Entry
Name
Cytokine-cytokine receptor interaction - Phyllostomus discolor (pale spear-nosed bat)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
pdic04060 Cytokine-cytokine receptor interaction
Organism
Phyllostomus discolor (pale spear-nosed bat) [GN:
pdic ]
Gene
114489094 IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055 ]
114489238 CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
114490557 TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
114491942 IL15RA; LOW QUALITY PROTEIN: interleukin-15 receptor subunit alpha [KO:K05074 ]
114494102 TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
114494604 IL20RA; interleukin-20 receptor subunit alpha isoform X2 [KO:K05136 ]
114495643 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149 ]
114496258 TNFRSF25; tumor necrosis factor receptor superfamily member 25 [KO:K05160 ]
114496392 TNFRSF14; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 14 [KO:K05152 ]
114496847 TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146 ]
114496861 TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145 ]
114497076 FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
114497355 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
114497489 EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X2 [KO:K05162 ]
114497570 TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142 ]
114497571 TNFRSF18; tumor necrosis factor receptor superfamily member 18 isoform X1 [KO:K05154 ]
114497620 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141 ]
114499981 RELT; tumor necrosis factor receptor superfamily member 19L isoform X1 [KO:K05156 ]
114500220 IL1RN; interleukin-1 receptor antagonist protein isoform X1 [KO:K05481 ]
114500775 IL10RA; interleukin-10 receptor subunit alpha isoform X2 [KO:K05134 ]
114500925 CLCF1; cardiotrophin-like cytokine factor 1 isoform X2 [KO:K05421 ]
114502364 TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
114503389 IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598 ]
114503627 TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
114504180 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
114504181 TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477 ]
114504996 IL2RG; cytokine receptor common subunit gamma isoform X2 [KO:K05070 ]
114505322 EDA2R; tumor necrosis factor receptor superfamily member 27 [KO:K05163 ]
114506470 TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143 ]
114506631 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A isoform X1 [KO:K05147 ]
114506775 CD40; tumor necrosis factor receptor superfamily member 5 isoform X2 [KO:K03160 ]
114506879 TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
114507589 CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
114508457 TNFRSF19; tumor necrosis factor receptor superfamily member 19 isoform X1 [KO:K05155 ]
114508672 TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
114508772 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
114510130 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
114510384 TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
114511461 OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057 ]
114511808 TNFSF18; tumor necrosis factor ligand superfamily member 18 [KO:K05479 ]
114512032 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
114512140 TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469 ]
114512425 TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376 ]
114512758 IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071 ]
114512809 LTBR; tumor necrosis factor receptor superfamily member 3 isoform X2 [KO:K03159 ]
114513933 CSF2RB; cytokine receptor common subunit beta isoform X1 [KO:K04738 ]
114514124 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
114514631 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
114515067 TNFSF13; tumor necrosis factor ligand superfamily member 13 [KO:K05475 ]
114515069 TNFSF12; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 12 [KO:K05474 ]
114515369 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B isoform X1 [KO:K05150 ]
118499198 TNFRSF13C; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 13C [KO:K05151 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway