KEGG   PATHWAY: slal04144
Entry
slal04144                   Pathway                                
Name
Endocytosis - Seriola lalandi dorsalis (Yellowtail amberjack)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
slal04144  Endocytosis
slal04144

Other DBs
GO: 0006897
Organism
Seriola lalandi dorsalis (Yellowtail amberjack) [GN:slal]
Gene
111672713  arf6; ADP-ribosylation factor 6 [KO:K07941]
111663210  ADP-ribosylation factor 6 [KO:K07941]
111660247  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like [KO:K00889] [EC:2.7.1.68]
111650106  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like isoform X1 [KO:K00889] [EC:2.7.1.68]
111653776  pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
111650904  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
111657570  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like [KO:K00889] [EC:2.7.1.68]
111658892  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like isoform X1 [KO:K00889] [EC:2.7.1.68]
111647953  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
111648082  pip5kl1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
111647269  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
111665871  phospholipase D1-like isoform X1 [KO:K01115] [EC:3.1.4.4]
111653988  phospholipase D2-like [KO:K01115] [EC:3.1.4.4]
111668200  dnm3; dynamin-3 [KO:K01528] [EC:3.6.5.5]
111646084  dynamin-1-like isoform X1 [KO:K01528] [EC:3.6.5.5]
111666524  dynamin-3-like [KO:K01528] [EC:3.6.5.5]
111664764  dnm1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
111665575  dynamin-2-like isoform X1 [KO:K23484] [EC:3.6.5.5]
111653662  dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
111659694  clta; clathrin light chain A isoform X1 [KO:K04644]
111652037  cltb; clathrin light chain B isoform X1 [KO:K04645]
111651340  clathrin heavy chain 1-like isoform X1 [KO:K04646]
111663922  cltc; clathrin heavy chain 1 isoform X1 [KO:K04646]
111665979  LOW QUALITY PROTEIN: clathrin heavy chain 1-like [KO:K04646]
111655621  ap2a1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
111672296  ap2a2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
111666192  AP-1 complex subunit beta-1 isoform X1 [KO:K11825]
111671091  ap2m1; AP-2 complex subunit mu isoform X1 [KO:K11826]
111655988  ap2s1; AP-2 complex subunit sigma [KO:K11827]
111649995  EH domain-containing protein 2-like [KO:K12469]
111662253  EH domain-containing protein 2-like isoform X1 [KO:K12469]
111673055  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
111664183  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
111644571  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
111657623  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
111666016  zinc finger FYVE domain-containing protein 16-like [KO:K04679]
111656315  zinc finger FYVE domain-containing protein 9-like isoform X1 [KO:K04679]
111658387  zfyve9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
111648020  mothers against decapentaplegic homolog 2 [KO:K04500]
111655756  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
111666993  smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
111661150  mothers against decapentaplegic homolog 3 [KO:K23605]
111666515  transferrin receptor protein 1-like [KO:K06503]
111645761  tfrc; transferrin receptor protein 1 [KO:K06503]
111652941  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
111647380  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
111644345  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
111658940  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
111646819  fgfr3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
111659966  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
111672288  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
111653328  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
111651622  E3 ubiquitin-protein ligase CBL-like [KO:K04707] [EC:2.3.2.27]
111652625  cbl; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
111653975  cblb; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
111657272  E3 ubiquitin-protein ligase CBL-like isoform X1 [KO:K22518] [EC:2.3.2.27]
111645765  sh3kbp1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
111649733  endophilin-A3-like [KO:K11247]
111656390  sh3gl1; endophilin-A2 isoform X1 [KO:K11247]
111671197  endophilin-A1-like isoform X1 [KO:K11247]
111669292  endophilin-A3-like isoform X1 [KO:K11247]
111658882  endophilin-A2-like isoform X1 [KO:K11247]
111673193  endophilin-A1-like isoform X1 [KO:K11247]
111648246  sh3glb1; endophilin-B1 [KO:K11248]
111648142  endophilin-B2-like isoform X1 [KO:K21269]
111652913  endophilin-B2-like isoform X1 [KO:K21269]
111665870  endophilin-B1-like [KO:K21269]
111651752  amph; amphiphysin isoform X1 [KO:K12562]
111672403  myc box-dependent-interacting protein 1-like [KO:K12562]
111671511  myc box-dependent-interacting protein 1-like isoform X1 [KO:K12562]
111653671  epsin-3-like isoform X1 [KO:K12471]
111665528  epsin-3-like [KO:K12471]
111669866  epsin-1-like isoform X1 [KO:K12471]
111647531  epn2; epsin-2 [KO:K12471]
111651862  eps15; epidermal growth factor receptor substrate 15 [KO:K12472]
111671694  eps15l1; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
111649039  uncharacterized protein LOC111649039 [KO:K12472]
111669119  epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
111662640  spart; spartin [KO:K19366]
111657813  spartin-like isoform X1 [KO:K19366]
111646262  nedd4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
111664746  nedd4l; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase NEDD4-like [KO:K13305] [EC:2.3.2.26]
111657669  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
111644323  traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
111661973  rnf41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
111655091  E3 ubiquitin-protein ligase Itchy-like [KO:K05632] [EC:2.3.2.26]
111655255  E3 ubiquitin-protein ligase Itchy-like [KO:K05632] [EC:2.3.2.26]
111659714  E3 ubiquitin-protein ligase SMURF2-like [KO:K04678] [EC:2.3.2.26]
111646327  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
111673792  E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
111659839  wwp1; NEDD4-like E3 ubiquitin-protein ligase WWP1 [KO:K05633] [EC:2.3.2.26]
111673794  ldlr; low-density lipoprotein receptor [KO:K12473]
111664553  low-density lipoprotein receptor-like [KO:K12473]
111647211  low density lipoprotein receptor adapter protein 1-like [KO:K12474]
111650097  ldlrap1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
111653481  low density lipoprotein receptor adapter protein 1-like [KO:K12474]
111671423  low density lipoprotein receptor adapter protein 1-B-like [KO:K12474]
111666811  dab2; disabled homolog 2 isoform X1 [KO:K12475]
111667413  C-X-C chemokine receptor type 1-like [KO:K05050]
111667474  C-X-C chemokine receptor type 2-like [KO:K05050]
111665268  C-X-C chemokine receptor type 1-like [KO:K05050]
111666497  C-X-C chemokine receptor type 4-like [KO:K04189]
111668748  cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
111668384  C-X-C chemokine receptor type 4-like [KO:K04189]
111661292  grk7; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
111649981  rhodopsin kinase 2-like [KO:K00909] [EC:2.7.11.14]
111653922  rhodopsin kinase-like [KO:K00909] [EC:2.7.11.14]
111662123  rhodopsin kinase-like [KO:K00909] [EC:2.7.11.14]
111668319  grk1; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
111664712  grk3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
111664583  grk6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
111659466  G protein-coupled receptor kinase 5-like [KO:K08291] [EC:2.7.11.16]
111644991  G protein-coupled receptor kinase 5-like [KO:K08291] [EC:2.7.11.16]
111664624  G protein-coupled receptor kinase 6-like isoform X1 [KO:K08291] [EC:2.7.11.16]
111669797  arrestin red cell [KO:K04439]
111667942  arrb2; beta-arrestin-2 [KO:K04439]
111663363  beta-arrestin-1 [KO:K04439]
111665087  neural Wiskott-Aldrich syndrome protein-like [KO:K23612]
111667708  wiskott-Aldrich syndrome protein-like [KO:K23612]
111663662  neural Wiskott-Aldrich syndrome protein-like [KO:K23612]
111672889  actin-related protein 2-A [KO:K17260]
111662009  actr2; actin-related protein 2 isoform X1 [KO:K17260]
111647195  actin-related protein 2-like [KO:K17260]
111663445  actin-related protein 3 [KO:K18584]
111651178  actin-related protein 3B-like [KO:K18584]
111665237  actin-related protein 3 [KO:K18584]
111663292  actin-related protein 2/3 complex subunit 1A [KO:K05757]
111663305  actin-related protein 2/3 complex subunit 1B-like [KO:K05757]
111667247  actin-related protein 2/3 complex subunit 1A-like [KO:K05757]
111665269  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
111652992  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
111667728  actin-related protein 2/3 complex subunit 4-like [KO:K05755]
111670949  arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
111645396  arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
111648408  actin-related protein 2/3 complex subunit 5-like [KO:K05754]
111646348  WAS/WASL-interacting protein family member 2-like [KO:K19475]
111669086  wipf1; WAS/WASL-interacting protein family member 1 [KO:K19475]
111673331  WAS/WASL-interacting protein family member 3-like [KO:K19475]
111658784  WAS/WASL-interacting protein family member 2-like [KO:K19475]
111664988  heat shock cognate 71 kDa protein-like [KO:K03283]
111646336  heat shock 70 kDa protein 1 [KO:K03283]
111652149  heat shock cognate 71 kDa protein [KO:K03283]
111653924  heat shock cognate 71 kDa protein-like [KO:K03283]
111670746  heat shock 70 kDa protein-like [KO:K03283]
111654027  heat shock cognate 71 kDa protein [KO:K03283]
111645389  dnajc6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
111661824  washc4; WASH complex subunit 4 isoform X1 [KO:K18465]
111658096  washc5; WASH complex subunit 5 [KO:K18464]
111654671  WASH complex subunit 2-like isoform X1 [KO:K18462]
111653360  washc1; WASH complex subunit 1 [KO:K18461]
111656502  washc3; WASH complex subunit 3 [KO:K18463]
111662370  F-actin-capping protein subunit alpha-1 [KO:K10364]
111668923  F-actin-capping protein subunit alpha-1-like [KO:K10364]
111672151  capza2; F-actin-capping protein subunit alpha-2 [KO:K10364]
111660805  capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
111659895  vps29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
111663532  vacuolar protein sorting-associated protein 26B-like [KO:K18466]
111645942  vps26a; vacuolar protein sorting-associated protein 26A [KO:K18466]
111652157  vps26b; vacuolar protein sorting-associated protein 26B [KO:K18466]
111672286  vps35; vacuolar protein sorting-associated protein 35 [KO:K18468]
111672113  snx12; sorting nexin-12 isoform X1 [KO:K17918]
111658326  snx3; sorting nexin-3 [KO:K17918]
111669872  sorting nexin-12-like [KO:K17918]
111656875  usp8; ubiquitin carboxyl-terminal hydrolase 8 [KO:K11839] [EC:3.4.19.12]
111660909  STAM-binding protein-like A [KO:K11866] [EC:3.4.19.12]
111649007  LOW QUALITY PROTEIN: STAM-binding protein-like A [KO:K11866] [EC:3.4.19.12]
111670680  ras-related protein Rab-7a-like [KO:K07897]
111649239  ras-related protein rab7-like [KO:K07897]
111667766  ras-related protein rab7-like [KO:K07897]
111670952  ras-related protein rab7 [KO:K07897]
111653666  hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
111657538  stam2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
111653166  stam; signal transducing adapter molecule 1 [KO:K04705]
111661805  tsg101; tumor susceptibility gene 101 protein [KO:K12183]
111645093  multivesicular body subunit 12B-like [KO:K12186]
111665529  mvb12a; multivesicular body subunit 12A [KO:K12186]
111648117  mvb12b; multivesicular body subunit 12B [KO:K12186]
111659399  vps28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
111647626  vps37c; vacuolar protein sorting-associated protein 37C [KO:K12185]
111648004  vps37b; vacuolar protein sorting-associated protein 37B [KO:K12185]
111652839  vps37a; vacuolar protein sorting-associated protein 37A [KO:K12185]
111673226  vacuolar protein sorting-associated protein 37D-like [KO:K12185]
111655400  snf8; vacuolar-sorting protein SNF8 [KO:K12188]
111666190  vps36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
111656129  vps25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
111657738  charged multivesicular body protein 6-like [KO:K12195]
111647709  charged multivesicular body protein 6-like [KO:K12195]
111670796  chmp4b; charged multivesicular body protein 4b [KO:K12194]
111649027  charged multivesicular body protein 4c [KO:K12194]
111665150  charged multivesicular body protein 4c-like [KO:K24782]
111648739  charged multivesicular body protein 4c-like [KO:K24782]
111659823  chmp3; charged multivesicular body protein 3 [KO:K12193]
111655449  chmp2a; charged multivesicular body protein 2a [KO:K12191]
111662727  chmp2b; charged multivesicular body protein 2b [KO:K12192]
111645098  chmp7; charged multivesicular body protein 7 isoform X1 [KO:K15053]
111647764  vps4a; vacuolar protein sorting-associated protein 4A [KO:K12196]
111669109  vacuolar protein sorting-associated protein 4B-like [KO:K12196]
111670491  vps4b; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
111658521  vta1; vacuolar protein sorting-associated protein VTA1 homolog isoform X1 [KO:K12199]
111653901  chmp1b; charged multivesicular body protein 1b [KO:K12197]
111647733  chmp1a; charged multivesicular body protein 1a [KO:K12197]
111646424  charged multivesicular body protein 1b-2-like isoform X1 [KO:K12197]
111656575  charged multivesicular body protein 5 [KO:K12198]
111656996  charged multivesicular body protein 5-like [KO:K12198]
111668332  ist1; IST1 homolog isoform X1 [KO:K19476]
111659297  pdcd6ip; programmed cell death 6-interacting protein isoform X1 [KO:K12200]
111669266  spg21; maspardin [KO:K19367]
111672612  igf2r; cation-independent mannose-6-phosphate receptor [KO:K06564]
111650365  sorting nexin-1-like [KO:K17917]
111651926  LOW QUALITY PROTEIN: sorting nexin-2-like [KO:K17917]
111670132  snx1; sorting nexin-1 [KO:K17917]
111652513  snx6; sorting nexin-6 [KO:K17920]
111669542  snx5; sorting nexin-5 [KO:K17920]
111667754  sorting nexin-6-like [KO:K17920]
111660679  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
111644184  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
111661823  hras; GTPase HRas [KO:K02833]
111646317  interleukin-2 receptor subunit beta-like isoform X1 [KO:K05069]
111671820  interleukin-2 receptor subunit beta-like [KO:K05069]
111671822  interleukin-2 receptor subunit beta-like isoform X1 [KO:K05069]
111672069  cytokine receptor common subunit gamma-like [KO:K05070]
111669019  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
111666387  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
111660814  transforming protein RhoA [KO:K04513]
111658866  rho-related GTP-binding protein RhoA-C [KO:K04513]
111663050  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
111666253  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
111647354  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
111661204  major histocompatibility complex class I-related gene protein-like [KO:K06751]
111645640  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
111645642  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
111645643  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
111645644  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
111644701  hereditary hemochromatosis protein homolog [KO:K06751]
111664121  major histocompatibility complex class I-related gene protein-like [KO:K06751]
111664195  major histocompatibility complex class I-related gene protein-like [KO:K06751]
111661187  HLA class I histocompatibility antigen, alpha chain F-like [KO:K06751]
111661201  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
111673813  riboflavin-binding protein-like [KO:K13649]
111655305  folr2; folate receptor beta [KO:K13649]
111672162  cav1; caveolin-1 [KO:K06278]
111653214  caveolin-2-like [KO:K12958]
111672165  cav2; caveolin-2 [KO:K12958]
111657843  caveolin-2-like [KO:K12958]
111651711  caveolin-3-like [KO:K12959]
111657852  caveolin-3-like [KO:K12959]
111672664  EH domain-containing protein 3 [KO:K12476]
111668267  EH domain-containing protein 4-like [KO:K12477]
111655352  eea1; early endosome antigen 1 isoform X1 [KO:K12478]
111659338  ras-related protein Rab-5A [KO:K07887]
111652636  ras-related protein Rab-5A [KO:K07887]
111659545  ras-related protein Rab-5B-like [KO:K07888]
111652822  rab5c; ras-related protein Rab-5C [KO:K07889]
111665760  ras-related protein Rab-5C-like [KO:K07889]
111657106  ras-related protein Rab-5C-like [KO:K07889]
111673214  rabep1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
111667163  rbsn; rabenosyn-5 [KO:K12481]
111668819  rab4a; ras-related protein Rab-4A [KO:K07879]
111652034  RUN and FYVE domain-containing protein 1-like [KO:K12482]
111645933  rufy2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
111655780  EH domain-containing protein 1-like [KO:K12483]
111651911  vps45; vacuolar protein sorting-associated protein 45 [KO:K12479]
111664246  sorting nexin-4-like [KO:K17919]
111671520  sorting nexin-4-like [KO:K17919]
111658406  rab31; ras-related protein Rab-31 [KO:K07891]
111660704  rab22a; ras-related protein Rab-22A [KO:K07891]
111661452  rab10; ras-related protein Rab-10 [KO:K07903]
111658520  ras-related protein Rab-40B-like [KO:K07901]
111654304  rab8a; ras-related protein Rab-8A [KO:K07901]
111669141  ras-related protein Rab-8A-like [KO:K07901]
111651171  ras-related protein Rab-35-like [KO:K07876]
111647983  rab35; ras-related protein Rab-35 isoform X1 [KO:K07876]
111655704  ras-related protein Rab-11A-like isoform X1 [KO:K07904]
111656874  rab11a; ras-related protein Rab-11A [KO:K07904]
111653784  ras-related protein Rab-11B-like [KO:K07905]
111653758  ras-related protein Rab-11B [KO:K07905]
111671131  ras-related protein Rab-11B-like [KO:K07905]
111657395  uncharacterized protein LOC111657395 [KO:K12484]
111669556  rab11fip2; rab11 family-interacting protein 2 [KO:K12484]
111645048  rab11 family-interacting protein 1-like isoform X1 [KO:K12484]
111672842  uncharacterized protein LOC111672842 [KO:K12484]
111659041  zfyve27; protrudin isoform X1 [KO:K19368]
111670721  kinesin heavy chain-like [KO:K10396]
111656763  kinesin heavy chain-like isoform X1 [KO:K10396]
111657043  kinesin-1 heavy chain-like isoform X1 [KO:K10396]
111659809  kif5a; kinesin heavy chain [KO:K10396]
111670325  kinesin heavy chain-like [KO:K10396]
111668409  kinesin-1 heavy chain [KO:K10396]
111658681  rab11fip3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
111669742  rab11 family-interacting protein 4A-like [KO:K12485]
111650960  rab11fip4; rab11 family-interacting protein 4 isoform X1 [KO:K12485]
111659829  partitioning defective 3 homolog [KO:K04237]
111668452  partitioning defective 3 homolog [KO:K04237]
111647698  partitioning defective 6 homolog alpha-like [KO:K06093]
111659227  partitioning defective 6 homolog gamma-like [KO:K06093]
111661962  pard6b; partitioning defective 6 homolog beta [KO:K06093]
111658840  prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
111669154  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
111668623  cell division control protein 42 homolog isoform X1 [KO:K04393]
111665702  cell division control protein 42 homolog [KO:K04393]
111669926  cell division control protein 42 homolog [KO:K04393]
111654176  cell division control protein 42 homolog isoform X1 [KO:K04393]
111669530  stromal membrane-associated protein 1-like isoform X1 [KO:K12486]
111666605  stromal membrane-associated protein 1-like [KO:K12486]
111673353  smap2; stromal membrane-associated protein 2 [KO:K12486]
111656442  git1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
111664802  ARF GTPase-activating protein GIT2-like isoform X1 [KO:K12487]
111660317  git2; ARF GTPase-activating protein GIT2 isoform X1 [KO:K12487]
111672712  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2-like isoform X1 [KO:K12488]
111659177  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1-like isoform X1 [KO:K12488]
111656586  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1-like isoform X1 [KO:K12488]
111662306  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2-like [KO:K12488]
111655895  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1-like isoform X1 [KO:K12488]
111644780  asap2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
111669367  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3-like isoform X1 [KO:K12489]
111650053  acap2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12489]
111663327  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3-like [KO:K12489]
111665749  acap1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [KO:K12489]
111667787  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3-like isoform X1 [KO:K12489]
111655282  arap1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
111671155  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1-like [KO:K18439]
111665765  arap2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K18440]
111665612  arap3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 [KO:K12490]
111653298  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3-like isoform X1 [KO:K12491]
111646881  agap1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12491]
111644227  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like isoform X1 [KO:K17848]
111667828  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like [KO:K17848]
111667780  arfgap1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
111651670  arfgap2; ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493]
111656497  arfgap3; ADP-ribosylation factor GTPase-activating protein 3 isoform X1 [KO:K12493]
111664725  PH and SEC7 domain-containing protein 3-like [KO:K12494]
111655436  uncharacterized protein LOC111655436 [KO:K12494]
111646470  psd2; PH and SEC7 domain-containing protein 2 isoform X1 [KO:K12494]
111656744  uncharacterized protein LOC111656744 [KO:K12494]
111673388  IQ motif and SEC7 domain-containing protein 1-like [KO:K12495]
111668564  IQ motif and SEC7 domain-containing protein 1-like isoform X1 [KO:K12495]
111653355  IQ motif and SEC7 domain-containing protein 3-like isoform X1 [KO:K12495]
111671932  LOW QUALITY PROTEIN: IQ motif and SEC7 domain-containing protein 3-like [KO:K12495]
111672208  IQ motif and SEC7 domain-containing protein 1-like isoform X1 [KO:K12495]
111654190  iqsec2; IQ motif and SEC7 domain-containing protein 2 [KO:K12495]
111644863  cytohesin-2-like [KO:K18441]
111667530  cytohesin-3 isoform X1 [KO:K18441]
111671829  cytohesin-4-like [KO:K18441]
111672010  cytohesin-3-like [KO:K18441]
111652177  cyth2; cytohesin-2 [KO:K18441]
111657719  cytohesin-1 isoform X1 [KO:K18441]
111673513  cytohesin-1-like isoform X1 [KO:K18441]
111661931  arfgef2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1 [KO:K18442]
111662961  arfgef1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 [KO:K18442]
111672961  gbf1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 [KO:K18443]
111653290  arf1; ADP-ribosylation factor 1 [KO:K07937]
111660541  ADP-ribosylation factor 1-like [KO:K07937]
111664351  ADP-ribosylation factor 1 [KO:K07937]
111667816  ADP-ribosylation factor 3 [KO:K07938]
111669035  arf3; ADP-ribosylation factor 3 [KO:K07938]
111670428  ADP-ribosylation factor 4 [KO:K07939]
111646825  ADP-ribosylation factor 4-like [KO:K07939]
111668210  ADP-ribosylation factor 1-like [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
slal04060  Cytokine-cytokine receptor interaction
slal04070  Phosphatidylinositol signaling system
slal04130  SNARE interactions in vesicular transport
slal04142  Lysosome
slal04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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