KEGG   PATHWAY: rno03013
Entry
rno03013                    Pathway                                
Name
Nucleocytoplasmic transport - Rattus norvegicus (rat)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
rno03013  Nucleocytoplasmic transport
rno03013

Other DBs
GO: 0050658
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
100359600  Kpna2l1; importin subunit alpha-1 [KO:K15043]
100360413  Eef1a1l1; elongation factor 1-alpha 1-like [KO:K03231]
100911798  Seh1l; nucleoporin SEH1 [KO:K14299]
103691939  Eef1a1l2; elongation factor 1-alpha 1-like [KO:K03231]
108351070  Sumo2l1; small ubiquitin-related modifier 2-like [KO:K12160]
113929  Nup88; nuclear pore complex protein Nup88 [KO:K14318]
113975  Pom121; nuclear envelope pore membrane protein POM 121 [KO:K14316]
114612  Ddx39b; spliceosome RNA helicase Ddx39b [KO:K12812] [EC:5.6.2.7]
116458  Ipo13; importin-13 [KO:K25202]
116555  Nup107; nuclear pore complex protein Nup107 [KO:K14301]
117021  Nup155; nuclear pore complex protein Nup155 [KO:K14312]
120095693  [KO:K12160]
120102380  [KO:K12160]
171361  Eef1a1; elongation factor 1-alpha 1 [KO:K03231]
245922  Nup58; nucleoporin p58/p45 [KO:K14307]
24799  Eef1a2; elongation factor 1-alpha 2 [KO:K03231]
24917  Kpnb1; importin subunit beta-1 [KO:K14293]
25281  Nup153; nuclear pore complex protein Nup153 [KO:K14296]
25497  Nup50; nuclear pore complex protein Nup50 [KO:K14295]
25573  Ube2i; SUMO-conjugating enzyme UBC9 [KO:K10577]
259170  Casc3; protein CASC3 [KO:K14323]
286917  Phax; phosphorylated adapter RNA export protein [KO:K14291]
287113  Rnps1; RNA-binding protein with serine-rich domain 1 [KO:K14325]
287830  Nup85; nuclear pore complex protein Nup85 [KO:K14304]
288064  Kpna1; importin subunit alpha-5 [KO:K23940]
290228  Ipo4; importin-4 [KO:K20221]
290280  Xpo4; exportin-4 [KO:K25203]
290284  Sap18; histone deacetylase complex subunit SAP18 [KO:K14324]
290519  Thoc3; THO complex subunit 3 [KO:K12880]
291797  Thoc1; THO complex subunit 1 isoform 2 [KO:K12878]
291874  Nup93; nuclear pore complex protein Nup93 [KO:K14309]
292022  Ddx19a; ATP-dependent RNA helicase DDX19A [KO:K18655] [EC:5.6.2.7]
292085  Nup133; nuclear pore complex protein Nup133 [KO:K14300]
293476  Xpo6; exportin-6 [KO:K25204]
294392  Kpna5; importin subunit alpha-6 [KO:K15042]
294429  Ranbp2; E3 SUMO-protein ligase RanBP2 [KO:K12172] [EC:2.3.2.-]
295284  Rbm8a; RNA-binding protein 8A [KO:K12876]
295692  Nup35; nucleoporin NUP35 [KO:K14313]
296219  Nxt1; NTF2-related export protein 1 [KO:K14285]
296634  Nup214; nuclear pore complex protein Nup214 [KO:K14317]
296954  Tnpo3; transportin-3 [KO:K15436]
297522  Sec13; protein SEC13 homolog [KO:K14004]
298075  Ncbp1; nuclear cap-binding protein subunit 1 [KO:K12882]
298385  Magoh; protein mago nashi homolog [KO:K12877]
299706  Nup37; nucleoporin Nup37 [KO:K14302]
300259  Aaas; aladin [KO:K14320]
301442  Sumo1; small ubiquitin-related modifier 1 [KO:K12160]
302591  Nxf3; nuclear RNA export factor 3 [KO:K14284]
302729  Da2-19; THO complex subunit 1 [KO:K12878]
303029  Ranbp17; ran-binding protein 17 [KO:K24115]
304670  Tnpo2; transportin-2 [KO:K18727]
304817  Ipo9; importin-9 [KO:K20224]
304862  Tpr; nucleoprotein TPR [KO:K09291]
305714  Thoc7; THO complex subunit 7 homolog isoform 1 [KO:K13176]
305884  Acin1; apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
306182  Ipo5; importin-5 [KO:K20222]
308653  Nxf2; nuclear RNA export factor 2 isoform X1 [KO:K14284]
308939  Ipo7; importin-7 [KO:K20223]
309126  Tnpo1; transportin-1 isoform b [KO:K18752]
310056  Ipo11; importin-11 isoform X1 [KO:K25201]
310512  Nmd3; 60S ribosomal export protein NMD3 [KO:K07562]
311182  Nup160; nuclear pore complex protein Nup160 [KO:K14303]
313163  1700009N14Rikl; uncharacterized protein LOC313163 [KO:K07936]
313308  Thoc2; THO complex subunit 2 [KO:K12879]
313449  Upf3b; regulator of nonsense transcripts 3B [KO:K14328]
313620  Srrm1; serine/arginine repetitive matrix protein 1 [KO:K13171]
314879  Xpot; exportin-T [KO:K14288]
315352  Nxt2; NTF2-related export protein 2 [KO:K14285]
316108  Snupn; snurportin-1 [KO:K13151]
360886  Ahctf1; protein ELYS [KO:K25129]
360972  Thoc5; THO complex subunit 5 homolog isoform 1 [KO:K13174]
361055  Kpna3; importin subunit alpha-4 [KO:K23583]
361070  Xpo7; exportin-7 [KO:K18460]
361176  Upf3a; regulator of nonsense transcripts 3A [KO:K14328]
361271  Upf2; regulator of nonsense transcripts 2 [KO:K14327]
361959  Kpna4; importin subunit alpha-3 [KO:K23583]
362098  Gle1; mRNA export factor GLE1 [KO:K18723]
362273  Cse1l; exportin-2 [KO:K18423]
362281  Rae1; mRNA export factor [KO:K14298]
362335  Nup205; nuclear pore complex protein Nup205 [KO:K14310]
362557  Ndc1; nucleoporin NDC1 [KO:K14315]
362607  Kpna6; importin subunit alpha-7 [KO:K15042]
362965  Rangap1; ran GTPase-activating protein 1 [KO:K14319]
363194  Xpo5; exportin-5 [KO:K14289]
365844  Nup210l; nuclear pore membrane glycoprotein 210-like [KO:K14314]
366016  Nup188; nucleoporin NUP188 isoform X1 [KO:K14311]
366790  Pym1; partner of Y14 and mago [KO:K14294]
368070  Pnn; pinin [KO:K13114]
408216  Senp17; Sumo1/sentrin/SMT3 specific peptidase 17 [KO:K03345] [EC:3.4.22.68]
408222  Senp18; Sumo1/sentrin/SMT3 specific peptidase 18 [KO:K03345] [EC:3.4.22.68]
499417  Sumo3; small ubiquitin-related modifier 3 [KO:K12160]
499974  Nup42; nucleoporin NUP42 [KO:K14321]
500697  Gle1l1; mRNA export factor GLE1-like [KO:K18723]
501621  Nxf7; nuclear RNA export factor 7 [KO:K14284]
502128  Pom121l2; POM121-like protein 2 isoform 1 [KO:K14316]
53372  Nup54; nuclear pore complex protein Nup54 [KO:K14308]
58958  Nup210; nuclear pore membrane glycoprotein 210 precursor [KO:K14314]
59087  Nxf1; nuclear RNA export factor 1 [KO:K14284]
59303  Tmem33; transmembrane protein 33 isoform 1 [KO:K20724]
65274  Nup62; nuclear pore glycoprotein p62 [KO:K14306]
679894  Thoc2l; similar to THO complex subunit 2 (Tho2) [KO:K12879]
683983  Nup43; nucleoporin Nup43 isoform 2 [KO:K14305]
684558  Upf1; UPF1, RNA helicase and ATPase [KO:K14326] [EC:5.6.2.5 5.6.2.3]
686774  Ipo8; importin-8 [KO:K18755]
688288  Eif4a3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
688526  Rnps1l1; RNA-binding protein with serine-rich domain 1-like [KO:K14325]
689116  Ncbp2; nuclear cap-binding protein subunit 2 [KO:K12883]
690244  Sumo2; small ubiquitin-related modifier 2 [KO:K12160]
690303  Magohb; protein mago nashi homolog 2 [KO:K12877]
690504  Kpna7; importin subunit alpha-8 [KO:K15043]
690585  Alyref; THO complex subunit 4 [KO:K12881]
690693  Ddx19b; ATP-dependent RNA helicase DDX19B [KO:K18655] [EC:5.6.2.7]
751812  Rasl2-9; GTP-binding nuclear protein Ran, testis-specific isoform [KO:K07936]
78973  Senp2; sentrin-specific protease 2 [KO:K03345] [EC:3.4.22.68]
79227  Thoc6; THO complex subunit 6 homolog [KO:K13175]
81738  Nup98; nuclear pore complex protein Nup98-Nup96 proprotein [KO:K14297]
84509  Ran; GTP-binding nuclear protein Ran [KO:K07936]
85245  Kpna2; importin subunit alpha-1 [KO:K15043]
85252  Xpo1; exportin-1 [KO:K14290]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
rno03015  mRNA surveillance pathway
KO pathway
ko03013   

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