KEGG    Network variation - Breast cancer
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ENTRYnt06270
NameBreast cancer
CategoryDisease view; Cancer
Pathwayhsa05224 Breast cancer
DiseaseH00031 Breast cancer
Display drug-target relation   disease type
ERK signaling
N00001    EGF→EGFR→GRB2→SOS→RAS→RAF→MEK→ERK→CCND1
N00041      EGFR*→GRB2→SOS→RAS→RAF→MEK→ERK
N00021    EGF→(ERBB2+EGFR)→GRB2→SOS→RAS→RAF→MEK→ERK
   D5,D6,D7,D8,D9,D10,D11,D12
 |		            
N00022    EGF→(ERBB2*+EGFR)→GRB2→SOS→RAS→RAF→MEK→ERK
N00019    FGF→FGFR→GRB2→SOS→RAS→RAF→MEK→ERK
N00020      FGFR*→GRB2→SOS→RAS→RAF→MEK→ERK
 
PI3K signaling
         D1
 |		  
N00033    EGF→EGFR→PI3K→PIP3→AKT⊣BAD
         D1
 |		 D17
 |		  
N00042      EGFR*→PI3K→PIP3→AKT→MTOR→S6K
   D5,D6,D7,D8,D9,D10,D11,D12
 |		     D1
 |		 D17
 |		  
N00034    EGF→(ERBB2*+EGFR)→PI3K→PIP3→AKT→MTOR→S6K
         D1
 |		 D17
 |		  
N00037    FGF→FGFR→PI3K→PIP3→AKT→MTOR→S6K
         D1
 |		 D17
 |
N00038      FGFR*→PI3K→PIP3→AKT→MTOR
     D19
 |		   D1
 |		 D17
 |		  
N00049        PI3K*→PIP3→AKT→MTOR→S6K
         D1
 |		 D17
 |		  
N00050        PI3K*→PIP3→AKT→MTOR→S6K
         D1
 |
N00220        PTEN⊣PIP3→AKT
         D1
 |
N00052        PTEN*⌿PIP3→AKT
 
WNT signaling
N00056    WNT→(FZD+LRP5/6)→(DVL+FRAT)⊣(GSK3B+AXIN+APC)⊣CTNNB1→TCF/LEF⇒(MYC,CCND1)
N00059    WNT→(FZD7*+LRP5/6)→(DVL+FRAT)⊣(GSK3B+AXIN+APC)⊣CTNNB1→TCF/LEF⇒(MYC,CCND1)
N00060    WNT→(FZD+LRP6*)→(DVL+FRAT)⊣(GSK3B+AXIN+APC)⊣CTNNB1→TCF/LEF⇒(MYC,CCND1)
 
NOTCH signaling
N00086    (DLL,JAG)→NOTCH→(NICD+RBPJ)⇒(HES1,HEY1)
N00087    (DLL,JAG)→(NOTCH1*,NOTCH4*)→(NICD+RBPJ)⇒(ERBB2,HES1,HES5,H..
 
Cell cycle
         D2,D3,D4
 |		    
N00066    CDKN2A⊣MDM2⊣TP53⇒CDKN1A⊣(CCND+CDK4/6)→RB1⌿E2F
         D2,D3,D4
 |		    
N00275            (CCND1*+CDK4)→RB1⌿E2F
 
Nuclear receptor signaling
   D13,D14,D15,D16
 |		 D18
 |
N00286    E2→((ESR1/2)+(NCOA1/2..⇒(BCL2,EBAG9,KRT19,..
N00287    E2→(ESR*+(NCOA3,NCOA1..⇒(CCND1,MYC)
 
Transcription
N00115    TP53*⌿(CDKN1A,GADD45,BAX..


Drug name
D1D11371Capivasertib (JAN/USAN)
D2D10372Palbociclib (JAN/USAN)
D3D10688Abemaciclib (JAN/USAN/INN)
D4D10979Ribociclib succinate (USAN)
D5D03257Trastuzumab (USAN/INN)
D6D04024Lapatinib ditosylate (USAN)
D7D05446Pertuzumab (USAN/INN)
D8D09980Trastuzumab emtansine (USAN/INN)
D9D10446Margetuximab (USAN/INN)
D10D10898Neratinib maleate
D11D11141Tucatinib (USAN/INN)
D12D11529Trastuzumab deruxtecan (USAN/INN)
D13D00554Ethinyl estradiol (USP)
D14D00966Tamoxifen citrate (JP18/USP)
D15D01161Fulvestrant (JAN/USP/INN)
D16D12217Imlunestrant tosylate (USAN)
D17D02714Everolimus (JAN/USAN/INN)
D18D00951Medroxyprogesterone acetate (JP18/USP)
D19D11011Alpelisib (JAN/USAN/INN)