KEGG   PATHWAY: prob04020
Entry
prob04020                   Pathway                                
Name
Calcium signaling pathway - Phodopus roborovskii (desert hamster)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
prob04020  Calcium signaling pathway
prob04020

Other DBs
GO: 0019722
Organism
Phodopus roborovskii (desert hamster) [GN:prob]
Gene
127212842  Fgf6; fibroblast growth factor 6 [KO:K04358]
127212923  Plcz1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
127212936  Grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
127212948  Fgf23; fibroblast growth factor 23 [KO:K22428]
127213143  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
127213172  Htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
127213474  Calml6; calmodulin-like protein 6 [KO:K02183]
127213605  Cckar; cholecystokinin receptor type A isoform X1 [KO:K04194]
127213641  Stim2; stromal interaction molecule 2 [KO:K18196]
127213665  Grin2d; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
127213676  Hrc; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
127213936  Sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
127213944  Fgf21; fibroblast growth factor 21 [KO:K22429]
127214138  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
127214148  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
127214320  Chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
127214367  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
127214533  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
127214725  Tgfa; LOW QUALITY PROTEIN: protransforming growth factor alpha [KO:K08774]
127214887  Slc8a1; sodium/calcium exchanger 1 [KO:K05849]
127214928  Calm2; calmodulin-2 [KO:K02183]
127214942  Lhcgr; lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
127215010  Trdn; triadin [KO:K23449]
127215290  [KO:K04197]
127215335  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
127215359  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
127215621  Erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
127215698  Avpr1a; vasopressin V1a receptor [KO:K04226]
127215916  P2rx2; P2X purinoceptor 2 [KO:K05216]
127216013  Nos1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
127216020  Tpcn1; two pore channel protein 1 [KO:K16896]
127216072  Atp2a2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
127216073  P2rx4; P2X purinoceptor 4 isoform X1 [KO:K05218]
127216075  P2rx7; P2X purinoceptor 7 [KO:K05220]
127216081  Orai1; calcium release-activated calcium channel protein 1 [KO:K16056]
127216147  Ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
127216565  Gna15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
127216566  Gna11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
127216567  Tbxa2r; thromboxane A2 receptor [KO:K04264]
127216648  Grin3b; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
127216811  Fgf22; fibroblast growth factor 22 [KO:K04358]
127216911  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
127217029  Plcd3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
127217333  Atp2b3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
127217422  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
127217671  Cysltr1; cysteinyl leukotriene receptor 1 [KO:K04322]
127217733  [KO:K05863]
127217734  Grpr; gastrin-releasing peptide receptor [KO:K04169]
127217897  Htr2c; 5-hydroxytryptamine receptor 2C [KO:K04157]
127217902  Phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
127217938  Phka1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
127218188  Vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
127218370  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
127218438  Fgf16; fibroblast growth factor 16 [KO:K04358]
127218483  Prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
127218748  Cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
127218827  Nos2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
127218948  P2rx1; P2X purinoceptor 1 [KO:K05215]
127218951  P2rx5; P2X purinoceptor 5 [KO:K05219]
127218952  Atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
127219023  Grin2c; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
127219155  Adora2b; adenosine receptor A2b [KO:K04267]
127219298  Vdac1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
127219362  Flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
127219401  Adra1b; alpha-1B adrenergic receptor [KO:K04136]
127219441  Fgf18; fibroblast growth factor 18 isoform X1 [KO:K04358]
127219495  Sphk1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
127219617  Adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
127219678  Grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
127220046  Adcy3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
127220323  Vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
127220342  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
127220380  Adrb3; beta-3 adrenergic receptor [KO:K04143]
127220441  Fgf20; fibroblast growth factor 20 [KO:K04358]
127220532  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
127220558  Vegfc; vascular endothelial growth factor C [KO:K05449]
127220624  Gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
127220711  Adcy2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
127221091  F2r; proteinase-activated receptor 1 [KO:K03914]
127221173  Fgf10; fibroblast growth factor 10 [KO:K04358]
127221312  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
127221390  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
127221392  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
127221415  Adra1d; alpha-1D adrenergic receptor [KO:K04137]
127221516  Fgf7; fibroblast growth factor 7 isoform X1 [KO:K04358]
127221612  Itpka; inositol-trisphosphate 3-kinase A isoform X1 [KO:K00911] [EC:2.7.1.127]
127221647  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
127221769  Chrm5; muscarinic acetylcholine receptor M5 [KO:K04133]
127221779  Ryr3; ryanodine receptor 3 [KO:K04963]
127222299  P2rx3; P2X purinoceptor 3 [KO:K05217]
127222365  Pde1a; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
127222557  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
127222586  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
127222787  Gnas; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
127222868  [KO:K04632]
127222969  Ppp3ca; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
127222984  Tacr3; neuromedin-K receptor [KO:K04224]
127223042  Egf; pro-epidermal growth factor [KO:K04357]
127223054  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
127223148  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
127223216  [KO:K17332]
127223306  Fgf2; fibroblast growth factor 2 [KO:K18497]
127223377  Agtr1; type-1 angiotensin II receptor [KO:K04166]
127223426  Cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
127223580  [KO:K02183]
127223607  Casq1; calsequestrin-1 [KO:K23468]
127223688  Itpkb; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
127223763  Tnnc2; troponin C, skeletal muscle [KO:K12042]
127223968  Camk1g; calcium/calmodulin-dependent protein kinase type 1G isoform X1 [KO:K08794] [EC:2.7.11.17]
127223994  Mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
127224014  Tacr2; substance-K receptor [KO:K04223]
127224093  Adora2a; adenosine receptor A2a [KO:K04266]
127224232  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
127224331  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
127224690  Grin3a; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3A [KO:K05213]
127224691  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
127225333  [KO:K17332]
127225470  Ptafr; platelet-activating factor receptor [KO:K04279]
127225799  Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
127225818  Cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
127225856  [KO:K05213]
127226177  Pde1b; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
127226409  Erbb4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
127226437  Plcd4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
127226644  Htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
127226926  P2rx6; P2X purinoceptor 6 isoform X1 [KO:K05221]
127227109  Mylk; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
127227742  Fgf4; fibroblast growth factor 4 [KO:K04358]
127227743  Fgf19; fibroblast growth factor 19 [KO:K22603]
127227818  Fgf3; fibroblast growth factor 3 [KO:K04358]
127227874  Grm5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
127228012  Stim1; stromal interaction molecule 1 isoform X1 [KO:K16059]
127228093  Cckbr; gastrin/cholecystokinin type B receptor [KO:K04195]
127228289  Prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
127228318  Atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
127228393  Phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
127228399  Orai3; protein orai-3 [KO:K16058]
127228434  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
127228600  Tpcn2; two pore channel protein 2 [KO:K14077]
127228642  Mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
127228774  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
127228778  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
127228801  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
127229038  [KO:K04634]
127229039  [KO:K04636]
127229167  Ntrk2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
127229199  Fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
127229221  Hrh2; histamine H2 receptor [KO:K04150]
127229224  Drd1; D(1A) dopamine receptor [KO:K04144]
127229364  Mylk4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
127229374  [KO:K04166]
127229776  Ryr2; ryanodine receptor 2 [KO:K04962]
127229782  Chrm3; muscarinic acetylcholine receptor M3 [KO:K04131]
127229809  [KO:K02183]
127229810  Calml5; calmodulin-like protein 5 [KO:K02183]
127229844  Camk1d; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
127229864  Ptger1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
127229872  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
127229890  [KO:K04344]
127229893  Mcoln2; mucolipin-2 [KO:K04993]
127229900  Mcoln3; mucolipin-3 [KO:K04994]
127229917  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
127229930  Mylk3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
127229936  Phkb; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
127229980  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
127230119  Ednrb; endothelin receptor type B [KO:K04198]
127230183  Htr2a; 5-hydroxytryptamine receptor 2A [KO:K04157]
127230191  Cysltr2; cysteinyl leukotriene receptor 2 [KO:K04323]
127230204  Ptgfr; prostaglandin F2-alpha receptor [KO:K04262]
127230207  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
127230240  Adra1a; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
127230243  Ptk2b; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
127230328  Fgf9; fibroblast growth factor 9 [KO:K04358]
127230357  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
127230359  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
127230370  Ltb4r2; leukotriene B4 receptor 2 [KO:K04297]
127230406  Ptger3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
127230491  Fgf17; fibroblast growth factor 17 [KO:K04358]
127230929  Slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
127231044  Bdkrb1; B1 bradykinin receptor [KO:K03915]
127231063  Calm1; calmodulin-1 [KO:K02183]
127231120  Bdkrb2; B2 bradykinin receptor [KO:K03916]
127231660  Asph; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
127231862  Calml4; calmodulin-like protein 4 [KO:K02183]
127232123  Fgf5; fibroblast growth factor 5 [KO:K04358]
127232306  Pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
127232486  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
127232596  Casq2; calsequestrin-2 [KO:K23445]
127232683  Ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
127232870  Pdgfc; platelet-derived growth factor C [KO:K05450]
127232874  Ngf; beta-nerve growth factor [KO:K02582]
127233219  Htr7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
127233311  Adrb1; beta-1 adrenergic receptor [KO:K04141]
127233323  Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
127233388  Fgf8; fibroblast growth factor 8 [KO:K04358]
127233635  Cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
127233656  Drd5; D(1B) dopamine receptor [KO:K05840]
127233692  Cd38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
127233728  Fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
127233865  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
127233912  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
127233970  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
127233971  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
127234052  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
127234079  Gnal; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
127234142  Adrb2; beta-2 adrenergic receptor [KO:K04142]
127234192  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
127234263  Pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
127234302  Htr4; 5-hydroxytryptamine receptor 4 [KO:K04160]
127234503  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
127234604  [KO:K04282]
127234658  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
127235059  Plcd1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
127235061  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
127235144  Camk4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
127235260  Trhr; thyrotropin-releasing hormone receptor [KO:K04282]
127235292  [KO:K05863]
127235293  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
127235638  Pde1c; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
127235683  Nos3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
127235758  Htr5a; 5-hydroxytryptamine receptor 5A [KO:K04161]
127236116  Atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
127236120  Camk1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
127236158  Oxtr; oxytocin receptor [KO:K04229]
127236163  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
127236213  Hrh1; histamine H1 receptor [KO:K04149]
127236214  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
127236239  Ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
127236412  Avpr1b; vasopressin V1b receptor [KO:K04227]
127236416  Cxcr4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
127236467  Atp2b4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
127236471  [KO:K04161]
127236677  Mst1; hepatocyte growth factor-like protein [KO:K23441]
127236779  Tfeb; transcription factor EB isoform X1 [KO:K15590]
127236801  Vegfa; vascular endothelial growth factor A [KO:K05448]
127236827  Mst1r; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
127236838  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
127236854  Tnnc1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
127236966  Orai2; protein orai-2 [KO:K16057]
127237009  Phkg1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
127237100  Flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
127237325  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
127237692  [KO:K04603]
127237766  [KO:K04603]
127237933  Atp2b1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
127238019  [KO:K04809]
127238144  Ntrk3; NT-3 growth factor receptor [KO:K05101] [EC:2.7.10.1]
127238375  Itpkc; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
127238587  Calm3; calmodulin-3 [KO:K02183]
127238613  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
127238615  Slc8a2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
127238770  Ryr1; ryanodine receptor 1 [KO:K04961]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
prob04010  MAPK signaling pathway
prob04070  Phosphatidylinositol signaling system
prob04210  Apoptosis
prob04720  Long-term potentiation
prob04730  Long-term depression
KO pathway
ko04020   

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