KEGG   PATHWAY: spu00310
Entry
spu00310                    Pathway                                
Name
Lysine degradation - Strongylocentrotus purpuratus (purple sea urchin)
Class
Metabolism; Amino acid metabolism
Pathway map
spu00310  Lysine degradation
spu00310

Module
spu_M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA [PATH:spu00310]
Other DBs
GO: 0006554
Organism
Strongylocentrotus purpuratus (purple sea urchin) [GN:spu]
Gene
592682  alpha-aminoadipic semialdehyde synthase, mitochondrial [KO:K14157] [EC:1.5.1.8 1.5.1.9]
588376  alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
592969  kynurenine/alpha-aminoadipate aminotransferase, mitochondrial [KO:K00825] [EC:2.6.1.7 2.6.1.39]
100891652  kynurenine/alpha-aminoadipate aminotransferase, mitochondrial [KO:K00825] [EC:2.6.1.7 2.6.1.39]
105444816  kynurenine/alpha-aminoadipate aminotransferase, mitochondrial-like [KO:K00825] [EC:2.6.1.7 2.6.1.39]
579472  kynurenine/alpha-aminoadipate aminotransferase, mitochondrial isoform X1 [KO:K00825] [EC:2.6.1.7 2.6.1.39]
764393  probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial [KO:K15791] [EC:1.2.4.-]
576084  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial [KO:K00658] [EC:2.3.1.61]
577103  dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
580832  glutaryl-CoA dehydrogenase, mitochondrial [KO:K00252] [EC:1.3.8.6]
115928713  glutaryl-CoA dehydrogenase, mitochondrial-like [KO:K00252] [EC:1.3.8.6]
585357  trifunctional enzyme subunit alpha, mitochondrial [KO:K07515] [EC:4.2.1.17 1.1.1.211]
588204  peroxisomal bifunctional enzyme isoform X1 [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
753669  peroxisomal bifunctional enzyme-like isoform X1 [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
575690  Echs1; enoyl CoA hydratase, short chain, 1, mitochondrial [KO:K07511] [EC:4.2.1.17]
582126  hydroxyacyl-coenzyme A dehydrogenase, mitochondrial [KO:K00022] [EC:1.1.1.35]
763037  acetyl-CoA acetyltransferase, cytosolic [KO:K00626] [EC:2.3.1.9]
584928  acetyl-CoA acetyltransferase, mitochondrial [KO:K00626] [EC:2.3.1.9]
115927929  acetyl-CoA acetyltransferase, cytosolic-like [KO:K00626] [EC:2.3.1.9]
579089  acetyl-CoA acetyltransferase, cytosolic-like [KO:K00626] [EC:2.3.1.9]
115928354  acetyl-CoA acetyltransferase, cytosolic-like [KO:K00626] [EC:2.3.1.9]
583471  hydroxylysine kinase [KO:K18201] [EC:2.7.1.81]
753377  hydroxylysine kinase isoform X3 [KO:K18201] [EC:2.7.1.81]
587491  hydroxylysine kinase isoform X1 [KO:K18201] [EC:2.7.1.81]
591772  LOW QUALITY PROTEIN: peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
592753  peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
575397  peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]
578086  peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
593952  peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
100892187  calmodulin-lysine N-methyltransferase [KO:K18826] [EC:2.1.1.60]
579728  uncharacterized protein LOC579728 [KO:K09186] [EC:2.1.1.354]
591084  histone-lysine N-methyltransferase 2C isoform X11 [KO:K09188] [EC:2.1.1.354]
580083  uncharacterized protein LOC580083 isoform X1 [KO:K09189] [EC:2.1.1.354]
586687  histone-lysine N-methyltransferase SETD1B-A [KO:K11422] [EC:2.1.1.354]
100890770  histone-lysine N-methyltransferase PRDM9 [KO:K20796] [EC:2.1.1.354]
589504  probable histone-lysine N-methyltransferase PRDM7 [KO:K20796] [EC:2.1.1.354]
105444724  probable histone-lysine N-methyltransferase PRDM7 [KO:K20796] [EC:2.1.1.354]
100893772  zinc finger protein 93 [KO:K20796] [EC:2.1.1.354]
100891891  histone-lysine N-methyltransferase PRDM9 [KO:K20796] [EC:2.1.1.354]
100888724  zinc finger protein 888 [KO:K20796] [EC:2.1.1.354]
115921155  histone-lysine N-methyltransferase PRDM9-like [KO:K20796] [EC:2.1.1.354]
583022  histone-lysine N-methyltransferase PRDM9 [KO:K20796] [EC:2.1.1.354]
100890919  zinc finger protein 345 [KO:K20796] [EC:2.1.1.354]
115921157  histone-lysine N-methyltransferase PRDM9-like [KO:K20796] [EC:2.1.1.354]
100890990  histone-lysine N-methyltransferase PRDM9 isoform X1 [KO:K20796] [EC:2.1.1.354]
105443953  histone-lysine N-methyltransferase PRDM9-like [KO:K20796] [EC:2.1.1.354]
586691  zinc finger protein 431 isoform X1 [KO:K20796] [EC:2.1.1.354]
579712  histone-lysine N-methyltransferase ASH1L isoform X1 [KO:K06101] [EC:2.1.1.354]
576115  histone-lysine N-methyltransferase SMYD3 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
105441505  histone-lysine N-methyltransferase SMYD3-like [KO:K11426] [EC:2.1.1.354 2.1.1.357]
577640  histone-lysine N-methyltransferase SUV39H2 [KO:K11419] [EC:2.1.1.355]
580814  histone-lysine N-methyltransferase EHMT2 isoform X1 [KO:K11420] [EC:2.1.1.355]
764341  histone-lysine N-methyltransferase eggless isoform X1 [KO:K11421] [EC:2.1.1.366]
100893443  PR domain zinc finger protein 2 [KO:K11432] [EC:2.1.1.355]
115924568  PR domain zinc finger protein 2-like [KO:K11432] [EC:2.1.1.355]
585842  histone-lysine N-methyltransferase EZH2 isoform X1 [KO:K11430] [EC:2.1.1.356]
577608  histone-lysine N-methyltransferase SETMAR [KO:K11433] [EC:2.1.1.357]
115918289  histone-lysine N-methyltransferase SETMAR-like [KO:K11433] [EC:2.1.1.357]
580047  histone-lysine N-methyltransferase NSD2 [KO:K11424] [EC:2.1.1.357]
578079  uncharacterized protein LOC578079 isoform X1 [KO:K11423] [EC:2.1.1.359]
100891935  histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 [KO:K11427] [EC:2.1.1.360]
592467  N-lysine methyltransferase KMT5A [KO:K11428] [EC:2.1.1.361]
115923119  N-lysine methyltransferase KMT5A-like [KO:K11428] [EC:2.1.1.361]
105442287  N-lysine methyltransferase KMT5A-like isoform X1 [KO:K11428] [EC:2.1.1.361]
115921240  N-lysine methyltransferase KMT5A-A-like [KO:K11428] [EC:2.1.1.361]
115921211  N-lysine methyltransferase KMT5A-like isoform X1 [KO:K11428] [EC:2.1.1.361]
115918102  N-lysine methyltransferase KMT5A-like [KO:K11428] [EC:2.1.1.361]
115926391  N-lysine methyltransferase KMT5A-A-like [KO:K11428] [EC:2.1.1.361]
100892850  N-lysine methyltransferase KMT5A isoform X1 [KO:K11428] [EC:2.1.1.361]
115917928  N-lysine methyltransferase KMT5A-like isoform X1 [KO:K11428] [EC:2.1.1.361]
105440265  N-lysine methyltransferase KMT5A-like isoform X1 [KO:K11428] [EC:2.1.1.361]
583266  histone-lysine N-methyltransferase KMT5B isoform X1 [KO:K11429] [EC:2.1.1.362]
100892779  histone-lysine N-methyltransferase MECOM [KO:K04462] [EC:2.1.1.367]
584681  trimethyllysine dioxygenase, mitochondrial isoform X1 [KO:K00474] [EC:1.14.11.8]
581754  aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
581706  aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
105445554  aldehyde dehydrogenase, dimeric NADP-preferring [KO:K00128] [EC:1.2.1.3]
593236  aldehyde dehydrogenase family 16 member A1 [KO:K00128] [EC:1.2.1.3]
105445170  aldehyde dehydrogenase family 3 member A2 isoform X1 [KO:K00128] [EC:1.2.1.3]
756945  aldehyde dehydrogenase, dimeric NADP-preferring [KO:K00128] [EC:1.2.1.3]
580956  4-trimethylaminobutyraldehyde dehydrogenase [KO:K00149] [EC:1.2.1.47 1.2.1.3]
583864  4-trimethylaminobutyraldehyde dehydrogenase A [KO:K00149] [EC:1.2.1.47 1.2.1.3]
115918585  4-trimethylaminobutyraldehyde dehydrogenase-like [KO:K00149] [EC:1.2.1.47 1.2.1.3]
577198  gamma-butyrobetaine dioxygenase [KO:K00471] [EC:1.14.11.1]
575977  uncharacterized protein LOC575977 [KO:K00471] [EC:1.14.11.1]
589740  gamma-butyrobetaine dioxygenase [KO:K00471] [EC:1.14.11.1]
579623  gamma-butyrobetaine dioxygenase isoform X1 [KO:K00471] [EC:1.14.11.1]
585058  gamma-butyrobetaine dioxygenase [KO:K00471] [EC:1.14.11.1]
583892  gamma-butyrobetaine dioxygenase [KO:K00471] [EC:1.14.11.1]
100889965  gamma-butyrobetaine dioxygenase isoform X1 [KO:K00471] [EC:1.14.11.1]
587148  gamma-butyrobetaine dioxygenase [KO:K00471] [EC:1.14.11.1]
577138  gamma-butyrobetaine dioxygenase [KO:K00471] [EC:1.14.11.1]
577713  procollagen galactosyltransferase 2 [KO:K11703] [EC:2.4.1.50]
Compound
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00037  Glycine
C00042  Succinate
C00047  L-Lysine
C00068  Thiamin diphosphate
C00136  Butanoyl-CoA
C00164  Acetoacetate
C00322  2-Oxoadipate
C00332  Acetoacetyl-CoA
C00408  L-Pipecolate
C00431  5-Aminopentanoate
C00449  N6-(L-1,3-Dicarboxypropyl)-L-lysine
C00450  (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate
C00487  Carnitine
C00489  Glutarate
C00527  Glutaryl-CoA
C00739  D-Lysine
C00877  Crotonoyl-CoA
C00956  L-2-Aminoadipate
C00990  5-Aminopentanamide
C01087  (R)-2-Hydroxyglutarate
C01142  (3S)-3,6-Diaminohexanoate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01149  4-Trimethylammoniobutanal
C01181  4-Trimethylammoniobutanoate
C01186  (3S,5S)-3,5-Diaminohexanoate
C01211  Procollagen 5-hydroxy-L-lysine
C01259  (3S)-3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
C01672  Cadaverine
C02188  Protein lysine
C02727  N6-Acetyl-L-lysine
C03087  5-Acetamidopentanoate
C03196  (S)-2-Hydroxyglutarate
C03239  6-Amino-2-oxohexanoate
C03273  5-Oxopentanoate
C03366  5-Phosphooxy-L-lysine
C03656  (S)-5-Amino-3-oxohexanoic acid
C03793  N6,N6,N6-Trimethyl-L-lysine
C04020  D-Lysopine
C04076  L-2-Aminoadipate 6-semialdehyde
C04092  Delta1-Piperideine-2-carboxylate
C04487  5-(D-Galactosyloxy)-L-lysine-procollagen
C05161  (2R,5S)-2,5-Diaminohexanoate
C05231  L-3-Aminobutyryl-CoA
C05544  Protein N6-methyl-L-lysine
C05545  Protein N6,N6-dimethyl-L-lysine
C05546  Protein N6,N6,N6-trimethyl-L-lysine
C05548  6-Acetamido-2-oxohexanoate
C05825  2-Amino-5-oxohexanoate
C06157  [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine
C12455  5-Aminopentanal
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16741  L-Hydroxylysine
C22667  4-Carboxy-1-hydroxybutyryl-ThPP
Reference
PMID:11802770
  Authors
Vaz FM, Wanders RJ.
  Title
Carnitine biosynthesis in mammals.
  Journal
Biochem J 361:417-29 (2002)
DOI:10.1042/bj3610417
Reference
PMID:1682209
  Authors
Large PJ, Robertson A.
  Title
The route of lysine breakdown in Candida tropicalis.
  Journal
FEMS Microbiol Lett 66:209-13 (1991)
DOI:10.1111/j.1574-6968.1990.tb03998.x
Related
pathway
spu00020  Citrate cycle (TCA cycle)
spu00780  Biotin metabolism
KO pathway
ko00310   
LinkDB

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