KEGG   PATHWAY: rro04150
Entry
rro04150                    Pathway                                
Name
mTOR signaling pathway - Rhinopithecus roxellana (golden snub-nosed monkey)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
rro04150  mTOR signaling pathway
rro04150

Organism
Rhinopithecus roxellana (golden snub-nosed monkey) [GN:rro]
Gene
104653638  RRAGC; ras-related GTP-binding protein C [KO:K16186]
104653996  MIOS; GATOR complex protein MIOS [KO:K20407]
104654119  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
104654186  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104654362  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
104654600  HRAS; GTPase HRas isoform X1 [KO:K02833]
104654721  FZD2; frizzled-2 [KO:K02235]
104654941  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
104655138  FZD6; frizzled-6 isoform X1 [KO:K02376]
104655141  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
104655162  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
104655247  FZD1; frizzled-1 [KO:K02432]
104655520  STRADB; STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
104655547  FZD10; frizzled-10 [KO:K02842]
104655818  TTI1; TELO2-interacting protein 1 homolog isoform X2 [KO:K20403]
104655997  SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780]
104656078  IRS1; insulin receptor substrate 1 [KO:K16172]
104656167  CAB39; calcium-binding protein 39 [KO:K08272]
104656419  FZD4; frizzled-4 isoform X2 [KO:K02354]
104656469  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
104656476  WNT8B; protein Wnt-8b [KO:K00714]
104656747  [KO:K16185]
104657354  TBC1D7; TBC1 domain family member 7 [KO:K20396]
104657459  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
104657652  GRB10; growth factor receptor-bound protein 10 isoform X2 [KO:K20064]
104657915  RRAGD; ras-related GTP-binding protein D [KO:K16186]
104657930  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
104658268  ATP6V1G3; V-type proton ATPase subunit G 3 isoform X2 [KO:K02152]
104658363  PRR5L; proline-rich protein 5-like isoform X1 [KO:K20411]
104658904  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
104658925  WNT2B; protein Wnt-2b [KO:K00182]
104659505  CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1 isoform X4 [KO:K23080]
104659700  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
104660036  WNT6; protein Wnt-6 [KO:K00445]
104660037  WNT10A; protein Wnt-10a [KO:K01357]
104660363  DEPDC5; GATOR complex protein DEPDC5 isoform X4 [KO:K20404]
104660614  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
104661334  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform isoform X1 [KO:K02147]
104661825  [KO:K06276] [EC:2.7.11.1]
104661911  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
104661913  TNF; tumor necrosis factor isoform X1 [KO:K03156]
104662024  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
104662124  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
104662531  WNT5B; protein Wnt-5b [KO:K00444]
104662575  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104662747  CAB39L; calcium-binding protein 39-like isoform X2 [KO:K08272]
104662932  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
104663024  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
104663050  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
104663179  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
104663222  WNT4; protein Wnt-4 [KO:K00408]
104663276  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
104664097  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
104664248  RPS6; 40S ribosomal protein S6 [KO:K02991]
104664256  RRAGA; ras-related GTP-binding protein A [KO:K16185]
104664292  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
104664386  MAPKAP1; LOW QUALITY PROTEIN: target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
104664635  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
104664740  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
104664820  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
104664912  LAMTOR2; ragulator complex protein LAMTOR2 isoform X2 [KO:K20398]
104665038  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
104665061  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
104665095  WNT11; protein Wnt-11 isoform X3 [KO:K01384]
104665159  LAMTOR1; ragulator complex protein LAMTOR1 isoform X1 [KO:K20397]
104665487  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104665751  RICTOR; rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
104665907  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
104666046  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
104666299  CLIP1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
104666559  PRR5; proline-rich protein 5 isoform X1 [KO:K20411]
104666909  NPRL2; GATOR complex protein NPRL2 isoform X1 [KO:K20405]
104667216  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
104667372  RHOA; transforming protein RhoA [KO:K04513]
104667885  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
104668161  DEPTOR; DEP domain-containing mTOR-interacting protein [KO:K20402]
104668245  FZD3; frizzled-3 [KO:K02329]
104668268  FLCN; folliculin isoform X3 [KO:K09594]
104668286  [KO:K02991]
104668335  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
104668846  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
104669078  NRAS; GTPase NRas [KO:K07828]
104669743  TSC1; hamartin isoform X2 [KO:K07206]
104669941  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
104670041  KRAS; GTPase KRas isoform X1 [KO:K07827]
104670605  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104670613  EIF4B; eukaryotic translation initiation factor 4B isoform X2 [KO:K03258]
104671422  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
104672033  WNT9A; protein Wnt-9a isoform X2 [KO:K01064]
104672034  WNT3A; protein Wnt-3a [KO:K00312]
104672053  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
104672558  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
104672659  SLC3A2; 4F2 cell-surface antigen heavy chain isoform X3 [KO:K06519]
104673041  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104673299  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
104673302  SEC13; protein SEC13 homolog [KO:K14004]
104673334  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
104673599  LAMTOR4; ragulator complex protein LAMTOR4 isoform X1 [KO:K20399]
104674321  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
104674437  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
104674688  LPIN3; LOW QUALITY PROTEIN: phosphatidate phosphatase LPIN3 [KO:K15728] [EC:3.1.3.4]
104675158  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
104675197  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
104675232  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X3 [KO:K04373] [EC:2.7.11.1]
104675428  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
104675464  STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
104675620  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104675706  SESN2; LOW QUALITY PROTEIN: sestrin-2 [KO:K20394]
104675748  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
104676027  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
104676099  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
104676121  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104676301  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
104676516  WNT5A; protein Wnt-5a [KO:K00444]
104676677  FNIP1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
104676897  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104676940  WDR24; GATOR complex protein WDR24 [KO:K20408]
104676941  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
104676971  NPRL3; GATOR complex protein NPRL3 isoform X2 [KO:K20406]
104677102  INS; insulin [KO:K04526]
104677192  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
104677318  WNT16; LOW QUALITY PROTEIN: protein Wnt-16 [KO:K01558]
104677833  WDR59; LOW QUALITY PROTEIN: GATOR complex protein WDR59 [KO:K20409]
104677948  FNIP2; folliculin-interacting protein 2 isoform X2 [KO:K20401]
104678238  [KO:K13302] [EC:2.7.11.1]
104678388  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
104678707  RHEB; GTP-binding protein Rheb [KO:K07208]
104679020  WNT7A; protein Wnt-7a [KO:K00572]
104679498  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
104679650  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
104679729  WNT1; proto-oncogene Wnt-1 [KO:K03209]
104679730  WNT10B; protein Wnt-10b [KO:K01357]
104679742  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
104680127  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
104680216  FZD5; frizzled-5 [KO:K02375]
104680338  LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344]
104680439  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
104680485  SLC38A9; sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
104680672  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
104680806  FZD7; frizzled-7 [KO:K02432]
104680990  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
104681150  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
104681229  FZD9; frizzled-9 [KO:K02842]
104681311  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
104681372  CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
104681512  TELO2; telomere length regulation protein TEL2 homolog [KO:K11137]
104681538  TSC2; tuberin isoform X1 [KO:K07207]
104681543  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
104681661  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
104681717  WNT8A; protein Wnt-8a isoform X1 [KO:K00714]
104681803  [KO:K16344]
104682257  RNF152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
104682399  WNT3; proto-oncogene Wnt-3 [KO:K00312]
104682400  WNT9B; protein Wnt-9b [KO:K01064]
104682628  WNT2; protein Wnt-2 [KO:K00182]
104682682  FZD8; frizzled-8 [KO:K02375]
104682713  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
104682751  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
115892949  [KO:K02991]
115893905  [KO:K04456] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
rro00561  Glycerolipid metabolism
rro04010  MAPK signaling pathway
rro04140  Autophagy - animal
rro04151  PI3K-Akt signaling pathway
rro04152  AMPK signaling pathway
rro04810  Regulation of actin cytoskeleton
rro04910  Insulin signaling pathway
KO pathway
ko04150   

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