KEGG   PATHWAY: pprm04520
Entry
pprm04520                   Pathway                                
Name
Adherens junction - Pimephales promelas (fathead minnow)
Description
Cell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation. At AJs, E-cadherin serves as an essential cell adhesion molecules (CAMs). The cytoplasmic tail binds beta-catenin, which in turn binds alpha-catenin. Alpha-catenin is associated with F-actin bundles directly and indirectly. The integrity of the cadherin-catenin complex is negatively regulated by phosphorylation of beta-catenin by receptor tyrosine kinases (RTKs) and cytoplasmic tyrosine kinases (Fer, Fyn, Yes, and Src), which leads to dissociation of the cadherin-catenin complex. Integrity of this complex is positively regulated by beta -catenin phosphorylation by casein kinase II, and dephosphorylation by protein tyrosine phosphatases. Changes in the phosphorylation state of beta-catenin affect cell-cell adhesion, cell migration and the level of signaling beta-catenin. Wnt signaling acts as a positive regulator of beta-catenin by inhibiting beta-catenin degradation, which stabilizes beta-catenin, and causes its accumulation. Cadherin may acts as a negative regulator of signaling beta-catenin as it binds beta-catenin at the cell surface and thereby sequesters it from the nucleus. Nectins also function as CAMs at AJs, but are more highly concentrated at AJs than E-cadherin. Nectins transduce signals through Cdc42 and Rac, which reorganize the actin cytoskeleton, regulate the formation of AJs, and strengthen cell-cell adhesion.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
pprm04520  Adherens junction
pprm04520

Other DBs
GO: 0005912
Organism
Pimephales promelas (fathead minnow) [GN:pprm]
Gene
120459883  nectin1b; nectin cell adhesion molecule 1b [KO:K06081]
120494737  nectin1a; nectin cell adhesion molecule 1a isoform X1 [KO:K06081]
120483500  pvrl2l; PVR cell adhesion molecule related 2 like isoform X1 [KO:K06531]
120484351  si:ch73-22o12.1; poliovirus receptor homolog isoform X1 [KO:K06531]
120490760  nectin3b; nectin-3-like protein isoform X1 [KO:K06592]
120459754  si:ch211-222f23.6; nectin-3 isoform X1 [KO:K06592]
120478492  nectin3a; nectin-3-like protein [KO:K06592]
120470131  nectin4a; nectin-4 isoform X1 [KO:K06593]
120471317  nectin4b; nectin-4 [KO:K06593]
120492272  pard3aa; partitioning defective 3 homolog [KO:K04237]
120495320  pard3ab; LOW QUALITY PROTEIN: par-3 family cell polarity regulator alpha, b [KO:K04237]
120463324  src; LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
120493080  farp2; FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1 [KO:K06082]
120484761  cdc42l; cell division cycle 42, like [KO:K04393]
120463350  cdc42l2; cell division cycle 42 like 2 isoform X1 [KO:K04393]
120480475  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
120463965  rac1a; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
120481534  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
120490585  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
120460263  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
120489161  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
120489651  rac3a; ras-related C3 botulinum toxin substrate 3a [KO:K07861]
120469017  rac3b; ras-related C3 botulinum toxin substrate 3b isoform X1 [KO:K07861]
120469264  wasla; WASP like actin nucleation promoting factor a isoform X1 [KO:K23612]
120483426  wasa; wiskott-Aldrich syndrome protein homolog [KO:K05747]
120469231  wasb; WASP actin nucleation promoting factor b [KO:K05747]
120464781  ras GTPase-activating-like protein IQGAP1 [KO:K16848]
120489936  baiap2a; brain-specific angiogenesis inhibitor 1-associated protein 2a isoform X1 [KO:K05627]
120474703  baiap2b; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
120462642  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 [KO:K05627]
120462665  zgc:158689; brain-specific angiogenesis inhibitor 1-associated protein 2 [KO:K05627]
120492016  wasf1; wiskott-Aldrich syndrome protein family member 1 [KO:K05753]
120485216  wasf2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
120476070  wasf3b; wiskott-Aldrich syndrome protein family member 3b [KO:K06083]
120462612  zgc:109889; wiskott-Aldrich syndrome protein family member 3 isoform X1 [KO:K06083]
120472392  wasf3a; wiskott-Aldrich syndrome protein family member 3 [KO:K06083]
120473696  si:ch73-362m14.4; LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein family member 3 [KO:K06083]
120493963  afdna; afadin isoform X1 [KO:K05702]
120466749  lmo7a; LIM domain only protein 7 isoform X1 [KO:K06084]
120477208  afadin- and alpha-actinin-binding protein-like [KO:K06085]
120477302  afadin- and alpha-actinin-binding protein-like isoform X1 [KO:K06085]
120460542  si:ch211-286b5.4; afadin- and alpha-actinin-binding protein isoform X1 [KO:K06085]
120481083  ssx2ipa; synovial sarcoma, X breakpoint 2 interacting protein a isoform X1 [KO:K06085]
120479520  sorbin and SH3 domain-containing protein 1 isoform X1 [KO:K06086]
120467709  actn1; alpha-actinin-1 isoform X1 [KO:K05699]
120470717  actn4; alpha-actinin-4 isoform X1 [KO:K05699]
120461957  vclb; vinculin b [KO:K05700]
120479560  vcla; vinculin a isoform X1 [KO:K05700]
120475995  tjp1a; tight junction protein ZO-1 isoform X1 [KO:K05701]
120459093  tjp1b; tight junction protein ZO-1 isoform X1 [KO:K05701]
120492656  cdh1; cadherin-1 [KO:K05689]
120491642  ctnnd1; catenin delta-1 isoform X1 [KO:K05690]
120465202  ctnnb1; catenin beta-1 isoform X1 [KO:K02105]
120483600  catenin beta-1-like [KO:K02105]
120491421  ctnna2; catenin alpha-2 isoform X1 [KO:K05691]
120461133  ctnna1; catenin alpha-1 [KO:K05691]
120489986  actb2; actin, cytoplasmic 2 [KO:K05692]
120463340  actb1; actin, cytoplasmic 1 [KO:K05692]
120473952  rhoac; rho-related GTP-binding protein RhoA-C [KO:K04513]
120473953  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
120483844  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
120483860  rhocb; rho-related GTP-binding protein RhoA-D [KO:K04513]
120493692  rhoca; ras homolog family member Ca [KO:K04513]
120486480  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
120463553  acp1; low molecular weight phosphotyrosine protein phosphatase isoform X1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
120467819  ptprma; protein tyrosine phosphatase receptor type Ma isoform X1 [KO:K05693] [EC:3.1.3.48]
120471340  receptor-type tyrosine-protein phosphatase mu-like [KO:K05693] [EC:3.1.3.48]
120478390  LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase beta-like [KO:K05694] [EC:3.1.3.48]
120470644  ptprb; receptor-type tyrosine-protein phosphatase beta [KO:K05694] [EC:3.1.3.48]
120470648  receptor-type tyrosine-protein phosphatase beta-like [KO:K05694] [EC:3.1.3.48]
120482810  ptprfb; receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:3.1.3.48]
120467899  ptprfa; protein tyrosine phosphatase receptor type Fa isoform X1 [KO:K05695] [EC:3.1.3.48]
120484216  ptpn1; tyrosine-protein phosphatase non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
120484723  ptpn6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
120490994  ptprja; receptor-type tyrosine-protein phosphatase eta isoform X1 [KO:K05698] [EC:3.1.3.48]
120473381  receptor-type tyrosine-protein phosphatase eta isoform X1 [KO:K05698] [EC:3.1.3.48]
120483424  zgc:86598; STKc_CK2_alpha domain-containing protein [KO:K03097] [EC:2.7.11.1]
120483425  casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
120484737  csnk2a1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
120460368  csnk2a2b; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
120492709  csnk2a2a; casein kinase 2, alpha prime polypeptide a [KO:K03097] [EC:2.7.11.1]
120473398  csnk2a4; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
120485350  csnk2b; casein kinase II subunit beta [KO:K03115]
120473621  tcf7; transcription factor 7 isoform X1 [KO:K02620]
120474207  tcf7l1a; transcription factor 7-like 1-A [KO:K04490]
120481307  tcf7l1b; transcription factor 7-like 1-B isoform X1 [KO:K04490]
120474612  tcf7l2; transcription factor 7-like 2 isoform X1 [KO:K04491]
120491182  lef1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
120469797  igf1rb; insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
120487871  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
120465058  insra; insulin receptor a [KO:K04527] [EC:2.7.10.1]
120486240  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
120486241  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
120458971  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
120463339  epidermal growth factor receptor-like isoform X1 [KO:K04361] [EC:2.7.10.1]
120488261  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
120467144  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
120482211  fibroblast growth factor receptor 1-A-like [KO:K04362] [EC:2.7.10.1]
120481189  fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
120472237  fer; tyrosine-protein kinase Fer [KO:K08889] [EC:2.7.10.2]
120467769  tyrosine-protein kinase fynb isoform X1 [KO:K05703] [EC:2.7.10.2]
120479329  fyna; tyrosine-protein kinase fyna [KO:K05703] [EC:2.7.10.2]
120482328  yes1; tyrosine-protein kinase yes [KO:K05705] [EC:2.7.10.2]
120469811  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
120488967  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
120488331  snai2; zinc finger protein SNAI2 [KO:K05706]
120491800  snai1b; snail family zinc finger 1b [KO:K05707]
120480717  snai1a; snail family zinc finger 1a [KO:K05707]
120482409  tgfbr1a; TGF-beta receptor type-1a [KO:K04674] [EC:2.7.11.30]
120475734  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
120461610  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
120462277  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
120491009  smad3a; mothers against decapentaplegic homolog 3a [KO:K23605]
120460054  mothers against decapentaplegic homolog 3-like [KO:K23605]
120487810  smad3b; LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 3b [KO:K23605]
120489318  smad4; mothers against decapentaplegic homolog 4 [KO:K04501]
120484418  smad10b; mothers against decapentaplegic homolog 4 [KO:K04501]
120485002  smad10a; mothers against decapentaplegic homolog 4 [KO:K04501]
120478430  smad4a; mothers against decapentaplegic homolog 4a isoform X1 [KO:K04501]
120464026  ep300a; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
120489504  CREB-binding protein-like [KO:K04498] [EC:2.3.1.48]
120462301  ep300b; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
120495222  crebbpa; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
120493637  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
120473200  nlk2; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
120489136  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
120481047  cdh5; cadherin-5 [KO:K06533]
120461535  heg1; protein HEG [KO:K24472]
120485238  krit1; krev interaction trapped protein 1 [KO:K17705]
120494192  ccm2; cerebral cavernous malformations protein 2 homolog isoform X1 [KO:K26416]
120464843  pdcd10a; programmed cell death protein 10-A [KO:K18269]
120488940  pdcd10b; programmed cell death protein 10-B [KO:K18269]
120489455  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
120462253  smurf2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
120484123  rap1aa; RAP1A, member of RAS oncogene family a isoform X1 [KO:K04353]
120476984  rap1b; ras-related protein Rap-1b [KO:K07836]
120484348  rasip1; ras-interacting protein 1 [KO:K26417]
120468846  radil; ras-associating and dilute domain-containing protein isoform X1 [KO:K26418]
120474878  si:ch73-281f12.4; RA_Radil_like and Myo5p-like_CBD_Rasip1 domain-containing protein [KO:K26418]
120464364  ras-associating and dilute domain-containing protein-like [KO:K26418]
120468583  arhgap29b; rho GTPase-activating protein 29 isoform X1 [KO:K20644]
120488121  arhgap29a; rho GTPase-activating protein 29 isoform X1 [KO:K20644]
120468740  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
120493647  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
120479411  rock2a; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
120471636  myl2a; myosin regulatory light chain 2a isoform X1 [KO:K10351]
120481296  myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
120473556  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
120467926  myl9b; myosin regulatory light polypeptide 9b [KO:K12755]
120463800  myl9a; myosin regulatory light polypeptide 9 [KO:K12755]
120481944  myl10; myosin regulatory light chain 10 [KO:K12756]
120482763  myl12.2; myosin, light chain 12, genome duplicate 2 [KO:K12757]
120477405  myl12.1; myosin, light chain 12, genome duplicate 1 isoform X1 [KO:K12757]
120489373  mylpfa; LOW QUALITY PROTEIN: myosin light chain, phosphorylatable, fast skeletal muscle a [KO:K12758]
120488829  mylpfb; myosin light chain, phosphorylatable, fast skeletal muscle b [KO:K12758]
Reference
PMID:15001769
  Authors
Nelson WJ, Nusse R.
  Title
Convergence of Wnt, beta-catenin, and cadherin pathways.
  Journal
Science 303:1483-7 (2004)
DOI:10.1126/science.1094291
Reference
PMID:10204118
  Authors
Potter E, Bergwitz C, Brabant G.
  Title
The cadherin-catenin system: implications for growth and differentiation of endocrine tissues.
  Journal
Endocr Rev 20:207-39 (1999)
DOI:10.1210/edrv.20.2.0362
Reference
PMID:10959047
  Authors
Beavon IR.
  Title
The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation.
  Journal
Eur J Cancer 36:1607-20 (2000)
DOI:10.1016/S0959-8049(00)00158-1
Reference
PMID:15489912
  Authors
Reynolds AB, Roczniak-Ferguson A.
  Title
Emerging roles for p120-catenin in cell adhesion and cancer.
  Journal
Oncogene 23:7947-56 (2004)
DOI:10.1038/sj.onc.1208161
Reference
PMID:11171368
  Authors
Angst BD, Marcozzi C, Magee AI.
  Title
The cadherin superfamily: diversity in form and function.
  Journal
J Cell Sci 114:629-41 (2001)
Reference
PMID:11984870
  Authors
Lilien J, Balsamo J, Arregui C, Xu G.
  Title
Turn-off, drop-out: functional state switching of cadherins.
  Journal
Dev Dyn 224:18-29 (2002)
DOI:10.1002/dvdy.10087
Reference
PMID:12640114
  Authors
Piedra J, Miravet S, Castano J, Palmer HG, Heisterkamp N, Garcia de Herreros A, Dunach M.
  Title
p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction.
  Journal
Mol Cell Biol 23:2287-97 (2003)
DOI:10.1128/MCB.23.7.2287-2297.2003
Reference
PMID:14623871
  Authors
Conacci-Sorrell M, Simcha I, Ben-Yedidia T, Blechman J, Savagner P, Ben-Ze'ev A.
  Title
Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK.
  Journal
J Cell Biol 163:847-57 (2003)
DOI:10.1083/jcb.200308162
Reference
PMID:11703922
  Authors
Ciruna B, Rossant J.
  Title
FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak.
  Journal
Dev Cell 1:37-49 (2001)
DOI:10.1016/S1534-5807(01)00017-X
Reference
PMID:12665527
  Authors
Peinado H, Quintanilla M, Cano A.
  Title
Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions.
  Journal
J Biol Chem 278:21113-23 (2003)
DOI:10.1074/jbc.M211304200
Reference
PMID:10890911
  Authors
Labbe E, Letamendia A, Attisano L.
  Title
Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways.
  Journal
Proc Natl Acad Sci U S A 97:8358-63 (2000)
DOI:10.1073/pnas.150152697
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Related
pathway
pprm04010  MAPK signaling pathway
pprm04060  Cytokine-cytokine receptor interaction
pprm04310  Wnt signaling pathway
pprm04350  TGF-beta signaling pathway
pprm04530  Tight junction
pprm04810  Regulation of actin cytoskeleton
KO pathway
ko04520   
LinkDB

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