; growth factor receptor-bound protein 10a [KO:K20064]
120477501  growth factor receptor-bound protein 10-like isoform X1 [KO:K20064]
120482907  lpin2; phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
120467924  zgc:123305 [KO:K15728] [EC:3.1.3.4]
120477488  lpin1a; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
120460349  lpin1b; phosphatidate phosphatase LPIN1 [KO:K15728] [EC:3.1.3.4]
120486900  phosphatidate phosphatase LPIN2-like [KO:K15728] [EC:3.1.3.4]
120490747  ulk1b; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
120485819  ulk1a; serine/threonine-protein kinase ULK1a isoform X1 [KO:K21357] [EC:2.7.11.1]
120478628  ulk2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
120490804  eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
120460828  eif4ea; eukaryotic translation initiation factor 4E-1A [KO:K03259]
120479305  eif4e1c; eukaryotic translation initiation factor 4E family member 1c isoform X1 [KO:K03259]
120471749  eif4e1b; eukaryotic translation initiation factor 4E-1B [KO:K03259]
120479549  eif4eb; eukaryotic translation initiation factor 4eb [KO:K03259]
120463317  eif4e2rs1; eukaryotic translation initiation factor 4E family member 2 related sequence 1 isoform X1 [KO:K03259]
120495304  eif4e2; eukaryotic translation initiation factor 4E type 2 [KO:K03259]
120483149  rps6kb1a; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
120478835  rps6kb1b; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
120491438  eif4bb; eukaryotic translation initiation factor 4Bb isoform X1 [KO:K03258]
120463161  eif4ba; eukaryotic translation initiation factor 4Ba isoform X1 [KO:K03258]
120491299  rps6; 40S ribosomal protein S6 [KO:K02991]
120489668  strada; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
120461117  stradb; STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
120471323  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
120475017  cab39l1; calcium binding protein 39, like 1 isoform X1 [KO:K08272]
120490462  cab39l; calcium-binding protein 39-like [KO:K08272]
120478943  cab39; calcium-binding protein 39 [KO:K08272]
120469577  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
120493933  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
120490767  tsc1b; TSC complex subunit 1b [KO:K07206]
120490776  hamartin-like [KO:K07206]
120469653  tsc1a; TSC complex subunit 1a isoform X1 [KO:K07206]
120488524  tsc2; tuberin isoform X1 [KO:K07207]
120492030  tbc1d7; TBC1 domain family member 7 isoform X1 [KO:K20396]
120466957  rhebl1; ras homolog, mTORC1 binding like 1 [KO:K07208]
120488072  GTP-binding protein Rheb-like [KO:K07208]
120488073  rheb; GTP-binding protein Rheb [KO:K07208]
120462343  ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
120463643  wnt1; protein Wnt-1 [KO:K03209]
120484036  wnt2bb; wingless-type MMTV integration site family, member 2Bb isoform X1 [KO:K00182]
120493943  wnt2ba; wingless-type MMTV integration site family, member 2Ba [KO:K00182]
120487629  wnt2; protein Wnt-2 [KO:K00182]
120484207  wnt3a; protein Wnt-3a [KO:K00312]
120471546  wnt3; proto-oncogene Wnt-3 isoform X1 [KO:K00312]
120484742  wnt4b; wingless-type MMTV integration site family, member 4b [KO:K00408]
120480813  wnt4; protein Wnt-4a isoform X1 [KO:K00408]
120481302  wnt5a; protein Wnt-5a [KO:K00444]
120476625  wnt5b; protein Wnt-5b isoform X1 [KO:K00444]
120466700  wnt6b; protein Wnt-6 [KO:K00445]
120491709  wnt6a; protein Wnt-6 isoform X1 [KO:K00445]
120476994  wnt7ba; protein Wnt-7b [KO:K00572]
120491826  protein Wnt-7a [KO:K00572]
120460451  wnt7bb; protein Wnt-7b isoform X1 [KO:K00572]
120480792  wnt7aa; wingless-type MMTV integration site family, member 7Aa [KO:K00572]
120474366  wnt8a; protein Wnt-8a ORF1 [KO:K00714]
120474368  protein Wnt-8a ORF2 [KO:K00714]
120479342  wnt8b; protein Wnt-8b isoform X1 [KO:K00714]
120489400  wnt9b; protein Wnt-9b [KO:K01064]
120484208  wnt9a; protein Wnt-9a [KO:K01064]
120466703  wnt10a; protein Wnt-10a [KO:K01357]
120463641  wnt10b; protein Wnt-10b isoform X1 [KO:K01357]
120483248  wnt11; protein Wnt-11 [KO:K01384]
120461814  wnt11f2; protein Wnt-11 [KO:K01384]
120476775  wnt16; protein Wnt-16 [KO:K01558]
120491593  fzd7b; frizzled-7b [KO:K02432]
120471176  fzd1; frizzled-1 [KO:K02432]
120487057  fzd7a; frizzled-7a [KO:K02432]
120489225  fzd2; frizzled-2 [KO:K02235]
120485985  fzd3b; LOW QUALITY PROTEIN: frizzled-3b [KO:K02329]
120493566  fzd3a; frizzled-3a isoform X1 [KO:K02329]
120470831  fzd4; frizzled-4 [KO:K02354]
120482221  frizzled-8-like [KO:K02375]
120482222  frizzled-8-like [KO:K02375]
120475808  fzd8a; frizzled-8a [KO:K02375]
120486320  fzd5; frizzled-5 [KO:K02375]
120487907  frizzled-6-like [KO:K02376]
120487908  LOW QUALITY PROTEIN: frizzled-6-like [KO:K02376]
120459880  fzd9b; frizzled-9b [KO:K02842]
120485582  fzd10; frizzled-10 [KO:K02842]
120472252  fzd9a; frizzled-9 [KO:K02842]
120468208  lrp5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
120470899  lrp6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
120482843  dvl3a; segment polarity protein dishevelled homolog DVL-3a [KO:K02353]
120459909  segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
120470251  dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
120495188  dvl1b; segment polarity protein dishevelled homolog DVL-1b [KO:K02353]
120480699  segment polarity protein dishevelled homolog DVL-1-like [KO:K02353]
120463562  dvl1a; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
120490965  gsk3bb; glycogen synthase kinase 3 beta, genome duplicate b [KO:K03083] [EC:2.7.11.26]
120487004  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
120485191  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
120495090  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
120489071  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
120460588  insb; preproinsulin b [KO:K04526]
120461675  ins; insulin [KO:K04526]
120477039  igf1; insulin-like growth factor I [KO:K05459]
120465058  insra; insulin receptor a [KO:K04527] [EC:2.7.10.1]
120486240  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
120486241  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
120469797  igf1rb; insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
120487871  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
120493186  grb2a; growth factor receptor-bound protein 2a isoform X1 [KO:K04364]
120462249  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
120467750  sos2; son of sevenless homolog 2 [KO:K03099]
120492108  sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
120464885  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
120473360  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
120489627  zgc:55558 [KO:K07827]
120458984  kras; GTPase KRas isoform X1 [KO:K07827]
120474677  nras; GTPase NRas [KO:K07828]
120476837  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
120460946  raf1b; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
120479037  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
120487665  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
120471345  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
120495436  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
120469811  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
120488967  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
120470374  rps6ka3a; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
120486113  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
120494820  rps6kal; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
120463322  rps6ka2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
120488338  rps6ka3b; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
120478817  irs1; insulin receptor substrate 1-B isoform X1 [KO:K16172]
120482851  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
120460087  pik3r3b; LOW QUALITY PROTEIN: phosphoinositide-3-kinase, regulatory subunit 3b (gamma) [KO:K02649]
120472399  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
120468781  pik3r3a; phosphoinositide-3-kinase, regulatory subunit 3a (gamma) [KO:K02649]
120468782  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
120464703  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
120463328  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
120463436  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
120480566  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
120490695  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
120467450  ptena; phosphatase and tensin homolog A isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
120489359  pdpk1a; 3-phosphoinositide-dependent protein kinase 1a [KO:K06276] [EC:2.7.11.1]
120479594  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
120473888  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120476176  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120479738  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120473207  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120489082  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120479686  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
120465357  mapkap1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
120490722  rictorb; rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
120469999  rictora; rapamycin-insensitive companion of mTOR [KO:K08267]
120469086  prr5a; proline-rich protein 5a [KO:K20411]
120469257  proline-rich protein 5-like isoform X1 [KO:K20411]
120469282  prr5l; proline-rich protein 5-like [KO:K20411]
120470907  prr5b; proline-rich protein 5 isoform X1 [KO:K20411]
120473952  rhoac; rho-related GTP-binding protein RhoA-C [KO:K04513]
120473953  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
120483844  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
120483860  rhocb; rho-related GTP-binding protein RhoA-D [KO:K04513]
120493692  rhoca; ras homolog family member Ca [KO:K04513]
120486480  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
120481535  si:ch73-374l24.1; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
120466805  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
120462903  prkcba; protein kinase C, beta a isoform X1 [KO:K19662] [EC:2.7.11.13]
120489096  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
120484709  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
120484280  sgk2b; serine/threonine-protein kinase Sgk2b [KO:K13302] [EC:2.7.11.1]
120485289  si:ch211-195b13.1; STKc_SGK domain-containing protein isoform X1 [KO:K13302] [EC:2.7.11.1]
120463096  sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
pprm00561  Glycerolipid metabolism
pprm04010  MAPK signaling pathway
pprm04140  Autophagy - animal
pprm04810  Regulation of actin cytoskeleton
pprm04910  Insulin signaling pathway
KO pathway
ko04150   
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