KEGG   PATHWAY: pflv04115
Entry
pflv04115                   Pathway                                
Name
p53 signaling pathway - Perca flavescens (yellow perch)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
pflv04115  p53 signaling pathway
pflv04115

Organism
Perca flavescens (yellow perch) [GN:pflv]
Gene
114545465  [KO:K04451]
114545689  serpine1; plasminogen activator inhibitor 1 [KO:K03982]
114545904  tsc2; tuberin isoform X1 [KO:K07207]
114546727  [KO:K16857]
114546735  atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
114546827  siva1; apoptosis regulatory protein Siva [KO:K22744]
114546860  tp53i3; quinone oxidoreductase PIG3 [KO:K10133] [EC:1.-.-.-]
114548494  [KO:K21770]
114548616  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
114549636  [KO:K02161]
114549943  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
114550043  [KO:K06625]
114550188  apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
114550246  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
114550465  [KO:K10151]
114550815  steap3; metalloreductase STEAP3 isoform X1 [KO:K10142] [EC:1.16.1.-]
114552350  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
114552441  [KO:K21770]
114552531  ppm1d; protein phosphatase 1D [KO:K10147] [EC:3.1.3.16]
114552598  [KO:K21770]
114552928  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
114553096  [KO:K10808] [EC:1.17.4.1]
114553233  ppp1r13l; relA-associated inhibitor [KO:K27356]
114553266  [KO:K10808] [EC:1.17.4.1]
114553544  [KO:K04570]
114553807  cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
114553865  [KO:K10152]
114554032  shisa5; protein shisa-5 isoform X1 [KO:K10135]
114554047  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
114554308  mdm4; protein Mdm4 isoform X1 [KO:K10127]
114554457  [KO:K06625]
114554612  [KO:K26543]
114555216  chek2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
114555291  [KO:K06509]
114555332  rchy1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
114555375  [KO:K10146]
114555572  [KO:K04402]
114556405  [KO:K04722]
114556708  [KO:K06509]
114557021  [KO:K06626]
114557242  [KO:K04596]
114558681  bcl2l1; bcl-2-like protein 1 [KO:K04570]
114558804  casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
114558983  tp73; tumor protein p73 isoform X1 [KO:K10148]
114559115  [KO:K26543]
114559177  [KO:K05459]
114559882  [KO:K10130]
114559996  gtse1; G2 and S phase-expressed protein 1 [KO:K10129]
114560042  ddb2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
114560146  [KO:K06509]
114560203  [KO:K02159]
114560206  ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
114560246  [KO:K04506] [EC:2.3.2.27]
114560416  [KO:K04726]
114560618  [KO:K04503]
114560707  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
114561307  gorab; RAB6-interacting golgin [KO:K19748]
114561373  [KO:K04402]
114561492  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
114561819  [KO:K10138]
114561839  zmat3; zinc finger matrin-type protein 3 [KO:K10137]
114562479  ccng1; cyclin-G1 [KO:K10145]
114562899  [KO:K10141]
114563090  [KO:K02187] [EC:3.4.22.56]
114563091  [KO:K02187] [EC:3.4.22.56]
114563975  [KO:K04398] [EC:3.4.22.61]
114564140  [KO:K10142] [EC:1.16.1.-]
114564175  [KO:K08738]
114564542  rprm; protein reprimo [KO:K10128]
114565084  [KO:K04402]
114565527  [KO:K10138]
114565630  [KO:K02161]
114565737  cop1; E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:2.3.2.27]
114565779  [KO:K04398] [EC:3.4.22.61]
114565858  [KO:K04398] [EC:3.4.22.61]
114566224  ei24; etoposide-induced protein 2.4 homolog [KO:K10134]
114566610  [KO:K10147] [EC:3.1.3.16]
114566919  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
114567872  rrm2b; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
114568049  [KO:K20394]
114568061  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
114568106  [KO:K06626]
114568885  [KO:K10151]
114569073  [KO:K10128]
114569518  bax; apoptosis regulator BAX [KO:K02159]
114569755  [KO:K02091] [EC:2.7.11.22]
114569810  [KO:K02159]
114570712  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
114570772  [KO:K04402]
114570899  [KO:K02187] [EC:3.4.22.56]
114571165  [KO:K10146]
114571241  [KO:K04722]
114571295  [KO:K04402]
114571810  aifm2; LOW QUALITY PROTEIN: apoptosis-inducing factor 2 [KO:K22745]
114571856  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
114571893  [KO:K08738]
114572137  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
114572155  [KO:K04390]
114572290  perp; p53 apoptosis effector related to PMP-22 [KO:K10136]
114573037  thbs1; thrombospondin-1 [KO:K16857]
114573051  sesn1; sestrin-1 isoform X1 [KO:K10141]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
pflv04110  Cell cycle
pflv04210  Apoptosis
pflv04218  Cellular senescence
KO pathway
ko04115   

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