KEGG   PATHWAY: rno05100
Entry
rno05100                    Pathway                                
Name
Bacterial invasion of epithelial cells - Rattus norvegicus (rat)
Description
Many pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-phagocytic host cells (e.g. epithelial cells) using two mechanisms referred to as zipper model and trigger model. Listeria, Staphylococcus, Streptococcus, and Yersinia are examples of bacteria that enter using the zipper model. These bacteria express proteins on their surfaces that interact with cellular receptors, initiating signalling cascades that result in close apposition of the cellular membrane around the entering bacteria. Shigella and Salmonella are the examples of bacteria entering cells using the trigger model. These bacteria use type III secretion systems to inject protein effectors that interact with the actin cytoskeleton.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
rno05100  Bacterial invasion of epithelial cells
rno05100

Organism
Rattus norvegicus (rat) [GN:rno]
Gene
100361457  Actg1l1; actin, gamma 1 propeptide-like [KO:K05692]
114858  Shc3; SHC-transforming protein 3 [KO:K17448]
116561  Cltb; clathrin light chain B [KO:K04645]
117273  Rhoa; transforming protein RhoA [KO:K04513]
117515  Septin2; septin-2 [KO:K16942]
120098222  [KO:K05692]
134484121  [KO:K00922] [EC:2.7.1.153]
140694  Dnm1; dynamin-1 [KO:K01528] [EC:3.6.5.5]
170911  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
170922  Ilk; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
171574  Dnm3; dynamin-3 [KO:K01528] [EC:3.6.5.5]
24511  Itgb1; integrin beta-1 precursor [KO:K05719]
24553  Met; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
25404  Cav1; caveolin-1 isoform alpha [KO:K06278]
25414  Bcar1; breast cancer anti-estrogen resistance protein 1 isoform 3 [KO:K05726]
25513  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
25614  Ptk2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
25661  Fn1; fibronectin precursor [KO:K05717]
25751  Dnm2; dynamin-2 [KO:K23484]
287876  Actg1; actin, cytoplasmic 2 [KO:K05692]
287942  Crkl; crk-like protein [KO:K04438]
288077  Hcls1; hematopoietic lineage cell-specific protein [KO:K06106]
288669  Arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
289820  Actr2; actin-related protein 2 [KO:K17260]
29161  Cav3; caveolin-3 [KO:K12959]
291962  Elmo3; engulfment and cell motility protein 3 [KO:K19241]
293507  Septin1; septin-1 [KO:K13737]
294568  Wasf1; actin-binding protein WASF1 [KO:K05753]
296710  Arpc5l; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
297173  RSA-14-44; ras homolog gene family, member A [KO:K04513]
297357  Ctnna2; catenin alpha-2 isoform 1 [KO:K05691]
29741  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
297518  Arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
301511  Arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
303135  Septin8; septin-8 isoform 2 [KO:K16939]
305227  Septin11; septin-11 [KO:K16939]
305679  Vcl; vinculin [KO:K05700]
307505  Ctnna1; catenin alpha-1 [KO:K05691]
308875  Rhog; rho-related GTP-binding protein RhoG [KO:K07863]
309081  Dock1; dedicator of cytokinesis protein 1 [KO:K13708]
310460  Arhgef26; Rho guanine nucleotide exchange factor 26 [KO:K13744]
313024  Wasf2; actin-binding protein WASF2 [KO:K05748]
313702  Mad2l2; mitotic spindle assembly checkpoint protein MAD2B isoform 2 [KO:K13728]
314612  Shc2; SHC-transforming protein 2 [KO:K17447]
315346  Itga5; integrin alpha-5 [KO:K06484]
316258  Cd2ap; CD2-associated protein [KO:K13738]
360820  Pxn; paxillin isoform 1 [KO:K05760]
360854  Arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
361251  Elmo1; engulfment and cell motility protein 1 [KO:K12366]
361388  Gab1; GRB2-associated-binding protein 1 [KO:K09593]
361839  Ctnna3; catenin alpha-3 [KO:K05691]
362271  Elmo2; engulfment and cell motility protein 2 [KO:K18985]
362298  Actr3b; actin-related protein 3B [KO:K18584]
363425  Cav2; caveolin-2 [KO:K12958]
363542  Septin12; septin-12 [KO:K16938]
363875  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
366508  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
500985  Cbl; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
54227  Arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
54241  Cltc; clathrin heavy chain 1 [KO:K04646]
54245  Crk; adapter molecule crk [KO:K04438]
56003  Septin3; neuronal-specific septin-3 [KO:K16938]
60465  Cttn; src substrate cortactin isoform 2 [KO:K06106]
60664  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
64465  Cdc42; cell division control protein 42 homolog [KO:K04393]
679845  Shc4; SHC-transforming protein 4 [KO:K17449]
682507  Wasl; actin nucleation-promoting factor WASL [KO:K23612]
688429  Arhgap10; rho GTPase-activating protein 10 [KO:K13736]
691335  Septin6; septin-6 [KO:K16939]
81732  Actr3; actin-related protein 3 [KO:K18584]
81822  Actb; actin, cytoplasmic 1 [KO:K05692]
81824  Arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
83502  Cdh1; cadherin-1 precursor [KO:K05689]
83788  Septin9; septin-9 isoform 2 [KO:K16938]
83800  Clta; clathrin light chain A [KO:K04644]
83805  Src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
84353  Ctnnb1; catenin beta-1 [KO:K02105]
85243  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
85385  Shc1; SHC-transforming protein 1 isoform b [KO:K06279]
Reference
PMID:19296488
  Authors
Mostowy S, Cossart P
  Title
Cytoskeleton rearrangements during Listeria infection: clathrin and septins as new players in the game.
  Journal
Cell Motil Cytoskeleton 66:816-23 (2009)
DOI:10.1002/cm.20353
Reference
PMID:16406780
  Authors
Hauck CR, Ohlsen K
  Title
Sticky connections: extracellular matrix protein recognition and integrin-mediated cellular invasion by Staphylococcus aureus.
  Journal
Curr Opin Microbiol 9:5-11 (2006)
DOI:10.1016/j.mib.2005.12.002
Reference
PMID:17298394
  Authors
Wang B, Li S, Dedhar S, Cleary PP
  Title
Paxillin phosphorylation: bifurcation point downstream of integrin-linked kinase (ILK) in streptococcal invasion.
  Journal
Cell Microbiol 9:1519-28 (2007)
DOI:10.1111/j.1462-5822.2007.00889.x
Reference
PMID:19185531
  Authors
Matsumoto H, Young GM
  Title
Translocated effectors of Yersinia.
  Journal
Curr Opin Microbiol 12:94-100 (2009)
DOI:10.1016/j.mib.2008.12.005
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:17719540
  Authors
Iwai H, Kim M, Yoshikawa Y, Ashida H, Ogawa M, Fujita Y, Muller D, Kirikae T, Jackson PK, Kotani S, Sasakawa C
  Title
A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling.
  Journal
Cell 130:611-23 (2007)
DOI:10.1016/j.cell.2007.06.043
Related
pathway
rno04110  Cell cycle
rno04144  Endocytosis
rno04510  Focal adhesion
rno04512  ECM-receptor interaction
rno04810  Regulation of actin cytoskeleton
KO pathway
ko05100   

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