KEGG   PATHWAY: tdw04141
Entry
tdw04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Triplophysa dalaica
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
tdw04141  Protein processing in endoplasmic reticulum
tdw04141

Other DBs
GO: 0030433 0034976
Organism
Triplophysa dalaica [GN:tdw]
Gene
130424865  sec61a1a; protein transport protein Sec61 subunit alpha-like 1 [KO:K10956]
130425096  sec61a1b; protein transport protein Sec61 subunit alpha-like 2 [KO:K10956]
130432875  sec61b; protein transport protein Sec61 subunit beta [KO:K09481]
130418009  sec62; translocation protein SEC62 [KO:K12275]
130434711  sec63; translocation protein SEC63 homolog [KO:K09540]
130410668  rpn1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [KO:K12666]
130410468  rpn2; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
130417851  dad1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
130409291  ddost; dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
130412106  stt3a; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
130432749  stt3b; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
130438374  magt1; magnesium transporter protein 1 [KO:K19478]
130407704  tumor suppressor candidate 3 [KO:K19478]
130408909  tumor suppressor candidate 3 [KO:K19478]
130418316  ostc; oligosaccharyltransferase complex subunit ostc [KO:K26501]
130413994  tmem258; transmembrane protein 258 [KO:K26502]
130412194  mogs; mannosyl-oligosaccharide glucosidase [KO:K01228] [EC:3.2.1.106]
130421167  ckap4; cytoskeleton-associated protein 4 [KO:K13999]
130430183  rrbp1b; LOW QUALITY PROTEIN: ribosome-binding protein 1b [KO:K14000]
130431500  rrbp1a; ribosome-binding protein 1a isoform X1 [KO:K14000]
130437626  sil1; nucleotide exchange factor SIL1 [KO:K14001]
130411646  hyou1; hypoxia up-regulated protein 1 [KO:K09486]
130420201  hspa5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
130418874  endoplasmic reticulum chaperone BiP-like [KO:K09490] [EC:3.6.4.10]
130427451  dnajb11; dnaJ homolog subfamily B member 11 [KO:K09517]
130418439  dnajc1; dnaJ homolog subfamily C member 1 [KO:K09521]
130426338  dnajc3b; dnaJ homolog subfamily C member 3b [KO:K09523]
130428085  dnajc3a; dnaJ homolog subfamily C member 3a [KO:K09523]
130427961  dnajc10; dnaJ homolog subfamily C member 10 [KO:K09530] [EC:1.8.4.-]
130421388  hsp90b1; endoplasmin [KO:K09487]
130438257  ganabb; neutral alpha-glucosidase AB [KO:K05546] [EC:3.2.1.207]
130419410  ganaba; neutral alpha-glucosidase AB isoform X1 [KO:K05546] [EC:3.2.1.207]
130438098  canx; calnexin isoform X1 [KO:K08054]
130414497  pdia3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
130433204  pdia7; protein disulfide isomerase family A, member 7 [KO:K08056] [EC:5.3.4.1]
130429931  calr3a; calreticulin 3a [KO:K08057]
130440042  calr; calreticulin [KO:K08057]
130418234  calr3b; calreticulin 3b [KO:K08057]
130432760  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA isoform X1 [KO:K01230] [EC:3.2.1.113]
130434333  man1a1; mannosyl-oligosaccharide 1,2-alpha-mannosidase IA [KO:K01230] [EC:3.2.1.113]
130427244  man1a2; mannosyl-oligosaccharide 1,2-alpha-mannosidase IB [KO:K01230] [EC:3.2.1.113]
130408484  man1b1a; endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase [KO:K23741] [EC:3.2.1.209]
130419197  man1b1b; mannosidase, alpha, class 1B, member 1b isoform X1 [KO:K23741] [EC:3.2.1.209]
130437929  lman2; vesicular integral-membrane protein VIP36 isoform X1 [KO:K10082]
130408145  lman1; protein ERGIC-53 [KO:K10080]
130433548  preb; prolactin regulatory element-binding protein [KO:K14003]
130431678  sar1ab; secretion associated, Ras related GTPase 1Ab [KO:K07953] [EC:3.6.5.-]
130438733  sar1aa; GTP-binding protein SAR1b isoform X1 [KO:K07953] [EC:3.6.5.-]
130407638  sar1b; GTP-binding protein SAR1b [KO:K07953] [EC:3.6.5.-]
130430115  sec13; protein SEC13 homolog [KO:K14004]
130411561  sec31a; protein transport protein Sec31A isoform X1 [KO:K14005]
130438978  sec31b; protein transport protein Sec31A [KO:K14005]
130436748  sec23a; protein transport protein Sec23A [KO:K14006]
130425138  sec23b; protein transport protein Sec23B [KO:K14006]
130420213  si:dkey-13n15.2; protein transport protein Sec24C isoform X1 [KO:K14007]
130438006  sec24b; protein transport protein Sec24B isoform X1 [KO:K14007]
130431790  sec24d; protein transport protein Sec24D [KO:K14007]
130438955  sec24c; protein transport protein Sec24C isoform X1 [KO:K14007]
130408117  sec24a; protein transport protein Sec24A isoform X1 [KO:K14007]
130417681  uggt1; UDP-glucose:glycoprotein glucosyltransferase 1 isoform X1 [KO:K11718] [EC:2.4.1.-]
130427661  uggt2; UDP-glucose:glycoprotein glucosyltransferase 2 [KO:K11718] [EC:2.4.1.-]
130425234  edem1; ER degradation-enhancing alpha-mannosidase-like protein 1 [KO:K10084]
130409753  edem2; ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
130407705  si:ch211-282j22.3; ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
130439838  edem3; ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
130424632  p4hb; protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
130413560  pdia4; protein disulfide-isomerase A4 [KO:K09582] [EC:5.3.4.1]
130434978  pdia6; protein disulfide-isomerase A6 [KO:K09584] [EC:5.3.4.1]
130413107  txndc5; thioredoxin domain-containing protein 5 [KO:K13984] [EC:5.3.4.1]
130436577  ero1a; ERO1-like protein alpha isoform X1 [KO:K10950] [EC:1.8.4.-]
130410758  ero1b; ERO1-like protein beta isoform X1 [KO:K10976] [EC:1.8.4.-]
130425078  os9; protein OS-9 isoform X1 [KO:K10088]
130432139  erlec1; endoplasmic reticulum lectin 1 isoform X1 [KO:K14008]
130413237  ssr1; translocon-associated protein subunit alpha isoform X1 [KO:K13249]
130415413  ssr2; translocon-associated protein subunit beta [KO:K13250]
130435183  ssr3; translocon-associated protein subunit gamma [KO:K13251]
130409414  ssr4; translocon-associated protein subunit delta [KO:K04571]
130407026  bcap31; B-cell receptor-associated protein 31 [KO:K14009]
130413607  tram1; translocating chain-associated membrane protein 1 [KO:K14010]
130432571  derl1; derlin-1 [KO:K11519]
130419807  derl2; derlin-2 [KO:K13989]
130440146  derl3; derlin-3 [KO:K13989]
130437756  ubxn1; UBX domain-containing protein 1 [KO:K24348]
130427623  ubxn4; UBX domain-containing protein 4 isoform X1 [KO:K24348]
130434441  ubxn2a; LOW QUALITY PROTEIN: UBX domain-containing protein 2A [KO:K24349]
130430358  ubxn6; UBX domain-containing protein 6 [KO:K14011]
130412257  ubxn8; UBX domain-containing protein 8 isoform X1 [KO:K24351]
130409481  nsfl1c; NSFL1 cofactor p47 [KO:K14012]
130413934  svip; small VCP/p97-interacting protein [KO:K14014]
130419658  vcp; LOW QUALITY PROTEIN: transitional endoplasmic reticulum ATPase [KO:K13525]
130413516  zgc:136908; transitional endoplasmic reticulum ATPase [KO:K13525]
130438960  nploc4; nuclear protein localization protein 4 homolog [KO:K14015]
130440113  ufd1l; ubiquitin recognition factor in ER-associated degradation protein 1 [KO:K14016]
130411634  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
130426370  heat shock 70 kDa protein-like [KO:K03283]
130426371  heat shock 70 kDa protein-like [KO:K03283]
130426372  heat shock 70 kDa protein-like [KO:K03283]
130426374  heat shock 70 kDa protein [KO:K03283]
130426375  heat shock 70 kDa protein-like [KO:K03283]
130426376  heat shock 70 kDa protein-like [KO:K03283]
130440299  hspa1b; LOW QUALITY PROTEIN: heat shock 70 kDa protein-like [KO:K03283]
130428391  hspa8b; LOW QUALITY PROTEIN: heat shock protein family A (Hsp70) member 8b [KO:K03283]
130428466  hsc70; heat shock cognate 71 kDa protein [KO:K03283]
130409330  dnaja1; dnaJ homolog subfamily A member 1 [KO:K09502]
130435995  dnaja2b; dnaJ homolog subfamily A member 2b [KO:K09503]
130425897  dnaja2a; dnaJ homolog subfamily A member 2a [KO:K09503]
130426533  dnajb1a; dnaJ homolog subfamily B member 1a [KO:K09507]
130435421  dnajb1b; dnaJ homolog subfamily B member 1b [KO:K09507]
130427471  dnajb2; dnaJ homolog subfamily B member 2 isoform X1 [KO:K09508]
130431666  dnajb12a; dnaJ homolog subfamily B member 12a [KO:K09518]
130439506  dnajb12b; dnaJ homolog subfamily B member 12b [KO:K09518]
130436762  dnajc5gb; dnaJ (Hsp40) homolog, subfamily C, member 5 gamma b [KO:K09525]
130413658  dnajc5b; dnaJ homolog subfamily C member 5 [KO:K09525]
130408836  dnajc5ab; dnaJ homolog subfamily C member 5 [KO:K09525]
130440324  dnajc5aa; dnaJ (Hsp40) homolog, subfamily C, member 5aa [KO:K09525]
130434521  dnajc5ga; dnaJ (Hsp40) homolog, subfamily C, member 5 gamma a isoform X1 [KO:K09525]
130434012  hsp90aa1.2; heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 [KO:K04079]
130434013  heat shock protein HSP 90-alpha 1 [KO:K04079]
130434367  hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
130436665  hspa4l; heat shock 70 kDa protein 4L [KO:K09485]
130428174  hsph1; LOW QUALITY PROTEIN: heat shock protein 105 kDa [KO:K09485]
130418069  bag1; BAG family molecular chaperone regulator 1 [KO:K09555]
130431778  bag2; BAG family molecular chaperone regulator 2 [KO:K09556]
130426485  hspbp1; hsp70-binding protein 1 [KO:K09562]
130419928  cryabb; crystallin, alpha B, b [KO:K09542]
130428154  cryaba; crystallin, alpha B, a [KO:K09542]
130410631  yod1; ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
130422169  plaa; phospholipase A-2-activating protein [KO:K14018]
130430744  rad23ab; RAD23 homolog A, nucleotide excision repair protein b [KO:K10839]
130407555  rad23aa; RAD23 homolog A, nucleotide excision repair protein a [KO:K10839]
130407714  rad23b; UV excision repair protein RAD23 homolog B [KO:K10839]
130433396  ubqln4; ubiquilin-4 isoform X1 [KO:K04523]
130415324  ngly1; peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
130436488  atxn3; ataxin-3 [KO:K11863] [EC:3.4.22.-]
130409369  ube4b; ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
130431638  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
130436842  eif2s1a; eukaryotic translation initiation factor 2 subunit 1a [KO:K03237]
130434132  eif2s1b; eukaryotic translation initiation factor 2 subunit 1b [KO:K03237]
130427172  nfe2l2a; nuclear factor erythroid 2-related factor 2a isoform X1 [KO:K05638]
130425294  atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
130426359  atf4b; activating transcription factor 4b [KO:K04374]
130424544  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
130413545  bcl2a; apoptosis regulator Bcl-2a [KO:K02161]
130418423  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
130434273  atf6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
130415943  atf6b; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
130438276  wfs1b; wolframin [KO:K14020]
130435393  wfs1a; wolframin [KO:K14020]
130435351  mbtps1; membrane-bound transcription factor site-1 protease [KO:K08653] [EC:3.4.21.112]
130413672  mbtps2; membrane-bound transcription factor site-2 protease isoform X1 [KO:K07765] [EC:3.4.24.85]
130420181  xbp1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
130409820  ern2; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
130425899  serine/threonine-protein kinase/endoribonuclease IRE1-like isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
130419591  traf2b; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
130419012  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
130419428  traf2a; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
130433109  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
130434052  map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
130439432  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
130431875  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
130407470  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
130407541  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
130428485  zgc:153993; apoptosis regulator BAX [KO:K02159]
130425762  apoptosis regulator BAX-like [KO:K02159]
130425763  apoptosis regulator BAX-like isoform X1 [KO:K02159]
130426334  apoptosis regulator BAX-like isoform X1 [KO:K02159]
130426953  apoptosis regulator BAX-like [KO:K02159]
130428658  capn1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
130436764  si:ch211-202f3.3; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
130429402  capn1b; calpain-1 catalytic subunit b [KO:K01367] [EC:3.4.22.52]
130431460  capn1a; calpain 1, (mu/I) large subunit a [KO:K01367] [EC:3.4.22.52]
130407563  si:dkeyp-50d11.2; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
130429403  capn2b; calpain 2, (m/II) large subunit b [KO:K03853] [EC:3.4.22.53]
130429719  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
130429728  calpain-2 catalytic subunit-like isoform X1 [KO:K03853] [EC:3.4.22.53]
130430172  capn2l; calpain 2, (m/II) large subunit, like [KO:K03853] [EC:3.4.22.53]
130431461  capn2a; calpain 2, (m/II) large subunit a [KO:K03853] [EC:3.4.22.53]
130418191  marchf6; E3 ubiquitin-protein ligase MARCH6 isoform X1 [KO:K10661] [EC:2.3.2.27]
130433853  ube2j1; ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
130409016  ube2j2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
130419627  ube2g1a; ubiquitin-conjugating enzyme E2 G1a [KO:K10575] [EC:2.3.2.23]
130407418  ube2g1b; ubiquitin-conjugating enzyme E2G 1b [KO:K10575] [EC:2.3.2.23]
130424694  ube2g2; ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
130437927  syvn1; E3 ubiquitin-protein ligase synoviolin [KO:K10601] [EC:2.3.2.27]
130415866  rnf5; E3 ubiquitin-protein ligase RNF5 [KO:K10666] [EC:2.3.2.27]
130418944  rnf185; E3 ubiquitin-protein ligase RNF185 isoform X1 [KO:K10666] [EC:2.3.2.27]
130414181  selenos; selenoprotein S [KO:K14025]
130434434  sel1l; protein sel-1 homolog 1 [KO:K14026]
130436030  herpud1; homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein [KO:K14027]
130414257  amfra; autocrine motility factor receptor a [KO:K10636] [EC:2.3.2.36]
130413057  stub1; E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
130437308  ube2d1a; ubiquitin-conjugating enzyme E2 D1a [KO:K06689] [EC:2.3.2.23]
130437610  ube2d2; ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
130431438  ube2d3; ubiquitin-conjugating enzyme E2 D3 isoform X1 [KO:K06689] [EC:2.3.2.23]
130438513  ube2d2l; ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast), like [KO:K06689] [EC:2.3.2.23]
130438935  ube2d1b; ubiquitin-conjugating enzyme E2 D1b [KO:K06689] [EC:2.3.2.23]
130440379  ube2d4; ubiquitin-conjugating enzyme E2 D4 [KO:K06689] [EC:2.3.2.23]
130431135  prkn; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
130426882  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
130413152  cul1b; cullin-1b [KO:K03347]
130418287  cul1a; cullin-1a [KO:K03347]
130408428  skp1; S-phase kinase-associated protein 1 [KO:K03094]
130410768  fbxo2; F-box only protein 2 [KO:K10099]
130409446  F-box only protein 44-like isoform X1 [KO:K10100]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
tdw00510  N-Glycan biosynthesis
tdw03050  Proteasome
tdw03060  Protein export
tdw04210  Apoptosis
KO pathway
ko04141   
LinkDB

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