KEGG   PATHWAY: tru04115
Entry
tru04115                    Pathway                                
Name
p53 signaling pathway - Takifugu rubripes (torafugu)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
tru04115  p53 signaling pathway
tru04115

Organism
Takifugu rubripes (torafugu) [GN:tru]
Gene
101079070  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
101063164  chek2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
101071938  atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
101069769  chek1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
101074668  gorab; RAB6-interacting golgin [KO:K19748]
101068181  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
101077886  mdm4; protein Mdm4 isoform X3 [KO:K10127]
101079595  cellular tumor antigen p53 [KO:K04451]
101063290  ppp1r13l; relA-associated inhibitor isoform X1 [KO:K27356]
105417819  cyclin-dependent kinase inhibitor 1-like isoform X1 [KO:K06625]
101079162  cyclin-dependent kinase inhibitor 1B-like [KO:K06625]
101061278  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
101080220  G1/S-specific cyclin-D2 [KO:K10151]
101073562  G1/S-specific cyclin-D2-like [KO:K10151]
101066871  G1/S-specific cyclin-D3-like [KO:K10151]
115249879  G1/S-specific cyclin-D3-like [KO:K10151]
101063905  ccnd3; G1/S-specific cyclin-D3 isoform X2 [KO:K10152]
101063081  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
101078305  cyclin-dependent kinase 6-like isoform X2 [KO:K02091] [EC:2.7.11.22]
101070296  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
101070855  ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
105419021  G1/S-specific cyclin-E1-like [KO:K06626]
101070487  G1/S-specific cyclin-E1-like [KO:K06626]
101065632  G1/S-specific cyclin-E1-like isoform X1 [KO:K06626]
101063185  G1/S-specific cyclin-E1-like isoform X1 [KO:K06626]
115251941  G1/S-specific cyclin-E1-like isoform X1 [KO:K06626]
115252159  G1/S-specific cyclin-E1-like isoform X1 [KO:K06626]
115252218  G1/S-specific cyclin-E1-like [KO:K06626]
101062041  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
101072829  rprm; protein reprimo [KO:K10128]
101075364  reprimo-like protein [KO:K10128]
101074701  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
115250234  LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B1-like [KO:K05868]
101074416  G2/mitotic-specific cyclin-B2-like isoform X1 [KO:K21770]
101076205  G2/mitotic-specific cyclin-B2-like [KO:K21770]
101065671  cyclin N-terminal domain-containing protein 2-like [KO:K21770]
101064374  cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
115248355  cyclin-dependent kinase 1-like [KO:K02087] [EC:2.7.11.22 2.7.11.23]
101076947  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
101077171  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
101067003  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
101072502  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
101074436  gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
101080011  growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
101077260  gtse1; G2 and S phase-expressed protein 1 isoform X2 [KO:K10129]
101064460  zinc finger protein 385A-like isoform X1 [KO:K26543]
101071690  zinc finger protein 385A-like isoform X1 [KO:K26543]
101067230  tumor necrosis factor receptor superfamily member 6 [KO:K04390]
101061417  pidd1; p53-induced death domain-containing protein 1 [KO:K10130]
101068795  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
101073992  tumor necrosis factor receptor superfamily member 6-like isoform X1 [KO:K04722]
101075191  caspase-8-like [KO:K04398] [EC:3.4.22.61]
101075631  caspase-8 [KO:K04398] [EC:3.4.22.61]
101061322  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
101068139  bax; apoptosis regulator BAX [KO:K02159]
101069964  apoptosis regulator BAX-like [KO:K02159]
101067511  apoptosis regulator BAX-like [KO:K02159]
101061171  siva1; apoptosis regulatory protein Siva [KO:K22744]
101063792  bcl-2-like protein 1 [KO:K04570]
101064016  bcl-2-like protein 1 [KO:K04570]
101069689  bcl-2-like protein 1 [KO:K04570]
101076691  bcl-2-like protein 1 [KO:K04570]
115250254  bcl-2-like protein 1 [KO:K04570]
115250055  bcl-2-like protein 1 [KO:K04570]
115250058  bcl-2-like protein 1 [KO:K04570]
101071405  bcl2; apoptosis regulator Bcl-2 [KO:K02161]
101073650  tp53i3; quinone oxidoreductase PIG3 [KO:K10133] [EC:1.-.-.-]
101078568  ei24; etoposide-induced protein 2.4 homolog isoform X1 [KO:K10134]
101068494  protein shisa-5-like [KO:K10135]
101066415  perp; p53 apoptosis effector related to PMP-22 [KO:K10136]
101067297  zmat3; zinc finger matrin-type protein 3 isoform X1 [KO:K10137]
101074163  E3 ubiquitin-protein ligase Siah1 isoform X1 [KO:K04506] [EC:2.3.2.27]
101079811  cytochrome c [KO:K08738]
101064386  cytochrome c-b [KO:K08738]
101067333  cytochrome c-a [KO:K08738]
101077993  cytochrome c [KO:K08738]
101076369  apaf1; apoptotic protease-activating factor 1 [KO:K02084]
101075121  casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
446083  casp3; caspase 3-like [KO:K02187] [EC:3.4.22.56]
101064506  aifm2; apoptosis-inducing factor 2 [KO:K22745]
101075107  igfbp3; insulin-like growth factor-binding protein 3 isoform X1 [KO:K10138]
115247245  insulin-like growth factor-binding protein 3 [KO:K10138]
115247338  insulin-like growth factor-binding protein 3 [KO:K10138]
100462939  igf1; insulin-like growth factor I precursor [KO:K05459]
101069978  serpine1; plasminogen activator inhibitor 1 [KO:K03982]
101072692  adgrb1; adhesion G protein-coupled receptor B1 isoform X1 [KO:K04596]
101079211  CD82 antigen-like [KO:K06509]
101079221  cd82; CD82 antigen [KO:K06509]
101065984  CD82 antigen-like [KO:K06509]
101061772  thbs1; thrombospondin-1 [KO:K16857]
101062487  thrombospondin-1-like [KO:K16857]
101074409  ddb2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
101070326  ribonucleoside-diphosphate reductase subunit M2 isoform X2 [KO:K10808] [EC:1.17.4.1]
101066979  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
101073908  rrm2b; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
101073463  sestrin-3-like [KO:K10141]
101069225  sesn1; sestrin-1 isoform X2 [KO:K10141]
101064774  sestrin-2-like isoform X1 [KO:K20394]
101079654  pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101078033  tsc2; tuberin isoform X1 [KO:K07207]
101061567  steap3; metalloreductase STEAP3 [KO:K10142] [EC:1.16.1.-]
101074435  cop1; E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:2.3.2.27]
101069635  rchy1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
101061358  ccng1; cyclin-G1 [KO:K10145]
101077778  cyclin-G2-like [KO:K10146]
101072587  cyclin-G2 [KO:K10146]
115246472  cyclin-G2-like [KO:K10146]
101061288  protein phosphatase 1D-like isoform X2 [KO:K10147] [EC:3.1.3.16]
101076388  ppm1d; protein phosphatase 1D [KO:K10147] [EC:3.1.3.16]
101074693  tp73; tumor protein p73 isoform X4 [KO:K10148]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
tru04110  Cell cycle
tru04210  Apoptosis
tru04218  Cellular senescence
KO pathway
ko04115   
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