KEGG   PATHWAY: tpai04530
Entry
tpai04530                   Pathway                                
Name
Tight junction - Tympanuchus pallidicinctus (lesser prairie-chicken)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
tpai04530  Tight junction
tpai04530

Other DBs
GO: 0005923
Organism
Tympanuchus pallidicinctus (lesser prairie-chicken) [GN:tpai]
Gene
128071595  CLDN10; claudin-10 isoform X1 [KO:K06087]
128071708  CLDN34; claudin-34 isoform X1 [KO:K06087]
128071888  CGN; cingulin isoform X1 [KO:K06102]
128071932  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
128072022  ARHGEF2; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 2 [KO:K12791]
128072044  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
128072185  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
128072440  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
128072448  JUN; transcription factor Jun [KO:K04448]
128072662  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
128072720  PATJ; inaD-like protein isoform X1 [KO:K06092]
128072854  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
128072856  JAM2; junctional adhesion molecule B [KO:K06735]
128073364  [KO:K07374]
128073373  [KO:K07374]
128073378  MYH9; myosin-9 [KO:K10352]
128073380  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
128073470  CFTR; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
128074051  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
128074103  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
128074167  [KO:K07374]
128074168  TUBA1A; tubulin alpha-1A chain [KO:K07374]
128074169  [KO:K07374]
128074187  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
128074278  [KO:K06448]
128074279  [KO:K06448]
128074312  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
128074476  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
128074502  MAP3K1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
128074940  RDX; radixin [KO:K05762]
128074951  AMOTL1; angiomotin-like protein 1 isoform X1 [KO:K06104]
128075170  [KO:K05692]
128075206  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
128075368  RAB8B; ras-related protein Rab-8B isoform X1 [KO:K07902]
128075481  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
128075547  CGNL1; cingulin-like protein 1 isoform X1 [KO:K21110]
128075577  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
128075748  MSN; moesin isoform X1 [KO:K05763]
128075758  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
128075862  CLDN2; claudin-2 [KO:K06087]
128075919  RAP2C; ras-related protein Rap-2c [KO:K07839]
128076002  AMOT; angiomotin isoform X1 [KO:K16819]
128076371  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
128076420  CLDN14; claudin-14 [KO:K06087]
128076423  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
128076433  [KO:K06087]
128076435  [KO:K06087]
128076564  IGSF5; immunoglobulin superfamily member 5 isoform X1 [KO:K06786]
128076633  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
128076767  [KO:K07374]
128076781  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
128077100  TJAP1; tight junction-associated protein 1 isoform X1 [KO:K06105]
128077258  ACTR3; actin-related protein 3 [KO:K18584]
128077282  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
128077313  MPP4; MAGUK p55 subfamily member 4 [KO:K21109]
128077592  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
128077983  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
128078539  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
128078544  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
128078777  RHOA; transforming protein RhoA [KO:K04513]
128078835  EZR; ezrin [KO:K08007]
128078842  ARPC1B; actin-related protein 2/3 complex subunit 1B isoform X1 [KO:K05757]
128078843  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
128079140  MYH11; myosin-11 isoform X1 [KO:K10352]
128079246  ACTB; actin, cytoplasmic 1 [KO:K05692]
128079273  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
128079295  MICALL2; MICAL-like protein 2 isoform X1 [KO:K21068]
128079308  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
128079347  ARHGAP17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
128079690  [KO:K07374]
128079883  [KO:K06087]
128079884  [KO:K06087]
128079966  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
128080032  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
128080254  CLDN23; claudin-23 [KO:K06087]
128080912  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
128080987  PARD6B; partitioning defective 6 homolog beta isoform X1 [KO:K06093]
128081145  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
128081310  SYNPO; synaptopodin [KO:K21112]
128081808  PRKCE; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
128081872  [KO:K06087]
128081995  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
128082117  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
128082126  AMOTL2; angiomotin-like protein 2 isoform X1 [KO:K06104]
128082161  CLDN18; claudin-18 [KO:K06087]
128082239  CLDN11; claudin-11 [KO:K06087]
128082313  MARVELD3; MARVEL domain-containing protein 3 [KO:K21099]
128082400  [KO:K07374]
128082569  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
128082673  CLDN20; claudin-20 [KO:K06087]
128082825  CLDN16; claudin-16 [KO:K06087]
128082826  CLDN1; claudin-1 [KO:K06087]
128082977  NHERF1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
128083009  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
128083066  ACTG1; actin, cytoplasmic 2 [KO:K05692]
128083257  MYH10; myosin-10 isoform X1 [KO:K10352]
128083470  [KO:K06087]
128083476  [KO:K06087]
128083531  [KO:K06087]
128083701  [KO:K16684]
128083805  NF2; merlin isoform X1 [KO:K16684]
128083811  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
128083845  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
128083876  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
128083919  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
128083965  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
128084060  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
128084251  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
128084359  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
128084662  CLDN5; claudin-5 [KO:K06087]
128084726  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
128084779  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
128085020  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
128085112  CLDN19; claudin-19 isoform X1 [KO:K06087]
128085113  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
128085131  [KO:K06087]
128085377  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
128085451  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
128085455  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
128085491  GATA4; transcription factor GATA-4 isoform X1 [KO:K09183]
128085527  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
128085538  CTTN; src substrate cortactin isoform X1 [KO:K06106]
128085555  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
128086495  PALS1; protein PALS1 [KO:K06091]
128086508  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
128087027  AFDN; afadin isoform X1 [KO:K05702]
128087318  CLDN12; claudin-12 [KO:K06087]
128087334  BVES; blood vessel epicardial substance isoform X1 [KO:K21108]
128087564  CLDN25; putative claudin-25 [KO:K06087]
128087683  JAM3; junctional adhesion molecule C [KO:K06785]
128087748  [KO:K21099]
128088024  RAP1A; ras-related protein Rap-1A [KO:K04353]
128088578  ACTR2; actin-related protein 2 [KO:K17260]
128088834  ARHGEF18; rho guanine nucleotide exchange factor 18 isoform X1 [KO:K21066]
128088841  RAB8A; ras-related protein Rab-8A [KO:K07901]
128088876  OCLN; occludin isoform X1 [KO:K06088]
128089037  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
128089339  MARVELD2; MARVEL domain-containing protein 2 [KO:K17291]
128089366  TJP2; tight junction protein ZO-2 isoform X1 [KO:K06098]
128089387  MPDZ; multiple PDZ domain protein isoform X1 [KO:K06095]
128090015  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
128090068  PCNA; proliferating cell nuclear antigen [KO:K04802]
128090132  TJP3; tight junction protein ZO-3 isoform X1 [KO:K06097]
128090309  [KO:K07374]
128090813  [KO:K12757]
128090814  [KO:K12757]
128091214  EPB41L4B; band 4.1-like protein 4B isoform X1 [KO:K21111]
128091286  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
128091426  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
128091920  YBX3; Y-box-binding protein 3 [KO:K06099]
128091955  HCLS1; hematopoietic lineage cell-specific protein isoform X1 [KO:K06106]
Compound
C00076  Calcium cation
Reference
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
tpai04520  Adherens junction
tpai04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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