KEGG   PATHWAY: tala00230
Entry
tala00230                   Pathway                                
Name
Purine metabolism - Tyto alba (Barn owl)
Class
Metabolism; Nucleotide metabolism
Pathway map
tala00230  Purine metabolism
tala00230

Module
tala_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:tala00230]
tala_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:tala00230]
tala_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:tala00230]
tala_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:tala00230]
tala_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:tala00230]
tala_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:tala00230]
Other DBs
GO: 0006163 0042278
Organism
Tyto alba (Barn owl) [GN:tala]
Gene
104364716  NUDT9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
104358472  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
104367680  NUDT5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
104365997  PGM1; phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
104355872  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
104363256  PRPS2; ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
104368853  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
104361029  PPAT; amidophosphoribosyltransferase isoform X1 [KO:K00764] [EC:2.4.2.14]
104361255  GART; trifunctional purine biosynthetic protein adenosine-3 isoform X1 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
104361256  trifunctional purine biosynthetic protein adenosine-3-like [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
104363918  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
104365508  ATIC; bifunctional purine biosynthesis protein ATIC isoform X1 [KO:K00602] [EC:2.1.2.3 3.5.4.10]
104359177  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
104359556  cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
104368792  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
104362785  NT5C2; cytosolic purine 5'-nucleotidase isoform X2 [KO:K01081] [EC:3.1.3.5]
104362705  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
104363845  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
104357508  cytosolic 5'-nucleotidase 1B [KO:K01081] [EC:3.1.3.5]
116959026  cytosolic purine 5'-nucleotidase-like isoform X1 [KO:K01081] [EC:3.1.3.5]
104362429  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
104359110  purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
104363685  LACC1; purine nucleoside phosphorylase LACC1 isoform X1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
104356774  hypoxanthine-guanine phosphoribosyltransferase isoform X1 [KO:K00760] [EC:2.4.2.8]
104360736  HPRT1; hypoxanthine-guanine phosphoribosyltransferase isoform X2 [KO:K00760] [EC:2.4.2.8]
104366669  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
104365950  NME7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
104356122  NME6; nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
116962205  nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
116963003  NME3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
104367287  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
104368042  AK9; adenylate kinase 9 isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
104363868  LOW QUALITY PROTEIN: ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
104358206  ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
116964210  ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
104360844  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
104365752  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
104363503  CANT1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
104363903  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
104367742  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
104355939  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
104358973  ITPA; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
104360092  XDH; xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
104367338  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
104364093  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
104357073  GMPR; GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
104369393  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
104368021  GUK1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
104355945  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
104367236  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
104367020  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
104355898  HDDC2; 5'-deoxynucleotidase HDDC2 [KO:K07023] [EC:3.1.3.89]
116959717  DGUOK; deoxyguanosine kinase, mitochondrial [KO:K00904] [EC:2.7.1.113]
104367925  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
104356318  deoxycytidine kinase 2 [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
116959053  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
116960147  exopolyphosphatase PRUNE1-like [KO:K01514] [EC:3.6.1.11]
116963786  exopolyphosphatase PRUNE1-like isoform X1 [KO:K01514] [EC:3.6.1.11]
104361601  ADCY1; adenylate cyclase type 1 isoform X4 [KO:K08041] [EC:4.6.1.1]
104359690  ADCY2; adenylate cyclase type 2 isoform X3 [KO:K08042] [EC:4.6.1.1]
116958839  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
104360348  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
116960680  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
104368104  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
104358260  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
104366998  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
104359210  GUCY1A1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
104361803  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
104367666  guanylate cyclase soluble subunit beta-2 isoform X1 [KO:K12319] [EC:4.6.1.2]
104361705  GUCY1B1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
104361832  GUCY2C; heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
104356975  GUCY2F; retinal guanylyl cyclase 2 isoform X1 [KO:K12322] [EC:4.6.1.2]
116960864  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
104357822  atrial natriuretic peptide receptor 1 [KO:K12324] [EC:4.6.1.2]
116964697  atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
104367134  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
104359121  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
116959394  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
116963031  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 [KO:K18283] [EC:3.1.4.17]
104363749  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
104361522  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
104357631  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X4 [KO:K13762] [EC:3.1.4.35]
104361350  PDE6B; LOW QUALITY PROTEIN: rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
104362561  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform X1 [KO:K13757] [EC:3.1.4.35]
104356433  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform X2 [KO:K13758]
116960852  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
104364949  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma isoform X2 [KO:K13760]
104359581  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
104358382  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
104366568  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
104358900  ADSS1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
104362437  ADSS2; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
104365420  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
104364595  AMPD1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
116962240  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
104366273  ADK; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
104359276  ADA; adenosine deaminase isoform X2 [KO:K01488] [EC:3.5.4.4]
104366617  ADA2; adenosine deaminase 2 isoform X2 [KO:K19572] [EC:3.5.4.4]
116965487  AK4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
104368863  AK8; adenylate kinase 8 isoform X2 [KO:K00939] [EC:2.7.4.3]
104366387  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
104357609  AK7; adenylate kinase 7 isoform X1 [KO:K00939] [EC:2.7.4.3]
116958829  AK1; adenylate kinase isoenzyme 1 isoform X1 [KO:K00939] [EC:2.7.4.3]
104366755  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
104369182  AK6; adenylate kinase isoenzyme 6 isoform X2 [KO:K18532] [EC:2.7.4.3]
104360955  AK3; GTP:AMP phosphotransferase AK3, mitochondrial isoform X1 [KO:K00944] [EC:2.7.4.10]
104367334  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 isoform X1 [KO:K01509] [EC:3.6.1.-]
104360364  NTPCR; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
104358691  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
104363775  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X2 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
104366973  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X6 [KO:K13293] [EC:3.1.4.53]
104356725  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
104369086  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
104358932  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X2 [KO:K18436] [EC:3.1.4.53]
104359395  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X2 [KO:K18436] [EC:3.1.4.53]
104366438  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
104357732  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
116965549  FHIT; bis(5'-adenosyl)-triphosphatase isoform X1 [KO:K01522] [EC:3.6.1.29]
104364466  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
104359161  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
104356983  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
tala00030  Pentose phosphate pathway
tala00220  Arginine biosynthesis
tala00250  Alanine, aspartate and glutamate metabolism
tala00260  Glycine, serine and threonine metabolism
tala00340  Histidine metabolism
tala00630  Glyoxylate and dicarboxylate metabolism
tala00730  Thiamine metabolism
tala00740  Riboflavin metabolism
tala00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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