KEGG   PATHWAY: snh04150
Entry
snh04150                    Pathway                                
Name
mTOR signaling pathway - Salvelinus namaycush (lake trout)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
snh04150  mTOR signaling pathway
snh04150

Organism
Salvelinus namaycush (lake trout) [GN:snh]
Gene
120024743  large neutral amino acids transporter small subunit 1-like [KO:K13780]
120042802  large neutral amino acids transporter small subunit 1-like [KO:K13780]
120058695  large neutral amino acids transporter small subunit 1-like [KO:K13780]
120053195  large neutral amino acids transporter small subunit 1-like [KO:K13780]
120066649  slc7a5; large neutral amino acids transporter small subunit 1 [KO:K13780]
120060906  large neutral amino acids transporter small subunit 1-like [KO:K13780]
120021345  4F2 cell-surface antigen heavy chain-like [KO:K06519]
120049448  4F2 cell-surface antigen heavy chain-like [KO:K06519]
120057230  4F2 cell-surface antigen heavy chain-like [KO:K06519]
120018671  4F2 cell-surface antigen heavy chain [KO:K06519]
120025457  slc38a9; sodium-coupled neutral amino acid transporter 9 [KO:K14995]
120021512  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
120027861  atp6v1ab; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
120050966  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
120057295  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
120017614  atp6v1ba; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
120021871  atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
120046543  V-type proton ATPase subunit B, brain isoform-like [KO:K02147]
120030876  V-type proton ATPase subunit C 1-A [KO:K02148]
120047669  V-type proton ATPase subunit C 1-A [KO:K02148]
120019176  V-type proton ATPase subunit D-like [KO:K02149]
120024048  V-type proton ATPase subunit D [KO:K02149]
120049363  V-type proton ATPase subunit E 1-like [KO:K02150]
120042012  V-type proton ATPase subunit E 1-like [KO:K02150]
120031941  V-type proton ATPase subunit E 1-like [KO:K02150]
120031976  V-type proton ATPase subunit F-like [KO:K02151]
120049859  V-type proton ATPase subunit F [KO:K02151]
120021511  V-type proton ATPase subunit G 1-like [KO:K02152]
120026252  V-type proton ATPase subunit G 1-like [KO:K02152]
120028576  ragulator complex protein LAMTOR1-like isoform X1 [KO:K20397]
120036055  ragulator complex protein LAMTOR1-like [KO:K20397]
120031103  ragulator complex protein LAMTOR2 [KO:K20398]
120047624  ragulator complex protein LAMTOR2 [KO:K20398]
120023714  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
120049325  ragulator complex protein LAMTOR4-like [KO:K20399]
120032190  ragulator complex protein LAMTOR4 [KO:K20399]
120059044  lamtor5; ragulator complex protein LAMTOR5 [KO:K16344]
120061524  ragulator complex protein LAMTOR5-like [KO:K16344]
120030825  folliculin-like [KO:K09594]
120048737  folliculin-like [KO:K09594]
120032014  folliculin-interacting protein 1-like isoform X1 [KO:K20400]
120056759  folliculin-interacting protein 1-like [KO:K20400]
120045100  rraga; ras-related GTP-binding protein A [KO:K16185]
120048333  ras-related GTP-binding protein C isoform X1 [KO:K16186]
120031050  rragca; ras-related GTP binding Ca [KO:K16186]
120026993  ras-related GTP-binding protein C-like [KO:K16186]
120060477  rragd; ras-related GTP-binding protein D [KO:K16186]
120022853  sesn2; sestrin-2 [KO:K20394]
120043805  cytosolic arginine sensor for mTORC1 subunit 1-like isoform X1 [KO:K23080]
120063403  cytosolic arginine sensor for mTORC1 subunit 1-like [KO:K23080]
120031712  cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
120056918  castor2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
120030786  GATOR complex protein MIOS [KO:K20407]
120048372  GATOR complex protein MIOS-like isoform X1 [KO:K20407]
120030822  nucleoporin SEH1-like [KO:K14299]
120026791  seh1l; nucleoporin SEH1 isoform X1 [KO:K14299]
120045493  wdr24; GATOR complex protein WDR24 [KO:K20408]
120060879  GATOR complex protein WDR24-like [KO:K20408]
120053364  wdr59; LOW QUALITY PROTEIN: GATOR complex protein WDR59 [KO:K20409]
120065497  sec13; protein SEC13 homolog [KO:K14004]
120025719  depdc5; GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
120059028  nprl2; GATOR complex protein NPRL2 isoform X1 [KO:K20405]
120034316  GATOR complex protein NPRL3-like isoform X1 [KO:K20406]
120036784  GATOR complex protein NPRL3-like isoform X1 [KO:K20406]
120025561  skp2; S-phase kinase-associated protein 2 [KO:K03875]
120044230  S-phase kinase-associated protein 2-like [KO:K03875]
120020738  E3 ubiquitin-protein ligase RNF152-like [KO:K15705] [EC:2.3.2.27]
120028147  E3 ubiquitin-protein ligase RNF152-like [KO:K15705] [EC:2.3.2.27]
120050432  E3 ubiquitin-protein ligase RNF152-like [KO:K15705] [EC:2.3.2.27]
120055257  E3 ubiquitin-protein ligase RNF152-like [KO:K15705] [EC:2.3.2.27]
120032502  regulatory-associated protein of mTOR-like [KO:K07204]
120066011  regulatory-associated protein of mTOR-like isoform X1 [KO:K07204]
120040292  uncharacterized protein LOC120040292 [KO:K16184]
120034221  uncharacterized protein LOC120034221 isoform X1 [KO:K16184]
120059396  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
120048895  deptor; DEP domain-containing mTOR-interacting protein [KO:K20402]
120065692  si:dkeyp-97e7.9; DEP domain-containing mTOR-interacting protein [KO:K20402]
120029567  mlst8; target of rapamycin complex subunit lst8 isoform X1 [KO:K08266]
120060876  telo2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
120061199  tti1; TELO2-interacting protein 1 homolog [KO:K20403]
120022158  CAP-Gly domain-containing linker protein 1-like isoform X1 [KO:K10421]
120026460  clip1b; CAP-Gly domain-containing linker protein 1 [KO:K10421]
120062988  clip1a; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
120022070  growth factor receptor-bound protein 10-like isoform X1 [KO:K20064]
120048490  growth factor receptor-bound protein 10-like isoform X1 [KO:K20064]
120031018  growth factor receptor-bound protein 10-like [KO:K20064]
120027049  growth factor receptor-bound protein 10-like [KO:K20064]
120023754  phosphatidate phosphatase LPIN1-like isoform X1 [KO:K15728] [EC:3.1.3.4]
120028030  phosphatidate phosphatase LPIN2-like [KO:K15728] [EC:3.1.3.4]
120051151  phosphatidate phosphatase LPIN2-like [KO:K15728] [EC:3.1.3.4]
120064157  phosphatidate phosphatase LPIN3-like isoform X1 [KO:K15728] [EC:3.1.3.4]
120065396  phosphatidate phosphatase LPIN2-like [KO:K15728] [EC:3.1.3.4]
120060219  phosphatidate phosphatase LPIN1-like [KO:K15728] [EC:3.1.3.4]
120021252  serine/threonine-protein kinase ULK1-like [KO:K21357] [EC:2.7.11.1]
120025438  serine/threonine-protein kinase ULK1-like isoform X1 [KO:K21357] [EC:2.7.11.1]
120063189  serine/threonine-protein kinase ULK1-like isoform X1 [KO:K21357] [EC:2.7.11.1]
120018128  serine/threonine-protein kinase ULK2-like [KO:K08269] [EC:2.7.11.1]
120028305  serine/threonine-protein kinase ULK2-like isoform X1 [KO:K08269] [EC:2.7.11.1]
120021905  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
120062657  eukaryotic translation initiation factor 4E-binding protein 2-like [KO:K07205]
120054804  eukaryotic translation initiation factor 4E-binding protein 2-like [KO:K07205]
120017737  eukaryotic translation initiation factor 4E-like [KO:K03259]
120019999  eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
120021102  eif4e1b; eukaryotic translation initiation factor 4E-1B [KO:K03259]
120023573  eukaryotic translation initiation factor 4E-like [KO:K03259]
120041698  eif4e2rs1; eukaryotic translation initiation factor 4E family member 2 related sequence 1 [KO:K03259]
120046714  eukaryotic translation initiation factor 4E-like isoform X1 [KO:K03259]
120047422  eif4ea; eukaryotic translation initiation factor 4E-1A [KO:K03259]
120060370  eukaryotic translation initiation factor 4E-like [KO:K03259]
120061880  eukaryotic translation initiation factor 4E-1A-like [KO:K03259]
120018156  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
120045201  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
120034672  ribosomal protein S6 kinase beta-2-like isoform X1 [KO:K04688] [EC:2.7.11.1]
120028826  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
120057066  ribosomal protein S6 kinase beta-1-like isoform X1 [KO:K04688] [EC:2.7.11.1]
120052805  ribosomal protein S6 kinase beta-2-like isoform X1 [KO:K04688] [EC:2.7.11.1]
120064200  eukaryotic translation initiation factor 4B-like isoform X1 [KO:K03258]
120065404  eukaryotic translation initiation factor 4B-like isoform X1 [KO:K03258]
120059578  eukaryotic translation initiation factor 4B-like [KO:K03258]
120060975  eukaryotic translation initiation factor 4B-like isoform X1 [KO:K03258]
120035117  40S ribosomal protein S6 [KO:K02991]
120052754  40S ribosomal protein S6 [KO:K02991]
120040680  STE20-related kinase adapter protein alpha-like isoform X1 [KO:K08271]
120034385  STE20-related kinase adapter protein alpha-like isoform X1 [KO:K08271]
120051507  stradb; STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
120020158  serine/threonine-protein kinase STK11-like [KO:K07298] [EC:2.7.11.1]
120056015  serine/threonine-protein kinase STK11-like isoform X1 [KO:K07298] [EC:2.7.11.1]
120053185  serine/threonine-protein kinase STK11-like [KO:K07298] [EC:2.7.11.1]
120054759  serine/threonine-protein kinase STK11-like [KO:K07298] [EC:2.7.11.1]
120018080  calcium-binding protein 39 [KO:K08272]
120033613  calcium-binding protein 39-like [KO:K08272]
120028368  calcium-binding protein 39 [KO:K08272]
120062457  cab39l1; calcium binding protein 39, like 1 [KO:K08272]
120051399  calcium-binding protein 39-like [KO:K08272]
120058175  calcium-binding protein 39-like [KO:K08272]
120020934  5'-AMP-activated protein kinase catalytic subunit alpha-1-like [KO:K07198] [EC:2.7.11.31]
120026489  5'-AMP-activated protein kinase catalytic subunit alpha-1-like [KO:K07198] [EC:2.7.11.31]
120052562  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
120054507  5'-AMP-activated protein kinase catalytic subunit alpha-2-like isoform X1 [KO:K07198] [EC:2.7.11.31]
120021274  hamartin-like isoform X1 [KO:K07206]
120025722  hamartin-like [KO:K07206]
120044832  tsc1a; TSC complex subunit 1a isoform X1 [KO:K07206]
120018258  tsc2; tuberin isoform X1 [KO:K07207]
120051894  tbc1d7; TBC1 domain family member 7 [KO:K20396]
120020312  GTP-binding protein Rheb-like [KO:K07208]
120028100  GTP-binding protein Rheb [KO:K07208]
120050354  GTP-binding protein Rheb-like [KO:K07208]
120065190  GTP-binding protein Rheb-like [KO:K07208]
120061304  GTP-binding protein Rheb-like [KO:K07208]
120017744  DNA damage-inducible transcript 4 protein-like [KO:K08270]
120017457  ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
120058823  protein Wnt-1-like [KO:K03209]
120060632  wnt1; protein Wnt-1 [KO:K03209]
120065034  protein Wnt-2b-like [KO:K00182]
120058859  wnt2ba; wingless-type MMTV integration site family, member 2Ba [KO:K00182]
120053521  protein Wnt-2-like [KO:K00182]
120066340  protein Wnt-2 [KO:K00182]
120020187  protein Wnt-3a [KO:K00312]
120045458  proto-oncogene Wnt-3-like [KO:K00312]
120029976  proto-oncogene Wnt-3 [KO:K00312]
120055592  wnt3a; protein Wnt-3a [KO:K00312]
120048609  protein Wnt-4-like [KO:K00408]
120048721  protein Wnt-4-like [KO:K00408]
120025131  wnt4; protein Wnt-4a [KO:K00408]
120065724  protein Wnt-4a-like [KO:K00408]
120043001  wnt5b; protein Wnt-5b [KO:K00444]
120061448  wnt5a; protein Wnt-5a [KO:K00444]
120063851  protein Wnt-6-like [KO:K00445]
120057846  protein Wnt-6-like [KO:K00445]
120049314  protein Wnt-7b-like [KO:K00572]
120032137  wnt7ba; protein Wnt-7b [KO:K00572]
120051780  protein Wnt-7b isoform X1 [KO:K00572]
120058992  protein Wnt-7a [KO:K00572]
120066151  protein Wnt-7b-like [KO:K00572]
120061338  protein Wnt-7a-like [KO:K00572]
120017963  protein Wnt-8b-like [KO:K00714]
120047931  protein Wnt-8a-like [KO:K00714]
120045658  protein Wnt-8b [KO:K00714]
120046922  protein Wnt-8a-like [KO:K00714]
120019794  protein Wnt-9a-like [KO:K01064]
120044538  wnt9b; protein Wnt-9b [KO:K01064]
120033973  protein Wnt-9b-like [KO:K01064]
120055978  protein Wnt-9a-like [KO:K01064]
120063852  protein Wnt-10a [KO:K01357]
120057755  protein Wnt-10a-like [KO:K01357]
120058822  protein Wnt-10b-like [KO:K01357]
120060633  wnt10b; protein Wnt-10b [KO:K01357]
120043682  protein Wnt-11-like [KO:K01384]
120044318  wnt11; protein Wnt-11 [KO:K01384]
120056520  protein Wnt-11-like [KO:K01384]
120057514  protein Wnt-11-like [KO:K01384]
120049399  protein Wnt-16-like [KO:K01558]
120031790  protein Wnt-16-like [KO:K01558]
120022692  frizzled-1-like [KO:K02432]
120040115  frizzled-7-A-like [KO:K02432]
120031410  frizzled-1-like [KO:K02432]
120048525  frizzled-1-like [KO:K02432]
120033702  frizzled-7-A-like [KO:K02432]
120027528  frizzled-1-like [KO:K02432]
120051282  frizzled-7-like [KO:K02432]
120044536  frizzled-2-like [KO:K02235]
120034387  frizzled-2-like [KO:K02235]
120019559  frizzled-3-like [KO:K02329]
120023851  frizzled-3-like [KO:K02329]
120024556  fzd3a; frizzled-3a [KO:K02329]
120060199  frizzled-3-like [KO:K02329]
120018062  frizzled-4-like [KO:K02354]
120029081  frizzled-4-like [KO:K02354]
120020122  frizzled-8-like [KO:K02375]
120039118  frizzled-5-like [KO:K02375]
120028076  fzd8a; frizzled-8a [KO:K02375]
120064112  frizzled-5-like [KO:K02375]
120058350  frizzled-5-like [KO:K02375]
120055563  frizzled-8-like [KO:K02375]
120031155  frizzled-6-like [KO:K02376]
120048534  frizzled-6-like [KO:K02376]
120018297  frizzled-9-like [KO:K02842]
120044348  frizzled-9-like isoform X1 [KO:K02842]
120028700  frizzled-9-like [KO:K02842]
120056493  frizzled-9 [KO:K02842]
120062850  frizzled-10-B-like [KO:K02842]
120051012  fzd10; frizzled-10 [KO:K02842]
120066168  low-density lipoprotein receptor-related protein 5-like isoform X1 [KO:K03068]
120053809  low-density lipoprotein receptor-related protein 5-like isoform X1 [KO:K03068]
120018700  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
120018701  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
120020466  segment polarity protein dishevelled homolog DVL-3-like isoform X1 [KO:K02353]
120030429  segment polarity protein dishevelled homolog DVL-2-like isoform X1 [KO:K02353]
120029025  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
120055815  segment polarity protein dishevelled homolog DVL-3-like isoform X1 [KO:K02353]
120049687  segment polarity protein dishevelled homolog DVL-2-like [KO:K02353]
120057399  segment polarity protein dishevelled homolog DVL-2-like [KO:K02353]
120059214  segment polarity protein dishevelled homolog DVL-1-like isoform X1 [KO:K02353]
120061325  segment polarity protein dishevelled homolog DVL-1-like isoform X1 [KO:K02353]
120033312  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
120051240  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
120064165  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
120058450  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
120022601  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
120027290  tumor necrosis factor-like [KO:K03156]
120031280  tumor necrosis factor-like [KO:K03156]
120048603  tumor necrosis factor receptor superfamily member 1A-like isoform X1 [KO:K03158]
120048707  tumor necrosis factor receptor superfamily member 1A-like isoform X1 [KO:K03158]
120039020  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
120044421  insulin [KO:K04526]
120046921  LOW QUALITY PROTEIN: insulin-like [KO:K04526]
120062047  insulin-like [KO:K04526]
120056420  insulin-like [KO:K04526]
120031740  insulin-like growth factor I isoform X1 [KO:K05459]
120049944  insulin-like growth factor I isoform X1 [KO:K05459]
120020095  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
120056144  insulin receptor-like isoform X1 [KO:K04527] [EC:2.7.10.1]
120052701  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
120055081  insrb; insulin receptor b isoform X1 [KO:K04527] [EC:2.7.10.1]
120065838  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
120053452  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
120032581  growth factor receptor-bound protein 2-like [KO:K04364]
120033929  growth factor receptor-bound protein 2 [KO:K04364]
120039012  growth factor receptor-bound protein 2-like isoform X1 [KO:K04364]
120066644  growth factor receptor-bound protein 2-like [KO:K04364]
120032369  son of sevenless homolog 1-like isoform X1 [KO:K03099]
120065085  son of sevenless homolog 1-like [KO:K03099]
120060118  sos2; son of sevenless homolog 2 [KO:K03099]
120054020  GTPase HRas-like [KO:K02833]
120066370  GTPase HRas [KO:K02833]
120043786  zgc:55558 [KO:K07827]
120054052  GTPase KRas isoform X1 [KO:K07827]
120066403  kras; GTPase KRas isoform X1 [KO:K07827]
120050158  braf; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
120059498  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
120061320  RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
120042460  dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
120020580  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
120056021  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
120052438  dual specificity mitogen-activated protein kinase kinase 2-like isoform X1 [KO:K04369] [EC:2.7.12.2]
120054777  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
120042809  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
120033084  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
120037194  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
120052722  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
120021459  ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
120023564  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
120045664  ribosomal protein S6 kinase alpha-2-like isoform X1 [KO:K04373] [EC:2.7.11.1]
120027827  ribosomal protein S6 kinase alpha-3-like isoform X1 [KO:K04373] [EC:2.7.11.1]
120029857  ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
120050951  ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
120057286  ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
120060162  ribosomal protein S6 kinase 2 alpha-like [KO:K04373] [EC:2.7.11.1]
120030427  si:ch73-335l21.1; insulin receptor substrate 1-B [KO:K16172]
120043800  insulin receptor substrate 1-B-like [KO:K16172]
120028247  irs1; insulin receptor substrate 1-B isoform X1 [KO:K16172]
120049688  insulin receptor substrate 1-B-like [KO:K16172]
120057482  si:ch211-284e13.4; insulin receptor substrate 1-B [KO:K16172]
120020037  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
120020698  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
120020967  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
120025946  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
120045060  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
120055801  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
120056045  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
120052671  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
120053720  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
120055170  phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
120018079  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
120020587  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
120028622  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
120055757  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
120058910  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
120054876  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
120017655  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
120030036  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
120046138  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
120046560  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
120044548  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
120034442  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
120046248  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
120060883  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
120023179  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
120018091  akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
120019020  RAC-alpha serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
120021584  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
120023915  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
120033010  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
120028361  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120029418  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120057353  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
120065545  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120060247  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120046219  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
120046430  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
120029505  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
120038402  mapkap1; target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
120025702  rapamycin-insensitive companion of mTOR-like [KO:K08267]
120044418  rapamycin-insensitive companion of mTOR-like [KO:K08267]
120045002  rapamycin-insensitive companion of mTOR-like [KO:K08267]
120032061  prr5b; proline-rich protein 5 [KO:K20411]
120053482  proline-rich protein 5-like [KO:K20411]
120066364  proline-rich protein 5-like [KO:K20411]
120066028  prr5l; proline-rich protein 5-like [KO:K20411]
120063372  transforming protein RhoA-like [KO:K04513]
120065029  rho-related GTP-binding protein RhoA-D [KO:K04513]
120059011  rho-related GTP-binding protein RhoA-A-like [KO:K04513]
120065359  transforming protein RhoA-like [KO:K04513]
120059302  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
120059445  rho-related GTP-binding protein RhoA-B [KO:K04513]
120061242  rho-related GTP-binding protein RhoA-C [KO:K04513]
120061269  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
120032664  protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
120065642  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
120042471  protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
120036642  protein kinase C alpha type-like [KO:K19663] [EC:2.7.11.13]
120022563  serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
120030978  serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
120048857  serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
120027205  serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
snh00561  Glycerolipid metabolism
snh04010  MAPK signaling pathway
snh04140  Autophagy - animal
snh04810  Regulation of actin cytoskeleton
snh04910  Insulin signaling pathway
KO pathway
ko04150   
LinkDB

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