KEGG   PATHWAY: ptg04530
Entry
ptg04530                    Pathway                                
Name
Tight junction - Panthera tigris altaica (Amur tiger)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
ptg04530  Tight junction
ptg04530

Other DBs
GO: 0005923
Organism
Panthera tigris altaica (Amur tiger) [GN:ptg]
Gene
102948549  [KO:K06448]
102948707  OCLN; occludin [KO:K06088]
102948833  [KO:K06448]
102948932  MPP4; membrane palmitoylated protein 4 [KO:K21109]
102948970  VASP; vasodilator-stimulated phosphoprotein [KO:K06274]
102948983  PRKACA; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102948988  MARVELD2; MARVEL domain containing 2 [KO:K17291]
102949054  PARD3; par-3 family cell polarity regulator [KO:K04237]
102949118  [KO:K06448]
102949140  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
102949361  STK11; serine/threonine kinase 11 [KO:K07298] [EC:2.7.11.1]
102949410  [KO:K06448]
102949476  EZR; ezrin [KO:K08007]
102949581  CLDN22; claudin-22 [KO:K06087]
102949607  AFDN; afadin, adherens junction formation factor [KO:K05702]
102949704  CLDN16; claudin 16 [KO:K06087]
102949872  PPP2R2D; protein phosphatase 2 regulatory subunit Bdelta [KO:K04354]
102949986  ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.39]
102949998  CLDN1; claudin 1 [KO:K06087]
102950338  YBX3; Y-box-binding protein 3 [KO:K06099]
102950622  CLDN15; claudin 15 [KO:K06087]
102950652  PARD6B; par-6 family cell polarity regulator beta [KO:K06093]
102950679  RAPGEF2; Rap guanine nucleotide exchange factor 2 [KO:K08018]
102950880  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
102950928  TUBA8; tubulin alpha 8 [KO:K07374]
102951074  NEDD4L; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase [KO:K13305] [EC:2.3.2.26]
102951141  PPP2R1A; protein phosphatase 2 scaffold subunit Aalpha [KO:K03456]
102951203  WAS; Wiskott-Aldrich syndrome [KO:K05747]
102951259  ARPC3; actin related protein 2/3 complex subunit 3 [KO:K05756]
102951261  PPP2R2B; protein phosphatase 2 regulatory subunit Bbeta [KO:K04354]
102951399  [KO:K07374]
102951466  CLDN19; claudin 19 [KO:K06087]
102951896  PRKAG1; protein kinase AMP-activated non-catalytic subunit gamma 1 [KO:K07200]
102951915  CLDN25; claudin 25 [KO:K06087]
102951957  ARHGAP17; Rho GTPase activating protein 17 [KO:K20638]
102952112  PRKAB1; protein kinase AMP-activated non-catalytic subunit beta 1 [KO:K07199]
102952555  RHOA; ras homolog family member A [KO:K04513]
102952641  JAM3; junctional adhesion molecule 3 [KO:K06785]
102952821  ARPC2; actin related protein 2/3 complex subunit 2 [KO:K05758]
102952971  PPP2R2A; protein phosphatase 2 regulatory subunit Balpha [KO:K04354]
102953046  CLDN7; claudin 7 [KO:K06087]
102953141  [KO:K07374]
102953170  ARPC5L; actin related protein 2/3 complex subunit 5 like [KO:K05754]
102953242  CLDN14; claudin 14 [KO:K06087]
102953244  ARHGEF18; Rho/Rac guanine nucleotide exchange factor 18 [KO:K21066]
102953578  CLDN10; claudin 10 [KO:K06087]
102953713  RAB13; RAB13, member RAS oncogene family [KO:K06109]
102953725  TUBA1C; tubulin alpha-1C chain [KO:K07374]
102954008  PPP2CA; protein phosphatase 2 catalytic subunit alpha [KO:K04382] [EC:3.1.3.16]
102954023  [KO:K07374]
102954567  HSPA4; heat shock protein family A (Hsp70) member 4 [KO:K09489]
102954811  MYL2; myosin light chain 2 [KO:K10351]
102955248  MYH10; myosin heavy chain 10 [KO:K10352]
102955331  BVES; blood vessel epicardial substance [KO:K21108]
102955456  TIAM1; T-cell lymphoma invasion and metastasis 1 [KO:K05731]
102955873  CLDN20; claudin 20 [KO:K06087]
102956058  CLDN12; claudin 12 [KO:K06087]
102956144  EPB41L4B; erythrocyte membrane protein band 4.1 like 4B [KO:K21111]
102956215  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
102956343  PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.31]
102956425  ARPC4; actin related protein 2/3 complex subunit 4 [KO:K05755]
102956451  PRKCE; protein kinase C epsilon [KO:K18050] [EC:2.7.11.13]
102956715  PPP2CB; protein phosphatase 2 catalytic subunit beta [KO:K04382] [EC:3.1.3.16]
102956919  RDX; radixin [KO:K05762]
102956922  WHAMM; WAS protein homolog associated with actin, golgi membranes and microtubules [KO:K20479]
102956932  AMOTL1; angiomotin like 1 [KO:K06104]
102957139  SCRIB; scribbled planar cell polarity protein [KO:K16175]
102957161  MARVELD3; MARVEL domain containing 3 [KO:K21099]
102957704  CGN; cingulin [KO:K06102]
102958065  HCLS1; hematopoietic cell-specific Lyn substrate 1 [KO:K06106]
102958432  TJP2; tight junction protein 2 [KO:K06098]
102958456  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
102958666  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
102958744  TJAP1; tight junction associated protein 1 [KO:K06105]
102958797  PRKCI; protein kinase C iota [KO:K06069] [EC:2.7.11.13]
102959107  RAB8B; RAB8B, member RAS oncogene family [KO:K07902]
102959115  PRKAG3; protein kinase AMP-activated non-catalytic subunit gamma 3 [KO:K07200]
102959159  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
102959341  SYMPK; symplekin [KO:K06100]
102959345  CLDN11; claudin 11 [KO:K06087]
102959409  RAB8A; RAB8A, member RAS oncogene family [KO:K07901]
102959906  CCND1; cyclin D1 [KO:K04503]
102960070  RAP2C; RAP2C, member of RAS oncogene family [KO:K07839]
102960269  PRKAG2; protein kinase AMP-activated non-catalytic subunit gamma 2 [KO:K07200]
102960317  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
102960685  [KO:K18952] [EC:2.7.11.13]
102960973  [KO:K18952] [EC:2.7.11.13]
102961510  AMOTL2; angiomotin like 2 [KO:K06104]
102961543  PPP2R1B; protein phosphatase 2 scaffold subunit Abeta [KO:K03456]
102961961  ERBB2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
102962068  TUBA4A; tubulin alpha 4a [KO:K07374]
102962597  MPP5; membrane palmitoylated protein 5 [KO:K06091]
102963096  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
102963243  RAP1A; RAP1A, member of RAS oncogene family [KO:K04353]
102963424  F11R; F11 receptor [KO:K06089]
102963508  CLDN4; claudin-4 [KO:K06087]
102963520  ROCK1; Rho associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.39]
102963554  ARPC1B; actin related protein 2/3 complex subunit 1B [KO:K05757]
102963650  MYL6B; myosin light chain 6B [KO:K12751]
102963652  NF2; neurofibromin 2 [KO:K16684]
102963733  ACTN4; actinin alpha 4 [KO:K05699]
102963813  MAGI1; membrane associated guanylate kinase, WW and PDZ domain containing 1 [KO:K05631]
102963836  ARPC1A; actin related protein 2/3 complex subunit 1A [KO:K05757]
102964214  MYH9; myosin heavy chain 9 [KO:K10352]
102964220  AMOT; angiomotin [KO:K16819]
102964235  MYL6; myosin light chain 6 [KO:K12751]
102964426  CLDN9; claudin 9 [KO:K06087]
102964746  SLC9A3R1; SLC9A3 regulator 1 [KO:K13365]
102964789  MYL9; myosin light chain 9 [KO:K12755]
102965154  CTTN; cortactin [KO:K06106]
102965254  CLDN2; claudin 2 [KO:K06087]
102965409  ACTR3B; ARP3 actin related protein 3 homolog B [KO:K18584]
102965456  ACTN1; actinin alpha 1 [KO:K05699]
102965652  MSN; moesin [KO:K05763]
102965872  ACTR3; ARP3 actin related protein 3 homolog [KO:K18584]
102966189  PCNA; proliferating cell nuclear antigen [KO:K04802]
102966253  LLGL1; LLGL1, scribble cell polarity complex component [KO:K06094]
102966315  TJP3; tight junction protein 3 [KO:K06097]
102966585  PARD6A; par-6 family cell polarity regulator alpha [KO:K06093]
102966696  CLDN8; claudin 8 [KO:K06087]
102966840  CLDN34; claudin 34 [KO:K06087]
102967151  PATJ; PATJ, crumbs cell polarity complex component [KO:K06092]
102967350  ITGB1; integrin subunit beta 1 [KO:K05719]
102967577  DLG3; discs large MAGUK scaffold protein 3 [KO:K21098]
102967640  SYNPO; synaptopodin [KO:K21112]
102968051  GATA4; GATA binding protein 4 [KO:K09183]
102968286  CLDN18; claudin 18 [KO:K06087]
102968345  ARPC5; actin related protein 2/3 complex subunit 5 [KO:K05754]
102968394  RAPGEF6; Rap guanine nucleotide exchange factor 6 [KO:K08020]
102968561  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
102968822  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
102969257  TUBAL3; tubulin alpha like 3 [KO:K07374]
102969284  ARHGEF2; rho guanine nucleotide exchange factor 2 [KO:K12791]
102969378  MYH11; myosin heavy chain 11 [KO:K10352]
102969594  MICALL2; MICAL like 2 [KO:K21068]
102970161  IGSF5; immunoglobulin superfamily member 5 [KO:K06786]
102970281  CDK4; cyclin dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
102970289  PPP2R2C; protein phosphatase 2 regulatory subunit Bgamma [KO:K04354]
102970408  CLDN24; claudin 24 [KO:K06087]
102970552  [KO:K06087]
102970831  PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2 [KO:K07198] [EC:2.7.11.31]
102970954  JAM2; junctional adhesion molecule 2 [KO:K06735]
102971040  DLG1; discs large MAGUK scaffold protein 1 [KO:K12076]
102971041  LLGL2; LLGL2, scribble cell polarity complex component [KO:K06094]
102971191  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
102971233  MYL12B; myosin regulatory light chain 12B [KO:K12757]
102971289  MPDZ; multiple PDZ domain crumbs cell polarity complex component [KO:K06095]
102971401  ACTB; actin beta [KO:K05692]
102971525  [KO:K12757]
102971629  ACTG1; actin gamma 1 [KO:K05692]
102971662  TJP1; tight junction protein 1 [KO:K05701]
102971744  ACTR2; ARP2 actin related protein 2 homolog [KO:K17260]
102971990  CD1E; T-cell surface glycoprotein CD1e, membrane-associated [KO:K06448]
102972119  MYH14; myosin heavy chain 14 [KO:K10352]
102972126  CLDN17; claudin 17 [KO:K06087]
102972156  DLG2; discs large MAGUK scaffold protein 2 [KO:K12075]
102972158  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
102972283  [KO:K06448]
102972403  PRKAB2; protein kinase AMP-activated non-catalytic subunit beta 2 [KO:K07199]
102972571  CD1C; T-cell surface glycoprotein CD1c [KO:K06448]
102972664  [KO:K06087]
102972850  [KO:K06448]
102972938  NEDD4; neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase [KO:K10591] [EC:2.3.2.26]
102972948  CGNL1; cingulin like 1 [KO:K21110]
102973021  CDC42; cell division cycle 42 [KO:K04393]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
ptg04520  Adherens junction
ptg04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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