PATHWAY: schu04010 Help
Entry
Name
MAPK signaling pathway - Siniperca chuatsi (mandarin fish)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Siniperca chuatsi (mandarin fish) [GN:
schu ]
Gene
122868473 cacna1aa; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344 ]
122873436 cacna1ab; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b [KO:K04344 ]
122875719 voltage-dependent N-type calcium channel subunit alpha-1B-like isoform X1 [KO:K04849 ]
122865182 cacna1bb; LOW QUALITY PROTEIN: voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849 ]
122871614 cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850 ]
122863128 cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851 ]
122882704 cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851 ]
122877219 voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852 ]
122887381 cacna1eb; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852 ]
122883241 cacna1fb; LOW QUALITY PROTEIN: calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853 ]
122883424 cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04853 ]
122867896 cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854 ]
122868463 cacna1ia; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856 ]
122872873 voltage-dependent T-type calcium channel subunit alpha-1I-like isoform X1 [KO:K04856 ]
122882919 dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857 ]
122861584 dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like isoform X1 [KO:K04857 ]
122875527 voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858 ]
122871350 voltage-dependent calcium channel subunit alpha-2/delta-1-like isoform X1 [KO:K04858 ]
122885222 cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a isoform X1 [KO:K04859 ]
122861432 voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859 ]
122882449 cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860 ]
122864651 cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860 ]
122875593 voltage-dependent calcium channel subunit alpha-2/delta-4-like isoform X1 [KO:K04861 ]
122871386 cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861 ]
122869143 cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862 ]
122867053 cacnb2a; voltage-dependent L-type calcium channel subunit beta-2a isoform X1 [KO:K04863 ]
122883421 cacnb3b; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04864 ]
122883621 cacnb3a; voltage-dependent L-type calcium channel subunit beta-3a isoform X1 [KO:K04864 ]
122872190 voltage-dependent L-type calcium channel subunit beta-4-like isoform X1 [KO:K04865 ]
122885103 cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a isoform X1 [KO:K04865 ]
122869470 cacng1b; voltage-dependent calcium channel gamma-1 subunit [KO:K04866 ]
122873483 cacng1a; calcium channel, voltage-dependent, gamma subunit 1a [KO:K04866 ]
122868919 cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867 ]
122871536 voltage-dependent calcium channel gamma-2 subunit-like isoform X1 [KO:K04867 ]
122874068 cacng3a; voltage-dependent calcium channel gamma-3 subunit isoform X1 [KO:K04868 ]
122869359 voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869 ]
122873482 voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869 ]
122868702 cacng5b; voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870 ]
122873476 voltage-dependent calcium channel gamma-5 subunit-like isoform X1 [KO:K04870 ]
122882083 cacng6b; voltage-dependent calcium channel gamma-6 subunit [KO:K04871 ]
122864781 voltage-dependent calcium channel gamma-6 subunit-like isoform X1 [KO:K04871 ]
122882068 cacng7b; voltage-dependent calcium channel gamma-7 subunit [KO:K04872 ]
122864783 voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872 ]
122882054 cacng8b; voltage-dependent calcium channel gamma-4 subunit [KO:K04873 ]
122864764 voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873 ]
122868669 prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345 ] [EC:2.7.11.11 ]
122874052 gna12a; guanine nucleotide-binding protein subunit alpha-12a [KO:K04346 ]
122868440 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347 ]
122877490 gng12b; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347 ]
122887267 gng12a; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12a isoform X1 [KO:K04347 ]
122888786 ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348 ] [EC:3.1.3.16 ]
122869868 serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
122879818 ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
122877539 ras-specific guanine nucleotide-releasing factor 1-like isoform X1 [KO:K04349 ]
122874365 rasgrf1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349 ]
122876259 rasgrf2b; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326 ]
122865384 rasgrf2a; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326 ]
122880728 rapgef2b; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018 ]
122868816 pdgfab; platelet-derived growth factor alpha polypeptide b [KO:K04359 ]
122871754 si:ch211-79m20.1; serine/threonine-protein kinase Doa [KO:K17386 ]
122881622 vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448 ]
122862871 vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448 ]
122863626 pgfa; vascular endothelial growth factor A isoform X1 [KO:K16859 ]
122876743 gdnfb; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452 ]
122865171 gdnfa; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452 ]
122869189 ngfra; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
122881332 nradd; death domain-containing membrane protein NRADD isoform X1 [KO:K02583 ]
122871634 atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374 ]
122862755 fosab; v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379 ]
122868961 maptb; LOW QUALITY PROTEIN: microtubule-associated protein tau [KO:K04380 ]
122864206 tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156 ]
122882056 tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158 ]
122883787 si:ch211-112c15.8; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
122878277 faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
122884034 fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
122869368 ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
122867758 ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392 ]
122867496 rac3b; ras-related C3 botulinum toxin substrate 3b isoform X1 [KO:K07861 ]
122875669 tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
122866653 myd88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729 ]
122861943 growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402 ]
122876144 gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402 ]
122877489 gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402 ]
122877856 growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402 ]
122865550 gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402 ]
122865551 growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402 ]
122887265 gadd45aa; growth arrest and DNA-damage-inducible, alpha, a isoform X1 [KO:K04402 ]
122871523 tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403 ]
122863405 tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404 ]
122870766 ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405 ]
122880073 si:zfos-2326c3.2; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407 ] [EC:2.7.11.1 ]
122867152 map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430 ] [EC:2.7.12.2 ]
122877246 mapk8ip1b; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434 ]
122874471 C-Jun-amino-terminal kinase-interacting protein 1-like isoform X1 [KO:K04434 ]
122874687 mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435 ]
122881863 nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446 ]
122864285 nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446 ]
122873658 nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333 ]
122874443 nfatc3b; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333 ]
122865896 june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448 ]
122885712 atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450 ]
122879104 hspa8b; heat shock protein family A (Hsp70) member 8b [KO:K03283 ]
122867472 nuclear receptor subfamily 4 group A member 1-like isoform X1 [KO:K04465 ]
122880708 nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
122884252 nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference
Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
Title
MAP kinases.
Journal
Reference
Authors
Tanoue T, Nishida E.
Title
Docking interactions in the mitogen-activated protein kinase cascades.
Journal
Reference
Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
Title
MAPK pathways in radiation responses.
Journal
Reference
Authors
Huang EJ, Reichardt LF.
Title
Trk receptors: roles in neuronal signal transduction.
Journal
Reference
Authors
Harper SJ, LoGrasso P.
Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
Journal
Reference
Authors
Takeda K, Ichijo H
Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
Journal
Reference
Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
Title
Transcriptional regulation by the MAP kinase signaling cascades.
Journal
Reference
Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
Journal
Reference
Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
Journal
Reference
Authors
Lemmon MA, Schlessinger J
Title
Cell signaling by receptor tyrosine kinases.
Journal
Reference
Authors
Skaper SD
Title
The neurotrophin family of neurotrophic factors: an overview.
Journal
Reference
Authors
Chu WM
Title
Tumor necrosis factor.
Journal
Reference
Authors
Newton K, Dixit VM
Title
Signaling in innate immunity and inflammation.
Journal
Reference
Authors
Gaestel M, Kotlyarov A, Kracht M
Title
Targeting innate immunity protein kinase signalling in inflammation.
Journal
Reference
Authors
Ajibade AA, Wang HY, Wang RF
Title
Cell type-specific function of TAK1 in innate immune signaling.
Journal
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Related pathway
schu04070 Phosphatidylinositol signaling system
KO pathway
LinkDB
All DBs