KEGG   PATHWAY: schu04150
Entry
schu04150                   Pathway                                
Name
mTOR signaling pathway - Siniperca chuatsi (mandarin fish)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
schu04150  mTOR signaling pathway
schu04150

Organism
Siniperca chuatsi (mandarin fish) [GN:schu]
Gene
122861346  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122861392  eif4eb; eukaryotic translation initiation factor 4eb isoform X1 [KO:K03259]
122861471  atp6v1c2; V-type proton ATPase subunit C 1-B isoform X1 [KO:K02148]
122861654  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
122861899  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
122862118  rragd; ras-related GTP-binding protein D isoform X1 [KO:K16186]
122862135  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
122862324  slc3a2b; solute carrier family 3 member 2b [KO:K06519]
122862747  lpin1b; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
122863121  wnt7aa; wingless-type MMTV integration site family, member 7Aa isoform X1 [KO:K00572]
122863241  sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
122863304  atp6v1d; V-type proton ATPase subunit D [KO:K02149]
122863687  fzd3a; frizzled-3a isoform X1 [KO:K02329]
122864206  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
122864685  atp6v1c1b; V-type proton ATPase subunit C 1-B [KO:K02148]
122864847  sesn2; sestrin-2 isoform X1 [KO:K20394]
122865010  si:ch211-195b13.1; STKc_SGK domain-containing protein isoform X1 [KO:K13302] [EC:2.7.11.1]
122865033  rragcb; ras-related GTP binding Cb [KO:K16186]
122865064  [KO:K20064]
122865177  clip1b; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
122865188  tsc1b; TSC complex subunit 1b isoform X1 [KO:K07206]
122865334  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
122865389  skp2; S-phase kinase-associated protein 2 [KO:K03875]
122865410  mapkap1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
122865456  [KO:K07205]
122865571  slc38a9; sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
122865590  atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
122866112  atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
122866114  ulk1b; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
122866157  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
122866290  atp6v1ab; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
122866386  rps6ka3b; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
122866506  [KO:K07208]
122866710  rnf152; E3 ubiquitin-protein ligase rnf152 [KO:K15705] [EC:2.3.2.27]
122866917  [KO:K15728] [EC:3.1.3.4]
122866965  fzd8a; frizzled-8a [KO:K02375]
122867099  rhebl1; ras homolog, mTORC1 binding like 1 isoform X1 [KO:K07208]
122867304  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
122867361  ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
122867521  mlst8; target of rapamycin complex subunit lst8 [KO:K08266]
122867580  telo2; telomere length regulation protein TEL2 homolog [KO:K11137]
122867598  wnt3; proto-oncogene Wnt-3 [KO:K00312]
122867938  wdr24; GATOR complex protein WDR24 [KO:K20408]
122868056  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
122868207  [KO:K04467] [EC:2.7.11.10]
122868338  fzd2; frizzled-2 [KO:K02235]
122868364  wnt9b; protein Wnt-9b [KO:K01064]
122868525  eif4ba; eukaryotic translation initiation factor 4Ba isoform X1 [KO:K03258]
122868537  nprl3; GATOR complex protein NPRL3 isoform X1 [KO:K20406]
122868586  strada; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
122868651  [KO:K15728] [EC:3.1.3.4]
122868700  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
122868740  akt1s1; uncharacterized protein akt1s1 [KO:K16184]
122869414  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
122870088  [KO:K00922] [EC:2.7.1.153]
122870169  sec13; protein SEC13 homolog [KO:K14004]
122870283  eif4e2rs1; eukaryotic translation initiation factor 4E family member 2 related sequence 1 [KO:K03259]
122870454  dvl2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
122870498  slc3a2a; solute carrier family 3 member 2a [KO:K06519]
122870633  si:ch73-335l21.1; insulin receptor substrate 1-B isoform X1 [KO:K16172]
122870904  atp6v1f; V-type proton ATPase subunit F [KO:K02151]
122870905  lamtor4; ragulator complex protein LAMTOR4 [KO:K20399]
122871017  atp6v1e1b; V-type proton ATPase subunit E 1 [KO:K02150]
122871072  wnt7ba; protein Wnt-7b isoform X1 [KO:K00572]
122871238  wnt5b; protein Wnt-5b isoform X1 [KO:K00444]
122871272  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
122871403  wnt16; protein Wnt-16 [KO:K01558]
122871413  [KO:K20411]
122871437  lrp6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
122871522  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
122871937  [KO:K02432]
122872102  cab39l; calcium-binding protein 39-like isoform X1 [KO:K08272]
122872237  stradb; STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
122872739  [KO:K07208]
122872748  rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
122872843  [KO:K03099]
122873006  rps6; 40S ribosomal protein S6 [KO:K02991]
122873144  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122873242  [KO:K04688] [EC:2.7.11.1]
122873474  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
122873522  tsc2; tuberin isoform X1 [KO:K07207]
122874066  [KO:K19662] [EC:2.7.11.13]
122874411  [KO:K20411]
122874447  lrp5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
122874657  wnt2; protein Wnt-2 isoform X1 [KO:K00182]
122874834  kras; GTPase KRas isoform X1 [KO:K07827]
122874917  atp6v1e1a; V-type proton ATPase subunit E 1a [KO:K02150]
122874941  igf1rb; insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
122874987  slc7a5; large neutral amino acids transporter small subunit 1 [KO:K13780]
122875095  prr5a; proline-rich protein 5a [KO:K20411]
122875098  wnt7bb; protein Wnt-7b isoform X1 [KO:K00572]
122875107  [KO:K02833]
122875138  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
122875174  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
122875692  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
122875904  lpin1a; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
122875907  ulk1a; serine/threonine-protein kinase ULK1a isoform X1 [KO:K21357] [EC:2.7.11.1]
122876093  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122876153  tsc1a; TSC complex subunit 1a [KO:K07206]
122876270  clip1a; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
122876408  castor1; cytosolic arginine sensor for mTORC1 subunit 1 [KO:K23080]
122876516  fzd10; frizzled-10 [KO:K02842]
122876592  eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
122876614  [KO:K08267]
122876770  [KO:K02649]
122877156  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
122877476  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
122877580  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
122877636  [KO:K02329]
122878004  insrb; insulin receptor b [KO:K04527] [EC:2.7.10.1]
122878127  [KO:K02649]
122878181  [KO:K00922] [EC:2.7.1.153]
122878344  tbc1d7; TBC1 domain family member 7 [KO:K20396]
122878451  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122878474  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
122878478  cab39; calcium-binding protein 39 [KO:K08272]
122878761  rps6kb1b; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
122878780  rps6ka2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
122878953  ulk2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
122879216  fzd9b; frizzled-9b [KO:K02842]
122879270  [KO:K02353]
122879436  lamtor1; ragulator complex protein LAMTOR1 [KO:K20397]
122879448  fzd4; frizzled-4 [KO:K02354]
122879633  si:dkey-202g17.3; 4F2 cell-surface antigen heavy chain isoform X1 [KO:K06519]
122879814  cab39l1; calcium binding protein 39, like 1 [KO:K08272]
122879944  [KO:K03259]
122879947  rps6kal; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
122880866  [KO:K00714]
122880867  [KO:K00714]
122880879  insb; preproinsulin b [KO:K04526]
122881046  wdr59; GATOR complex protein WDR59 isoform X1 [KO:K20409]
122881121  flcn; folliculin isoform X1 [KO:K09594]
122881148  grb10b; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
122881569  deptor; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
122881638  sgk2b; serine/threonine-protein kinase Sgk2b [KO:K13302] [EC:2.7.11.1]
122881679  mios; GATOR complex protein MIOS isoform X1 [KO:K20407]
122881710  lamtor2; ragulator complex protein LAMTOR2 [KO:K20398]
122881806  rragca; ras-related GTP binding Ca [KO:K16186]
122881912  fzd1; frizzled-1 [KO:K02432]
122882022  prkcg; LOW QUALITY PROTEIN: protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
122882056  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
122882063  wnt4b; wingless-type MMTV integration site family, member 4b isoform X1 [KO:K00408]
122882149  atp6v1c1a; V-type proton ATPase subunit C 1-A [KO:K02148]
122882241  [KO:K02376]
122882262  seh1l; nucleoporin SEH1 isoform X1 [KO:K14299]
122882422  [KO:K00182]
122882438  [KO:K04513]
122882439  [KO:K04513]
122882452  wnt5a; protein Wnt-5a isoform X1 [KO:K00444]
122882512  lamtor5; ragulator complex protein LAMTOR5 [KO:K16344]
122882898  tti1; TELO2-interacting protein 1 homolog isoform X1 [KO:K20403]
122882961  [KO:K13780]
122883019  wnt10b; protein Wnt-10b isoform X1 [KO:K01357]
122883020  wnt1; protein Wnt-1 [KO:K03209]
122883178  dvl1a; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
122883224  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
122883280  mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
122883413  [KO:K00572]
122883454  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
122883572  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
122883743  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
122883752  igf3; insulin-like growth factor 3 [KO:K05459]
122883787  si:ch211-112c15.8; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
122884033  ptena; phosphatase and tensin homolog A [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
122884080  eif4e1c; eukaryotic translation initiation factor 4E family member 1c isoform X1 [KO:K03259]
122884099  atp6v1ba; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
122884449  wnt8b; protein Wnt-8b [KO:K00714]
122884474  [KO:K04513]
122884588  [KO:K04467] [EC:2.7.11.10]
122884762  [KO:K04513]
122884781  [KO:K08270]
122884935  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122885065  fzd5; frizzled-5 [KO:K02375]
122885106  nprl2; GATOR complex protein NPRL2 [KO:K20405]
122885418  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
122885667  [KO:K02432]
122885907  wnt10a; protein Wnt-10a [KO:K01357]
122885941  wnt6b; protein Wnt-6 [KO:K00445]
122886281  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
122886332  [KO:K02375]
122886483  depdc5; GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
122886515  eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
122886527  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
122886563  rheb; GTP-binding protein Rheb isoform X1 [KO:K07208]
122886592  [KO:K00922] [EC:2.7.1.153]
122886819  [KO:K02353]
122887016  wnt2ba; wingless-type MMTV integration site family, member 2Ba [KO:K00182]
122887088  wnt9a; protein Wnt-9a [KO:K01064]
122887161  wnt3a; protein Wnt-3a [KO:K00312]
122887224  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
122887535  [KO:K02649]
122887603  insra; insulin receptor a isoform X1 [KO:K04527] [EC:2.7.10.1]
122887651  lpin2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
122887658  atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
122887843  castor2; cytosolic arginine sensor for mTORC1 subunit 2 isoform X1 [KO:K23081]
122887910  [KO:K02145] [EC:7.1.2.2]
122888190  rps6kb1a; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
122888298  ins; insulin [KO:K04526]
122888423  [KO:K04456] [EC:2.7.11.1]
122888528  wnt4; protein Wnt-4a isoform X1 [KO:K00408]
122888622  wnt11; protein Wnt-11 [KO:K01384]
122888662  rraga; ras-related GTP-binding protein A isoform X1 [KO:K16185]
122888740  fnip1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
122888843  si:ch211-284e13.4; insulin receptor substrate 1-B isoform X1 [KO:K16172]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
schu00561  Glycerolipid metabolism
schu04010  MAPK signaling pathway
schu04140  Autophagy - animal
schu04810  Regulation of actin cytoskeleton
schu04910  Insulin signaling pathway
KO pathway
ko04150   

DBGET integrated database retrieval system