KEGG   PATHWAY: pruf04110
Entry
pruf04110                   Pathway                                
Name
Cell cycle - Pyrgilauda ruficollis (rufous-necked snowfinch)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
pruf04110  Cell cycle
pruf04110

Other DBs
GO: 0000278
Organism
Pyrgilauda ruficollis (rufous-necked snowfinch) [GN:pruf]
Gene
121348610  RAD21L1; double-strand-break repair protein rad21-like protein 1 [KO:K06670]
121348691  ANAPC4; anaphase-promoting complex subunit 4 [KO:K03351]
121348771  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
121348774  ORC6; origin recognition complex subunit 6 isoform X1 [KO:K02608]
121348798  E2F4; transcription factor E2F4 isoform X1 [KO:K04682]
121348860  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
121349085  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
121349153  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
121349263  TRIP13; pachytene checkpoint protein 2 homolog [KO:K22399]
121349774  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
121350175  SMC3; structural maintenance of chromosomes protein 3 isoform X1 [KO:K06669]
121350349  BUB3; mitotic checkpoint protein BUB3 [KO:K02180]
121350556  DBF4B; protein DBF4 homolog B [KO:K06629]
121350843  [KO:K04498] [EC:2.3.1.48]
121350944  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
121351041  CDC6; cell division control protein 6 homolog isoform X1 [KO:K02213]
121351231  SFN; 14-3-3 protein sigma [KO:K06644]
121351233  E2F2; transcription factor E2F2 [KO:K09389]
121351402  ZBTB17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
121351746  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
121351949  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
121351983  E2F5; transcription factor E2F5 [KO:K04682]
121352021  [KO:K05866] [EC:3.1.3.48]
121352085  WEE1; wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
121352380  FZR1; fizzy-related protein homolog [KO:K03364]
121352474  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
121352484  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
121352585  MCM2; DNA replication licensing factor MCM2 [KO:K02540] [EC:5.6.2.3]
121352625  TFDP1; transcription factor Dp-1 isoform X1 [KO:K04683]
121352803  ANAPC11; anaphase-promoting complex subunit 11 isoform X1 [KO:K03358]
121352838  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
121352843  [KO:K06672]
121352852  CUL1; cullin-1 [KO:K03347]
121352890  SGO1; shugoshin 1 [KO:K11580]
121352903  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
121353169  DBF4; protein DBF4 homolog A isoform X1 [KO:K06629]
121353236  RB1; retinoblastoma-associated protein [KO:K06618]
121353526  [KO:K04501]
121353919  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
121354002  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
121354076  [KO:K06671]
121354088  CDC16; cell division cycle protein 16 homolog [KO:K03353]
121354426  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
121354553  TICRR; treslin [KO:K26117]
121354608  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
121354727  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
121354784  BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
121354787  KNL1; LOW QUALITY PROTEIN: kinetochore scaffold 1 [KO:K11542]
121354923  FBXO5; F-box only protein 5 [KO:K10292]
121355164  PDS5A; sister chromatid cohesion protein PDS5 homolog A isoform X1 [KO:K11267]
121355309  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
121355338  [KO:K26116]
121355352  RAD21; double-strand-break repair protein rad21 homolog [KO:K06670]
121355434  CDK7; cyclin-dependent kinase 7 isoform X1 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
121355562  MAU2; MAU2 chromatid cohesion factor homolog [KO:K11266]
121355988  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
121356115  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
121356447  ORC4; origin recognition complex subunit 4 isoform X1 [KO:K02606]
121356492  ORC2; origin recognition complex subunit 2 isoform X1 [KO:K02604]
121356502  MCM6; DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
121356858  PRKDC; DNA-dependent protein kinase catalytic subunit [KO:K06642] [EC:2.7.11.1]
121356900  MCM4; DNA replication licensing factor MCM4 [KO:K02212] [EC:5.6.2.3]
121357020  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
121357084  ANAPC1; anaphase-promoting complex subunit 1 [KO:K03348]
121357168  CDC25A; M-phase inducer phosphatase 1 [KO:K06645] [EC:3.1.3.48]
121357298  PCNA; proliferating cell nuclear antigen [KO:K04802]
121357426  ORC5; origin recognition complex subunit 5 [KO:K02607]
121357455  [KO:K06672]
121357526  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
121357581  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
121357667  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
121357722  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
121357828  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
121357843  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
121357845  WAPL; wings apart-like protein homolog isoform X1 [KO:K25163]
121357871  [KO:K04500]
121357917  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
121357926  TFDP2; transcription factor Dp-2 isoform X1 [KO:K09392]
121358012  CCNH; cyclin-H [KO:K06634]
121358212  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
121358224  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
121358415  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B isoform X1 [KO:K13728]
121358527  [KO:K26093]
121358567  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
121358714  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
121359047  NDC80; kinetochore protein NDC80 homolog [KO:K11547]
121359060  ESCO1; N-acetyltransferase ESCO1 isoform X1 [KO:K11268] [EC:2.3.1.-]
121359128  YWHAQ; 14-3-3 protein theta [KO:K16197]
121359269  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
121359607  E2F1; transcription factor E2F1 [KO:K17454]
121359714  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
121359882  HDAC1; LOW QUALITY PROTEIN: histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
121360500  TTK; dual specificity protein kinase TTK [KO:K08866] [EC:2.7.12.1]
121360508  ORC3; origin recognition complex subunit 3 isoform X1 [KO:K02605]
121360614  CHEK1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
121360685  CDC14B; dual specificity protein phosphatase CDC14B isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
121360772  MCM3; DNA replication licensing factor MCM3 [KO:K02541] [EC:5.6.2.3]
121360919  CDKN1C; cyclin-dependent kinase inhibitor 1C [KO:K09993]
121361115  MCM5; DNA replication licensing factor MCM5 [KO:K02209] [EC:5.6.2.3]
121361199  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
121361225  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
121361270  [KO:K04501]
121361303  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
121361304  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
121361517  CCNA2; cyclin-A2 [KO:K06627]
121361542  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
121361601  YWHAG; 14-3-3 protein gamma [KO:K16198]
121361701  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
121361769  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
121361901  CDC20; cell division cycle protein 20 homolog [KO:K03363]
121361940  CDC14A; dual specificity protein phosphatase CDC14A isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
121362016  CDC7; cell division cycle 7-related protein kinase [KO:K02214] [EC:2.7.11.1]
121362054  ORC1; origin recognition complex subunit 1 [KO:K02603]
121362083  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
121362252  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
121362690  DDX11; ATP-dependent DNA helicase DDX11 isoform X1 [KO:K11273] [EC:3.6.4.13]
121362752  [KO:K06637] [EC:2.7.11.1]
121362806  ATRX; transcriptional regulator ATRX isoform X1 [KO:K10779]
121362833  CDT1; DNA replication factor Cdt1 [KO:K10727]
121362864  HDAC8; histone deacetylase 8 isoform X1 [KO:K11405] [EC:3.5.1.98]
121363265  STAG2; cohesin subunit SA-2 isoform X1 [KO:K06671]
121363556  SMC1B; structural maintenance of chromosomes protein 1B [KO:K06636]
121363772  [KO:K04685]
121363778  [KO:K04685]
121363946  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
121363968  [KO:K02365] [EC:3.4.22.49]
121364056  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
121364085  STAG1; cohesin subunit SA-1 isoform X1 [KO:K06671]
121364215  CCNA1; cyclin-A1 [KO:K06627]
121364216  PDS5B; sister chromatid cohesion protein PDS5 homolog B isoform X1 [KO:K11267]
121364252  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
121364327  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
121364331  WEE2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
121364591  PTTG1; securin isoform X1 [KO:K06635]
121364668  MYC; myc proto-oncogene protein [KO:K04377]
121364853  YWHAH; 14-3-3 protein eta [KO:K16198]
121364905  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
121364929  CDC45; cell division control protein 45 homolog [KO:K06628]
121364949  ANAPC7; anaphase-promoting complex subunit 7 [KO:K03354]
121365101  ANAPC5; anaphase-promoting complex subunit 5 [KO:K03352]
121365230  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
121365647  CDC23; cell division cycle protein 23 homolog [KO:K03355]
121365837  PLK1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
121365908  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
Reference
PMID:7908906
  Authors
Matsuoka S, Yamaguchi M, Matsukage A
  Title
D-type cyclin-binding regions of proliferating cell nuclear antigen.
  Journal
J Biol Chem 269:11030-6 (1994)
Reference
PMID:8242749
  Authors
Welch PJ, Wang JY
  Title
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.
  Journal
Cell 75:779-90 (1993)
DOI:10.1016/0092-8674(93)90497-E
Reference
PMID:16936746
  Authors
Macaluso M, Montanari M, Giordano A
  Title
Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes.
  Journal
Oncogene 25:5263-7 (2006)
DOI:10.1038/sj.onc.1209680
Reference
PMID:15838516
  Authors
Cobrinik D
  Title
Pocket proteins and cell cycle control.
  Journal
Oncogene 24:2796-809 (2005)
DOI:10.1038/sj.onc.1208619
Reference
PMID:17568790
  Authors
Boutros R, Lobjois V, Ducommun B
  Title
CDC25 phosphatases in cancer cells: key players? Good targets?
  Journal
Nat Rev Cancer 7:495-507 (2007)
DOI:10.1038/nrc2169
Reference
PMID:9832503
  Authors
Diehl JA, Cheng M, Roussel MF, Sherr CJ
  Title
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
  Journal
Genes Dev 12:3499-511 (1998)
DOI:10.1101/gad.12.22.3499
Reference
PMID:19020303
  Authors
Klein EA, Assoian RK
  Title
Transcriptional regulation of the cyclin D1 gene at a glance.
  Journal
J Cell Sci 121:3853-7 (2008)
DOI:10.1242/jcs.039131
Reference
PMID:10385618
  Authors
Sherr CJ, Roberts JM
  Title
CDK inhibitors: positive and negative regulators of G1-phase progression.
  Journal
Genes Dev 13:1501-12 (1999)
DOI:10.1101/gad.13.12.1501
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:12925736
  Authors
Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K, Nakayama KI
  Title
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
  Journal
Proc Natl Acad Sci U S A 100:10231-6 (2003)
DOI:10.1073/pnas.1831009100
Reference
PMID:16212951
  Authors
Bond M, Sala-Newby GB, Wu YJ, Newby AC
  Title
Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
  Journal
Cardiovasc Res 69:198-206 (2006)
DOI:10.1016/j.cardiores.2005.08.020
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11099028
  Authors
Vogelstein B, Lane D, Levine AJ
  Title
Surfing the p53 network.
  Journal
Nature 408:307-10 (2000)
DOI:10.1038/35042675
Reference
PMID:7973727
  Authors
Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr
  Title
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
  Journal
Science 266:1376-80 (1994)
DOI:10.1126/science.7973727
Reference
PMID:9889196
  Authors
Petersen BO, Lukas J, Sorensen CS, Bartek J, Helin K
  Title
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
  Journal
EMBO J 18:396-410 (1999)
DOI:10.1093/emboj/18.2.396
Reference
PMID:17018296
  Authors
Sheu YJ, Stillman B
  Title
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
  Journal
Mol Cell 24:101-13 (2006)
DOI:10.1016/j.molcel.2006.07.033
Reference
PMID:9029154
  Authors
Martinez AM, Afshar M, Martin F, Cavadore JC, Labbe JC, Doree M
  Title
Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
  Journal
EMBO J 16:343-54 (1997)
DOI:10.1093/emboj/16.2.343
Reference
PMID:15876871
  Authors
Lolli G, Johnson LN
  Title
CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
  Journal
Cell Cycle 4:572-7 (2005)
DOI:10.4161/cc.4.4.1607
Reference
PMID:17426725
  Authors
Musacchio A, Salmon ED
  Title
The spindle-assembly checkpoint in space and time.
  Journal
Nat Rev Mol Cell Biol 8:379-93 (2007)
DOI:10.1038/nrm2163
Reference
PMID:12573239
  Authors
Uhlmann F
  Title
Chromosome cohesion and separation: from men and molecules.
  Journal
Curr Biol 13:R104-14 (2003)
DOI:10.1016/S0960-9822(03)00039-3
Reference
PMID:15568976
  Authors
Stegmeier F, Amon A
  Title
Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
  Journal
Annu Rev Genet 38:203-32 (2004)
DOI:10.1146/annurev.genet.38.072902.093051
Reference
PMID:9618481
  Authors
Moustakas A, Kardassis D
  Title
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
  Journal
Proc Natl Acad Sci U S A 95:6733-8 (1998)
DOI:10.1073/pnas.95.12.6733
Reference
PMID:26650195
  Authors
de Boer HR, Guerrero Llobet S, van Vugt MA
  Title
Controlling the response to DNA damage by the APC/C-Cdh1.
  Journal
Cell Mol Life Sci 73:949-60 (2016)
DOI:10.1007/s00018-015-2096-7
Reference
PMID:20935501
  Authors
Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
  Title
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
  Journal
Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
pruf03030  DNA replication
pruf04010  MAPK signaling pathway
pruf04120  Ubiquitin mediated proteolysis
pruf04210  Apoptosis
KO pathway
ko04110   

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