KEGG   PATHWAY: pps04115
Entry
pps04115                    Pathway                                
Name
p53 signaling pathway - Pan paniscus (bonobo)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
pps04115  p53 signaling pathway
pps04115

Organism
Pan paniscus (bonobo) [GN:pps]
Gene
100967395  PERP; p53 apoptosis effector related to PMP-22 [KO:K10136]
100967848  TP53I3; quinone oxidoreductase PIG3 isoform X3 [KO:K10133] [EC:1.-.-.-]
100968381  TP73; tumor protein p73 isoform X2 [KO:K10148]
100968640  ZNF385A; zinc finger protein 385A isoform X1 [KO:K26543]
100968756  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
100969234  SFN; 14-3-3 protein sigma [KO:K06644]
100969410  TP53AIP1; p53-regulated apoptosis-inducing protein 1 isoform X1 [KO:K13773]
100969626  [KO:K08738]
100969800  SIVA1; apoptosis regulatory protein Siva [KO:K22744]
100970241  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
100970552  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 isoform X1 [KO:K10144] [EC:2.3.2.27]
100971044  TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722]
100971050  TSC2; tuberin isoform X16 [KO:K07207]
100972365  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
100972595  CCND3; G1/S-specific cyclin-D3 isoform X2 [KO:K10152]
100973227  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X2 [KO:K04722]
100973457  SERPINE1; plasminogen activator inhibitor 1 isoform X2 [KO:K03982]
100973941  TP53; cellular tumor antigen p53 isoform X2 [KO:K04451]
100973958  GTSE1; G2 and S phase-expressed protein 1 [KO:K10129]
100974104  RPRM; protein reprimo [KO:K10128]
100974112  BBC3; bcl-2-binding component 3 isoform X3 [KO:K10132]
100974358  SESN1; sestrin-1 isoform X1 [KO:K10141]
100974934  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
100974989  AIFM2; ferroptosis suppressor protein 1 [KO:K22745]
100975153  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
100975637  CDKN2A; cyclin-dependent kinase inhibitor 2A isoform X1 [KO:K06621]
100976050  CD82; CD82 antigen [KO:K06509]
100976294  CDK4; cyclin-dependent kinase 4 isoform X2 [KO:K02089] [EC:2.7.11.22]
100977916  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100978164  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
100978497  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
100979152  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
100979216  SESN3; sestrin-3 isoform X1 [KO:K10141]
100979315  [KO:K10131]
100979809  BCL2L1; bcl-2-like protein 1 isoform X2 [KO:K04570]
100981258  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
100981338  MDM4; protein Mdm4 isoform X1 [KO:K10127]
100981659  SHISA5; protein shisa-5 isoform X1 [KO:K10135]
100981695  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
100982317  CHEK1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
100982610  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
100982764  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta isoform X2 [KO:K04402]
100982783  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
100982830  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
100982978  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
100983020  COP1; E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:2.3.2.27]
100983152  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100983318  EI24; etoposide-induced protein 2.4 homolog isoform X3 [KO:K10134]
100985136  [KO:K04506] [EC:2.3.2.27]
100986059  SERPINB5; serpin B5 [KO:K10139]
100986481  [KO:K08738]
100986996  CCNG2; cyclin-G2 [KO:K10146]
100987115  ADGRB1; adhesion G protein-coupled receptor B1 isoform X3 [KO:K04596]
100987176  SESN2; sestrin-2 [KO:K20394]
100987687  CHEK2; serine/threonine-protein kinase Chk2 isoform X2 [KO:K06641] [EC:2.7.11.1]
100988290  GORAB; RAB6-interacting golgin isoform X1 [KO:K19748]
100988526  FAS; tumor necrosis factor receptor superfamily member 6 isoform X3 [KO:K04390]
100989555  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
100989617  PIDD1; p53-induced death domain-containing protein 1 isoform X1 [KO:K10130]
100990548  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
100990850  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100991344  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
100991820  BAX; apoptosis regulator BAX isoform X3 [KO:K02159]
100992567  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
100992692  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
100992881  PPP1R13L; relA-associated inhibitor isoform X2 [KO:K27356]
100992917  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
100992951  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
100993714  STEAP3; metalloreductase STEAP3 [KO:K10142] [EC:1.16.1.-]
100994890  THBS1; thrombospondin-1 [KO:K16857]
100995163  ZMAT3; zinc finger matrin-type protein 3 isoform X1 [KO:K10137]
100995377  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100995524  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
100995605  CCND1; G1/S-specific cyclin-D1 isoform X2 [KO:K04503]
100996071  CDK1; cyclin-dependent kinase 1 isoform X2 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
100996074  PPM1D; protein phosphatase 1D [KO:K10147] [EC:3.1.3.16]
100996173  CCNG1; cyclin-G1 [KO:K10145]
103785895  [KO:K08738]
106634335  [KO:K08738]
106634558  [KO:K08738]
106635123  [KO:K08738]
106635415  [KO:K08738]
117975808  [KO:K08738]
117976221  [KO:K08738]
117981750  [KO:K08738]
129397948  [KO:K08738]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
pps04110  Cell cycle
pps04210  Apoptosis
pps04218  Cellular senescence
KO pathway
ko04115   

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