KEGG   PATHWAY: zca04622
Entry
zca04622                    Pathway                                
Name
RIG-I-like receptor signaling pathway - Zalophus californianus (California sea lion)
Description
Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.
Class
Organismal Systems; Immune system
Pathway map
zca04622  RIG-I-like receptor signaling pathway
zca04622

Organism
Zalophus californianus (California sea lion) [GN:zca]
Gene
113933994  DDX58; antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]
113920745  IFIH1; interferon-induced helicase C domain-containing protein 1 isoform X1 [KO:K12647] [EC:5.6.2.6]
113938268  ZNFX1; NFX1-type zinc finger-containing protein 1 [KO:K27391]
113938749  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
113938951  DHX58; probable ATP-dependent RNA helicase DHX58 isoform X1 [KO:K12649] [EC:5.6.2.6]
113908816  TRAF3; LOW QUALITY PROTEIN: TNF receptor-associated factor 3 [KO:K03174]
113920122  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
113916474  AZI2; 5-azacytidine-induced protein 2 [KO:K12651]
113907988  TBKBP1; TANK-binding kinase 1-binding protein 1 isoform X1 [KO:K12652]
113930597  NF-kappa-B essential modulator isoform X1 [KO:K07210]
113930605  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
118356554  NF-kappa-B essential modulator-like isoform X1 [KO:K07210]
113921986  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
113932728  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
113936398  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
113914873  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
113934655  interferon alpha-1-like [KO:K05414]
113934682  LOW QUALITY PROTEIN: interferon alpha-3-like [KO:K05414]
113934985  interferon alpha-14-like [KO:K05414]
113934667  LOW QUALITY PROTEIN: interferon alpha-1/2-like [KO:K05414]
113934678  LOW QUALITY PROTEIN: interferon alpha-1/2-like [KO:K05414]
113912225  LOW QUALITY PROTEIN: interferon alpha-1/2-like [KO:K05414]
113934419  IFNB1; interferon beta [KO:K05415]
113934677  IFNE; interferon epsilon [KO:K05442]
113934672  IFNK; interferon kappa [KO:K05441]
113935781  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
113914747  FADD; FAS-associated death domain protein [KO:K02373]
113931151  LOW QUALITY PROTEIN: FAS-associated death domain protein-like [KO:K02373]
113927116  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
113919983  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
113920561  CASP10; caspase-10 isoform X1 [KO:K04400] [EC:3.4.22.63]
113923411  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
113924180  IKBKB; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
113936110  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
113910226  NFKBIA; NF-kappa-B inhibitor alpha isoform X1 [KO:K04734]
113924266  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
113914948  RELA; transcription factor p65 [KO:K04735]
113934602  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
113926671  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
113913973  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
113929708  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
113928769  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
113922602  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
113925863  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
113923113  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
113926549  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
113921975  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
113927499  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
113925270  CXCL8; interleukin-8 [KO:K10030]
113927740  TNF; tumor necrosis factor [KO:K03156]
113916510  IL12A; interleukin-12 subunit alpha isoform X1 [KO:K05406]
113929340  IL12B; interleukin-12 subunit beta [KO:K05425]
113924908  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
113932110  ADAR; double-stranded RNA-specific adenosine deaminase isoform X1 [KO:K12968] [EC:3.5.4.37]
113939158  TRIM25; E3 ubiquitin/ISG15 ligase TRIM25 isoform X1 [KO:K10652] [EC:2.3.2.27]
113935490  CYLD; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
113913142  RNF125; E3 ubiquitin-protein ligase RNF125 isoform X1 [KO:K12170] [EC:2.3.2.27]
113937949  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
113927456  ATG5; autophagy protein 5 isoform X1 [KO:K08339]
113928795  ATG12; ubiquitin-like protein ATG12 isoform X1 [KO:K08336]
113915177  NLRX1; NLR family member X1 [KO:K12653]
113929903  STING1; stimulator of interferon genes protein isoform X1 [KO:K12654]
113930932  OTUD5; OTU domain-containing protein 5 isoform X1 [KO:K12655] [EC:3.4.19.12]
113937802  SIKE1; suppressor of IKBKE 1 isoform X1 [KO:K12656]
113930323  DDX3X; ATP-dependent RNA helicase DDX3X isoform X1 [KO:K11594] [EC:5.6.2.7]
118356611  ATP-dependent RNA helicase DDX3X-like isoform X1 [KO:K11594] [EC:5.6.2.7]
113917158  PIN1; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [KO:K09578] [EC:5.2.1.8]
113913494  TKFC; triokinase/FMN cyclase isoform X1 [KO:K00863] [EC:2.7.1.28 2.7.1.29 4.6.1.15]
Compound
C00046  RNA
Reference
PMID:15208624
  Authors
Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T
  Title
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
  Journal
Nat Immunol 5:730-7 (2004)
DOI:10.1038/ni1087
Reference
PMID:18272355
  Authors
Takeuchi O, Akira S
  Title
MDA5/RIG-I and virus recognition.
  Journal
Curr Opin Immunol 20:17-22 (2008)
DOI:10.1016/j.coi.2008.01.002
Reference
PMID:19120475
  Authors
Yoneyama M, Fujita T
  Title
RNA recognition and signal transduction by RIG-I-like receptors.
  Journal
Immunol Rev 227:54-65 (2009)
DOI:10.1111/j.1600-065X.2008.00727.x
Reference
PMID:19539500
  Authors
Nakhaei P, Genin P, Civas A, Hiscott J
  Title
RIG-I-like receptors: sensing and responding to RNA virus infection.
  Journal
Semin Immunol 21:215-22 (2009)
DOI:10.1016/j.smim.2009.05.001
Reference
PMID:18549796
  Authors
Moore CB, Ting JP
  Title
Regulation of mitochondrial antiviral signaling pathways.
  Journal
Immunity 28:735-9 (2008)
DOI:10.1016/j.immuni.2008.05.005
Reference
PMID:19615405
  Authors
Barral PM, Sarkar D, Su ZZ, Barber GN, DeSalle R, Racaniello VR, Fisher PB
  Title
Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity.
  Journal
Pharmacol Ther 124:219-34 (2009)
DOI:10.1016/j.pharmthera.2009.06.012
Reference
PMID:19120476
  Authors
Schlee M, Hartmann E, Coch C, Wimmenauer V, Janke M, Barchet W, Hartmann G
  Title
Approaching the RNA ligand for RIG-I?
  Journal
Immunol Rev 227:66-74 (2009)
DOI:10.1111/j.1600-065X.2008.00724.x
Reference
PMID:18591413
  Authors
Saito T, Gale M Jr
  Title
Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.
  Journal
J Exp Med 205:1523-7 (2008)
DOI:10.1084/jem.20081210
Reference
PMID:19076341
  Authors
Kawai T, Akira S
  Title
Toll-like receptor and RIG-I-like receptor signaling.
  Journal
Ann N Y Acad Sci 1143:1-20 (2008)
DOI:10.1196/annals.1443.020
Reference
PMID:18439848
  Authors
Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, Konig M, Kalinke U, Pasparakis M, Tschopp J
  Title
TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
  Journal
Immunity 28:651-61 (2008)
DOI:10.1016/j.immuni.2008.03.013
Reference
PMID:18984593
  Authors
Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T
  Title
TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.
  Journal
J Biol Chem 283:36211-20 (2008)
DOI:10.1074/jbc.M806576200
Reference
PMID:19224920
  Authors
Mikkelsen SS, Jensen SB, Chiliveru S, Melchjorsen J, Julkunen I, Gaestel M, Arthur JS, Flavell RA, Ghosh S, Paludan SR
  Title
RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.
  Journal
J Biol Chem 284:10774-82 (2009)
DOI:10.1074/jbc.M807272200
Reference
PMID:32668226
  Authors
Liu G, Gack MU
  Title
Distinct and Orchestrated Functions of RNA Sensors in Innate Immunity.
  Journal
Immunity 53:26-42 (2020)
DOI:10.1016/j.immuni.2020.03.017
Related
pathway
zca04010  MAPK signaling pathway
zca04120  Ubiquitin mediated proteolysis
zca04210  Apoptosis
zca04630  JAK-STAT signaling pathway
KO pathway
ko04622   
LinkDB

DBGET integrated database retrieval system