KEGG   PATHWAY: ptr04723
Entry
ptr04723                    Pathway                                
Name
Retrograde endocannabinoid signaling - Pan troglodytes (chimpanzee)
Description
Endogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic acid; the two best characterized are arachydonoyl ethanolamide (anandamide, AEA) and 2-arachydonoil glycerol (2AG). They are released from postsynaptic neurons upon postsynaptic depolarization and/or receptor activation. The released endocannabinoids then activate the CB1 receptors (CB1R) at presynaptic terminals and suppress the release of inhibitory transmitter GABA (depolarization-induced suppression of inhibition, DSI) or excitatory transmitter glutamate (depolarization-induced suppression of excitation, DSE) by inhibiting Ca2+ channels. Besides the well-known expression of the CB1R in the plasma membrane, this receptor is also present in mitochondrial membranes, where it reduces the mitochondrial respiration and contributes to DSI. Whereas DSI and DSE result in short-term synaptic plasticity, endocannabinoids also mediate long-term synaptic changes (eCB-LTD). Persistent activation of CB1 receptors over a period of minutes triggers eCB-LTD by a RIM1alpha-dependent mechanism.
Class
Organismal Systems; Nervous system
Pathway map
ptr04723  Retrograde endocannabinoid signaling
ptr04723

Other DBs
GO: 0071926
Organism
Pan troglodytes (chimpanzee) [GN:ptr]
Gene
452161  SLC17A8; vesicular glutamate transporter 3 [KO:K12302]
100610704  SLC17A6; vesicular glutamate transporter 2 isoform X1 [KO:K12302]
456204  SLC17A7; vesicular glutamate transporter 1 [KO:K12302]
471714  GRIA1; glutamate receptor 1 isoform X4 [KO:K05197]
461570  GRIA2; glutamate receptor 2 isoform 1 precursor [KO:K05198]
465842  GRIA3; glutamate receptor 3 isoform X2 [KO:K05199]
466768  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
466915  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
460447  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X20 [KO:K04851]
740711  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
469635  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
463049  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
451472  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
472962  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
453330  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
458093  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X5 [KO:K05858] [EC:3.1.4.11]
469875  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [KO:K05858] [EC:3.1.4.11]
451290  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
460134  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
473389  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X2 [KO:K04959]
462618  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
472476  NAPEPLD; N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1 [KO:K13985] [EC:3.1.4.54]
454832  PRKCA; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
453993  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
456276  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
451241  DAGLA; diacylglycerol lipase-alpha isoform X1 [KO:K13806] [EC:3.1.1.116]
472286  DAGLB; diacylglycerol lipase-beta isoform X1 [KO:K13806] [EC:3.1.1.116]
469616  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
470830  ABHD6; monoacylglycerol lipase ABHD6 isoform X3 [KO:K13700] [EC:3.1.1.23]
456559  FAAH; fatty-acid amide hydrolase 1 [KO:K15528] [EC:3.5.1.99]
472066  CNR1; cannabinoid receptor 1 isoform X1 [KO:K04277]
457093  GNAI3; guanine nucleotide-binding protein G(I) subunit alpha-3 [KO:K04630]
472425  GNAI1; guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1 [KO:K04630]
744773  GNAI2; guanine nucleotide-binding protein G(I) subunit alpha-2 [KO:K04630]
450173  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X2 [KO:K04534]
469458  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
739897  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
100612078  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
460862  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
745402  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
467457  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
740869  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
743331  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
456977  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
129136331  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
744391  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
107969769  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X2 [KO:K04544]
100611518  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
129137227  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
747185  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
100609242  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1 [KO:K04347]
107969673  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
107968762  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
747170  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
749133  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
737029  KCNJ3; G protein-activated inward rectifier potassium channel 1 isoform X1 [KO:K04997]
474111  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
469548  KCNJ9; G protein-activated inward rectifier potassium channel 3 [KO:K05002]
451660  KCNJ5; G protein-activated inward rectifier potassium channel 4 [KO:K04999]
455766  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X3 [KO:K04344]
464893  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
454037  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
458680  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
450445  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
462336  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
461358  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
450161  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
462644  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
747077  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
104003820  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
463392  ADCY1; adenylate cyclase type 1 isoform X2 [KO:K08041] [EC:4.6.1.1]
100608010  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
459070  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
452819  ADCY4; adenylate cyclase type 4 isoform X2 [KO:K08044] [EC:4.6.1.1]
470905  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
451866  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
473278  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
464400  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
453869  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
469367  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X6 [KO:K04345] [EC:2.7.11.11]
472944  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
107966260  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
739167  MGLL; monoglyceride lipase isoform X8 [KO:K01054] [EC:3.1.1.23]
807867  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
807865  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
807870  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
807863  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
807868  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
807860  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
807861  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
747209  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial precursor [KO:K03942] [EC:7.1.1.2]
455295  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial precursor [KO:K03943] [EC:7.1.1.2]
736470  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial precursor [KO:K03944]
100608263  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
462119  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 isoform X3 [KO:K03946]
100614219  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
741211  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
739861  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
107970442  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
107968821  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
463686  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
458981  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
743262  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
464897  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
451766  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial precursor [KO:K03953]
470696  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial precursor [KO:K03954]
744435  NDUFAB1; acyl carrier protein, mitochondrial precursor [KO:K03955]
739803  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
452134  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
455877  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
453115  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
129143618  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
463780  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial precursor [KO:K03958]
459871  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
107968313  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
460612  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
461194  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
471008  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial precursor [KO:K03961]
100611615  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
468748  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
744716  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial precursor [KO:K03964]
464380  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
746648  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
473588  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial precursor [KO:K11351]
459896  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor [KO:K03934] [EC:7.1.1.2]
747334  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial precursor [KO:K03935] [EC:7.1.1.2]
451175  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial precursor [KO:K03936] [EC:7.1.1.2]
461878  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial precursor [KO:K03937]
456776  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
107969209  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
742848  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial precursor [KO:K03939]
100126358  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial precursor [KO:K03940] [EC:7.1.1.2]
451375  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
461494  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
451445  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
469940  SLC32A1; vesicular inhibitory amino acid transporter [KO:K15015]
472054  RIMS1; regulating synaptic membrane exocytosis protein 1 isoform X3 [KO:K15291]
462241  GABRA1; gamma-aminobutyric acid receptor subunit alpha-1 [KO:K05175]
465914  GABRA3; gamma-aminobutyric acid receptor subunit alpha-3 [KO:K05175]
471392  GABRA4; gamma-aminobutyric acid receptor subunit alpha-4 isoform X2 [KO:K05175]
471725  GABRA6; gamma-aminobutyric acid receptor subunit alpha-6 [KO:K05175]
744855  GABRA5; gamma-aminobutyric acid receptor subunit alpha-5 [KO:K05175]
461355  GABRA2; gamma-aminobutyric acid receptor subunit alpha-2 isoform X1 [KO:K05175]
461352  GABRB1; gamma-aminobutyric acid receptor subunit beta-1 isoform X1 [KO:K05181]
453265  GABRB3; gamma-aminobutyric acid receptor subunit beta-3 isoform X1 [KO:K05181]
462240  GABRB2; gamma-aminobutyric acid receptor subunit beta-2 isoform X1 [KO:K05181]
462242  GABRG2; gamma-aminobutyric acid receptor subunit gamma-2 isoform X1 [KO:K05186]
467624  GABRG3; gamma-aminobutyric acid receptor subunit gamma-3 isoform X1 [KO:K05186]
747186  GABRD; gamma-aminobutyric acid receptor subunit delta isoform X1 [KO:K05184]
107971226  GABRE; gamma-aminobutyric acid receptor subunit epsilon [KO:K05185]
107966421  GABRQ; gamma-aminobutyric acid receptor subunit theta [KO:K05192]
471736  GABRP; gamma-aminobutyric acid receptor subunit PI [KO:K05189]
472068  GABRR1; gamma-aminobutyric acid receptor subunit rho-1 isoform X1 [KO:K05190]
472069  GABRR2; gamma-aminobutyric acid receptor subunit rho-2 [KO:K05190]
470869  GABRR3; gamma-aminobutyric acid receptor subunit rho-3 [KO:K05190]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00116  Glycerol
C00157  Phosphatidylcholine
C00165  Diacylglycerol
C00189  Ethanolamine
C00219  Arachidonate
C00238  Potassium cation
C00334  4-Aminobutanoate
C00350  Phosphatidylethanolamine
C00427  Prostaglandin H2
C00575  3',5'-Cyclic AMP
C00689  alpha,alpha'-Trehalose 6-phosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C11695  Anandamide
C13856  2-Arachidonoylglycerol
C19912  N-Arachidonoyl-phosphatidylethanolamine
C19913  Phospho-anandamide
Reference
PMID:17419048
  Authors
Hashimotodani Y, Ohno-Shosaku T, Kano M
  Title
Ca(2+)-assisted receptor-driven endocannabinoid release: mechanisms that associate presynaptic and postsynaptic activities.
  Journal
Curr Opin Neurobiol 17:360-5 (2007)
DOI:10.1016/j.conb.2007.03.012
Reference
PMID:21531987
  Authors
Ohno-Shosaku T, Tanimura A, Hashimotodani Y, Kano M
  Title
Endocannabinoids and retrograde modulation of synaptic transmission.
  Journal
Neuroscientist 18:119-32 (2012)
DOI:10.1177/1073858410397377
Reference
PMID:18084639
  Authors
Basavarajappa BS
  Title
Neuropharmacology of the endocannabinoid signaling system-molecular mechanisms, biological actions and synaptic plasticity.
  Journal
Curr Neuropharmacol 5:81-97 (2007)
DOI:10.2174/157015907780866910
Reference
PMID:16968947
  Authors
Pacher P, Batkai S, Kunos G
  Title
The endocannabinoid system as an emerging target of pharmacotherapy.
  Journal
Pharmacol Rev 58:389-462 (2006)
DOI:10.1124/pr.58.3.2
Reference
PMID:15340387
  Authors
Di Marzo V, Bifulco M, De Petrocellis L
  Title
The endocannabinoid system and its therapeutic exploitation.
  Journal
Nat Rev Drug Discov 3:771-84 (2004)
DOI:10.1038/nrd1495
Reference
PMID:17404373
  Authors
Hashimotodani Y, Ohno-Shosaku T, Kano M
  Title
Endocannabinoids and synaptic function in the CNS.
  Journal
Neuroscientist 13:127-37 (2007)
DOI:10.1177/1073858406296716
Reference
PMID:19126760
  Authors
Kano M, Ohno-Shosaku T, Hashimotodani Y, Uchigashima M, Watanabe M
  Title
Endocannabinoid-mediated control of synaptic transmission.
  Journal
Physiol Rev 89:309-80 (2009)
DOI:10.1152/physrev.00019.2008
Reference
PMID:19640475
  Authors
Regehr WG, Carey MR, Best AR
  Title
Activity-dependent regulation of synapses by retrograde messengers.
  Journal
Neuron 63:154-70 (2009)
DOI:10.1016/j.neuron.2009.06.021
Reference
PMID:17636069
  Authors
Benarroch E
  Title
Endocannabinoids in basal ganglia circuits: implications for Parkinson disease.
  Journal
Neurology 69:306-9 (2007)
DOI:10.1212/01.wnl.0000267407.79757.75
Reference
PMID:16085309
  Authors
Ohno-Shosaku T, Hashimotodani Y, Maejima T, Kano M
  Title
Calcium signaling and synaptic modulation: regulation of endocannabinoid-mediated synaptic modulation by calcium.
  Journal
Cell Calcium 38:369-74 (2005)
DOI:10.1016/j.ceca.2005.06.014
Reference
PMID:18801434
  Authors
Harkany T, Mackie K, Doherty P
  Title
Wiring and firing neuronal networks: endocannabinoids take center stage.
  Journal
Curr Opin Neurobiol 18:338-45 (2008)
DOI:10.1016/j.conb.2008.08.007
Reference
PMID:18515270
  Authors
Hosking RD, Zajicek JP
  Title
Therapeutic potential of cannabis in pain medicine.
  Journal
Br J Anaesth 101:59-68 (2008)
DOI:10.1093/bja/aen119
Reference
PMID:21187849
  Authors
Di Marzo V
  Title
Endocannabinoid signaling in the brain: biosynthetic mechanisms in the limelight.
  Journal
Nat Neurosci 14:9-15 (2011)
DOI:10.1038/nn.2720
Reference
PMID:18948642
  Authors
McPartland JM
  Title
The endocannabinoid system: an osteopathic perspective.
  Journal
J Am Osteopath Assoc 108:586-600 (2008)
DOI:10.7556/jaoa.2008.108.10.586
Reference
PMID:17553427
  Authors
Chevaleyre V, Heifets BD, Kaeser PS, Sudhof TC, Castillo PE
  Title
Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1alpha.
  Journal
Neuron 54:801-12 (2007)
DOI:10.1016/j.neuron.2007.05.020
Reference
PMID:19553483
  Authors
Lafourcade CA
  Title
Presynaptic mechanisms of endocannabinoid-mediated long-term depression in the hippocampus.
  Journal
J Neurophysiol 102:2009-12 (2009)
DOI:10.1152/jn.00441.2009
Reference
PMID:21328621
  Authors
Ueda N, Tsuboi K, Uyama T, Ohnishi T
  Title
Biosynthesis and degradation of the endocannabinoid 2-arachidonoylglycerol.
  Journal
Biofactors 37:1-7 (2011)
DOI:10.1002/biof.131
Reference
PMID:14978245
  Authors
Guo J, Ikeda SR
  Title
Endocannabinoids modulate N-type calcium channels and G-protein-coupled inwardly rectifying potassium channels via CB1 cannabinoid receptors heterologously expressed in mammalian neurons.
  Journal
Mol Pharmacol 65:665-74 (2004)
DOI:10.1124/mol.65.3.665
Reference
PMID:22388959
  Authors
Benard G, Massa F, Puente N, Lourenco J, Bellocchio L, Soria-Gomez E, Matias I, Delamarre A, Metna-Laurent M, Cannich A, Hebert-Chatelain E, Mulle C, Ortega-Gutierrez S, Martin-Fontecha M, Klugmann M, Guggenhuber S, Lutz B, Gertsch J, Chaouloff F, Lopez-Rodriguez ML, Grandes P, Rossignol R, Marsicano G
  Title
Mitochondrial CB(1) receptors regulate neuronal energy metabolism.
  Journal
Nat Neurosci 15:558-64 (2012)
DOI:10.1038/nn.3053
Reference
PMID:26260530
  Authors
Busquets-Garcia A, Desprez T, Metna-Laurent M, Bellocchio L, Marsicano G, Soria-Gomez E
  Title
Dissecting the cannabinergic control of behavior: The where matters.
  Journal
Bioessays 37:1215-25 (2015)
DOI:10.1002/bies.201500046
Reference
PMID:28076767
  Authors
Harkany T, Horvath TL
  Title
(S)Pot on Mitochondria: Cannabinoids Disrupt Cellular Respiration to Limit Neuronal Activity.
  Journal
Cell Metab 25:8-10 (2017)
DOI:10.1016/j.cmet.2016.12.020
Reference
PMID:22449955
  Authors
Alger BE, Tang AH
  Title
Do cannabinoids reduce brain power?
  Journal
Nat Neurosci 15:499-501 (2012)
DOI:10.1038/nn.3072
Related
pathway
ptr00190  Oxidative phosphorylation
ptr04020  Calcium signaling pathway
ptr04721  Synaptic vesicle cycle
ptr04724  Glutamatergic synapse
ptr04727  GABAergic synapse
KO pathway
ko04723   
LinkDB

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