KEGG   PATHWAY: salp04150
Entry
salp04150                   Pathway                                
Name
mTOR signaling pathway - Salvelinus sp. IW2-2015 (Arctic char)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
salp04150  mTOR signaling pathway
salp04150

Organism
Salvelinus sp. IW2-2015 (Arctic char) [GN:salp]
Gene
111949345  [KO:K02842]
111949357  [KO:K02150]
111949408  [KO:K00922] [EC:2.7.1.153]
111949553  [KO:K02842]
111949694  [KO:K02353]
111949774  [KO:K04688] [EC:2.7.11.1]
111949910  [KO:K06519]
111950092  [KO:K04456] [EC:2.7.11.1]
111950155  [KO:K16172]
111950241  [KO:K06519]
111950386  [KO:K23081]
111950475  [KO:K20400]
111950601  [KO:K04373] [EC:2.7.11.1]
111950623  [KO:K02145] [EC:7.1.2.2]
111950631  [KO:K02353]
111950700  [KO:K01384]
111950763  [KO:K04526]
111950899  [KO:K02151]
111950906  [KO:K20399]
111951049  [KO:K02842]
111951073  [KO:K04688] [EC:2.7.11.1]
111951103  [KO:K01384]
111951403  wnt16; protein Wnt-16 isoform X1 [KO:K01558]
111951417  [KO:K00572]
111951443  [KO:K05459]
111951512  [KO:K20399]
111951513  [KO:K02151]
111951543  [KO:K02150]
111951601  [KO:K08270]
111951781  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111951941  [KO:K03259]
111951975  [KO:K00714]
111952297  [KO:K07827]
111952380  [KO:K02833]
111952482  [KO:K00182]
111952507  [KO:K13780]
111952526  [KO:K05087] [EC:2.7.10.1]
111952830  [KO:K07298] [EC:2.7.11.1]
111952930  [KO:K03068]
111952984  [KO:K02649]
111953280  lpin2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
111953459  [KO:K03083] [EC:2.7.11.26]
111953503  [KO:K02432]
111953850  [KO:K15705] [EC:2.3.2.27]
111953930  [KO:K16172]
111953960  [KO:K07208]
111954163  [KO:K02149]
111954329  [KO:K04456] [EC:2.7.11.1]
111954353  [KO:K02329]
111955260  [KO:K02432]
111955269  [KO:K13302] [EC:2.7.11.1]
111955329  [KO:K16186]
111955417  [KO:K13302] [EC:2.7.11.1]
111955894  [KO:K20064]
111956075  [KO:K20394]
111956213  [KO:K00572]
111956472  [KO:K04527] [EC:2.7.10.1]
111956498  [KO:K00312]
111956562  [KO:K00922] [EC:2.7.1.153]
111956577  [KO:K04369] [EC:2.7.12.2]
111956658  [KO:K02649]
111956763  [KO:K02353]
111956885  [KO:K07298] [EC:2.7.11.1]
111956917  [KO:K01064]
111957031  [KO:K03099]
111957172  [KO:K02375]
111957232  [KO:K15705] [EC:2.3.2.27]
111957424  [KO:K02677] [EC:2.7.11.13]
111957660  [KO:K07205]
111957788  [KO:K02842]
111957844  [KO:K21357] [EC:2.7.11.1]
111958010  [KO:K23080]
111958035  clip1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
111958062  [KO:K20064]
111958124  eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
111958210  [KO:K04688] [EC:2.7.11.1]
111958214  [KO:K07209] [EC:2.7.11.10]
111958360  [KO:K04688] [EC:2.7.11.1]
111958430  [KO:K04456] [EC:2.7.11.1]
111958733  [KO:K16186]
111958758  mios; GATOR complex protein MIOS [KO:K20407]
111959017  [KO:K20398]
111959052  [KO:K03156]
111959056  [KO:K02148]
111959140  [KO:K16186]
111960107  [KO:K16172]
111960248  [KO:K02353]
111960647  irs1; insulin receptor substrate 1 isoform X1 [KO:K16172]
111960706  [KO:K08269] [EC:2.7.11.1]
111960773  [KO:K08272]
111960775  [KO:K00922] [EC:2.7.1.153]
111960854  [KO:K07205]
111961359  [KO:K10421]
111961420  [KO:K08267]
111961421  [KO:K03875]
111961525  depdc5; GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
111961557  [KO:K07206]
111961680  ulk1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
111961727  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111961744  [KO:K02152]
111961799  [KO:K07198] [EC:2.7.11.31]
111961940  slc38a9; LOW QUALITY PROTEIN: sodium-coupled neutral amino acid transporter 9 [KO:K14995]
111961997  prr5l; proline-rich protein 5-like [KO:K20411]
111962219  [KO:K00572]
111962231  [KO:K03258]
111962254  [KO:K03068]
111962268  slc7a5; large neutral amino acids transporter small subunit 1 [KO:K13780]
111962340  [KO:K15728] [EC:3.1.3.4]
111962390  igf1r; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
111962485  [KO:K07827]
111962569  [KO:K20411]
111962576  [KO:K02833]
111962617  [KO:K02150]
111962720  [KO:K00182]
111963120  [KO:K15728] [EC:3.1.3.4]
111963228  [KO:K04456] [EC:2.7.11.1]
111963259  [KO:K04513]
111963377  [KO:K03259]
111963388  [KO:K04370]
111963854  [KO:K07198] [EC:2.7.11.31]
111963920  [KO:K02152]
111964075  [KO:K07206]
111964164  slc3a2; 4F2 cell-surface antigen heavy chain [KO:K06519]
111964289  [KO:K04373] [EC:2.7.11.1]
111964291  [KO:K02145] [EC:7.1.2.2]
111964321  [KO:K03259]
111964418  [KO:K04456] [EC:2.7.11.1]
111964508  [KO:K21357] [EC:2.7.11.1]
111964909  [KO:K02376]
111964922  [KO:K02432]
111965063  [KO:K02235]
111965117  [KO:K20398]
111965161  [KO:K03156]
111965823  [KO:K03259]
111965986  [KO:K17532]
111966200  [KO:K00572]
111966206  [KO:K04366] [EC:2.7.11.1]
111966285  [KO:K04513]
111966398  [KO:K13780]
111966495  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
111966501  [KO:K04513]
111966742  [KO:K07208]
111966801  [KO:K01357]
111966803  [KO:K03209]
111967220  [KO:K04526]
111967269  [KO:K08272]
111967645  [KO:K04467] [EC:2.7.11.10]
111967676  [KO:K00312]
111967778  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111967927  mlst8; target of rapamycin complex subunit LST8 [KO:K08266]
111968118  [KO:K04373] [EC:2.7.11.1]
111968260  [KO:K04456] [EC:2.7.11.1]
111968467  [KO:K16186]
111968604  [KO:K04370]
111968618  [KO:K03259]
111968784  [KO:K04456] [EC:2.7.11.1]
111968930  [KO:K04373] [EC:2.7.11.1]
111969745  [KO:K04513]
111969749  [KO:K00182]
111969876  [KO:K20402]
111969984  [KO:K20405]
111970088  [KO:K07208]
111970379  [KO:K00182]
111970399  [KO:K04513]
111970446  [KO:K15728] [EC:3.1.3.4]
111970455  [KO:K03258]
111970924  [KO:K02432]
111970998  [KO:K03083] [EC:2.7.11.26]
111971373  [KO:K20396]
111971393  pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
111971459  [KO:K04371] [EC:2.7.11.24]
111971515  [KO:K02991]
111971797  [KO:K00572]
111972098  [KO:K04369] [EC:2.7.12.2]
111972164  [KO:K07208]
111972285  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
111972511  [KO:K02329]
111972696  [KO:K00445]
111972736  [KO:K02149]
111972741  [KO:K04456] [EC:2.7.11.1]
111973133  [KO:K02375]
111973177  [KO:K02145] [EC:7.1.2.2]
111973233  [KO:K08272]
111973382  [KO:K15705] [EC:2.3.2.27]
111974042  [KO:K08267]
111974089  wnt6; protein Wnt-6 [KO:K00445]
111974092  [KO:K01357]
111974310  [KO:K01357]
111974511  [KO:K10421]
111974525  [KO:K02649]
111974585  [KO:K02842]
111974703  tsc1; hamartin isoform X1 [KO:K07206]
111974710  [KO:K23080]
111975375  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111975623  [KO:K07298] [EC:2.7.11.1]
111975763  [KO:K04369] [EC:2.7.12.2]
111976090  [KO:K02649]
111976168  [KO:K07198] [EC:2.7.11.31]
111976242  [KO:K00572]
111976268  [KO:K03209]
111976354  [KO:K01357]
111976650  [KO:K03158]
111976661  [KO:K06276] [EC:2.7.11.1]
111976721  tti1; TELO2-interacting protein 1 homolog [KO:K20403]
111976743  [KO:K02375]
111976752  [KO:K03258]
111976869  [KO:K04366] [EC:2.7.11.1]
111976879  [KO:K04513]
111976966  telo2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
111977021  [KO:K20408]
111977180  [KO:K04513]
111977244  [KO:K13780]
111977430  [KO:K00312]
111977468  [KO:K00714]
111977529  [KO:K06276] [EC:2.7.11.1]
111977816  [KO:K02147]
111977820  [KO:K02147]
111978057  [KO:K04467] [EC:2.7.11.10]
111978075  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111978162  [KO:K03259]
111978258  [KO:K04467] [EC:2.7.11.10]
111978529  [KO:K20408]
111978672  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111978824  [KO:K04373] [EC:2.7.11.1]
111978999  [KO:K04369] [EC:2.7.12.2]
111979128  [KO:K03083] [EC:2.7.11.26]
111979148  [KO:K07298] [EC:2.7.11.1]
111979256  [KO:K02353]
111979394  [KO:K02649]
111979424  [KO:K15705] [EC:2.3.2.27]
111979466  [KO:K01064]
111979489  [KO:K02649]
111979496  [KO:K00312]
111979632  [KO:K04527] [EC:2.7.10.1]
111979730  [KO:K02375]
111980033  [KO:K10421]
111980213  [KO:K04688] [EC:2.7.11.1]
111980351  [KO:K16172]
111980424  [KO:K04364]
111980548  [KO:K04364]
111980583  strada; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
111980736  [KO:K02353]
111980782  [KO:K08267]
111980960  [KO:K02235]
111981122  nprl3; LOW QUALITY PROTEIN: GATOR complex protein NPRL3 [KO:K20406]
111981201  [KO:K23081]
111981261  [KO:K16185]
111981264  [KO:K01384]
111981304  [KO:K04526]
111981382  [KO:K02235]
111981396  skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
111981426  [KO:K08271]
111981643  [KO:K01384]
111981743  fnip1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
111981817  [KO:K06276] [EC:2.7.11.1]
111981866  [KO:K02842]
111982013  [KO:K04371] [EC:2.7.11.24]
111982249  [KO:K02677] [EC:2.7.11.13]
111982431  [KO:K04456] [EC:2.7.11.1]
111982470  rptor; regulatory-associated protein of mTOR [KO:K07204]
111982639  [KO:K08269] [EC:2.7.11.1]
111982815  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111982834  [KO:K08272]
111982846  [KO:K05459]
112067730  [KO:K04364]
112067753  [KO:K06276] [EC:2.7.11.1]
112067754  [KO:K04364]
112068245  [KO:K07203] [EC:2.7.11.1]
112068573  [KO:K07208]
112068897  [KO:K04456] [EC:2.7.11.1]
112069263  [KO:K03099]
112069342  [KO:K02353]
112069649  [KO:K20411]
112070149  [KO:K16344]
112070190  [KO:K02145] [EC:7.1.2.2]
112070257  [KO:K20406]
112070579  [KO:K00714]
112070580  [KO:K00714]
112070765  [KO:K02432]
112070823  mapkap1; target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
112071022  [KO:K04688] [EC:2.7.11.1]
112071185  sec13; protein SEC13 homolog [KO:K14004]
112071321  [KO:K20397]
112071600  [KO:K16344]
112071697  tnfrsf1a; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A [KO:K03158]
112071957  [KO:K03156]
112071991  fzd7; frizzled-7 [KO:K02432]
112072043  atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
112072282  [KO:K09594]
112072530  [KO:K02991]
112072642  [KO:K08272]
112073326  [KO:K16184]
112073398  [KO:K00408]
112073787  [KO:K03156]
112074293  [KO:K02376]
112074558  [KO:K03099]
112074588  [KO:K04513]
112074672  [KO:K09594]
112075464  ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
112075884  fzd4; frizzled-4 [KO:K02354]
112076192  [KO:K07827]
112076927  [KO:K03259]
112077103  wnt4; protein Wnt-4 [KO:K00408]
112077197  [KO:K20397]
112077565  [KO:K00444]
112077631  [KO:K16184]
112077742  [KO:K00444]
112078191  [KO:K20411]
112079366  [KO:K14299]
112080070  [KO:K07205]
112080388  [KO:K15728] [EC:3.1.3.4]
112080447  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
112080716  [KO:K03099]
112080951  [KO:K07204]
112081041  [KO:K00408]
112081046  [KO:K01064]
112081265  [KO:K02375]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
salp00561  Glycerolipid metabolism
salp04010  MAPK signaling pathway
salp04140  Autophagy - animal
salp04810  Regulation of actin cytoskeleton
salp04910  Insulin signaling pathway
KO pathway
ko04150   

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