KEGG   PATHWAY: xma04814
Entry
xma04814                    Pathway                                
Name
Motor proteins - Xiphophorus maculatus (southern platyfish)
Class
Cellular Processes; Cell motility
Pathway map
xma04814  Motor proteins
xma04814

Organism
Xiphophorus maculatus (southern platyfish) [GN:xma]
Gene
102224928  dync1h1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413]
102220918  dync2h1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
102216642  cytoplasmic dynein 1 intermediate chain 2-like isoform X2 [KO:K10415]
102234260  cytoplasmic dynein 1 intermediate chain 2-like isoform X2 [KO:K10415]
102220424  dync1i1; cytoplasmic dynein 1 intermediate chain 1 isoform X3 [KO:K10415]
102236636  cytoplasmic dynein 1 light intermediate chain 1-like [KO:K10416]
102231867  dync1li2; cytoplasmic dynein 1 light intermediate chain 2 isoform X3 [KO:K10416]
102232620  dync2li1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417]
102224538  dynein light chain 2, cytoplasmic-like [KO:K10418]
102236607  dynein light chain 2, cytoplasmic [KO:K10418]
102227793  dynein light chain 2, cytoplasmic-like [KO:K10418]
102228081  dynein light chain roadblock-type 1-like [KO:K10419]
102228332  dynein light chain roadblock-type 1 [KO:K10419]
102225912  dynlrb2; dynein light chain roadblock-type 2 [KO:K10419]
102232341  dynlt3; dynein light chain Tctex-type 3 [KO:K10420]
102237012  dynlt1; dynein light chain Tctex-type 1 [KO:K10420]
102233096  dynein light chain Tctex-type 1-like [KO:K10420]
102225569  tctex1 domain-containing protein 1-like [KO:K25421]
102216740  dnah7; dynein heavy chain 7, axonemal [KO:K10408]
102234985  dynein heavy chain 9, axonemal isoform X1 [KO:K10408]
102220862  dnah12; dynein heavy chain 12, axonemal isoform X1 [KO:K10408]
102226113  dnah8; dynein heavy chain 8, axonemal [KO:K10408]
102223002  dnah10; dynein heavy chain 10, axonemal [KO:K10408]
102235794  dynein heavy chain 11, axonemal-like [KO:K10408]
102221507  dynein heavy chain 11, axonemal-like [KO:K10408]
102220208  dnah5; dynein heavy chain 5, axonemal [KO:K10408]
102234779  dnah3; dynein heavy chain 3, axonemal [KO:K10408]
102224369  dnah2; dynein heavy chain 2, axonemal [KO:K10408]
102234611  dnah1; dynein heavy chain 1, axonemal [KO:K10408]
102235026  dnai1; dynein intermediate chain 1, axonemal [KO:K10409]
102231521  dnai2; dynein intermediate chain 2, axonemal [KO:K11143]
102227182  wdr63; WD repeat-containing protein 63 [KO:K24722]
102218912  wdr78; WD repeat-containing protein 78 [KO:K24723]
102216802  WD repeat-containing protein 78-like [KO:K24723]
102230514  dnali1; axonemal dynein light intermediate polypeptide 1 isoform X2 [KO:K10410]
102219472  dnal1; dynein light chain 1, axonemal [KO:K10411]
102231362  dnal4; dynein light chain 4, axonemal [KO:K10412]
102238322  dctn1; dynactin subunit 1 isoform X3 [KO:K04648]
102224407  dynactin subunit 1-like isoform X1 [KO:K04648]
102237333  dctn2; dynactin subunit 2 isoform X3 [KO:K10424]
102230272  dctn3; dynactin subunit 3 [KO:K10425]
102237498  dctn4; dynactin subunit 4 isoform X1 [KO:K10426]
102228124  dctn5; dynactin subunit 5 [KO:K10427]
102236166  dctn6; dynactin subunit 6 [KO:K10428]
102225238  dynactin subunit 6-like [KO:K10428]
102228756  beta-centractin [KO:K16575]
102221583  actr10; actin-related protein 10 [KO:K16576]
102217961  capza2; F-actin-capping protein subunit alpha-2 [KO:K10364]
102218227  F-actin-capping protein subunit alpha-1 [KO:K10364]
102234141  capzb; F-actin-capping protein subunit beta isoform X2 [KO:K10365]
102217030  BICD family-like cargo adapter 2 isoform X1 [KO:K16756]
106699685  BICD family-like cargo adapter 1 [KO:K16756]
102230196  bicdl1; BICD family-like cargo adapter 1 isoform X1 [KO:K16756]
102225922  hook3; protein Hook homolog 3 isoform X4 [KO:K16536]
102234423  tubulin alpha-1B chain [KO:K07374]
102223550  tubulin alpha chain [KO:K07374]
102224061  tubulin alpha chain-like [KO:K07374]
102217094  tubulin alpha-1A chain [KO:K07374]
102217348  tubulin alpha-1B chain-like isoform X2 [KO:K07374]
102226394  tubulin alpha chain-like [KO:K07374]
102218092  tubulin alpha-8 chain-like [KO:K07374]
102223804  tubulin alpha-1C chain-like [KO:K07374]
102223433  tuba4a; tubulin alpha-4A chain [KO:K07374]
102224440  tubulin alpha-1B chain-like [KO:K07374]
102221968  tubulin alpha-1C chain-like [KO:K07374]
102217235  tubulin alpha chain-like [KO:K07374]
102223894  tubulin alpha-1B chain-like [KO:K07374]
106700148  tubulin alpha-1B chain-like [KO:K07374]
102226042  tubulin beta chain-like isoform X1 [KO:K07375]
102217151  tubulin beta-4B chain-like isoform X2 [KO:K07375]
102231664  tubulin beta chain-like [KO:K07375]
102232796  tubulin beta chain [KO:K07375]
102228617  tubulin beta-4B chain-like [KO:K07375]
102229930  tubulin beta-4B chain-like [KO:K07375]
102226155  tubulin beta-4B chain-like [KO:K07375]
102230583  tubulin beta-4B chain isoform X1 [KO:K07375]
102237703  tubulin beta chain-like [KO:K07375]
102236594  tubulin beta-1 chain [KO:K07375]
102228734  tubb4b; tubulin beta-4B chain [KO:K07375]
111610383  tubulin beta chain-like [KO:K07375]
102224984  tubg1; tubulin gamma-1 chain [KO:K10389]
102237189  tubd1; tubulin delta chain [KO:K10390]
102220807  tube1; tubulin epsilon chain [KO:K10391]
102231314  kinesin heavy chain-like [KO:K10396]
102224761  kinesin heavy chain [KO:K10396]
102222665  kinesin heavy chain-like [KO:K10396]
102235968  kinesin-1 heavy chain [KO:K10396]
102237623  kif5b; kinesin-1 heavy chain isoform X2 [KO:K10396]
102230096  kif5a; kinesin heavy chain isoform X2 [KO:K10396]
102233978  kinesin light chain 1 isoform X5 [KO:K10407]
102225315  kinesin light chain 1-like isoform X1 [KO:K10407]
102235667  klc1; kinesin light chain 1 isoform X5 [KO:K10407]
102234750  klc2; kinesin light chain 2 isoform X1 [KO:K10407]
102219873  kif3a; kinesin-like protein KIF3A isoform X2 [KO:K10394]
102232460  kif3b; kinesin-like protein KIF3B [KO:K20196]
102235632  kinesin-associated protein 3-like [KO:K25388]
102230041  kinesin-associated protein 3 isoform X1 [KO:K25388]
102234436  kif3c; kinesin-like protein KIF3C [KO:K20197]
102229400  kinesin-like protein KIF3B [KO:K20197]
102225452  kif17; kinesin-like protein KIF17 isoform X2 [KO:K20198]
102227622  kif1b; kinesin-like protein KIF1B isoform X1 [KO:K10392]
102225825  kinesin-like protein KIF1A isoform X3 [KO:K10392]
102218078  kinesin-like protein KIF1A isoform X5 [KO:K10392]
102225243  kif1c; kinesin-like protein KIF1C [KO:K10392]
102237530  kinesin-like protein KIF13B isoform X1 [KO:K17914]
102235825  kif13a; kinesin-like protein KIF13A isoform X2 [KO:K17914]
102233541  kif13b; kinesin-like protein KIF13B isoform X1 [KO:K17914]
102235726  kif14; kinesin-like protein KIF14 [KO:K17915]
102225398  kinesin-like protein KIF16B isoform X1 [KO:K17916]
102230698  kinesin-like protein KIF16B [KO:K17916]
111606535  uncharacterized protein LOC111606535 [KO:K17916]
102222769  stard9; stAR-related lipid transfer protein 9 [KO:K16491]
102225792  chromosome-associated kinesin KIF4-like [KO:K10395]
102226675  kif7; kinesin-like protein KIF7 [KO:K18806]
102221868  kif21a; kinesin-like protein KIF21A isoform X1 [KO:K24185]
102234227  kinesin-like protein KIF21A isoform X1 [KO:K24185]
102218349  kif21b; kinesin-like protein KIF21B isoform X1 [KO:K24185]
102224627  kif27; kinesin-like protein KIF27 [KO:K24186]
102230504  kif11; kinesin-like protein KIF11 isoform X1 [KO:K10398]
106700311  kinesin-like protein KIF11 [KO:K10398]
102220950  kif20a; kinesin-like protein KIF20A isoform X1 [KO:K10402]
102218030  kif20b; kinesin-like protein KIF20B isoform X1 [KO:K10402]
102222550  kinesin-like protein KIF20A isoform X1 [KO:K10402]
102221346  kinesin-like protein KIF20A [KO:K10402]
102222800  kif23; kinesin-like protein KIF23 isoform X1 [KO:K17387]
102231121  cenpe; centromere-associated protein E isoform X1 [KO:K11498]
102229543  kif18a; kinesin-like protein KIF18A [KO:K10401]
102238363  kif19; kinesin-like protein KIF19 [KO:K26157]
102232702  kif6; kinesin-like protein KIF6 [KO:K10397]
102231006  kif22; kinesin-like protein KIF22 [KO:K10403]
102224437  kinesin-like protein KIF26A [KO:K10404]
102232858  kif26b; kinesin-like protein KIF26B isoform X1 [KO:K10404]
102224400  kinesin-like protein KIF26A isoform X1 [KO:K10404]
102222219  kinesin-like protein KIF26B [KO:K10404]
102228112  kif15; kinesin-like protein KIF15 [KO:K10400]
102230810  kif2a; kinesin-like protein KIF2A isoform X2 [KO:K10393]
102228162  kinesin-like protein KIF2A [KO:K10393]
102217401  kinesin-like protein KIF2C [KO:K10393]
111610260  uncharacterized protein LOC111610260 [KO:K10393]
102222950  kifc1; kinesin-like protein KIFC1 [KO:K10405]
102230990  kinesin-like protein KIFC3 isoform X1 [KO:K10406]
102231643  kifc3; kinesin-like protein KIFC3 isoform X1 [KO:K10406]
102222274  kinesin-like protein KIN-14I isoform X1 [KO:K10406]
102217266  unconventional myosin-Ig-like [KO:K10356]
102235911  myo1c; unconventional myosin-Ic isoform X4 [KO:K10356]
102223667  unconventional myosin-Ih-like isoform X1 [KO:K10356]
102225469  unconventional myosin-Ic-like isoform X1 [KO:K10356]
102229034  unconventional myosin-Ie-like isoform X1 [KO:K10356]
102231648  myo1b; unconventional myosin-Ib isoform X1 [KO:K10356]
102223764  myo1e; unconventional myosin-Ie isoform X1 [KO:K10356]
102236585  unconventional myosin-If-like [KO:K10356]
102229940  unconventional myosin-Ih-like isoform X1 [KO:K10356]
102220657  myo1d; unconventional myosin-Id [KO:K10356]
102225967  myo3b; myosin-IIIb [KO:K08834] [EC:2.7.11.1]
102228729  myo3a; myosin-IIIa isoform X1 [KO:K08834] [EC:2.7.11.1]
102219846  myo5c; unconventional myosin-Vc isoform X1 [KO:K10357]
102225555  myo5a; unconventional myosin-Va isoform X1 [KO:K10357]
102219593  unconventional myosin-Va-like isoform X1 [KO:K10357]
102234667  unconventional myosin-Va-like [KO:K10357]
102217816  myo5b; unconventional myosin-Vb isoform X1 [KO:K10357]
102223118  unconventional myosin-VI-like [KO:K10358]
102231856  myo6; unconventional myosin-VI isoform X1 [KO:K10358]
102236352  unconventional myosin-VIIa-like isoform X3 [KO:K10359]
102217549  myo7a; unconventional myosin-VIIa [KO:K10359]
102222184  unconventional myosin-VIIb-like [KO:K21868]
102216410  unconventional myosin-VIIa-like [KO:K21868]
102227332  myo9b; unconventional myosin-IXb [KO:K10360]
102222963  myo9a; unconventional myosin-IXa isoform X1 [KO:K10360]
102225529  unconventional myosin-X-like isoform X1 [KO:K12559]
102232083  myo10; unconventional myosin-X [KO:K12559]
102220193  unconventional myosin-XV-like [KO:K10361]
111609842  myo15b; myosin XVB [KO:K10361]
102234448  myo15a; unconventional myosin-XV isoform X1 [KO:K10361]
102227412  myo16; unconventional myosin-XVI isoform X1 [KO:K17481]
102222876  unconventional myosin-XVIIIa-like isoform X1 [KO:K10362]
102224456  myo18b; unconventional myosin-XVIIIb isoform X1 [KO:K10362]
102230140  myo18a; unconventional myosin-XVIIIa isoform X1 [KO:K10362]
102231504  myo19; unconventional myosin-XIX isoform X2 [KO:K25838]
102220390  myosin heavy chain, fast skeletal muscle-like [KO:K24220]
102233637  myosin heavy chain, fast skeletal muscle-like [KO:K24220]
102237286  myosin heavy chain, fast skeletal muscle-like [KO:K24220]
111605768  myosin heavy chain, fast skeletal muscle [KO:K24220]
102226824  myosin heavy chain, fast skeletal muscle-like [KO:K24220]
102227480  myosin heavy chain, fast skeletal muscle-like [KO:K24220]
102227738  myosin heavy chain, fast skeletal muscle-like [KO:K24220]
102227699  myosin-7B-like [KO:K24220]
102232954  myosin-7 isoform X1 [KO:K17751]
102229576  myosin-7-like isoform X1 [KO:K17751]
102232694  myosin-7 [KO:K17751]
102230019  myosin-6 [KO:K17751]
102237249  myosin-10 isoform X1 [KO:K10352]
102223721  myosin-9 isoform X2 [KO:K10352]
102233824  myh11; myosin-11 isoform X3 [KO:K10352]
102225124  myosin-10 isoform X1 [KO:K10352]
102230362  myosin-9-like [KO:K10352]
102224566  myosin light chain 1, skeletal muscle isoform [KO:K05738]
102217899  myosin light chain 3-like [KO:K12749]
102226792  myosin light chain 4-like [KO:K12750]
102236739  myosin light polypeptide 6-like [KO:K12751]
102221965  myosin light polypeptide 6 isoform X1 [KO:K12751]
102221311  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
102235799  myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
102229585  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
102224997  myosin regulatory light polypeptide 9 [KO:K12755]
102237517  myosin regulatory light polypeptide 9 [KO:K12757]
102228027  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
102234161  myosin regulatory light chain 2, skeletal muscle isoform-like isoform X1 [KO:K12758]
102228744  myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
102235924  acta2; actin, aortic smooth muscle [KO:K12313]
102230365  actc1; actin, alpha cardiac muscle 1 [KO:K12314]
102233599  actin, alpha cardiac [KO:K12314]
102225200  actin, alpha skeletal muscle A [KO:K12314]
102227614  actin, alpha cardiac [KO:K12314]
102218394  actin, cytoplasmic 2 [KO:K05692]
102222885  actb; actin, cytoplasmic 1 [KO:K05692]
102228942  troponin C, slow skeletal and cardiac muscles-like [KO:K05865]
102236084  troponin C, slow skeletal and cardiac muscles isoform X2 [KO:K05865]
102233471  troponin I, slow skeletal muscle-like [KO:K10371]
102229076  troponin I, slow skeletal muscle-like [KO:K10371]
102237966  troponin I, slow skeletal muscle-like [KO:K10371]
102233211  troponin I, slow skeletal muscle-like [KO:K10371]
102230737  troponin I, slow skeletal muscle-like [KO:K10371]
102232786  troponin I, slow skeletal muscle-like isoform X1 [KO:K10371]
102233987  troponin I, slow skeletal muscle-like [KO:K10371]
102237870  troponin T, slow skeletal muscle-like isoform X1 [KO:K10372]
102228327  tnnt1; troponin T, slow skeletal muscle isoform X2 [KO:K10372]
102220172  troponin C, skeletal muscle [KO:K12042]
102220434  troponin C, skeletal muscle-like [KO:K12042]
102231808  troponin I, fast skeletal muscle-like isoform X1 [KO:K12043]
102237572  troponin I, fast skeletal muscle-like [KO:K12043]
102225943  troponin I, fast skeletal muscle-like [KO:K12043]
102226204  troponin I, fast skeletal muscle-like [KO:K12043]
102227660  troponin I, fast skeletal muscle-like [KO:K12043]
102222819  troponin T, fast skeletal muscle isoforms-like isoform X2 [KO:K12046]
102229637  troponin T, fast skeletal muscle isoforms-like isoform X1 [KO:K12046]
102234247  troponin T, cardiac muscle isoforms-like [KO:K12045]
102231446  troponin T, cardiac muscle isoforms [KO:K12045]
102234348  troponin T, cardiac muscle isoforms-like isoform X1 [KO:K12045]
102223124  troponin T, cardiac muscle isoforms-like isoform X1 [KO:K12045]
102230712  tpm1; tropomyosin alpha-1 chain isoform X2 [KO:K10373]
102217146  tropomyosin alpha-1 chain-like isoform X2 [KO:K10373]
102218310  tropomyosin beta chain [KO:K10374]
102237830  tropomyosin alpha-4 chain-like isoform X1 [KO:K09290]
102232298  tropomyosin alpha-3 chain [KO:K09290]
102224849  tpm4; tropomyosin alpha-4 chain isoform X2 [KO:K10375]
102218802  tropomyosin alpha-3 chain-like isoform X3 [KO:K10375]
Reference
PMID:21092854
  Authors
Hirokawa N, Niwa S, Tanaka Y
  Title
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.
  Journal
Neuron 68:610-38 (2010)
DOI:10.1016/j.neuron.2010.09.039
Reference
PMID:25470043 (PDB:4RH7)
  Authors
Schmidt H, Zalyte R, Urnavicius L, Carter AP
  Title
Structure of human cytoplasmic dynein-2 primed for its power stroke.
  Journal
Nature 518:435-438 (2015)
DOI:10.1038/nature14023
Reference
PMID:22398446 (PDB:3VKG 3VKH)
  Authors
Kon T, Oyama T, Shimo-Kon R, Imamula K, Shima T, Sutoh K, Kurisu G
  Title
The 2.8 A crystal structure of the dynein motor domain.
  Journal
Nature 484:345-50 (2012)
DOI:10.1038/nature10955
Reference
PMID:22997337 (PDB:3J1T 3J1U)
  Authors
Redwine WB, Hernandez-Lopez R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE
  Title
Structural basis for microtubule binding and release by dynein.
  Journal
Science 337:1532-1536 (2012)
DOI:10.1126/science.1224151
Reference
PMID:26410600
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:28602352 (PDB:5NUG 5NVS 5NVU 5NW4)
  Authors
Zhang K, Foster HE, Rondelet A, Lacey SE, Bahi-Buisson N, Bird AW, Carter AP
  Title
Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
  Journal
Cell 169:1303-1314.e18 (2017)
DOI:10.1016/j.cell.2017.05.025
Reference
PMID:25814576 (PDB:5ADX 5AFR 5AFU)
  Authors
Urnavicius L, Zhang K, Diamant AG, Motz C, Schlager MA, Yu M, Patel NA, Robinson CV, Carter AP
  Title
The structure of the dynactin complex and its interaction with dynein.
  Journal
Science 347:1441-1446 (2015)
DOI:10.1126/science.aaa4080
Reference
PMID:29420470 (PDB:5OWO 6F1T 6F1U 6F1V 6F1Y 6F1Z 6F38 6F3A)
  Authors
Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP
  Title
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
  Journal
Nature 554:202-206 (2018)
DOI:10.1038/nature25462
Reference
PMID:29662141
  Authors
Reck-Peterson SL, Redwine WB, Vale RD, Carter AP
  Title
The cytoplasmic dynein transport machinery and its many cargoes.
  Journal
Nat Rev Mol Cell Biol 19:382-398 (2018)
DOI:10.1038/s41580-018-0004-3
Reference
PMID:23434508 (PDB:3J2U)
  Authors
Asenjo AB, Chatterjee C, Tan D, DePaoli V, Rice WJ, Diaz-Avalos R, Silvestry M, Sosa H
  Title
Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases.
  Journal
Cell Rep 3:759-68 (2013)
DOI:10.1016/j.celrep.2013.01.030
Reference
PMID:10338210 (PDB:1B7T)
  Authors
Houdusse A, Kalabokis VN, Himmel D, Szent-Gyorgyi AG, Cohen C
  Title
Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head.
  Journal
Cell 97:459-70 (1999)
DOI:10.1016/s0092-8674(00)80756-4
Reference
PMID:9428521 (PDB:3KIN)
  Authors
Kozielski F, Sack S, Marx A, Thormahlen M, Schonbrunn E, Biou V, Thompson A, Mandelkow EM, Mandelkow E
  Title
The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
  Journal
Cell 91:985-94 (1997)
DOI:10.1016/s0092-8674(00)80489-4
Reference
PMID:8316857 (PDB:2MYS)
  Authors
Rayment I, Rypniewski WR, Schmidt-Base K, Smith R, Tomchick DR, Benning MM, Winkelmann DA, Wesenberg G, Holden HM
  Title
Three-dimensional structure of myosin subfragment-1: a molecular motor.
  Journal
Science 261:50-8 (1993)
DOI:10.1126/science.8316857
Reference
PMID:20428469
  Authors
Parker D, Bryant Z, Delp SL
  Title
Coarse-Grained Structural Modeling of Molecular Motors Using Multibody Dynamics.
  Journal
Cell Mol Bioeng 2:366-374 (2009)
DOI:10.1007/s12195-009-0084-4
Reference
PMID:21314430
  Authors
Dominguez R, Holmes KC
  Title
Actin structure and function.
  Journal
Annu Rev Biophys 40:169-86 (2011)
DOI:10.1146/annurev-biophys-042910-155359
Reference
PMID:31919429 (PDB:6KN7 6KN8)
  Authors
Yamada Y, Namba K, Fujii T
  Title
Cardiac muscle thin filament structures reveal calcium regulatory mechanism.
  Journal
Nat Commun 11:153 (2020)
DOI:10.1038/s41467-019-14008-1
Reference
PMID:33912943
  Authors
Kruppa AJ, Buss F
  Title
Motor proteins at the mitochondria-cytoskeleton interface.
  Journal
J Cell Sci 134:239092 (2021)
DOI:10.1242/jcs.226084
KO pathway
ko04814   
LinkDB

DBGET integrated database retrieval system