R04130                      Reaction                               
2,6-dihydroxypyridine,NADH:oxygen oxidoreductase (3-hydroxylating)
2,6-Dihydroxypyridine + Oxygen + NADH + H+ <=> 2,3,6-Trihydroxypyridine + NAD+ + H2O
Reaction class
RC00001  C00003_C00004
RC00046  C03056_C03458
rn00760  Nicotinate and nicotinamide metabolism
rn01120  Microbial metabolism in diverse environments
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
     R04130  2,6-Dihydroxypyridine + Oxygen + NADH + H+ <=> 2,3,6-Trihydroxypyridine + NAD+ + H2O
K19189  2,6-dihydroxypyridine 3-monooxygenase [EC:]
Other DBs
RHEA: 16920

RC00046                     RClass                                 
Reactant pair
C00082_C00355    C00090_C00146    C00108_C00632
C00156_C00230    C00180_C00805    C00223_C00323
C00223_C22070    C00230_C00587    C00230_C01424
C00328_C03227    C00389_C05903    C00389_C10107
C00398_C21762    C00406_C12203    C00406_C21459
C00423_C01772    C00463_C05658    C00468_C05298
C00483_C03758    C00509_C05631    C00530_C02814
C00544_C05593    C00587_C00628    C00590_C12205
C00642_C01161    C00799_C02921    C00811_C01197
C00814_C10520    C00814_C12135    C00852_C12208
 » show all
Related class
Enzyme     1.14.13.-     1.14.14.-       1.14.16.-       1.14.18.-      1.14.-.-
 » show all
rn00130  Ubiquinone and other terpenoid-quinone biosynthesis
rn00140  Steroid hormone biosynthesis
rn00350  Tyrosine metabolism
rn00360  Phenylalanine metabolism
rn00361  Chlorocyclohexane and chlorobenzene degradation
rn00362  Benzoate degradation
rn00363  Bisphenol degradation
rn00380  Tryptophan metabolism
rn00401  Novobiocin biosynthesis
rn00623  Toluene degradation
rn00624  Polycyclic aromatic hydrocarbon degradation
rn00627  Aminobenzoate degradation
rn00643  Styrene degradation
rn00760  Nicotinate and nicotinamide metabolism
rn00901  Indole alkaloid biosynthesis
rn00940  Phenylpropanoid biosynthesis
rn00941  Flavonoid biosynthesis
rn00943  Isoflavonoid biosynthesis
rn00944  Flavone and flavonol biosynthesis
rn00945  Stilbenoid, diarylheptanoid and gingerol biosynthesis
rn00950  Isoquinoline alkaloid biosynthesis
rn00965  Betalain biosynthesis
rn00980  Metabolism of xenobiotics by cytochrome P450
rn00982  Drug metabolism - cytochrome P450
rn00996  Biosynthesis of various alkaloids
rn00999  Biosynthesis of various plant secondary metabolites
rn01057  Biosynthesis of type II polyketide products
rn01059  Biosynthesis of enediyne antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
rn01240  Biosynthesis of cofactors
RM006  Dihydroxylation of aromatic ring, type 2 (two monooxygenase reactions)
RM007  Dihydroxylation of aromatic ring, type 3 (dealkylation and monooxygenase reactions)
RM012  Dihydroxylation and meta-cleavage of aromatic ring, type 3a
RM026  Hydoxylation and decarboxylation motif
RM027  Hydroxylation and methylation motif
RM029  Pterocarpan synthesis
K00422  polyphenol oxidase [EC:]
K00481  p-hydroxybenzoate 3-monooxygenase [EC:]
K00483  4-hydroxyphenylacetate 3-monooxygenase [EC:]
K00484  flavin reductase (NADH) [EC:]
K00486  kynurenine 3-monooxygenase [EC:]
K00501  tyrosine 3-monooxygenase [EC:]
K00505  tyrosinase [EC:]
K03380  phenol 2-monooxygenase (NADPH) [EC:]
K05280  flavonoid 3'-monooxygenase [EC:]
K06126  ubiquinone biosynthesis monooxygenase Coq6 [EC:1.14.13.-]
K06892  feruloyl-CoA 6-hydroxylase [EC:]
K07408  cytochrome P450 family 1 subfamily A1 [EC:]
K07409  cytochrome P450 family 1 subfamily A2 [EC:]
K07410  cytochrome P450 family 1 subfamily B1 [EC:]
K09754  5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase [EC:]
K09755  ferulate-5-hydroxylase [EC:1.14.-.-]
K10437  phenylacetate 2-hydroxylase [EC:]
K10438  3-hydroxyphenylacetate 6-hydroxylase [EC:]
K10676  2,4-dichlorophenol 6-monooxygenase [EC:]
K13083  flavonoid 3',5'-hydroxylase [EC:]
K13260  isoflavone/4'-methoxyisoflavone 2'-hydroxylase [EC:]
K13267  flavonoid 6-hydroxylase [EC:1.14.13.-]
K13385  N-methylcoclaurine 3'-monooxygenase [EC:]
K14338  cytochrome P450 / NADPH-cytochrome P450 reductase [EC:]
K14630  two-component flavin-dependent monooxygenase [EC:1.14.14.-]
K15930  bifunctional oxygenase/reductase
K15932  reductase LndZ4/LanZ4
K15933  oxygenase LndZ5/LanZ5
K15945  C-1 hydroxylase
K16242  phenol/toluene 2-monooxygenase (NADH) P3/A3 [EC:]
K16243  phenol/toluene 2-monooxygenase (NADH) P1/A1 [EC:]
K16244  phenol/toluene 2-monooxygenase (NADH) P2/A2 [EC:]
K16245  phenol/toluene 2-monooxygenase (NADH) P4/A4 [EC:]
K16246  phenol/toluene 2-monooxygenase (NADH) P5/A5 [EC:]
K16249  phenol/toluene 2-monooxygenase (NADH) P0/A0
K16901  anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase [EC:]
K16902  FAD reductase [NAD(P)H] [EC:]
K17689  cytochrome P450 family 3 subfamily A4 [EC: 1.14.14.-]
K18800  2-polyprenylphenol 6-hydroxylase [EC:]
K19065  3-hydroxybenzoate 4-monooxygenase [EC:]
K19189  2,6-dihydroxypyridine 3-monooxygenase [EC:]
K20208  3-methyl-L-tyrosine peroxygenase [EC:]
K20942  resorcinol 4-hydroxylase (FADH2) [EC:]
K20943  resorcinol 4-hydroxylase (NADPH) [EC:]
K20944  resorcinol 4-hydroxylase (NADH) [EC:]
K21184  two-component FAD-dependent monooxygenase [EC: 1.14.14.-]
K21205  bursehernin 5'-monooxygenase [EC:]
K21726  4-nitrophenol 2-monooxygenase / 4-nitrocatechol 4-monooxygenase, oxygenase component [EC:]
K21727  4-nitrophenol 2-monooxygenase / 4-nitrocatechol 4-monooxygenase, reductase component
K22270  3-hydroxybenzoate 6-monooxygenase [EC:]
K22434  tryptamine 4-monooxygenase [EC:]
K22932  isoflavone 3'-hydroxylase [EC:]
K23378  feruloyl-CoA 6-hydroxylase / trans-4-coumaroyl-CoA 2-hydroxylase [EC:]
K23470  4-hydroxyphenylacetate 3-hydroxylase, reductase component [EC:]
K23492  4-hydroxyphenylacetate 3-monooxygenase [EC:]
K24287  L-tyrosine peroxygenase [EC:]
K26037  tyrosine hydroxylase / L-DOPA oxygenase [EC:1.14.-.-]

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