KEGG NETWORK: Network variation - JAK-STAT signaling

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ENTRY	nt06518
Name	JAK-STAT signaling
Category	Pathway view; Signal transduction
Pathway	hsa04630 JAK-STAT signaling pathway
Display	drug-target relation disease type

N01554		(IL2,IL4,IL7,IL9,I..	→	((IL2RG+IL2RB+(IL2..	→	(JAK1+JAK3)	→	(STAT1,STAT3,STAT5..
	IMD63			IL2RB*
	SCID/IMD6			IL2RG*
	SCID			IL7R*
	SCID					JAK3*
N00491	HTLV-1	P12	→	IL2RB/G	→	JAK1/3	→	STAT5	⇒	IL2
N00486	EBV			LMP1	→	JAK3	→	(STAT3+STAT1)

N01804		(IL3/5,CSF2)	→	(IL3RA,IL5RA,CSF2R..	→	JAK2	→	STAT5
	SMDP4			CSF2RA*
	SMDP5			CSF2RB*

N01556		(IL6,IL11,IL13,IL2..	→	((IL6ST+(IL6R,IL11..	→	(JAK1+JAK2+TYK2)	→	(STAT1,STAT3,STAT6..
	CISS2	CLCF1*
	HIES4/STWS2			IL6ST*
	HIES5			IL6R*
	IMD134			IL27RA*
	PLCA1			OSMR*
	PLCA2			IL31RA*
	STWS1			LIFR*
	AIIDE					JAK1*↗
	HIES1							STAT3*
	ADMIO1							STAT3*↗
	HIES6							STAT6*↗
N00181	KSHV	vIL6	→	IL6ST	→	JAK2	→	STAT3
N00548	HBV					X	→	STAT3

N00415		(IL10,IL19,IL20,IL..	→	((IL10RB+(IL10RA,I..	→	(JAK1+TYK2)	→	STAT3
	IBD28			IL10RA*
	IBD25			IL10RB*
N00416	HCMV	vIL10	→	IL10R	→	JAK1	→	STAT3

				D1 \|
N01557		(IL12,IL23A)	→	((IL12RB1+IL12RB2)..	→	(JAK2+TYK2)	→	(STAT3,STAT4)
	IMD29	IL12B*
	IMD30			IL12RB1*
	IBD17			IL23R*

				D2 \|
N01555		(EPO,GH,PRL,THPO,C..	→	(EPOR,GHR,PRLR,MPL..	→	JAK2	→	(STAT5A,STAT5B,STA..
	THCYT1	THPO*↗
	ECYT5	EPO*↗
	IGHD1	GH*
	SCN14	CSF3*
	LEPD	LEP*
	THCYT2/MF			MPL*↗
	ECYT1			EPOR*↗
	Laron syndrome			GHR*
	SCN7			CSF3R*
	LEPRD			LEPR*
	HPRL			PRLR*
	THCYT3/ECYT1/MF					JAK2*↗
	GHISID							STAT5B*

N01558		(IFNA,IFNB1,IFNW1,..	→	(IFNAR1+IFNAR2)	→	(JAK1+TYK2)	→	(STAT1+STAT2)	=	IRF9
	IMD45			IFNAR2*
	IMD44							STAT2*
	PTORCH3							STAT2*↗
	IMD65									IRF9*
N01560		USP18	⊣	(IFNAR2,STAT2)
	PTORCH2	USP18*

N01559		IFNG	→	(IFNGR1,IFNGR2)	→	(JAK1+JAK2)	→	(STAT1,STAT3)	⇒	(IL27,IFNA,IFNG)
	IMD69	IFNG*
	IMD27			IFNGR1*
	IMD28			IFNGR2*
	IMD31/CANDF7							STAT1*

		Disease name	Disease category
IMD63	H02525	Disorders of innate immunity	Immune system disease
SCID/IMD6	H00091	T-B+Severe combined immunodeficiency	Primary immunodeficiency
	H00093	Combined immunodeficiency	Primary immunodeficiency
SCID	H00091	T-B+Severe combined immunodeficiency	Primary immunodeficiency
HTLV-1	H00009	Adult T-cell leukemia	Cancer
EBV	H00008	Burkitt lymphoma	Cancer
	H00007	Hodgkin lymphoma	Cancer
	H00054	Nasopharyngeal cancer	Cancer
SMDP4	H01122	Congenital pulmonary alveolar proteinosis	Respiratory system disease
SMDP5	H01122	Congenital pulmonary alveolar proteinosis	Respiratory system disease
CISS2	H00935	Cold-induced sweating syndrome	Congenital malformation
HIES4/STWS2	H01968	Hyper-IgE syndrome	Immune system disease
	H00462	Stuve-Wiedemann syndrome	Congenital malformation
HIES5	H01968	Hyper-IgE syndrome	Immune system disease
IMD134	H01725	Primary immunodeficiency disease	Immune system disease
PLCA1	H01217	Primary localized cutaneous amyloidosis	Skin disease
PLCA2	H01217	Primary localized cutaneous amyloidosis	Skin disease
STWS1	H00462	Stuve-Wiedemann syndrome	Congenital malformation
AIIDE	H02537	Autoinflammation, immune dysregulation, and eosinophilia	Immune system disease
HIES1	H01968	Hyper-IgE syndrome	Immune system disease
ADMIO1	H02540	Infantile-onset multisystem autoimmune disease	Immune system disease
HIES6	H01968	Hyper-IgE syndrome	Immune system disease
KSHV	H00041	Kaposi sarcoma	Cancer
HBV	H00048	Hepatocellular carcinoma	Cancer
IBD28	H01227	Inflammatory bowel disease (IBD)	Immune system disease
IBD25	H01227	Inflammatory bowel disease (IBD)	Immune system disease
HCMV	H00368	Cytomegalovirus infection	Viral infectious disease
IMD29	H00089	IFN-gamma/IL-12 axis	Primary immunodeficiency
IMD30	H00089	IFN-gamma/IL-12 axis	Primary immunodeficiency
IBD17	H01227	Inflammatory bowel disease (IBD)	Immune system disease
THCYT1	H01612	Essential thrombocythemia	Hematologic disease
ECYT5	H00236	Congenital polycythemia	Hematologic disease
IGHD1	H02035	Isolated growth hormone deficiency	Endocrine and metabolic disease
SCN14	H00100	Neutropenic disorders	Primary immunodeficiency
LEPD	H02059	Leptin deficiency	Endocrine and metabolic disease
THCYT2/MF	H01612	Essential thrombocythemia	Hematologic disease
	H01605	Myelofibrosis	Cancer
ECYT1	H00236	Congenital polycythemia	Hematologic disease
Laron syndrome	H02037	Laron syndrome	Endocrine and metabolic disease
SCN7	H00100	Neutropenic disorders	Primary immunodeficiency
LEPRD	H02060	Leptin receptor deficiency	Endocrine and metabolic disease
HPRL	H01388	Hyperprolactinemia	Endocrine and metabolic disease
THCYT3/ECYT1/MF	H01612	Essential thrombocythemia	Hematologic disease
	H00236	Congenital polycythemia	Hematologic disease
	H01605	Myelofibrosis	Cancer
GHISID	H00931	Growth hormone insensitivity with immunodeficiency	Endocrine and metabolic disease
IMD45	H02525	Disorders of innate immunity	Immune system disease
IMD44	H02525	Disorders of innate immunity	Immune system disease
PTORCH3	H00840	Pseudo-TORCH syndrome	Congenital malformation
IMD65	H02525	Disorders of innate immunity	Immune system disease
PTORCH2	H00840	Pseudo-TORCH syndrome	Congenital malformation
IMD69	H01725	Primary immunodeficiency disease	Immune system disease
IMD27	H00089	IFN-gamma/IL-12 axis	Primary immunodeficiency
IMD28	H00089	IFN-gamma/IL-12 axis	Primary immunodeficiency
IMD31/CANDF7	H00089	IFN-gamma/IL-12 axis	Primary immunodeficiency
	H01109	Chronic mucocutaneous candidiasis	Immune system disease

		Drug name
D1	D13093	Icotrokinra hydrochloride (JAN/USAN)
D2	D03297	Mecasermin (USAN/INN)