KEGG   PATHWAY: pruf04350
Entry
pruf04350                   Pathway                                
Name
TGF-beta signaling pathway - Pyrgilauda ruficollis (rufous-necked snowfinch)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
pruf04350  TGF-beta signaling pathway
pruf04350

Other DBs
GO: 0007179
Organism
Pyrgilauda ruficollis (rufous-necked snowfinch) [GN:pruf]
Gene
121353850  CHRD; chordin isoform X1 [KO:K04657]
121350905  noggin-2-like [KO:K04658]
121363453  NOG; noggin [KO:K04658]
121351386  neuroblastoma suppressor of tumorigenicity 1 [KO:K19558]
121354880  GREM2; gremlin-2 [KO:K23318]
121349592  GREM1; gremlin-1 [KO:K23318]
121349463  THBS1; thrombospondin-1 [KO:K16857]
121357239  DCN; decorin [KO:K04660]
121355243  FMOD; fibromodulin [KO:K08121]
121357085  left-right determination factor 2-like [KO:K04668]
121355465  FST; follistatin [KO:K04661]
121350125  bone morphogenetic protein 2-like [KO:K21283]
121357049  BMP2; bone morphogenetic protein 2 [KO:K21283]
121354039  BMP4; bone morphogenetic protein 4 isoform X1 [KO:K04662]
121357758  BMP6; bone morphogenetic protein 6 [KO:K16620]
121356660  INHBB; inhibin beta B chain [KO:K22687]
121363982  ovotransferrin-like [KO:K14736]
121358894  BMP5; bone morphogenetic protein 5 isoform X1 [KO:K04663]
121359457  BMP7; bone morphogenetic protein 7 [KO:K16621]
121349946  bone morphogenetic protein 8B-like [KO:K16622]
121365915  GDF5; growth/differentiation factor 5 [KO:K04664]
121355406  GDF6; growth/differentiation factor 6 [KO:K20012]
121360762  GDF7; growth/differentiation factor 7 [KO:K20013]
121353355  AMH; muellerian-inhibiting factor isoform X1 [KO:K04665]
121352566  IFNG; interferon gamma [KO:K04687]
121348557  tumor necrosis factor-like [KO:K03156]
121354399  THSD4; thrombospondin type-1 domain-containing protein 4 isoform X1 [KO:K23377]
121354417  FBN1; fibrillin-1 [KO:K06825]
121358778  LTBP1; latent-transforming growth factor beta-binding protein 1 [KO:K19559]
121358714  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
121355988  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
121353070  INHBA; inhibin beta A chain isoform X1 [KO:K04667]
121357472  inhibin beta C chain-like [KO:K22688]
121357475  inhibin beta C chain-like [KO:K22689]
121360001  NODAL; nodal homolog [KO:K04666]
121356647  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
121362603  BMPR1B; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
121352783  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
121356435  BMPR2; bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
121356446  ACVR2A; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
121357695  HJV; hemojuvelin [KO:K23100]
121354449  NEO1; neogenin isoform X1 [KO:K06766]
121353660  TFRC; transferrin receptor protein 1 [KO:K06503]
121354494  RGMA; repulsive guidance molecule A [KO:K23096]
121357144  RGMB; RGM domain family member B isoform X1 [KO:K06847]
121356099  AMHR2; anti-Muellerian hormone type-2 receptor isoform X1 [KO:K04672] [EC:2.7.11.30]
121349262  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
121353051  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
121356695  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
121350542  LRRC32; transforming growth factor beta activator LRRC32 [KO:K26316]
121363088  transforming growth factor beta activator LRRC32-like [KO:K26316]
121364000  NRROS; transforming growth factor beta activator LRRC33 [KO:K26317]
121356344  ACVR1B; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
121364655  ACVR2B; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
121352808  ACVR1C; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
121364399  BAMBI; BMP and activin membrane-bound inhibitor homolog [KO:K10162]
121365239  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
121361313  SMAD5; mothers against decapentaplegic homolog 5 [KO:K16790]
121353337  SMAD9; mothers against decapentaplegic homolog 9 [KO:K16791]
121357871  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
121354426  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
121353526  mothers against decapentaplegic homolog 4-like [KO:K04501]
121361270  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
121357722  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
121354567  SMAD6; mothers against decapentaplegic homolog 6 [KO:K04677]
121352182  mothers against decapentaplegic homolog 6-like isoform X1 [KO:K04677]
121350389  SMAD7; mothers against decapentaplegic homolog 7 isoform X1 [KO:K19631]
121358166  mothers against decapentaplegic homolog 7-like [KO:K19631]
121350803  SMURF1; E3 ubiquitin-protein ligase SMURF1 [KO:K04678] [EC:2.3.2.26]
121363370  SMURF2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
121361921  ZFYVE9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
121351278  ZFYVE16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
121361199  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
121352852  CUL1; cullin-1 [KO:K03347]
121361304  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
121365143  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121349586  RHOA; transforming protein RhoA [KO:K04513]
121359005  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
121362083  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
121349153  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
121361303  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
121355154  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
121361560  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
121348566  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
121359167  ID2; DNA-binding protein inhibitor ID-2 [KO:K17693]
121351252  ID3; DNA-binding protein inhibitor ID-3 [KO:K17694]
121357851  ID4; DNA-binding protein inhibitor ID-4 isoform X1 [KO:K17695]
121365908  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
121348798  E2F4; transcription factor E2F4 isoform X1 [KO:K04682]
121351983  E2F5; transcription factor E2F5 [KO:K04682]
121352625  TFDP1; transcription factor Dp-1 isoform X1 [KO:K04683]
121361225  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
121350843  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
121356081  SP1; transcription factor Sp1 [KO:K04684]
121353725  SKIL; ski-like protein [KO:K18499]
121351494  SKI; ski oncogene [KO:K26503]
121365510  SIN3A; paired amphipathic helix protein Sin3a isoform X1 [KO:K11644]
121359269  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
121359882  HDAC1; LOW QUALITY PROTEIN: histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
121361828  NCOR1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
121358974  TGIF1; homeobox protein TGIF1 isoform X1 [KO:K19383]
121365907  TGIF2; homeobox protein TGIF2 [KO:K19553]
121364668  MYC; myc proto-oncogene protein [KO:K04377]
121363772  cyclin-dependent kinase 4 inhibitor B-like [KO:K04685]
121363778  cyclin-dependent kinase 4 inhibitor B-like [KO:K04685]
121360224  PITX2; pituitary homeobox 2 isoform X1 [KO:K04686]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
  Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
  Journal
Int J Mol Sci 22:ijms22094591 (2021)
DOI:10.3390/ijms22094591
Reference
PMID:20495575
  Authors
Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
  Journal
Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Related
pathway
pruf04010  MAPK signaling pathway
pruf04110  Cell cycle
pruf04120  Ubiquitin mediated proteolysis
pruf04210  Apoptosis
KO pathway
ko04350   
LinkDB

DBGET integrated database retrieval system