KEGG   PATHWAY: schu04010
Entry
schu04010                   Pathway                                
Name
MAPK signaling pathway - Siniperca chuatsi (mandarin fish)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
schu04010  MAPK signaling pathway
schu04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Siniperca chuatsi (mandarin fish) [GN:schu]
Gene
122861346  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122861432  [KO:K04859]
122861438  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
122861558  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
122861584  [KO:K04857]
122861654  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
122861795  [KO:K04427] [EC:2.7.11.25]
122861834  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
122861870  [KO:K04350]
122861882  [KO:K04453]
122861899  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
122861943  [KO:K04402]
122861980  pgfb; placenta growth factor isoform X1 [KO:K16859]
122862135  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
122862146  map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
122862302  fosaa; proto-oncogene c-Fos isoform X1 [KO:K04379]
122862311  rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
122862351  efna2a; ephrin-A2 isoform X1 [KO:K05462]
122862374  [KO:K04457] [EC:3.1.3.16]
122862735  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
122862755  fosab; v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379]
122862756  si:ch211-153j24.3; proto-oncogene c-Fos [KO:K04379]
122862871  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
122862874  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
122863083  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122863128  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
122863227  max; protein max isoform X1 [KO:K04453]
122863261  [KO:K13377]
122863269  [KO:K04423] [EC:2.7.11.25]
122863405  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
122863488  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
122863522  tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
122863626  pgfa; vascular endothelial growth factor A isoform X1 [KO:K16859]
122863832  angpt1; angiopoietin-1 [KO:K05465]
122864027  angpt2b; angiopoietin-2b [KO:K05466]
122864127  stk3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
122864134  [KO:K04393]
122864206  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
122864285  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
122864416  daxx; death domain-associated protein 6 isoform X1 [KO:K02308]
122864473  [KO:K04388] [EC:2.7.11.30]
122864641  [KO:K04444] [EC:2.7.11.1]
122864651  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
122864713  [KO:K04381]
122864764  [KO:K04873]
122864781  [KO:K04871]
122864783  [KO:K04872]
122864873  efna1a; ephrin-A1a isoform X1 [KO:K05462]
122864875  efna3a; ephrin-A3 [KO:K05462]
122865171  gdnfa; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
122865182  cacna1bb; LOW QUALITY PROTEIN: voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
122865199  traf2b; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
122865318  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
122865384  rasgrf2a; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
122865520  [KO:K05462]
122865536  [KO:K03173] [EC:2.3.2.27]
122865550  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
122865551  [KO:K04402]
122865556  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b isoform X1 [KO:K04360] [EC:2.7.10.1]
122865644  [KO:K04455]
122865648  mef2ca; myocyte enhancer factor 2ca isoform X1 [KO:K04454]
122865666  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
122865691  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122865728  fgfr1b; fibroblast growth factor receptor 1b [KO:K04362] [EC:2.7.10.1]
122865786  taok3b; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
122865877  elk4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
122865896  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
122866117  crkl; crk-like protein [KO:K04438]
122866261  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
122866262  flt3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
122866331  myca; transcriptional regulator Myc-A isoform X1 [KO:K04377]
122866386  rps6ka3b; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
122866464  [KO:K04361] [EC:2.7.10.1]
122866616  tgfbr1b; TGF-beta receptor type-1b isoform X1 [KO:K04674] [EC:2.7.11.30]
122866647  map3k22; mitogen-activated protein kinase kinase kinase 22 [KO:K04421] [EC:2.7.11.25]
122866653  myd88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
122866695  map3k8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
122866755  [KO:K04353]
122866933  erbb3a; receptor tyrosine-protein kinase erbB-3a [KO:K05084] [EC:2.7.10.1]
122867053  cacnb2a; voltage-dependent L-type calcium channel subunit beta-2a isoform X1 [KO:K04863]
122867152  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430] [EC:2.7.12.2]
122867173  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
122867228  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
122867451  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
122867466  taok2b; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
122867472  [KO:K04465]
122867496  rac3b; ras-related C3 botulinum toxin substrate 3b isoform X1 [KO:K07861]
122867526  ppm1bb; protein phosphatase 1bb isoform X1 [KO:K04461] [EC:3.1.3.16]
122867590  fgf21; fibroblast growth factor 21 isoform X1 [KO:K22429]
122867601  dusp3a; dual specificity protein phosphatase 3 isoform X1 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
122867604  map2k6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
122867750  mapkapk2a; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
122867751  ngfrb; nerve growth factor receptor b [KO:K02583]
122867758  [KO:K04392]
122867896  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
122867963  [KO:K04466] [EC:2.7.11.25]
122868207  [KO:K04467] [EC:2.7.11.10]
122868209  mapta; microtubule-associated protein tau isoform X1 [KO:K04380]
122868217  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
122868362  map3k14a; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
122868405  [KO:K17614] [EC:3.1.3.16 3.1.3.48]
122868440  [KO:K04347]
122868463  cacna1ia; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
122868473  cacna1aa; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
122868669  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
122868700  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
122868702  cacng5b; voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870]
122868816  pdgfab; platelet-derived growth factor alpha polypeptide b [KO:K04359]
122868882  [KO:K04430] [EC:2.7.12.2]
122868911  [KO:K04433] [EC:2.7.12.2]
122868919  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
122868961  maptb; LOW QUALITY PROTEIN: microtubule-associated protein tau [KO:K04380]
122869030  [KO:K03283]
122869033  taok2a; LOW QUALITY PROTEIN: serine/threonine-protein kinase TAO2 [KO:K04429] [EC:2.7.11.1]
122869034  [KO:K03283]
122869035  nlk1; nemo-like kinase, type 1 isoform X1 [KO:K04468] [EC:2.7.11.24]
122869128  map3k3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
122869143  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
122869189  ngfra; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
122869250  [KO:K16342] [EC:3.1.1.4]
122869359  [KO:K04869]
122869368  [KO:K04392]
122869414  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
122869470  cacng1b; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
122869585  si:ch211-195b15.8; dual specificity protein phosphatase 16 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122869588  rras; ras-related protein R-Ras [KO:K07830]
122869789  [KO:K12361]
122869868  [KO:K04348] [EC:3.1.3.16]
122869870  [KO:K04419] [EC:2.7.11.25]
122869985  [KO:K04439]
122870059  tp53; cellular tumor antigen p53 [KO:K04451]
122870061  angpt4; angiopoietin-4 isoform X1 [KO:K05465]
122870071  [KO:K04411]
122870615  rela; transcription factor p65 isoform X1 [KO:K04735]
122870668  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
122870766  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
122870771  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
122870946  ptprr; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
122870990  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
122870998  [KO:K05461]
122871016  fgf23; fibroblast growth factor 23 [KO:K22428]
122871018  [KO:K04358]
122871272  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
122871338  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
122871339  [KO:K04441] [EC:2.7.11.24]
122871350  [KO:K04858]
122871386  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
122871473  ntf3; neurotrophin-3 isoform X1 [KO:K04356]
122871483  [KO:K05460]
122871503  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
122871522  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
122871523  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
122871536  [KO:K04867]
122871538  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122871593  [KO:K07836]
122871614  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
122871634  atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
122871754  si:ch211-79m20.1; serine/threonine-protein kinase Doa [KO:K17386]
122871787  [KO:K05085] [EC:2.7.10.1]
122871829  [KO:K04359]
122871834  map3k2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
122871853  [KO:K04407] [EC:2.7.11.1]
122872190  [KO:K04865]
122872426  [KO:K05449]
122872843  [KO:K03099]
122872873  [KO:K04856]
122872877  fgf7; fibroblast growth factor 7 [KO:K04358]
122873103  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
122873144  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122873228  kitb; KIT proto-oncogene, receptor tyrosine kinase b isoform X1 [KO:K05091] [EC:2.7.10.1]
122873322  vegfc; vascular endothelial growth factor C [KO:K05449]
122873333  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
122873436  cacna1ab; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b [KO:K04344]
122873474  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
122873476  [KO:K04870]
122873482  [KO:K04869]
122873483  cacng1a; calcium channel, voltage-dependent, gamma subunit 1a [KO:K04866]
122873507  [KO:K04378]
122873627  [KO:K25416]
122873647  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122873658  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
122873660  fgf8b; fibroblast growth factor 8b [KO:K04358]
122873701  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
122873795  [KO:K04358]
122873927  [KO:K04406] [EC:2.7.11.1]
122874052  gna12a; guanine nucleotide-binding protein subunit alpha-12a [KO:K04346]
122874066  [KO:K19662] [EC:2.7.11.13]
122874068  cacng3a; voltage-dependent calcium channel gamma-3 subunit isoform X1 [KO:K04868]
122874264  ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
122874265  dusp8a; dual specificity protein phosphatase 8a isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122874303  mapk12a; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
122874365  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
122874443  nfatc3b; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
122874471  [KO:K04434]
122874514  vegfd; vascular endothelial growth factor D [KO:K05449]
122874646  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
122874651  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
122874687  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
122874761  [KO:K22428]
122874762  [KO:K04358]
122874834  kras; GTPase KRas isoform X1 [KO:K07827]
122874941  igf1rb; insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
122874962  kitlga; kit ligand a isoform X1 [KO:K05461]
122874968  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
122875015  igf2b; insulin-like growth factor 2b isoform X1 [KO:K13769]
122875107  [KO:K02833]
122875138  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
122875174  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
122875527  [KO:K04858]
122875530  [KO:K05460]
122875593  [KO:K04861]
122875669  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
122875692  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
122875719  [KO:K04849]
122875854  mef2cb; myocyte enhancer factor 2cb isoform X1 [KO:K04454]
122875979  dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122876046  [KO:K04352]
122876063  efna5b; ephrin-A5b isoform X1 [KO:K05462]
122876076  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
122876093  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122876144  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
122876204  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a isoform X1 [KO:K04360] [EC:2.7.10.1]
122876259  rasgrf2b; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
122876283  fgf10b; fibroblast growth factor 10b [KO:K04358]
122876285  fgfr1a; fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
122876305  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
122876306  traf2a; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
122876333  taok3a; LOW QUALITY PROTEIN: serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
122876438  fgf19; fibroblast growth factor 19 [KO:K22603]
122876446  fgf3; fibroblast growth factor 3 [KO:K04358]
122876450  fgf4; fibroblast growth factor 4 [KO:K04358]
122876702  [KO:K09784]
122876709  fgf5; fibroblast growth factor 5 [KO:K04358]
122876711  [KO:K04519]
122876743  gdnfb; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
122876921  mapkapk5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
122877020  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
122877022  rras2; ras-related protein R-Ras2 [KO:K07830]
122877170  pak2b; serine/threonine-protein kinase PAK 2b [KO:K04410] [EC:2.7.11.1]
122877219  [KO:K04852]
122877246  mapk8ip1b; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
122877458  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
122877459  kita; mast/stem cell growth factor receptor kita isoform X1 [KO:K05091] [EC:2.7.10.1]
122877465  [KO:K25415]
122877466  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
122877476  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
122877489  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
122877490  gng12b; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
122877539  [KO:K04349]
122877624  pla2g4ab; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
122877654  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
122877848  [KO:K05462]
122877856  [KO:K04402]
122877921  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
122878002  fgf22; fibroblast growth factor 22 [KO:K04358]
122878004  insrb; insulin receptor b [KO:K04527] [EC:2.7.10.1]
122878064  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2b [KO:K04372] [EC:2.7.11.1]
122878118  [KO:K04449]
122878277  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
122878280  jun; transcription factor AP-1 [KO:K04448]
122878442  nf1a; neurofibromin isoform X1 [KO:K08052]
122878451  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122878575  [KO:K04723]
122878707  crk; adapter molecule crk [KO:K04438]
122878780  rps6ka2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
122878823  nlk2; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
122878911  mecom; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
122878951  si:ch211-167j9.5; tyrosine kinase receptor Cad96Ca [KO:K05093] [EC:2.7.10.1]
122879077  rasgrp4; RAS guanyl-releasing protein 4 isoform X1 [KO:K04350]
122879104  hspa8b; heat shock protein family A (Hsp70) member 8b [KO:K03283]
122879188  arrb1; beta-arrestin-1 isoform X1 [KO:K04439]
122879337  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
122879417  taok1a; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
122879451  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
122879497  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
122879501  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
122879632  ppm1na; protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative) isoform X1 [KO:K04457] [EC:3.1.3.16]
122879646  relb; transcription factor RelB isoform X1 [KO:K09253]
122879654  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
122879698  rasa2; ras GTPase-activating protein 2 [KO:K08053]
122879777  [KO:K02187] [EC:3.4.22.56]
122879801  fgf20b; fibroblast growth factor 20b [KO:K04358]
122879818  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122879886  cd40lg; CD40 ligand [KO:K04389]
122879892  fgf2; fibroblast growth factor 2 [KO:K18497]
122879918  fgf16; fibroblast growth factor 16 [KO:K04358]
122879947  rps6kal; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
122879980  fgf1a; putative fibroblast growth factor 1 [KO:K18496]
122879987  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
122880049  [KO:K04358]
122880065  fgf24; fibroblast growth factor 24 isoform X1 [KO:K04358]
122880073  si:zfos-2326c3.2; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
122880119  [KO:K04358]
122880167  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
122880230  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
122880357  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
122880362  csf1ra; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
122880393  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
122880534  vegfba; vascular endothelial growth factor A [KO:K05448]
122880573  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
122880594  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
122880618  egf; pro-epidermal growth factor isoform X1 [KO:K04357]
122880708  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
122880728  rapgef2b; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
122880879  insb; preproinsulin b [KO:K04526]
122880882  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
122880976  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
122881213  tgfbr2b; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
122881332  nradd; death domain-containing membrane protein NRADD isoform X1 [KO:K02583]
122881434  [KO:K03283]
122881515  ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
122881622  vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448]
122881813  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
122881863  [KO:K04446]
122882022  prkcg; LOW QUALITY PROTEIN: protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
122882054  cacng8b; voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
122882056  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
122882068  cacng7b; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
122882083  cacng6b; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
122882097  cdc42l; cell division cycle 42, like [KO:K04393]
122882132  stmn1b; stathmin 1b [KO:K04381]
122882178  efna1b; ephrin-A1b [KO:K05462]
122882180  efna3b; ephrin-A3b isoform X1 [KO:K05462]
122882181  si:dkey-246i14.3; ephrin-A4 [KO:K05462]
122882429  ngfa; neurotrophin-7 [KO:K02582]
122882449  cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
122882634  [KO:K18019] [EC:3.1.3.48]
122882657  elk1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
122882679  zgc:171775; STKc_p38 domain-containing protein isoform X1 [KO:K04441] [EC:2.7.11.24]
122882704  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
122882845  map3k12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
122882853  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
122882912  [KO:K04353]
122882919  [KO:K04857]
122882937  hspa1b; heat shock 70 kDa protein-like [KO:K03283]
122883015  erbb3b; receptor tyrosine-protein kinase erbB-3b [KO:K05084] [EC:2.7.10.1]
122883045  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
122883086  epha2b; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
122883096  flna; filamin-A isoform X1 [KO:K04437]
122883122  [KO:K04393]
122883241  cacna1fb; LOW QUALITY PROTEIN: calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
122883274  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
122883345  mapkapk2b; MAP kinase-activated protein kinase 2b isoform X1 [KO:K04443] [EC:2.7.11.1]
122883421  cacnb3b; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04864]
122883424  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04853]
122883528  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
122883572  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
122883582  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122883621  cacnb3a; voltage-dependent L-type calcium channel subunit beta-3a isoform X1 [KO:K04864]
122883655  nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
122883752  igf3; insulin-like growth factor 3 [KO:K05459]
122883787  si:ch211-112c15.8; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
122883942  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
122884034  fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
122884057  ppm1ba; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
122884098  pla2g4f.1; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
122884142  [KO:K06268]
122884252  nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
122884314  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
122884436  angpt2a; angiopoietin-2a [KO:K05466]
122884479  srfb; serum response factor b isoform X1 [KO:K04378]
122884511  map3k21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
122884588  [KO:K04467] [EC:2.7.11.10]
122884627  ngfb; nerve growth factor [KO:K02582]
122884672  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
122884692  [KO:K04406] [EC:2.7.11.1]
122884744  fgf8a; fibroblast growth factor 8 isoform X1 [KO:K04358]
122884779  rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
122884854  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
122884935  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122885028  [KO:K04407] [EC:2.7.11.1]
122885075  fgf9; fibroblast growth factor 4A [KO:K04358]
122885103  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a isoform X1 [KO:K04865]
122885136  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
122885222  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a isoform X1 [KO:K04859]
122885265  mrasa; ras-related protein M-Ras [KO:K07831]
122885339  epha2a; ephrin type-A receptor 2a [KO:K05103] [EC:2.7.10.1]
122885537  zak; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
122885571  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
122885592  [KO:K05085] [EC:2.7.10.1]
122885640  si:ch211-45c16.2; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
122885712  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
122885992  [KO:K04386]
122886115  [KO:K04393]
122886268  egfra; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
122886281  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
122886325  [KO:K04424] [EC:2.7.11.25]
122886971  [KO:K04377]
122887014  map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X6 [KO:K04463] [EC:2.7.12.2]
122887221  [KO:K25414]
122887227  [KO:K04449]
122887260  [KO:K25415]
122887265  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a isoform X1 [KO:K04402]
122887267  gng12a; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12a isoform X1 [KO:K04347]
122887381  cacna1eb; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
122887397  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
122887568  [KO:K04448]
122887603  insra; insulin receptor a isoform X1 [KO:K04527] [EC:2.7.10.1]
122887729  [KO:K04439]
122887817  [KO:K04438]
122888143  rps6ka4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
122888263  hspb1; heat shock protein beta-1 [KO:K04455]
122888270  csf1rb; macrophage colony-stimulating factor 1 receptor 2 isoform X1 [KO:K05090] [EC:2.7.10.1]
122888272  [KO:K05089] [EC:2.7.10.1]
122888298  ins; insulin [KO:K04526]
122888340  [KO:K03283]
122888341  [KO:K03283]
122888350  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
122888423  [KO:K04456] [EC:2.7.11.1]
122888669  ppm1nb; protein phosphatase, Mg2+/Mn2+ dependent, 1Nb (putative) [KO:K04457] [EC:3.1.3.16]
122888753  [KO:K18496]
122888786  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
122888881  [KO:K04429] [EC:2.7.11.1]
122888902  mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
122888972  [KO:K04410] [EC:2.7.11.1]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
schu04070  Phosphatidylinositol signaling system
schu04110  Cell cycle
schu04115  p53 signaling pathway
schu04210  Apoptosis
schu04310  Wnt signaling pathway
KO pathway
ko04010   

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