KEGG   PATHWAY: salp03320
Entry
salp03320                   Pathway                                
Name
PPAR signaling pathway - Salvelinus sp. IW2-2015 (Arctic char)
Description
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
Class
Organismal Systems; Endocrine system
Pathway map
salp03320  PPAR signaling pathway
salp03320

Organism
Salvelinus sp. IW2-2015 (Arctic char) [GN:salp]
Gene
111949360  [KO:K06272] [EC:2.7.11.1]
111949382  [KO:K08757]
111950231  [KO:K08755]
111950342  [KO:K01897] [EC:6.2.1.3]
111950708  [KO:K01897] [EC:6.2.1.3]
111951617  [KO:K06086]
111952065  [KO:K00507] [EC:1.14.19.1]
111952132  plin1; perilipin-1 [KO:K08768]
111952134  [KO:K08765] [EC:2.3.1.21]
111952336  acox3; peroxisomal acyl-coenzyme A oxidase 3 isoform X1 [KO:K00232] [EC:1.3.3.6]
111952856  [KO:K01059] [EC:3.1.1.34]
111952857  [KO:K01059] [EC:3.1.1.34]
111953153  [KO:K08762]
111953319  [KO:K01596] [EC:4.1.1.32]
111953324  [KO:K00232] [EC:1.3.3.6]
111953394  [KO:K00488] [EC:1.14.15.15]
111953447  [KO:K00232] [EC:1.3.3.6]
111954576  [KO:K17284]
111954577  [KO:K08756]
111955045  [KO:K08525]
111955428  [KO:K08752]
111955576  fabp3; fatty acid-binding protein, heart [KO:K08752]
111955635  [KO:K08525]
111955705  [KO:K06259]
111956354  adipoq; adiponectin [KO:K07296]
111956365  [KO:K00489] [EC:1.14.14.23]
111956831  [KO:K08767]
111956862  [KO:K07431] [EC:1.14.14.139]
111957145  [KO:K08524]
111957691  [KO:K01897] [EC:6.2.1.3]
111957797  [KO:K15013] [EC:6.2.1.3]
111957991  [KO:K01897] [EC:6.2.1.3]
111959197  [KO:K08758]
111959758  [KO:K08762]
111959818  [KO:K00488] [EC:1.14.15.15]
111960359  [KO:K08757]
111960384  [KO:K17284]
111960779  acadl; LOW QUALITY PROTEIN: long-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00255] [EC:1.3.8.8]
111960836  [KO:K08524]
111961263  slc27a4; long-chain fatty acid transport protein 4 [KO:K08745] [EC:6.2.1.-]
111961341  [KO:K00507] [EC:1.14.19.1]
111961621  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
111961733  [KO:K08761]
111961946  [KO:K01641] [EC:2.3.3.10]
111961974  slc27a6; long-chain fatty acid transport protein 6 [KO:K08749]
111961975  [KO:K08749]
111961989  [KO:K08765] [EC:2.3.1.21]
111962222  [KO:K07294]
111962764  [KO:K08771]
111963101  [KO:K04504]
111964059  fabp1; fatty acid-binding protein, liver [KO:K08750]
111964535  [KO:K08524]
111965132  [KO:K08758]
111965149  [KO:K00029] [EC:1.1.1.40]
111965295  [KO:K00029] [EC:1.1.1.40]
111965990  [KO:K01897] [EC:6.2.1.3]
111966207  [KO:K08530]
111967298  [KO:K01897] [EC:6.2.1.3]
111967359  [KO:K08755]
111969202  [KO:K08536]
111970368  [KO:K04504]
111970520  [KO:K08761]
111970920  [KO:K00488] [EC:1.14.15.15]
111971531  acsl1; long-chain-fatty-acid--CoA ligase 1 isoform X1 [KO:K01897] [EC:6.2.1.3]
111971543  [KO:K08751]
111972033  [KO:K08746] [EC:6.2.1.- 6.2.1.3]
111972135  [KO:K17284]
111972157  [KO:K15013] [EC:6.2.1.3]
111972759  [KO:K01596] [EC:4.1.1.32]
111973250  [KO:K08756]
111973399  [KO:K07296]
111973685  [KO:K01897] [EC:6.2.1.3]
111973799  rxra; retinoic acid receptor RXR-alpha [KO:K08524]
111973814  [KO:K00488] [EC:1.14.15.15]
111974002  [KO:K08536]
111974516  [KO:K15013] [EC:6.2.1.3]
111974992  [KO:K08750]
111975354  cpt2; carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
111975383  [KO:K15013] [EC:6.2.1.3]
111975751  [KO:K01059] [EC:3.1.1.34]
111975815  [KO:K01059] [EC:3.1.1.34]
111976661  [KO:K06276] [EC:2.7.11.1]
111976916  [KO:K04504]
111977529  [KO:K06276] [EC:2.7.11.1]
111977693  [KO:K00507] [EC:1.14.19.1]
111977778  acsl5; LOW QUALITY PROTEIN: long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
111978221  [KO:K06086]
111978433  dbi; acyl-CoA-binding protein isoform X1 [KO:K08762]
111978590  [KO:K08765] [EC:2.3.1.21]
111979018  [KO:K08767]
111979049  [KO:K01897] [EC:6.2.1.3]
111979347  [KO:K08524]
111979725  [KO:K00489] [EC:1.14.14.23]
111980173  [KO:K08755]
111980457  [KO:K01897] [EC:6.2.1.3]
111981303  [KO:K01897] [EC:6.2.1.3]
111981507  [KO:K08757]
111981732  [KO:K00507] [EC:1.14.19.1]
111981817  [KO:K06276] [EC:2.7.11.1]
111982072  [KO:K08745] [EC:6.2.1.-]
112067753  [KO:K06276] [EC:2.7.11.1]
112068421  [KO:K01897] [EC:6.2.1.3]
112068599  [KO:K06259]
112068695  [KO:K01897] [EC:6.2.1.3]
112068900  [KO:K06272] [EC:2.7.11.1]
112069430  pparg; peroxisome proliferator-activated receptor gamma [KO:K08530]
112069550  [KO:K08764] [EC:2.3.1.176]
112069626  [KO:K08751]
112069910  [KO:K08751]
112070630  [KO:K08752]
112071060  gk; glycerol kinase isoform X1 [KO:K00864] [EC:2.7.1.30]
112071110  [KO:K10226] [EC:1.14.19.3]
112072912  [KO:K08752]
112072998  ehhadh; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
112075267  [KO:K08745] [EC:6.2.1.-]
112076234  acadm; medium-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00249] [EC:1.3.8.7]
112076835  acaa1; 3-ketoacyl-CoA thiolase, peroxisomal [KO:K07513] [EC:2.3.1.16]
112078144  [KO:K08753]
112078662  [KO:K08746] [EC:6.2.1.- 6.2.1.3]
Compound
C02165  Leukotriene B4
C14762  13(S)-HODE
C14767  9(S)-HODE
C14776  8(S)-HETE
C15493  9-cis-Retinoic acid
Reference
PMID:15828220
  Authors
Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T.
  Title
[The structures and functions of peroxisome proliferator-activated receptors (PPARs)]
  Journal
Nippon Rinsho 63:557-64 (2005)
Reference
PMID:15828221
  Authors
Fujii H.
  Title
[PPARs-mediated intracellular signal transduction]
  Journal
Nippon Rinsho 63:565-71 (2005)
Reference
PMID:15828222
  Authors
Takada I, Kato S.
  Title
[PPARs target genes]
  Journal
Nippon Rinsho 63:573-7 (2005)
Reference
PMID:15828223
  Authors
Inoue H.
  Title
[Endogenous ligands for PPARs]
  Journal
Nippon Rinsho 63:578-83 (2005)
Reference
PMID:16476485
  Authors
Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W.
  Title
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.
  Journal
Prog Lipid Res 45:120-59 (2006)
DOI:10.1016/j.plipres.2005.12.002
Reference
PMID:16601267
  Authors
Desvergne B, Michalik L, Wahli W.
  Title
Transcriptional regulation of metabolism.
  Journal
Physiol Rev 86:465-514 (2006)
DOI:10.1152/physrev.00025.2005
Reference
PMID:14999402
  Authors
Mandard S, Muller M, Kersten S.
  Title
Peroxisome proliferator-activated receptor alpha target genes.
  Journal
Cell Mol Life Sci 61:393-416 (2004)
DOI:10.1007/s00018-003-3216-3
Reference
PMID:10529898
  Authors
Desvergne B, Wahli W.
  Title
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
  Journal
Endocr Rev 20:649-88 (1999)
DOI:10.1210/edrv.20.5.0380
Reference
PMID:15673477
  Authors
Savage DB.
  Title
PPARgamma as a metabolic regulator: insights from genomics and pharmacology.
  Journal
Expert Rev Mol Med 2005:1-16 (2005)
DOI:10.1017/S1462399405008793
Reference
PMID:16511590
  Authors
Semple RK, Chatterjee VK, O'Rahilly S.
  Title
PPAR gamma and human metabolic disease.
  Journal
J Clin Invest 116:581-9 (2006)
DOI:10.1172/JCI28003
Reference
PMID:16360030
  Authors
Lehrke M, Lazar MA.
  Title
The many faces of PPARgamma.
  Journal
Cell 123:993-9 (2005)
DOI:10.1016/j.cell.2005.11.026
Reference
PMID:11921433
  Authors
Hauner H.
  Title
The mode of action of thiazolidinediones.
  Journal
Diabetes Metab Res Rev 18 Suppl 2:S10-5 (2002)
DOI:10.1002/dmrr.249
Related
pathway
salp00071  Fatty acid degradation
salp00120  Primary bile acid biosynthesis
salp00564  Glycerophospholipid metabolism
salp04920  Adipocytokine signaling pathway
KO pathway
ko03320   

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