KEGG   PATHWAY: tfd04350
Entry
tfd04350                    Pathway                                
Name
TGF-beta signaling pathway - Tachysurus fulvidraco (yellow catfish)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
tfd04350  TGF-beta signaling pathway
tfd04350

Other DBs
GO: 0007179
Organism
Tachysurus fulvidraco (yellow catfish) [GN:tfd]
Gene
113637814  chrd; chordin [KO:K04657]
113662554  nog3; noggin-3 [KO:K04658]
125140804  nog2; noggin-2 [KO:K04658]
113648824  nbl1; neuroblastoma suppressor of tumorigenicity 1 [KO:K19558]
113655662  grem1a; gremlin-1a [KO:K23318]
113634065  grem2b; gremlin-2b [KO:K23318]
113650983  grem2a; gremlin-2 [KO:K23318]
113660266  grem1b; gremlin-1 [KO:K23318]
113655652  thbs1b; thrombospondin-1 [KO:K16857]
113660295  thrombospondin-1 [KO:K16857]
113651572  dcn; decorin [KO:K04660]
113656109  fmodb; fibromodulin [KO:K08121]
113641560  fmoda; fibromodulin a [KO:K08121]
113647056  lft1; lefty1 [KO:K04668]
113659727  lft2; lefty2 [KO:K04668]
113653309  fsta; follistatin-A isoform X1 [KO:K04661]
113640617  fstb; follistatin b isoform X1 [KO:K04661]
113649645  bmp16; bone morphogenetic protein 16 [KO:K21283]
113644575  bmp2b; bone morphogenetic protein 2b [KO:K21283]
113650676  bone morphogenetic protein 2-like [KO:K21283]
113659797  bmp2a; bone morphogenetic protein 2 [KO:K21283]
113645282  anti-dorsalizing morphogenic protein [KO:K21283]
113659289  bmp4; bone morphogenetic protein 4 [KO:K04662]
113659639  bmp6; bone morphogenetic protein 6 isoform X1 [KO:K16620]
113654075  inhibin beta B chain-like [KO:K22687]
113654265  inhbb; inhibin beta B chain [KO:K22687]
113642706  inhibin beta B chain [KO:K22687]
113636907  serotransferrin-2 isoform X3 [KO:K14736]
113636912  serotransferrin-2-like [KO:K14736]
113636908  serotransferrin-2-like [KO:K14736]
113655402  bmp5; bone morphogenetic protein 5 isoform X1 [KO:K04663]
113661927  bmp7a; bone morphogenetic protein 7a [KO:K16621]
113661426  bmp8a; bone morphogenetic protein 8A [KO:K16622]
113643160  gdf5; growth/differentiation factor 5 [KO:K04664]
113661616  gdf6b; growth/differentiation factor 6-B [KO:K20012]
113644256  gdf6a; growth/differentiation factor 6-A [KO:K20012]
113659647  gdf7; growth/differentiation factor 6-A [KO:K20013]
113646123  amh; muellerian-inhibiting factor isoform X1 [KO:K04665]
113645804  ifng1; interferon gamma 1 isoform X1 [KO:K04687]
113634667  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
113652346  adamtsl7; thrombospondin type-1 domain-containing protein 4 isoform X1 [KO:K23377]
113664003  fbn1; fibrillin-1 [KO:K06825]
113662038  ltbp1; latent-transforming growth factor beta-binding protein 1 isoform X1 [KO:K19559]
113651967  tgfb1b; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
113653216  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
113644518  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
113636131  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
113659809  tgfb3; transforming growth factor beta-3 proprotein isoform X2 [KO:K13377]
113640225  inhbab; inhibin subunit beta Ab [KO:K04667]
113644198  inhbaa; inhibin subunit beta Aa [KO:K04667]
113638673  ndr1; nodal-related 1 [KO:K04666]
113648146  spaw; southpaw [KO:K04666]
113634785  ndr2; nodal-related 2 [KO:K04666]
113661026  bmpr1aa; bone morphogenetic protein receptor, type IAa [KO:K04673] [EC:2.7.11.30]
113653487  bmpr1ab; bone morphogenetic protein receptor, type IAb [KO:K04673] [EC:2.7.11.30]
113638483  bmpr1bb; bone morphogenetic protein receptor, type IBb isoform X1 [KO:K13578] [EC:2.7.11.30]
113660865  activin receptor type-1 isoform X1 [KO:K04675] [EC:2.7.11.30]
113644079  acvr1l; activin receptor type-1 isoform X1 [KO:K04675] [EC:2.7.11.30]
113654295  bmpr2b; bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
113663629  bmpr2a; bone morphogenetic protein receptor type-2a isoform X1 [KO:K04671] [EC:2.7.11.30]
113646266  acvr2aa; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
113651132  acvr2ab; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
113644232  hjv; hemojuvelin [KO:K23100]
113646680  neo1a; neogenin 1a isoform X1 [KO:K06766]
113654060  neogenin isoform X1 [KO:K06766]
113653065  tfr2; transferrin receptor protein 2 [KO:K23910]
113650136  tfr1a; transferrin receptor 1a [KO:K06503]
113650137  transferrin receptor protein 1-like [KO:K06503]
113660336  tfr1b; transferrin receptor 1b [KO:K06503]
113657931  rgmd; RGM domain family, member D [KO:K23096]
113637717  rgmb; RGM domain family member B [KO:K06847]
113644833  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
113644505  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
113654227  tgfbr2l; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
113648975  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
113657237  emp3a; epithelial membrane protein 3 isoform X2 [KO:K26257]
113640630  emp3b; epithelial membrane protein 3b [KO:K26257]
113648242  lrrc32; transforming growth factor beta activator LRRC32 isoform X2 [KO:K26316]
113647502  nrros; transforming growth factor beta activator LRRC33 [KO:K26317]
113658176  acvr1ba; activin A receptor type 1Ba isoform X1 [KO:K13567] [EC:2.7.11.30]
113642667  activin receptor type-1B-like [KO:K13567] [EC:2.7.11.30]
113644789  acvr2ba; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
113645308  activin receptor type-2B isoform X2 [KO:K13596] [EC:2.7.11.30]
113660845  activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
113662537  bambia; BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a [KO:K10162]
113655519  bambib; BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) b [KO:K10162]
113662634  smad1; mothers against decapentaplegic homolog 1 [KO:K04676]
113635807  smad5; mothers against decapentaplegic homolog 5 [KO:K16790]
113638026  smad9; mothers against decapentaplegic homolog 9 isoform X1 [KO:K16791]
113639291  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
125145338  smad3a; mothers against decapentaplegic homolog 3a isoform X1 [KO:K23605]
113652352  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
113644556  smad10b; mothers against decapentaplegic homolog 4 isoform X2 [KO:K04501]
113662831  smad10a; mothers against decapentaplegic homolog 4 isoform X2 [KO:K04501]
113637368  smad4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
113638482  smad4a; mothers against decapentaplegic homolog 4a isoform X1 [KO:K04501]
113652658  smad6b; mothers against decapentaplegic homolog 6b [KO:K04677]
113636805  smad6a; mothers against decapentaplegic homolog 6a [KO:K04677]
113646444  smad7; mothers against decapentaplegic homolog 7 [KO:K19631]
113639683  smurf2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
113660597  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
113634456  E3 ubiquitin-protein ligase SMURF2-like isoform X1 [KO:K04678] [EC:2.3.2.26]
113638398  zfyve16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
113657819  zfyve9b; zinc finger FYVE domain-containing protein 9 [KO:K04679]
113651693  zfyve9a; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
113640136  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
113655494  cul1a; cullin-1a [KO:K03347]
113660248  cul1b; cullin-1b isoform X1 [KO:K03347]
113646584  skp1; S-phase kinase-associated protein 1 [KO:K03094]
113653322  mapk1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
113652158  mapk3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
113637004  rho-related GTP-binding protein RhoA-B-like isoform X1 [KO:K04513]
113655778  rhocb; rho-related GTP-binding protein RhoA-D [KO:K04513]
113656907  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
113650696  rhoac; rho-related GTP-binding protein RhoA-C [KO:K04513]
113642944  rhoca; ras homolog family member Ca [KO:K04513]
113634850  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
113635005  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
113663392  ppp2r1ba; protein phosphatase 2, regulatory subunit A, beta a [KO:K03456]
113660463  ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
113653720  ppp2caa; protein phosphatase 2 catalytic subunit alpha a [KO:K04382] [EC:3.1.3.16]
113639288  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
113650019  ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
113658886  rps6kb1b; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
113647193  hepcidin-1 [KO:K23106]
113661820  id1; DNA-binding protein inhibitor ID-1 [KO:K04680]
113637430  DNA-binding protein inhibitor ID-1-like [KO:K04680]
113655577  id2b; DNA-binding protein inhibitor ID-2b [KO:K17693]
113659438  id2a; DNA-binding protein inhibitor ID-2a [KO:K17693]
113640561  id3; DNA-binding protein inhibitor ID-3 [KO:K17694]
113644244  id4; DNA-binding protein inhibitor ID-4 [KO:K17695]
113643085  rbl1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
113636018  e2f4; transcription factor E2F4 [KO:K04682]
113657529  e2f5; transcription factor E2F5 [KO:K04682]
113654378  tfdp1a; transcription factor Dp-1a [KO:K04683]
113648875  tfdp1b; transcription factor Dp-1b [KO:K04683]
113637131  ep300a; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
113639600  crebbpb; CREB binding protein b isoform X1 [KO:K04498] [EC:2.3.1.48]
113640116  ep300b; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
113657009  crebbpa; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
113643964  sp1; transcription factor Sp1 isoform X1 [KO:K04684]
113647136  skila; ski-like protein isoform X1 [KO:K18499]
113660355  skilb; SKI-like proto-oncogene b [KO:K18499]
113655118  skib; v-ski avian sarcoma viral oncogene homolog b [KO:K26503]
113648147  skia; v-ski avian sarcoma viral oncogene homolog a [KO:K26503]
113636778  sin3ab; paired amphipathic helix protein Sin3a isoform X1 [KO:K11644]
113660207  sin3aa; SIN3 transcription regulator family member Aa [KO:K11644]
113634700  hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
113634166  ncor1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
113647585  tgif1; homeobox protein TGIF1 isoform X2 [KO:K19383]
113642919  homeobox protein TGIF2 isoform X1 [KO:K19553]
113657589  mycb; transcriptional regulator Myc-B [KO:K04377]
113660062  myca; transcriptional regulator Myc-A [KO:K04377]
113646500  cdkn2a/b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
113648173  pitx2; pituitary homeobox 2 isoform X1 [KO:K04686]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
  Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
  Journal
Int J Mol Sci 22:ijms22094591 (2021)
DOI:10.3390/ijms22094591
Reference
PMID:20495575
  Authors
Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
  Journal
Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Related
pathway
tfd04010  MAPK signaling pathway
tfd04110  Cell cycle
tfd04120  Ubiquitin mediated proteolysis
tfd04210  Apoptosis
KO pathway
ko04350   
LinkDB

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