KEGG   PATHWAY: pdic04144
Entry
pdic04144                   Pathway                                
Name
Endocytosis - Phyllostomus discolor (pale spear-nosed bat)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
pdic04144  Endocytosis
pdic04144

Other DBs
GO: 0006897
Organism
Phyllostomus discolor (pale spear-nosed bat) [GN:pdic]
Gene
114491358  ARF6; ADP-ribosylation factor 6 [KO:K07941]
114502378  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X5 [KO:K00889] [EC:2.7.1.68]
114488721  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X3 [KO:K00889] [EC:2.7.1.68]
114493464  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
114507652  PIP5KL1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1 [KO:K13712] [EC:2.7.1.68]
114490843  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
114515080  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
114511987  DNM3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
114494810  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
114502895  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
114494710  CLTA; clathrin light chain A isoform X1 [KO:K04644]
114509532  CLTB; clathrin light chain B isoform X2 [KO:K04645]
114504142  CLTC; clathrin heavy chain 1 isoform X2 [KO:K04646]
114499329  AP2A2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
114510861  AP2A1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
114502875  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
114490318  AP2M1; AP-2 complex subunit mu [KO:K11826]
114510997  AP2S1; AP-2 complex subunit sigma [KO:K11827]
114511646  EHD2; EH domain-containing protein 2 [KO:K12469]
114499676  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
114501577  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
114496087  ZFYVE9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
114513164  ZFYVE16; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
114493028  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
114506330  SMAD2; LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 2 [KO:K04500]
114491384  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
114490442  TFRC; transferrin receptor protein 1 [KO:K06503]
114507607  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
114493180  PDGFRA; platelet-derived growth factor receptor alpha isoform X2 [KO:K04363] [EC:2.7.10.1]
114496712  FGFR2; fibroblast growth factor receptor 2 isoform X8 [KO:K05093] [EC:2.7.10.1]
114489924  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
114509287  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
114488551  IGF1R; insulin-like growth factor 1 receptor isoform X2 [KO:K05087] [EC:2.7.10.1]
114499969  CBL; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
114489417  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
114511452  CBLC; E3 ubiquitin-protein ligase CBL-C isoform X1 [KO:K22518] [EC:2.3.2.27]
114504690  SH3KBP1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
114488547  SH3GL3; endophilin-A3 isoform X2 [KO:K11247]
114503403  SH3GL1; endophilin-A2 isoform X2 [KO:K11247]
114512411  SH3GL2; endophilin-A1 [KO:K11247]
114496384  SH3GLB1; endophilin-B1 isoform X1 [KO:K11248]
114510020  SH3GLB2; endophilin-B2 isoform X1 [KO:K21269]
114493955  BIN1; myc box-dependent-interacting protein 1 isoform X5 [KO:K12562]
114508096  AMPH; LOW QUALITY PROTEIN: amphiphysin [KO:K12562]
114503729  EPN3; epsin-3 isoform X1 [KO:K12471]
114511418  EPN1; epsin-1 isoform X2 [KO:K12471]
114515108  EPN2; epsin-2 isoform X1 [KO:K12471]
114502416  EPS15L1; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
114496077  EPS15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
114508753  SPART; spartin isoform X1 [KO:K19366]
114492503  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
114506304  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X14 [KO:K13305] [EC:2.3.2.26]
114513642  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
114500758  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
114512724  RNF41; E3 ubiquitin-protein ligase NRDP1 isoform X1 [KO:K11981] [EC:2.3.2.27]
114506905  ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]
114502376  SMURF2; E3 ubiquitin-protein ligase SMURF2 isoform X2 [KO:K04678] [EC:2.3.2.26]
114509284  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
114501274  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X3 [KO:K05633] [EC:2.3.2.26]
114503660  LDLR; low-density lipoprotein receptor isoform X1 [KO:K12473]
114497759  LDLRAP1; low density lipoprotein receptor adapter protein 1 [KO:K12474]
114506014  DAB2; disabled homolog 2 isoform X1 [KO:K12475]
114501604  C-C chemokine receptor type 5-like [KO:K04180]
114494642  CXCR1; C-X-C chemokine receptor type 1 [KO:K04175]
114494636  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
114494698  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
114501325  GRK7; LOW QUALITY PROTEIN: rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
114508889  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
114509548  GRK3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
114499827  GRK2; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
114509375  GRK6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
114496447  GRK5; G protein-coupled receptor kinase 5 isoform X2 [KO:K08291] [EC:2.7.11.16]
114489914  GRK4; G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
114499574  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
114515025  ARRB2; beta-arrestin-2 isoform X3 [KO:K04439]
114507266  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
114499279  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
114493907  ACTR3; actin-related protein 3 [KO:K18584]
114507778  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
114496519  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
114502923  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
114502123  actin-related protein 2/3 complex subunit 2-like [KO:K05758]
114494438  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
114509417  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
114501467  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
114512029  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
114494139  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
114502783  WIPF2; WAS/WASL-interacting protein family member 2 [KO:K19475]
114494596  WIPF1; WAS/WASL-interacting protein family member 1 [KO:K19475]
114507963  WIPF3; WAS/WASL-interacting protein family member 3 [KO:K19475]
114510108  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
114493937  heat shock 70 kDa protein 1 [KO:K03283]
114495179  heat shock 70 kDa protein 1-like [KO:K03283]
114497906  DNAJC6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
114512803  WASHC4; LOW QUALITY PROTEIN: WASH complex subunit 4 [KO:K18465]
114514690  WASHC5; WASH complex subunit 5 [KO:K18464]
114496189  WASHC2C; LOW QUALITY PROTEIN: WASH complex subunit 2C [KO:K18462]
114514049  WASHC1; WASH complex subunit 1 isoform X1 [KO:K18461]
114514077  WASHC3; LOW QUALITY PROTEIN: WASH complex subunit 3 [KO:K18463]
114488826  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
114513683  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
114507575  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
114497600  CAPZB; F-actin-capping protein subunit beta isoform X5 [KO:K10365]
114507542  LOW QUALITY PROTEIN: F-actin-capping protein subunit beta-like [KO:K10365]
114509933  VPS29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
114509725  VPS26B; vacuolar protein sorting-associated protein 26B [KO:K18466]
114496394  VPS26A; vacuolar protein sorting-associated protein 26A isoform X1 [KO:K18466]
114504988  SNX12; sorting nexin-12 [KO:K17918]
114494653  SNX3; sorting nexin-3 isoform X1 [KO:K17918]
114491512  USP8; LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase 8 [KO:K11839] [EC:3.4.19.12]
114499602  STAM-binding protein isoform X1 [KO:K11866] [EC:3.4.19.12]
114506480  RAB7A; ras-related protein Rab-7a [KO:K07897]
114503396  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
114491677  STAM; signal transducing adapter molecule 1 isoform X2 [KO:K04705]
114494587  STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
114499944  TSG101; tumor susceptibility gene 101 protein isoform X1 [KO:K12183]
114502763  MVB12A; multivesicular body subunit 12A [KO:K12186]
114513338  MVB12B; multivesicular body subunit 12B isoform X2 [KO:K12186]
114514581  VPS28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
114510040  VPS37B; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 37B [KO:K12185]
114511174  VPS37D; vacuolar protein sorting-associated protein 37D [KO:K12185]
114499703  VPS37C; vacuolar protein sorting-associated protein 37C [KO:K12185]
114508375  VPS37A; vacuolar protein sorting-associated protein 37A [KO:K12185]
114502754  SNF8; vacuolar-sorting protein SNF8 isoform X1 [KO:K12188]
114508615  VPS36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
114503549  VPS25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
114503477  CHMP6; charged multivesicular body protein 6 [KO:K12195]
114492266  CHMP4A; charged multivesicular body protein 4a [KO:K12194]
114506372  CHMP4B; charged multivesicular body protein 4b [KO:K12194]
114501775  CHMP4C; LOW QUALITY PROTEIN: charged multivesicular body protein 4c [KO:K24782]
114495298  charged multivesicular body protein 3-like [KO:K12193]
114511696  CHMP2A; charged multivesicular body protein 2a [KO:K12191]
114490888  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
114503058  CHMP7; charged multivesicular body protein 7 isoform X1 [KO:K15053]
114488087  VPS4A; vacuolar protein sorting-associated protein 4A isoform X1 [KO:K12196]
114506641  VPS4B; vacuolar protein sorting-associated protein 4B [KO:K12196]
114494370  VTA1; vacuolar protein sorting-associated protein VTA1 homolog isoform X1 [KO:K12199]
114509308  LOW QUALITY PROTEIN: charged multivesicular body protein 1b-2-like [KO:K12197]
114489200  charged multivesicular body protein 1b-2-like [KO:K12197]
114490136  CHMP1A; charged multivesicular body protein 1a [KO:K12197]
114504794  charged multivesicular body protein 1b-2 isoform X4 [KO:K12197]
114506845  CHMP1B; charged multivesicular body protein 1b [KO:K12197]
114507236  CHMP5; charged multivesicular body protein 5 [KO:K12198]
114488086  IST1; IST1 homolog isoform X2 [KO:K19476]
114488203  IST1 homolog isoform X3 [KO:K19476]
114501438  programmed cell death 6-interacting protein isoform X1 [KO:K12200]
114493237  SPG21; LOW QUALITY PROTEIN: maspardin [KO:K19367]
114494500  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
114505457  sorting nexin-2-like [KO:K17917]
114492376  SNX1; sorting nexin-1 isoform X2 [KO:K17917]
114494032  SNX2; sorting nexin-2 isoform X1 [KO:K17917]
114488538  LOW QUALITY PROTEIN: sorting nexin-6-like [KO:K17920]
114506221  SNX5; sorting nexin-5 [KO:K17920]
114492358  SNX6; sorting nexin-6 isoform X1 [KO:K17920]
114506489  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
114499504  HRAS; GTPase HRas isoform X2 [KO:K02833]
114491940  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
114513750  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
114504996  IL2RG; cytokine receptor common subunit gamma isoform X2 [KO:K05070]
114502952  transforming protein RhoA-like [KO:K04513]
114501483  RHOA; transforming protein RhoA [KO:K04513]
114509744  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
114510724  class I histocompatibility antigen, Gogo-C*0202 alpha chain-like [KO:K06751]
114510729  HLA class I histocompatibility antigen, alpha chain F-like isoform X2 [KO:K06751]
114510746  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X2 [KO:K06751]
114510749  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
114510755  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
114510758  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
114510764  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
114510832  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
114510833  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
114510835  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X2 [KO:K06751]
114510837  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
114510840  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X2 [KO:K06751]
114510842  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
114510968  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
114490215  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
114489982  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751]
114493833  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
114493857  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X2 [KO:K06751]
114493871  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
114493931  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
114493932  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
114494996  class I histocompatibility antigen, Gogo-OKO alpha chain-like isoform X2 [KO:K06751]
114510838  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
114510766  HLA class I histocompatibility antigen, alpha chain F-like [KO:K06751]
114510722  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like [KO:K06751]
114510923  patr class I histocompatibility antigen, alpha chain E-like isoform X1 [KO:K06751]
114510788  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
114510850  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X1 [KO:K06751]
114510843  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, alpha chain E-like [KO:K06751]
114510738  popy class I histocompatibility antigen, alpha chain E-like [KO:K06751]
114510761  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0201 alpha chain-like [KO:K06751]
114510844  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
114510739  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
114510783  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
114498866  folate receptor alpha-like [KO:K13649]
114499468  LOW QUALITY PROTEIN: folate receptor beta-like [KO:K13649]
114500346  folate receptor alpha-like [KO:K13649]
114500347  FOLR2; folate receptor beta isoform X1 [KO:K13649]
114507852  CAV1; caveolin-1 isoform X1 [KO:K06278]
114507681  CAV2; caveolin-2 isoform X1 [KO:K12958]
114501333  CAV3; caveolin-3 [KO:K12959]
114500349  EHD3; EH domain-containing protein 3 [KO:K12476]
114492642  EHD4; LOW QUALITY PROTEIN: EH domain-containing protein 4 [KO:K12477]
114512675  EEA1; early endosome antigen 1 isoform X4 [KO:K12478]
114501435  RAB5A; ras-related protein Rab-5A [KO:K07887]
114512721  RAB5B; ras-related protein Rab-5B isoform X1 [KO:K07888]
114506938  ras-related protein Rab-5B [KO:K07888]
114503432  RAB5C; ras-related protein Rab-5C [KO:K07889]
114515403  RABEP1; rab GTPase-binding effector protein 1 [KO:K12480]
114501593  RBSN; LOW QUALITY PROTEIN: rabenosyn-5 [KO:K12481]
114512295  RAB4A; ras-related protein Rab-4A [KO:K07879]
114510007  RUFY1; RUN and FYVE domain-containing protein 1 [KO:K12482]
114496572  RUFY2; RUN and FYVE domain-containing protein 2 isoform X3 [KO:K12482]
114499506  EHD1; LOW QUALITY PROTEIN: EH domain-containing protein 1 [KO:K12483]
114488961  VPS45; vacuolar protein sorting-associated protein 45 [KO:K12479]
114490579  SNX4; sorting nexin-4 [KO:K17919]
114506780  RAB22A; ras-related protein Rab-22A [KO:K07891]
114506786  RAB31; ras-related protein Rab-31 isoform X2 [KO:K07891]
114498591  RAB10; ras-related protein Rab-10 [KO:K07903]
114503502  RAB8A; ras-related protein Rab-8A [KO:K07901]
114509989  RAB35; ras-related protein Rab-35 isoform X1 [KO:K07876]
114491715  RAB11A; ras-related protein Rab-11A [KO:K07904]
114502741  RAB11B; ras-related protein Rab-11B [KO:K07905]
114515056  LOW QUALITY PROTEIN: ras-related protein Rab-11B-like [KO:K07905]
114514236  LOW QUALITY PROTEIN: ras-related protein Rab-11B-like [KO:K07905]
114514622  ras-related protein Rab-11B-like [KO:K07905]
114514449  LOW QUALITY PROTEIN: ras-related protein Rab-11B-like [KO:K07905]
114498093  RAB11FIP2; rab11 family-interacting protein 2 [KO:K12484]
114499557  RAB11FIP5; rab11 family-interacting protein 5 isoform X1 [KO:K12484]
114508904  RAB11FIP1; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
114497248  ZFYVE27; protrudin isoform X1 [KO:K19368]
114493385  KIF5B; kinesin-1 heavy chain [KO:K10396]
114514097  KIF5A; kinesin heavy chain isoform X2 [KO:K10396]
114493947  KIF5C; kinesin heavy chain [KO:K10396]
114496534  RAB11FIP3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
114504114  RAB11FIP4; rab11 family-interacting protein 4 isoform X1 [KO:K12485]
114492546  PARD3; partitioning defective 3 homolog isoform X6 [KO:K04237]
114488206  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
114506469  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
114506714  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
114496467  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
114490418  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
114496144  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
114507316  LOW QUALITY PROTEIN: cell division control protein 42 homolog [KO:K04393]
114497464  SMAP2; stromal membrane-associated protein 2 [KO:K12486]
114494112  SMAP1; stromal membrane-associated protein 1 isoform X1 [KO:K12486]
114502435  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
114509277  GIT2; ARF GTPase-activating protein GIT2 isoform X3 [KO:K12487]
114498020  ASAP3; LOW QUALITY PROTEIN: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 [KO:K12488]
114499569  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X2 [KO:K12488]
114514703  ASAP1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X3 [KO:K12488]
114496416  ACAP3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X2 [KO:K12489]
114489163  ACAP2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12489]
114515260  ACAP1; LOW QUALITY PROTEIN: arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [KO:K12489]
114499292  ARAP1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
114492955  ARAP2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K18440]
114509280  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
114507588  AGAP3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X4 [KO:K12491]
114494610  AGAP1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X9 [KO:K12491]
114512695  AGAP2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
114506485  ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
114499276  ARFGAP2; ADP-ribosylation factor GTPase-activating protein 2 isoform X2 [KO:K12493]
114513294  ARFGAP3; ADP-ribosylation factor GTPase-activating protein 3 isoform X1 [KO:K12493]
114509815  PSD2; PH and SEC7 domain-containing protein 2 isoform X2 [KO:K12494]
114496440  PSD; PH and SEC7 domain-containing protein 1 [KO:K12494]
114500729  PSD4; PH and SEC7 domain-containing protein 4 isoform X1 [KO:K12494]
114508513  PSD3; PH and SEC7 domain-containing protein 3 isoform X2 [KO:K12494]
114490736  IQSEC1; IQ motif and SEC7 domain-containing protein 1 isoform X5 [KO:K12495]
114504568  IQSEC2; IQ motif and SEC7 domain-containing protein 2 isoform X2 [KO:K12495]
114513501  IQSEC3; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
114510275  CYTH3; cytohesin-3 [KO:K18441]
114502945  CYTH1; cytohesin-1 isoform X1 [KO:K18441]
114511195  CYTH2; cytohesin-2 isoform X1 [KO:K18441]
114513306  CYTH4; cytohesin-4 [KO:K18441]
114506218  ARFGEF2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 [KO:K18442]
114514651  ARFGEF1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 [KO:K18442]
114496337  GBF1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X2 [KO:K18443]
114492073  LOW QUALITY PROTEIN: ADP-ribosylation factor 1-like [KO:K07937]
114499470  LOW QUALITY PROTEIN: ADP-ribosylation factor 1-like [KO:K07937]
114514984  ARF1; ADP-ribosylation factor 1 [KO:K07937]
114512716  ARF3; LOW QUALITY PROTEIN: ADP-ribosylation factor 3 [KO:K07938]
114501506  ARF4; ADP-ribosylation factor 4 [KO:K07939]
114507512  ARF5; ADP-ribosylation factor 5 [KO:K07940]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
pdic04060  Cytokine-cytokine receptor interaction
pdic04070  Phosphatidylinositol signaling system
pdic04130  SNARE interactions in vesicular transport
pdic04142  Lysosome
pdic04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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