KEGG   PATHWAY: prob04723
Entry
prob04723                   Pathway                                
Name
Retrograde endocannabinoid signaling - Phodopus roborovskii (desert hamster)
Description
Endogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic acid; the two best characterized are arachydonoyl ethanolamide (anandamide, AEA) and 2-arachydonoil glycerol (2AG). They are released from postsynaptic neurons upon postsynaptic depolarization and/or receptor activation. The released endocannabinoids then activate the CB1 receptors (CB1R) at presynaptic terminals and suppress the release of inhibitory transmitter GABA (depolarization-induced suppression of inhibition, DSI) or excitatory transmitter glutamate (depolarization-induced suppression of excitation, DSE) by inhibiting Ca2+ channels. Besides the well-known expression of the CB1R in the plasma membrane, this receptor is also present in mitochondrial membranes, where it reduces the mitochondrial respiration and contributes to DSI. Whereas DSI and DSE result in short-term synaptic plasticity, endocannabinoids also mediate long-term synaptic changes (eCB-LTD). Persistent activation of CB1 receptors over a period of minutes triggers eCB-LTD by a RIM1alpha-dependent mechanism.
Class
Organismal Systems; Nervous system
Pathway map
prob04723  Retrograde endocannabinoid signaling
prob04723

Other DBs
GO: 0071926
Organism
Phodopus roborovskii (desert hamster) [GN:prob]
Gene
127237877  Slc17a8; vesicular glutamate transporter 3 [KO:K12302]
127213716  Slc17a7; vesicular glutamate transporter 1 [KO:K12302]
127213833  Slc17a6; vesicular glutamate transporter 2 [KO:K12302]
127219258  Gria1; glutamate receptor 1 [KO:K05197]
127232868  Gria2; glutamate receptor 2 isoform X1 [KO:K05198]
127217657  Gria3; glutamate receptor 3 isoform X1 [KO:K05199]
127216913  Gria4; glutamate receptor 4 isoform X1 [KO:K05200]
127236163  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
127236838  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
127218370  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
127221312  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
127237692  metabotropic glutamate receptor 1 [KO:K04603]
127237766  LOW QUALITY PROTEIN: metabotropic glutamate receptor 1-like [KO:K04603]
127227874  Grm5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
127229038  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
127228774  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
127221390  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
127221392  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
127221647  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
127236214  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
127213143  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
127224232  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
127214392  Napepld; N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D [KO:K13985] [EC:3.1.4.54]
127218483  Prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
127228289  Prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
127238613  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
127228845  Dagla; diacylglycerol lipase-alpha [KO:K13806] [EC:3.1.1.116]
127237145  Daglb; diacylglycerol lipase-beta isoform X1 [KO:K13806] [EC:3.1.1.116]
127223393  Ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
127238196  Abhd6; monoacylglycerol lipase ABHD6 isoform X1 [KO:K13700] [EC:3.1.1.23]
127225189  Faah; fatty-acid amide hydrolase 1 [KO:K15528] [EC:3.5.1.99]
127224475  Cnr1; cannabinoid receptor 1 [KO:K04277]
127216863  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
127236958  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
127214410  Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
127230018  Gnao1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
127213531  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
127237177  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
127212957  Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
127223334  Gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
127231981  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
127228816  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
127229769  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
127216480  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
127222509  Kcnj3; G protein-activated inward rectifier potassium channel 1 [KO:K04997]
127227550  Kcnj6; G protein-activated inward rectifier potassium channel 2 isoform X1 [KO:K05000]
127223613  Kcnj9; G protein-activated inward rectifier potassium channel 3 [KO:K05002]
127231511  Kcnj5; G protein-activated inward rectifier potassium channel 4 [KO:K04999]
127229890  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
127222557  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
127228340  Mapk3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
127216731  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
127226948  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
127235390  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
127219360  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
127232178  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
127224210  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
127224217  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
127225455  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
127225941  Mapk12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
127225942  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
127233912  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
127220711  Adcy2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
127220046  Adcy3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
127230359  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
127227112  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
127226028  Adcy6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
127229980  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
127235293  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
127219617  Adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
127229872  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
127229917  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
127235989  Mgll; monoglyceride lipase isoform X1 [KO:K01054] [EC:3.1.1.23]
30213863  BOP69_gp13; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
30213866  BOP69_gp12; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
30213875  BOP69_gp06; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
30213853  BOP69_gp04; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
30213876  BOP69_gp05; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
30213879  BOP69_gp03; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
30213855  BOP69_gp02; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
127228621  Ndufv1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
127226765  Ndufv2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
127224173  Ndufv3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial [KO:K03944]
127235179  Ndufa2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
127225561  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
127238962  Ndufa3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
127215662  Ndufa4l2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
127227199  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
127215318  Ndufa4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
127215361  Ndufa5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
127225860  Ndufa6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
127217788  Ndufa7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
127222829  Ndufa8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
127212845  Ndufa9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
127218502  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial-like [KO:K03954]
127226704  Ndufa10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
127228294  Ndufab1; acyl carrier protein, mitochondrial [KO:K03955]
127216779  Ndufa11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
127237896  Ndufa12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
127217171  Ndufa13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
127214232  Ndufb2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
127226334  Ndufb3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
127213479  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
127227152  Ndufb4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
127227382  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
127223336  Ndufb5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
127224505  Ndufb6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
127229861  Ndufb7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
127233334  Ndufb8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
127235381  Ndufb9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
127219546  Ndufb10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
127218277  Ndufb11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
127230881  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial-like [KO:K11351]
127237386  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial-like [KO:K11351]
127226362  Ndufs1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
127223568  Ndufs2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
127222286  Ndufs3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
127225317  Ndufs5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
127231389  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
127233027  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
127220858  Ndufs6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
127216631  Ndufs7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
127228614  Ndufs8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
127216294  Ndufc1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
127227923  Ndufc2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
127224425  Slc32a1; vesicular inhibitory amino acid transporter [KO:K15015]
127236603  Rims1; regulating synaptic membrane exocytosis protein 1 [KO:K15291]
127217304  Gabra3; gamma-aminobutyric acid receptor subunit alpha-3 [KO:K05175]
127219410  Gabra1; gamma-aminobutyric acid receptor subunit alpha-1 isoform X1 [KO:K05175]
127219412  Gabra6; gamma-aminobutyric acid receptor subunit alpha-6 [KO:K05175]
127232106  Gabra4; gamma-aminobutyric acid receptor subunit alpha-4 isoform X1 [KO:K05175]
127232293  Gabra2; gamma-aminobutyric acid receptor subunit alpha-2 [KO:K05175]
127213876  Gabra5; gamma-aminobutyric acid receptor subunit alpha-5 [KO:K05175]
127219413  Gabrb2; gamma-aminobutyric acid receptor subunit beta-2 [KO:K05181]
127232107  Gabrb1; gamma-aminobutyric acid receptor subunit beta-1 isoform X1 [KO:K05181]
127213874  Gabrb3; gamma-aminobutyric acid receptor subunit beta-3 isoform X1 [KO:K05181]
127219414  Gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 isoform X1 [KO:K05186]
127232340  Gabrg1; gamma-aminobutyric acid receptor subunit gamma-1 [KO:K05186]
127213817  Gabrg3; gamma-aminobutyric acid receptor subunit gamma-3 isoform X1 [KO:K05186]
127213522  Gabrd; gamma-aminobutyric acid receptor subunit delta [KO:K05184]
127217301  Gabre; gamma-aminobutyric acid receptor subunit epsilon [KO:K05185]
127217303  Gabrq; gamma-aminobutyric acid receptor subunit theta isoform X1 [KO:K05192]
127219436  Gabrp; gamma-aminobutyric acid receptor subunit pi [KO:K05189]
127224450  Gabrr2; gamma-aminobutyric acid receptor subunit rho-2 [KO:K05190]
127224451  gamma-aminobutyric acid receptor subunit rho-1 [KO:K05190]
127227364  Gabrr3; gamma-aminobutyric acid receptor subunit rho-3 [KO:K05190]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00116  Glycerol
C00157  Phosphatidylcholine
C00165  Diacylglycerol
C00189  Ethanolamine
C00219  Arachidonate
C00238  Potassium cation
C00334  4-Aminobutanoate
C00350  Phosphatidylethanolamine
C00427  Prostaglandin H2
C00575  3',5'-Cyclic AMP
C00689  alpha,alpha'-Trehalose 6-phosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C11695  Anandamide
C13856  2-Arachidonoylglycerol
C19912  N-Arachidonoyl-phosphatidylethanolamine
C19913  Phospho-anandamide
Reference
PMID:17419048
  Authors
Hashimotodani Y, Ohno-Shosaku T, Kano M
  Title
Ca(2+)-assisted receptor-driven endocannabinoid release: mechanisms that associate presynaptic and postsynaptic activities.
  Journal
Curr Opin Neurobiol 17:360-5 (2007)
DOI:10.1016/j.conb.2007.03.012
Reference
PMID:21531987
  Authors
Ohno-Shosaku T, Tanimura A, Hashimotodani Y, Kano M
  Title
Endocannabinoids and retrograde modulation of synaptic transmission.
  Journal
Neuroscientist 18:119-32 (2012)
DOI:10.1177/1073858410397377
Reference
PMID:18084639
  Authors
Basavarajappa BS
  Title
Neuropharmacology of the endocannabinoid signaling system-molecular mechanisms, biological actions and synaptic plasticity.
  Journal
Curr Neuropharmacol 5:81-97 (2007)
DOI:10.2174/157015907780866910
Reference
PMID:16968947
  Authors
Pacher P, Batkai S, Kunos G
  Title
The endocannabinoid system as an emerging target of pharmacotherapy.
  Journal
Pharmacol Rev 58:389-462 (2006)
DOI:10.1124/pr.58.3.2
Reference
PMID:15340387
  Authors
Di Marzo V, Bifulco M, De Petrocellis L
  Title
The endocannabinoid system and its therapeutic exploitation.
  Journal
Nat Rev Drug Discov 3:771-84 (2004)
DOI:10.1038/nrd1495
Reference
PMID:17404373
  Authors
Hashimotodani Y, Ohno-Shosaku T, Kano M
  Title
Endocannabinoids and synaptic function in the CNS.
  Journal
Neuroscientist 13:127-37 (2007)
DOI:10.1177/1073858406296716
Reference
PMID:19126760
  Authors
Kano M, Ohno-Shosaku T, Hashimotodani Y, Uchigashima M, Watanabe M
  Title
Endocannabinoid-mediated control of synaptic transmission.
  Journal
Physiol Rev 89:309-80 (2009)
DOI:10.1152/physrev.00019.2008
Reference
PMID:19640475
  Authors
Regehr WG, Carey MR, Best AR
  Title
Activity-dependent regulation of synapses by retrograde messengers.
  Journal
Neuron 63:154-70 (2009)
DOI:10.1016/j.neuron.2009.06.021
Reference
PMID:17636069
  Authors
Benarroch E
  Title
Endocannabinoids in basal ganglia circuits: implications for Parkinson disease.
  Journal
Neurology 69:306-9 (2007)
DOI:10.1212/01.wnl.0000267407.79757.75
Reference
PMID:16085309
  Authors
Ohno-Shosaku T, Hashimotodani Y, Maejima T, Kano M
  Title
Calcium signaling and synaptic modulation: regulation of endocannabinoid-mediated synaptic modulation by calcium.
  Journal
Cell Calcium 38:369-74 (2005)
DOI:10.1016/j.ceca.2005.06.014
Reference
PMID:18801434
  Authors
Harkany T, Mackie K, Doherty P
  Title
Wiring and firing neuronal networks: endocannabinoids take center stage.
  Journal
Curr Opin Neurobiol 18:338-45 (2008)
DOI:10.1016/j.conb.2008.08.007
Reference
PMID:18515270
  Authors
Hosking RD, Zajicek JP
  Title
Therapeutic potential of cannabis in pain medicine.
  Journal
Br J Anaesth 101:59-68 (2008)
DOI:10.1093/bja/aen119
Reference
PMID:21187849
  Authors
Di Marzo V
  Title
Endocannabinoid signaling in the brain: biosynthetic mechanisms in the limelight.
  Journal
Nat Neurosci 14:9-15 (2011)
DOI:10.1038/nn.2720
Reference
PMID:18948642
  Authors
McPartland JM
  Title
The endocannabinoid system: an osteopathic perspective.
  Journal
J Am Osteopath Assoc 108:586-600 (2008)
DOI:10.7556/jaoa.2008.108.10.586
Reference
PMID:17553427
  Authors
Chevaleyre V, Heifets BD, Kaeser PS, Sudhof TC, Castillo PE
  Title
Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1alpha.
  Journal
Neuron 54:801-12 (2007)
DOI:10.1016/j.neuron.2007.05.020
Reference
PMID:19553483
  Authors
Lafourcade CA
  Title
Presynaptic mechanisms of endocannabinoid-mediated long-term depression in the hippocampus.
  Journal
J Neurophysiol 102:2009-12 (2009)
DOI:10.1152/jn.00441.2009
Reference
PMID:21328621
  Authors
Ueda N, Tsuboi K, Uyama T, Ohnishi T
  Title
Biosynthesis and degradation of the endocannabinoid 2-arachidonoylglycerol.
  Journal
Biofactors 37:1-7 (2011)
DOI:10.1002/biof.131
Reference
PMID:14978245
  Authors
Guo J, Ikeda SR
  Title
Endocannabinoids modulate N-type calcium channels and G-protein-coupled inwardly rectifying potassium channels via CB1 cannabinoid receptors heterologously expressed in mammalian neurons.
  Journal
Mol Pharmacol 65:665-74 (2004)
DOI:10.1124/mol.65.3.665
Reference
PMID:22388959
  Authors
Benard G, Massa F, Puente N, Lourenco J, Bellocchio L, Soria-Gomez E, Matias I, Delamarre A, Metna-Laurent M, Cannich A, Hebert-Chatelain E, Mulle C, Ortega-Gutierrez S, Martin-Fontecha M, Klugmann M, Guggenhuber S, Lutz B, Gertsch J, Chaouloff F, Lopez-Rodriguez ML, Grandes P, Rossignol R, Marsicano G
  Title
Mitochondrial CB(1) receptors regulate neuronal energy metabolism.
  Journal
Nat Neurosci 15:558-64 (2012)
DOI:10.1038/nn.3053
Reference
PMID:26260530
  Authors
Busquets-Garcia A, Desprez T, Metna-Laurent M, Bellocchio L, Marsicano G, Soria-Gomez E
  Title
Dissecting the cannabinergic control of behavior: The where matters.
  Journal
Bioessays 37:1215-25 (2015)
DOI:10.1002/bies.201500046
Reference
PMID:28076767
  Authors
Harkany T, Horvath TL
  Title
(S)Pot on Mitochondria: Cannabinoids Disrupt Cellular Respiration to Limit Neuronal Activity.
  Journal
Cell Metab 25:8-10 (2017)
DOI:10.1016/j.cmet.2016.12.020
Reference
PMID:22449955
  Authors
Alger BE, Tang AH
  Title
Do cannabinoids reduce brain power?
  Journal
Nat Neurosci 15:499-501 (2012)
DOI:10.1038/nn.3072
Related
pathway
prob00190  Oxidative phosphorylation
prob04020  Calcium signaling pathway
prob04721  Synaptic vesicle cycle
prob04724  Glutamatergic synapse
prob04727  GABAergic synapse
KO pathway
ko04723   
LinkDB

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