KEGG   PATHWAY: rro04151
Entry
rro04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Rhinopithecus roxellana (golden snub-nosed monkey)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
rro04151  PI3K-Akt signaling pathway
rro04151

Other DBs
GO: 0043491
Organism
Rhinopithecus roxellana (golden snub-nosed monkey) [GN:rro]
Gene
104653553  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
104653720  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
104653721  MTCP1; protein p13 MTCP-1 [KO:K16837]
104653928  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
104654186  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104654349  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
104654362  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
104654382  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
104654438  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
104654440  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
104654484  TCL1A; T-cell leukemia/lymphoma protein 1A isoform X2 [KO:K10167]
104654485  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
104654600  HRAS; GTPase HRas isoform X1 [KO:K02833]
104654704  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
104654717  ITGA2B; integrin alpha-IIb [KO:K06476]
104654754  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
104654795  PRL; prolactin isoform X1 [KO:K05439]
104654819  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
104654840  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
104654892  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
104654941  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
104655034  G6PC2; LOW QUALITY PROTEIN: glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
104655117  CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
104655162  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
104655283  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
104655298  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
104655400  ITGB5; integrin beta-5 [KO:K06588]
104655485  F2R; proteinase-activated receptor 1 [KO:K03914]
104656078  IRS1; insulin receptor substrate 1 [KO:K16172]
104656155  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
104656314  FGF9; fibroblast growth factor 9 [KO:K04358]
104656317  FGF10; fibroblast growth factor 10 [KO:K04358]
104656442  [KO:K06238]
104656469  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
104656501  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
104656623  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
104656782  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
104656917  FGF7; fibroblast growth factor 7 [KO:K04358]
104657305  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
104657459  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
104657467  HSP90B1; endoplasmin [KO:K09487]
104658033  COL6A3; collagen alpha-3(VI) chain isoform X4 [KO:K06238]
104658109  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
104658202  FGF20; fibroblast growth factor 20 [KO:K04358]
104658250  RBL2; retinoblastoma-like protein 2 [KO:K16332]
104658283  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
104658296  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
104658520  TLR4; toll-like receptor 4 isoform X2 [KO:K10160]
104658643  ITGB8; integrin beta-8 [KO:K06591]
104658667  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
104658748  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
104658750  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
104658850  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
104658855  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
104658857  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
104658903  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
104658979  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
104658982  FGF23; fibroblast growth factor 23 [KO:K22428]
104658983  FGF6; fibroblast growth factor 6 [KO:K04358]
104659494  OSM; oncostatin-M isoform X1 [KO:K05418]
104659600  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
104659681  THBS1; thrombospondin-1 [KO:K16857]
104659743  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
104659744  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X5 [KO:K04354]
104659760  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
104659809  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
104659825  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
104659834  IL4; interleukin-4 isoform X1 [KO:K05430]
104659849  IL3; interleukin-3 [KO:K04736]
104660161  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
104660331  CCNE2; G1/S-specific cyclin-E2 isoform X2 [KO:K06626]
104660365  YWHAH; 14-3-3 protein eta [KO:K16198]
104660433  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691]
104660500  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
104660513  PKN3; serine/threonine-protein kinase N3 isoform X6 [KO:K23692]
104660568  LAMC3; laminin subunit gamma-3 [KO:K06247]
104660816  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
104660849  [KO:K04542]
104660869  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
104660892  GYS2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
104660908  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
104660959  JAK3; tyrosine-protein kinase JAK3 isoform X2 [KO:K11218] [EC:2.7.10.2]
104661045  [KO:K06071] [EC:2.7.11.13]
104661322  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
104661639  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
104661662  TP53; cellular tumor antigen p53 [KO:K04451]
104661678  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
104661748  IL2; interleukin-2 [KO:K05429]
104661758  FGF2; fibroblast growth factor 2 [KO:K18497]
104661825  [KO:K06276] [EC:2.7.11.1]
104662002  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
104662008  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
104662030  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
104662124  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
104662215  KITLG; kit ligand isoform X1 [KO:K05461]
104662315  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
104662513  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
104662575  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104662593  ITGA11; integrin alpha-11 [KO:K06587]
104662705  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X2 [KO:K01596] [EC:4.1.1.32]
104662759  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
104662840  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
104662932  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
104663024  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
104663050  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
104663301  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
104663347  IL3RA; interleukin-3 receptor subunit alpha isoform X2 [KO:K04737]
104663356  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
104663471  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
104663476  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
104663477  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
104663493  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
104663511  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
104663514  CRTC2; CREB-regulated transcription coactivator 2 isoform X3 [KO:K16333]
104663566  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
104663782  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
104663822  LAMA5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
104663835  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
104663951  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
104664097  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
104664137  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
104664159  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
104664167  LAMB3; laminin subunit beta-3 [KO:K06244]
104664248  RPS6; 40S ribosomal protein S6 [KO:K02991]
104664292  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
104664532  VEGFD; vascular endothelial growth factor D [KO:K05449]
104664613  SPP1; osteopontin [KO:K06250]
104664696  [KO:K06856]
104664740  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
104664815  RELA; transcription factor p65 [KO:K04735]
104664846  IL2RA; interleukin-2 receptor subunit alpha isoform X4 [KO:K05068]
104664975  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
104665061  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
104665145  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
104665373  PSPN; persephin [KO:K25416]
104665390  NRTN; neurturin [KO:K25414]
104665486  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
104665487  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104665530  TNN; tenascin-N isoform X1 [KO:K06252]
104665533  TNR; tenascin-R isoform X1 [KO:K06252]
104665638  IL4R; LOW QUALITY PROTEIN: interleukin-4 receptor subunit alpha [KO:K05071]
104665700  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
104665752  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
104665760  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
104665823  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104665836  IL7; interleukin-7 [KO:K05431]
104665913  IBSP; bone sialoprotein 2 [KO:K06253]
104666046  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
104666538  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
104666549  FGF21; fibroblast growth factor 21 [KO:K22429]
104666588  ITGA4; integrin alpha-4 [KO:K06483]
104666795  LAMC1; laminin subunit gamma-1 [KO:K05635]
104666798  LAMC2; laminin subunit gamma-2 [KO:K06246]
104667046  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
104667175  NTF4; neurotrophin-4 [KO:K12457]
104667195  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X7 [KO:K05454]
104667309  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
104667330  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
104667362  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
104667373  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
104667404  COL6A5; LOW QUALITY PROTEIN: collagen alpha-5(VI) chain [KO:K06238]
104667469  LAMB2; laminin subunit beta-2 [KO:K06243]
104667559  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
104667602  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
104667603  COL6A1; collagen alpha-1(VI) chain isoform X1 [KO:K06238]
104667754  ITGAV; integrin alpha-V isoform X2 [KO:K06487]
104667785  GHR; growth hormone receptor [KO:K05080]
104667809  [KO:K09487]
104668042  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
104668074  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
104668169  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
104668221  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
104668286  [KO:K02991]
104668343  CDKN1B; cyclin-dependent kinase inhibitor 1B isoform X1 [KO:K06624]
104668385  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
104668793  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
104668803  [KO:K13304] [EC:2.7.11.1]
104668941  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
104669041  ARTN; artemin [KO:K25415]
104669070  NGF; beta-nerve growth factor [KO:K02582]
104669078  NRAS; GTPase NRas [KO:K07828]
104669238  FN1; fibronectin isoform X1 [KO:K05717]
104669368  VTN; vitronectin [KO:K06251]
104669493  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
104669600  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
104669710  RXRA; retinoic acid receptor RXR-alpha isoform X3 [KO:K08524]
104669743  TSC1; hamartin isoform X2 [KO:K07206]
104669941  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
104670041  KRAS; GTPase KRas isoform X1 [KO:K07827]
104670122  FGF18; fibroblast growth factor 18 [KO:K04358]
104670221  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
104670273  [KO:K05414]
104670275  IFNA8; interferon alpha-8 [KO:K05414]
104670276  [KO:K05414]
104670278  IFNA6; interferon alpha-6 [KO:K05414]
104670280  [KO:K05414]
104670290  [KO:K05414]
104670292  [KO:K05414]
104670295  IFNB1; interferon beta [KO:K05415]
104670310  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
104670407  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
104670408  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
104670444  EPOR; erythropoietin receptor [KO:K05079]
104670477  CDC37; hsp90 co-chaperone Cdc37 isoform X2 [KO:K09554]
104670562  ITGA5; integrin alpha-5 [KO:K06484]
104670580  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
104670605  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104670606  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
104670613  EIF4B; eukaryotic translation initiation factor 4B isoform X2 [KO:K03258]
104670651  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
104670827  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
104671046  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
104671126  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
104671381  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
104671422  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
104671441  FGF22; fibroblast growth factor 22 isoform X2 [KO:K04358]
104671455  EFNA2; ephrin-A2 [KO:K05462]
104671523  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
104671965  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
104671966  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
104672365  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
104672399  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
104672444  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
104672477  ITGA2; integrin alpha-2 [KO:K06481]
104672685  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
104672686  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
104672775  ITGA9; integrin alpha-9 [KO:K06585]
104672906  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1 [KO:K07826]
104673041  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104673082  VEGFB; vascular endothelial growth factor B isoform X2 [KO:K16858]
104673141  BAD; bcl2-associated agonist of cell death [KO:K02158]
104673173  AREG; amphiregulin [KO:K09782]
104673174  EREG; proepiregulin [KO:K09784]
104673233  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
104673299  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
104673514  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
104673554  RELN; reelin [KO:K06249] [EC:3.4.21.-]
104673624  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
104673627  EPO; erythropoietin isoform X1 [KO:K05437]
104673694  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
104673700  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
104673715  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
104673903  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
104673923  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
104673955  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
104674035  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
104674099  [KO:K06252]
104674262  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
104674294  [KO:K06856]
104674686  FGF16; fibroblast growth factor 16 [KO:K04358]
104674711  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
104674798  MYC; myc proto-oncogene protein [KO:K04377]
104674848  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
104675158  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
104675211  YWHAQ; 14-3-3 protein theta [KO:K16197]
104675233  IL6; interleukin-6 isoform X1 [KO:K05405]
104675393  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
104675428  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
104675453  [KO:K05438]
104675456  [KO:K05438]
104675458  [KO:K05438]
104675500  [KO:K05438]
104675501  [KO:K05438]
104675502  [KO:K05438]
104675620  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104675733  [KO:K06238]
104675847  FGFR2; fibroblast growth factor receptor 2 isoform X3 [KO:K05093] [EC:2.7.10.1]
104675886  EGFR; LOW QUALITY PROTEIN: epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
104676121  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104676442  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
104676532  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
104676897  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104676941  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
104677074  [KO:K06856]
104677102  INS; insulin [KO:K04526]
104677104  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
104677136  FGF3; fibroblast growth factor 3 [KO:K04358]
104677137  FGF4; fibroblast growth factor 4 [KO:K04358]
104677138  FGF19; fibroblast growth factor 19 [KO:K22603]
104677168  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
104677192  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
104677337  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
104677402  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
104677415  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
104677475  FOXO3; forkhead box protein O3 [KO:K09408]
104677497  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
104677501  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
104677582  PGF; placenta growth factor isoform X1 [KO:K16859]
104677696  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
104677747  TLR2; toll-like receptor 2 [KO:K10159]
104678039  [KO:K06240]
104678160  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
104678238  [KO:K13302] [EC:2.7.11.1]
104678707  RHEB; GTP-binding protein Rheb [KO:K07208]
104678733  VEGFC; vascular endothelial growth factor C [KO:K05449]
104678745  PRLR; prolactin receptor [KO:K05081]
104678862  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
104678887  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
104678934  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
104679005  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
104679173  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
104679242  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
104679243  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
104679259  TNC; tenascin isoform X1 [KO:K06252]
104679339  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
104679498  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
104679640  FGFR1; fibroblast growth factor receptor 1 isoform X2 [KO:K04362] [EC:2.7.10.1]
104679650  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
104679749  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
104679853  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
104679987  G6PC; glucose-6-phosphatase isoform X1 [KO:K01084] [EC:3.1.3.9]
104680094  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
104680109  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
104680130  VWF; LOW QUALITY PROTEIN: von Willebrand factor [KO:K03900]
104680131  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
104680172  THBS4; thrombospondin-4 [KO:K04659]
104680210  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
104680220  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
104680261  ITGA3; integrin alpha-3 [KO:K06482]
104680270  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
104680276  CHAD; chondroadherin [KO:K06248]
104680325  CSF1; LOW QUALITY PROTEIN: macrophage colony-stimulating factor 1 [KO:K05453]
104680368  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
104680402  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
104680439  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
104680447  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
104680632  COMP; cartilage oligomeric matrix protein [KO:K04659]
104680662  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
104680672  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
104680728  [KO:K05414]
104680990  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
104681026  THEM4; acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
104681074  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
104681150  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
104681212  YWHAG; 14-3-3 protein gamma [KO:K16198]
104681299  ITGB4; integrin beta-4 isoform X4 [KO:K06525]
104681311  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
104681538  TSC2; tuberin isoform X1 [KO:K07207]
104681543  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
104681576  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
104681837  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
104681895  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
104681915  THBS2; thrombospondin-2 [KO:K04659]
104682142  CD19; B-lymphocyte antigen CD19 isoform X2 [KO:K06465]
104682248  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
104682250  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
104682344  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
104682421  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
104682498  IL2RB; interleukin-2 receptor subunit beta isoform X2 [KO:K05069]
104682558  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
104682563  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
104682584  [KO:K04079]
104682633  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
104682713  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
104682750  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
104682751  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
104682783  COL1A2; collagen alpha-2(I) chain [KO:K06236]
104682787  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
104682791  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
104682824  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X2 [KO:K12230]
104682880  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
115892007  PKN1; LOW QUALITY PROTEIN: serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
115892187  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
115892949  [KO:K02991]
115893879  [KO:K16197]
115893905  [KO:K04456] [EC:2.7.11.1]
115893964  [KO:K05414]
115893973  [KO:K05414]
115895307  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
115895932  [KO:K11583]
115898383  [KO:K04540]
115899165  [KO:K06071] [EC:2.7.11.13]
115900349  [KO:K04542]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
rro00010  Glycolysis / Gluconeogenesis
rro04010  MAPK signaling pathway
rro04012  ErbB signaling pathway
rro04062  Chemokine signaling pathway
rro04064  NF-kappa B signaling pathway
rro04068  FoxO signaling pathway
rro04110  Cell cycle
rro04115  p53 signaling pathway
rro04150  mTOR signaling pathway
rro04210  Apoptosis
rro04370  VEGF signaling pathway
rro04510  Focal adhesion
rro04620  Toll-like receptor signaling pathway
rro04630  JAK-STAT signaling pathway
rro04662  B cell receptor signaling pathway
rro04910  Insulin signaling pathway
KO pathway
ko04151   

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