Entry Name Fc epsilon RI signaling pathway - Pan troglodytes (chimpanzee)
Description Fc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation pathways are regulated both positively and negatively by the interactions of numerous signaling molecules. Mast cells that are thus activated release preformed granules which contain biogenic amines (especially histamines) and proteoglycans (especially heparin). The activation of phospholipase A2 causes the release of membrane lipids followed by development of lipid mediators such as leukotrienes (LTC4, LTD4 and LTE4) and prostaglandins (especially PDG2). There is also secretion of cytokines, the most important of which are TNF-alpha, IL-4 and IL-5. These mediators and cytokines contribute to inflammatory responses.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map ptr04664 Fc epsilon RI signaling pathway
Other DBs Organism Pan troglodytes (chimpanzee) [GN:
ptr ]
Gene 100612300 FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983 ]
452520 ALOX5AP; arachidonate 5-lipoxygenase-activating protein isoform X1 [KO:K20735 ]
452897 SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099 ]
454268 PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859 ] [EC:3.1.4.11 ]
455065 MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X4 [KO:K04430 ] [EC:2.7.12.2 ]
456565 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649 ]
457076 VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730 ]
457922 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
458253 PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X3 [KO:K01116 ] [EC:3.1.4.11 ]
459171 SOS1; son of sevenless homolog 1 isoform X2 [KO:K03099 ]
460182 RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366 ] [EC:2.7.11.1 ]
460858 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
461836 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649 ]
468310 MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X2 [KO:K04433 ] [EC:2.7.12.2 ]
469538 FCER1A; high affinity immunoglobulin epsilon receptor subunit alpha [KO:K08089 ]
470683 INPP5D; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1 [KO:K03084 ] [EC:3.1.3.86 ]
471079 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
471627 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
471734 LCP2; lymphocyte cytosolic protein 2 isoform X1 [KO:K07361 ]
473114 VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730 ]
736459 MS4A2; high affinity immunoglobulin epsilon receptor subunit beta [KO:K08090 ]
737245 GRB2; growth factor receptor-bound protein 2 [KO:K04364 ]
741907 RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392 ]
742575 RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860 ]
743199 MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X3 [KO:K04431 ] [EC:2.7.12.2 ]
743259 SPNS1; protein spinster homolog 1 isoform X6 [KO:K07362 ]
747131 RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
748918 GAB2; GRB2-associated-binding protein 2 isoform X1 [KO:K08091 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Kawakami T, Galli SJ.
Title Regulation of mast-cell and basophil function and survival by IgE.
Journal Reference Authors Siraganian RP.
Title Mast cell signal transduction from the high-affinity IgE receptor.
Journal Reference Authors Janeway CA, Travers P, Walport M, Shlomchik MJ.
Title Immunobiology 6th edition
Journal Garland Science Publishing (2005)
Reference Authors Turner H, Kinet JP.
Title Signalling through the high-affinity IgE receptor Fc epsilonRI.
Journal Reference Authors Gilfillan AM, Tkaczyk C.
Title Integrated signalling pathways for mast-cell activation.
Journal Reference Authors Nadler MJ, Matthews SA, Turner H, Kinet JP.
Title Signal transduction by the high-affinity immunoglobulin E receptor Fc epsilon RI: coupling form to function.
Journal Reference Authors Gu H, Saito K, Klaman LD, Shen J, Fleming T, Wang Y, Pratt JC, Lin G, Lim B, Kinet JP, Neel BG.
Title Essential role for Gab2 in the allergic response.
Journal Reference Authors Nadler MJ, Kinet JP.
Title Uncovering new complexities in mast cell signaling.
Journal Related ptr04070 Phosphatidylinositol signaling system
KO pathway
