KEGG   PATHWAY: zca04010
Entry
zca04010                    Pathway                                
Name
MAPK signaling pathway - Zalophus californianus (California sea lion)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
zca04010  MAPK signaling pathway
zca04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Zalophus californianus (California sea lion) [GN:zca]
Gene
113908122  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
113908156  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
113908216  MAP2K6; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
113908308  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
113908317  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
113908643  [KO:K04393]
113908724  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
113908965  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
113908972  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
113908979  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
113909166  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
113909202  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
113909391  MAP3K9; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
113909636  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
113909653  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
113909873  PGF; placenta growth factor isoform X1 [KO:K16859]
113909878  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
113909959  MAX; protein max isoform X1 [KO:K04453]
113909981  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
113909997  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
113910017  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113910110  PLA2G4F; LOW QUALITY PROTEIN: cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
113910160  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
113910186  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
113910278  FOS; proto-oncogene c-Fos [KO:K04379]
113911009  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
113911010  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
113911321  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
113911366  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
113911568  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
113911759  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
113912320  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
113912477  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
113912750  CRKL; crk-like protein [KO:K04438]
113912820  TAOK3; LOW QUALITY PROTEIN: serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
113912884  STK3; serine/threonine-protein kinase 3 [KO:K04412]
113913496  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
113913503  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
113913517  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
113913731  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
113913798  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
113913949  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
113913973  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
113914038  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
113914097  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
113914350  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
113914420  FGF3; fibroblast growth factor 3 [KO:K04358]
113914448  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
113914579  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
113914580  INS; insulin [KO:K04526]
113914876  HRAS; GTPase HRas isoform X1 [KO:K02833]
113914948  RELA; transcription factor p65 [KO:K04735]
113914974  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
113915141  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
113915290  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
113915497  FGF4; fibroblast growth factor 4 [KO:K04358]
113915522  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
113916129  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
113916135  EFNA2; LOW QUALITY PROTEIN: ephrin-A2 [KO:K05462]
113916244  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
113916383  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
113916407  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
113916493  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
113916517  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
113916580  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
113916584  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
113916693  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
113916795  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X2 [KO:K04851]
113916866  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
113916907  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
113916913  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
113916979  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
113917006  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
113917379  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
113917472  PSPN; persephin [KO:K25416]
113917532  [KO:K04723]
113917773  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
113917831  NRTN; neurturin [KO:K25414]
113917968  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
113918149  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
113918291  MRAS; ras-related protein M-Ras isoform X8 [KO:K07831]
113918427  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
113918470  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
113918550  JUND; transcription factor jun-D [KO:K04449]
113918834  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
113919173  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
113919193  FGF9; fibroblast growth factor 9 [KO:K04358]
113919414  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
113919427  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
113919467  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
113919740  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
113919946  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
113919987  [KO:K04392]
113920047  [KO:K04393]
113920155  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
113920171  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
113920594  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
113921413  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
113921458  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
113921522  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
113921540  RAP1B; ras-related protein Rap-1b [KO:K07836]
113921738  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
113921757  CACNA1C; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
113921771  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
113921792  KRAS; GTPase KRas isoform X1 [KO:K07827]
113921804  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
113921944  KITLG; kit ligand isoform X1 [KO:K05461]
113921962  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
113921975  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
113921998  DUSP6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
113922015  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
113922030  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
113922054  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
113922091  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
113922141  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
113922200  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
113922232  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
113922256  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
113922508  FGF23; fibroblast growth factor 23 [KO:K22428]
113922563  NTF3; neurotrophin-3 [KO:K04356]
113922602  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
113922696  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
113922743  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
113922869  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
113922956  PTPRR; LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
113922988  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
113923057  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
113923113  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
113923116  FGF6; fibroblast growth factor 6 [KO:K04358]
113923160  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
113923411  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
113923577  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
113923614  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
113923690  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
113923941  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
113924071  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
113924138  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
113924180  IKBKB; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
113924266  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
113924272  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
113924290  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
113924318  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
113924319  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
113924404  [KO:K04381]
113924414  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
113924509  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
113924566  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
113924698  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
113925034  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
113925050  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
113925082  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
113925283  FGF17; fibroblast growth factor 17 [KO:K04358]
113925340  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
113925488  [KO:K03283]
113925505  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
113925632  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
113925688  AREG; amphiregulin [KO:K09782]
113925708  FGF20; fibroblast growth factor 20 [KO:K04358]
113925832  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
113925863  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
113926172  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
113926391  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
113926397  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
113926549  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
113926671  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
113926954  MAP3K6; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
113927193  STMN1; stathmin [KO:K04381]
113927218  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
113927399  SRF; serum response factor isoform X1 [KO:K04378]
113927499  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
113927704  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
113927705  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
113927727  HSPA1L; heat shock 70 kDa protein 1-like isoform X1 [KO:K03283]
113927729  HSPA1B; heat shock 70 kDa protein 1B [KO:K03283]
113927740  TNF; tumor necrosis factor [KO:K03156]
113927959  VEGFA; vascular endothelial growth factor A [KO:K05448]
113928405  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
113928522  [KO:K04453]
113928528  [KO:K03283]
113928623  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
113928668  MEF2C; LOW QUALITY PROTEIN: myocyte-specific enhancer factor 2C [KO:K04454]
113928740  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
113928769  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
113928886  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
113929012  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
113929013  CD14; LOW QUALITY PROTEIN: monocyte differentiation antigen CD14 [KO:K04391]
113929051  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
113929338  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
113929359  FGF18; fibroblast growth factor 18 [KO:K04358]
113929419  RASA1; ras GTPase-activating protein 1 [KO:K04352]
113929513  RASGRF2; LOW QUALITY PROTEIN: ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
113929708  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
113929757  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
113929766  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
113929802  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
113929889  FGF10; fibroblast growth factor 10 [KO:K04358]
113929939  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
113930205  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
113930372  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
113930435  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
113930576  [KO:K03283]
113930597  [KO:K07210]
113930605  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
113930606  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
113930660  FLNA; filamin-A isoform X1 [KO:K04437]
113931031  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
113931090  FGF16; fibroblast growth factor 16 [KO:K04358]
113931136  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
113931206  VEGFD; vascular endothelial growth factor D [KO:K05449]
113931272  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
113931754  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
113931821  PRKACB; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
113931879  NRAS; GTPase NRas [KO:K07828]
113931995  [KO:K04393]
113932035  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113932093  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
113932123  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
113932130  EFNA4; ephrin-A4 [KO:K05462]
113932169  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
113932280  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
113932378  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
113932406  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
113932425  HSPB1; heat shock protein beta-1 [KO:K04455]
113932478  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
113932722  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
113932876  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
113933137  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
113933160  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
113933210  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
113933249  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
113933251  EFNA1; ephrin-A1 [KO:K05462]
113933258  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
113933523  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
113933539  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
113933605  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
113933614  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
113933703  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
113934058  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
113934126  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
113934203  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
113934282  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
113934484  TGFBR1; LOW QUALITY PROTEIN: TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
113934602  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
113934797  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
113934908  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
113934992  [KO:K04393]
113935281  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
113935521  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
113935527  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
113935534  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
113935537  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113935588  CSF1; LOW QUALITY PROTEIN: macrophage colony-stimulating factor 1 [KO:K05453]
113935777  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
113935781  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
113935801  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
113935864  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
113935871  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
113936017  RELB; transcription factor RelB isoform X1 [KO:K09253]
113936043  PPP5C; serine/threonine-protein phosphatase 5 isoform X1 [KO:K04460] [EC:3.1.3.16]
113936078  NGF; beta-nerve growth factor [KO:K02582]
113936085  RRAS; ras-related protein R-Ras isoform X1 [KO:K07829]
113936173  [KO:K04393]
113936296  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
113936412  [KO:K04393]
113936418  NTF4; neurotrophin-4 [KO:K12457]
113936424  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
113936764  FGF21; fibroblast growth factor 21 [KO:K22429]
113936996  ARTN; LOW QUALITY PROTEIN: artemin [KO:K25415]
113937087  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
113937127  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
113937198  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
113937297  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
113937320  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
113937385  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
113937489  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
113937693  DUSP2; LOW QUALITY PROTEIN: dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
113937704  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
113937839  IL1B; interleukin-1 beta [KO:K04519]
113937844  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
113938191  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
113938273  IL1A; interleukin-1 alpha isoform X1 [KO:K04383]
113938587  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
113938754  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
113938968  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
113939006  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
113939072  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
113939264  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
113939270  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
113939343  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
113939477  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
113939500  CRK; adapter molecule crk isoform X1 [KO:K04438]
113939562  NF1; LOW QUALITY PROTEIN: neurofibromin [KO:K08052]
113939569  JUN; transcription factor AP-1 [KO:K04448]
113939579  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
113939587  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
113939636  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
113939743  NLK; LOW QUALITY PROTEIN: serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
113939775  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
113939784  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
113939823  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
113939885  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
113939897  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
118356046  [KO:K25414]
118356554  [KO:K07210]
118356749  [KO:K04393]
118357183  [KO:K03283]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
zca04070  Phosphatidylinositol signaling system
zca04110  Cell cycle
zca04115  p53 signaling pathway
zca04210  Apoptosis
zca04310  Wnt signaling pathway
zca04668  TNF signaling pathway
KO pathway
ko04010   

DBGET integrated database retrieval system