KEGG   PATHWAY: pflv04115
Entry
pflv04115                   Pathway                                
Name
p53 signaling pathway - Perca flavescens (yellow perch)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
pflv04115  p53 signaling pathway
pflv04115

Organism
Perca flavescens (yellow perch) [GN:pflv]
Gene
114552350  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
114555216  chek2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
114546735  atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
114566919  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
114561307  gorab; RAB6-interacting golgin [KO:K19748]
114550246  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
114554308  mdm4; protein Mdm4 isoform X1 [KO:K10127]
114545465  cellular tumor antigen p53-like isoform X1 [KO:K04451]
114553233  ppp1r13l; relA-associated inhibitor [KO:K27356]
114554457  cyclin-dependent kinase inhibitor 1-like isoform X1 [KO:K06625]
114550043  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
114552928  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
114560618  G1/S-specific cyclin-D1-like [KO:K04503]
114568885  G1/S-specific cyclin-D2-like [KO:K10151]
114560206  ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
114550465  G1/S-specific cyclin-D2-like isoform X1 [KO:K10151]
114553865  G1/S-specific cyclin-D2-like [KO:K10152]
114554047  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
114568061  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
114569755  cyclin-dependent kinase 6-like [KO:K02091] [EC:2.7.11.22]
114568106  G1/S-specific cyclin-E2-like [KO:K06626]
114560707  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
114557021  G1/S-specific cyclin-E2-like isoform X1 [KO:K06626]
114553807  cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
114564542  rprm; protein reprimo [KO:K10128]
114569073  reprimo-like protein [KO:K10128]
114570712  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
114552441  G2/mitotic-specific cyclin-B2-like isoform X1 [KO:K21770]
114552598  cyclin N-terminal domain-containing protein 2-like isoform X1 [KO:K21770]
114548494  G2/mitotic-specific cyclin-B2-like isoform X1 [KO:K21770]
114571856  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
114570772  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
114571295  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
114561373  growth arrest and DNA damage-inducible protein GADD45 alpha-like isoform X1 [KO:K04402]
114561492  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
114555572  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
114565084  growth arrest and DNA damage-inducible protein GADD45 alpha-like isoform X1 [KO:K04402]
114559996  gtse1; G2 and S phase-expressed protein 1 [KO:K10129]
114559115  zinc finger protein 385A-like isoform X1 [KO:K26543]
114554612  zinc finger protein 385A-like [KO:K26543]
114572155  tumor necrosis factor receptor superfamily member 6-like isoform X1 [KO:K04390]
114559882  p53-induced death domain-containing protein 1-like [KO:K10130]
114571241  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
114556405  tumor necrosis factor receptor superfamily member 10A-like isoform X1 [KO:K04722]
114565779  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
114565858  caspase-3-like isoform X1 [KO:K04398] [EC:3.4.22.61]
114563975  caspase-8-like [KO:K04398] [EC:3.4.22.61]
114560416  BH3-interacting domain death agonist-like [KO:K04726]
114560203  apoptosis regulator BAX-like [KO:K02159]
114569518  bax; apoptosis regulator BAX [KO:K02159]
114569810  apoptosis regulator BAX-like isoform X1 [KO:K02159]
114546827  siva1; apoptosis regulatory protein Siva [KO:K22744]
114558681  bcl2l1; bcl-2-like protein 1 [KO:K04570]
114553544  bcl-2-like protein 1 [KO:K04570]
114565630  apoptosis regulator Bcl-2-like [KO:K02161]
114549636  apoptosis regulator Bcl-2-like [KO:K02161]
114546860  tp53i3; quinone oxidoreductase PIG3 [KO:K10133] [EC:1.-.-.-]
114566224  ei24; etoposide-induced protein 2.4 homolog [KO:K10134]
114554032  shisa5; protein shisa-5 isoform X1 [KO:K10135]
114572290  perp; p53 apoptosis effector related to PMP-22 [KO:K10136]
114561839  zmat3; zinc finger matrin-type protein 3 [KO:K10137]
114560246  E3 ubiquitin-protein ligase Siah1 isoform X1 [KO:K04506] [EC:2.3.2.27]
114571893  cytochrome c [KO:K08738]
114564175  cytochrome c-like [KO:K08738]
114550188  apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
114558804  casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
114570899  caspase-3-like [KO:K02187] [EC:3.4.22.56]
114563090  caspase-3-like isoform X1 [KO:K02187] [EC:3.4.22.56]
114563091  caspase-3-like [KO:K02187] [EC:3.4.22.56]
114571810  aifm2; LOW QUALITY PROTEIN: apoptosis-inducing factor 2 [KO:K22745]
114565527  insulin-like growth factor-binding protein 3 [KO:K10138]
114561819  insulin-like growth factor-binding protein 3 [KO:K10138]
114559177  insulin-like growth factor I [KO:K05459]
114549943  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
114545689  serpine1; plasminogen activator inhibitor 1 [KO:K03982]
114557242  adhesion G protein-coupled receptor B1-like [KO:K04596]
114560146  CD82 antigen-like [KO:K06509]
114555291  CD82 antigen-like [KO:K06509]
114556708  CD82 antigen-like isoform X1 [KO:K06509]
114546727  thrombospondin-1-like [KO:K16857]
114573037  thbs1; thrombospondin-1 [KO:K16857]
114560042  ddb2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
114553096  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
114567872  rrm2b; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
114553266  LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase subunit M2-like [KO:K10808] [EC:1.17.4.1]
114573051  sesn1; sestrin-1 isoform X1 [KO:K10141]
114562899  sestrin-3-like [KO:K10141]
114568049  sestrin-2-like isoform X1 [KO:K20394]
114572137  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
114548616  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
114545904  tsc2; tuberin isoform X1 [KO:K07207]
114550815  steap3; metalloreductase STEAP3 isoform X1 [KO:K10142] [EC:1.16.1.-]
114564140  metalloreductase STEAP3-like [KO:K10142] [EC:1.16.1.-]
114565737  cop1; E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:2.3.2.27]
114555332  rchy1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
114562479  ccng1; cyclin-G1 [KO:K10145]
114571165  cyclin-G2-like [KO:K10146]
114555375  cyclin-G2-like [KO:K10146]
114552531  ppm1d; protein phosphatase 1D [KO:K10147] [EC:3.1.3.16]
114566610  protein phosphatase 1D-like [KO:K10147] [EC:3.1.3.16]
114558983  tp73; tumor protein p73 isoform X1 [KO:K10148]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
pflv04110  Cell cycle
pflv04210  Apoptosis
pflv04218  Cellular senescence
KO pathway
ko04115   
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