KEGG   REACTION: R05127
Entry
R05127                      Reaction                               
Name
thebaine,2-oxoglutarate:oxygen oxidoreductase (3-O-demethylating)
Definition
Thebaine + 2-Oxoglutarate + Oxygen <=> Oripavine + Formaldehyde + Succinate + CO2
Equation
C06173 + C00026 + C00007 <=> C06175 + C00067 + C00042 + C00011
Reaction class
RC00392  C06173_C06175
RC01533  C00067_C06173
Enzyme
1.14.11.32
Pathway
rn00950  Isoquinoline alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00944  Morphine biosynthesis, (S)-reticuline => morphine
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.32
     R05127  Thebaine + 2-Oxoglutarate + Oxygen <=> Oripavine + Formaldehyde + Succinate + CO2
Orthology
K14975  codeine 3-O-demethylase [EC:1.14.11.32]
LinkDB

KEGG   RCLASS: RC00392
Entry
RC00392                     RClass                                 
Definition
O1a-O2a:*-C1a:C8y-C8y
Reactant pair
C00090_C01502    C00146_C01403    C00156_C02519
C00230_C06672    C00323_C00406    C00389_C04443
C00390_C21860    C00411_C12203    C00482_C05619
C00509_C05334    C00509_C09833    C00547_C05589
C00590_C12206    C00632_C05831    C00758_C01557
C00780_C05659    C00788_C05588    C00814_C06563
C00841_C01864    C00858_C10208    C00961_C03683
C00961_C03686    C00978_C01598    C01091_C04318
C01161_C05582    C01197_C01494    C01265_C04443
C01265_C04444    C01424_C05616    C01448_C10343
C01470_C01477    C01514_C04293    C01516_C06174
C01592_C02922    C01610_C02864    C01795_C05315
C01821_C05990    C01874_C03575    C01907_C12432
C02105_C05202    C02105_C17592    C02105_C20712
C02106_C04118    C02162_C02951    C02325_C12205
C02379_C02381    C02470_C05830    C02496_C21159
C02666_C10945    C02890_C04118    C02916_C06517
C03074_C22375    C03582_C20154    C03758_C05587
C03944_C20445    C04109_C04527    C04207_C04208
C04552_C04581    C04831_C18062    C05178_C09555
C05178_C17592    C05193_C05316    C05194_C05247
C05200_C05313    C05203_C05317    C05203_C06350
C05298_C05299    C05301_C05302    C05576_C05594
C05580_C05584    C05610_C12204    C05616_C10833
C05631_C09756    C05635_C05660    C05801_C05802
C05811_C05812    C05902_C05903    C05903_C10098
C06160_C06161    C06173_C06175    C06346_C06348
C06517_C06518    C06517_C06520    C06520_C21630
C06563_C10521    C07031_C07032    C07098_C11510
C07304_C21566    C08604_C12141    C08650_C15531
C09084_C22931    C09330_C11813    C09390_C09421
C09390_C21584    C09592_C09593    C09827_C16419
C10107_C12633    C10192_C19739    C10193_C19739
C10193_C19807    C10208_C12125    C10287_C20154
C10428_C20464    C10452_C16930    C10453_C10454
C10462_C17748    C10469_C10478    C10516_C16230
C10557_C21184    C11432_C11433    C11468_C21307
C11620_C12633    C11643_C11675    C11814_C11815
C12138_C12139    C12368_C12369    C12369_C12370
C12397_C12398    C12399_C12400    C12428_C12429
C12628_C12629    C14314_C14536    C14519_C18259
C15525_C16405    C15567_C16190    C15571_C15572
C15615_C15616    C16204_C16208    C16292_C16293
C16294_C16295    C16295_C16296    C16416_C16417
C16417_C21492    C16417_C22048    C16701_C16702
C16704_C16705    C16708_C16709    C16713_C16714
C17551_C17552    C17554_C17559    C17745_C17746
C18072_C18073    C18260_C18261    C18347_C18348
C19895_C19896    C20134_C20135    C20444_C20445
C20513_C20607    C20805_C20980    C20841_C20857
C20871_C20872    C21183_C21191    C21343_C21344
C21346_C21347    C21569_C21570    C21590_C21591
C21630_C21631    C21764_C22450    C22079_C22086
C22929_C22930
 » show all
Related class
Reaction
R00827 R01239 R01306 R01942 R02157 R02379 R02534 R02671
R02882 R02912 R02920 R02931 R02982 R03111 R03112 R03130
R03229 R03304 R03366 R03456 R03551 R03571 R03587 R03623
R03633 R03697 R03721 R03731 R03746 R03832 R03835 R03934
R03955 R04077 R04301 R04398 R04421 R04505 R04705 R04707
R04711 R04714 R04715 R04762 R04764 R04881 R04887 R04905
R04981 R04988 R05035 R05123 R05127 R05162 R05212 R05213
R05214 R05274 R05323 R05657 R05676 R05754 R05885 R05888
R05890 R06548 R06549 R06564 R06574 R06575 R06576 R06577
R06578 R06651 R06654 R06687 R06693 R06701 R06702 R06794
R06807 R06815 R06816 R06824 R07240 R07242 R07330 R07331
R07375 R07668 R07694 R07717 R07722 R07724 R07750 R07901
R07905 R07906 R08004 R08012 R08029 R08031 R08437 R08446
R08449 R08455 R08538 R08769 R08771 R08787 R08788 R08803
R08804 R08973 R08987 R09177 R09180 R09270 R09271 R09275
R09402 R09612 R09613 R09678 R09791 R09792 R09852 R09870
R09871 R10136 R10250 R10251 R10252 R10307 R10403 R10472
R10588 R10605 R10606 R10824 R10962 R10963 R11189 R11230
R11364 R11413 R11416 R11545 R11670 R11681 R11685 R11686
R11692 R11731 R11740 R12213 R12262 R12264 R12301 R12336
R12657 R12854 R13339 R13341
 » show all
Enzyme
1.14.11.32      1.14.13.82      1.14.14.1       1.14.14.-       
1.14.99.15      2.1.1.4         2.1.1.6         2.1.1.25        
2.1.1.26        2.1.1.38        2.1.1.42        2.1.1.46        
2.1.1.64        2.1.1.65        2.1.1.68        2.1.1.69        
2.1.1.70        2.1.1.75        2.1.1.76        2.1.1.78        
2.1.1.82        2.1.1.83        2.1.1.84        2.1.1.88        
2.1.1.89        2.1.1.94        2.1.1.104       2.1.1.105       
2.1.1.108       2.1.1.109       2.1.1.110       2.1.1.114       
2.1.1.116       2.1.1.117       2.1.1.118       2.1.1.119       
2.1.1.120       2.1.1.121       2.1.1.128       2.1.1.136       
2.1.1.146       2.1.1.150       2.1.1.153       2.1.1.154       
2.1.1.155       2.1.1.169       2.1.1.175       2.1.1.212       
2.1.1.222       2.1.1.231       2.1.1.232       2.1.1.240       
2.1.1.241       2.1.1.267       2.1.1.270       2.1.1.279       
2.1.1.283       2.1.1.291       2.1.1.292       2.1.1.293       
2.1.1.302       2.1.1.303       2.1.1.323       2.1.1.330       
2.1.1.336       2.1.1.338       2.1.1.339       2.1.1.341       
2.1.1.352       2.1.1.353       2.1.1.382       2.1.1.395       
2.1.1.396       2.1.1.397       2.1.1.-         3.3.2.14
 » show all
Pathway
rn00130  Ubiquinone and other terpenoid-quinone biosynthesis
rn00140  Steroid hormone biosynthesis
rn00254  Aflatoxin biosynthesis
rn00333  Prodigiosin biosynthesis
rn00350  Tyrosine metabolism
rn00362  Benzoate degradation
rn00380  Tryptophan metabolism
rn00402  Benzoxazinoid biosynthesis
rn00404  Staurosporine biosynthesis
rn00624  Polycyclic aromatic hydrocarbon degradation
rn00627  Aminobenzoate degradation
rn00860  Porphyrin metabolism
rn00901  Indole alkaloid biosynthesis
rn00940  Phenylpropanoid biosynthesis
rn00941  Flavonoid biosynthesis
rn00942  Anthocyanin biosynthesis
rn00943  Isoflavonoid biosynthesis
rn00944  Flavone and flavonol biosynthesis
rn00945  Stilbenoid, diarylheptanoid and gingerol biosynthesis
rn00950  Isoquinoline alkaloid biosynthesis
rn00965  Betalain biosynthesis
rn00982  Drug metabolism - cytochrome P450
rn00998  Biosynthesis of various antibiotics
rn00999  Biosynthesis of various plant secondary metabolites
rn01051  Biosynthesis of ansamycins
rn01057  Biosynthesis of type II polyketide products
rn01059  Biosynthesis of enediyne antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
rn01240  Biosynthesis of cofactors
RModule
RM007  Dihydroxylation of aromatic ring, type 3 (dealkylation and monooxygenase reactions)
RM027  Hydroxylation and methylation motif
Orthology
K00543  acetylserotonin O-methyltransferase [EC:2.1.1.4]
K00545  catechol O-methyltransferase [EC:2.1.1.6]
K00568  2-polyprenyl-6-hydroxyphenyl methylase / 3-demethylubiquinone-9 3-methyltransferase [EC:2.1.1.222 2.1.1.64]
K00588  caffeoyl-CoA O-methyltransferase [EC:2.1.1.104]
K00591  polyprenyldihydroxybenzoate methyltransferase / 3-demethylubiquinol 3-O-methyltransferase [EC:2.1.1.114 2.1.1.64]
K00599  tRNA N(3)-methylcytidine methyltransferase METTL6 [EC:2.1.1.-]
K03862  vanillate monooxygenase [EC:1.14.13.82]
K03863  vanillate monooxygenase ferredoxin subunit
K05279  flavonol 3-O-methyltransferase [EC:2.1.1.76]
K12635  O-demethylpuromycin O-methyltransferase [EC:2.1.1.38]
K13066  caffeic acid 3-O-methyltransferase / acetylserotonin O-methyltransferase [EC:2.1.1.68 2.1.1.4]
K13067  putative caffeoyl-CoA 3-O-methyltransferase [EC:2.1.1.-]
K13230  2,4,7-trihydroxy-1,4-benzoxazin-3-one-glucoside 7-O-methyltransferase [EC:2.1.1.241]
K13259  2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase / isoflavone 4'-O-methyltransferase [EC:2.1.1.212 2.1.1.46]
K13262  isoflavone-7-O-methyltransferase [EC:2.1.1.150]
K13272  flavonoid O-methyltransferase [EC:2.1.1.267]
K13383  (RS)-norcoclaurine 6-O-methyltransferase [EC:2.1.1.128]
K13386  3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase [EC:2.1.1.116]
K13390  (R,S)-reticuline 7-O-methyltransferase [EC:2.1.1.291]
K13397  (S)-scoulerine 9-O-methyltransferase [EC:2.1.1.117]
K13398  columbamine O-methyltransferase [EC:2.1.1.118]
K14975  codeine 3-O-demethylase [EC:1.14.11.32]
K15060  5,5'-dehydrodivanillate O-demethylase oxygenase subunit [EC:1.14.13.-]
K15064  syringate O-demethylase [EC:2.1.1.-]
K15066  vanillate/3-O-methylgallate O-demethylase [EC:2.1.1.341]
K15886  multifunctional cyclase / dehydratase / O-methyltransferase [EC:2.3.1.235]
K15954  carminomycin 4-O-methyltransferase [EC:2.1.1.292]
K15970  8-O-methyltransferase
K16034  20-O-methyltransferase
K17057  (iso)eugenol O-methyltransferase [EC:2.1.1.146]
K17058  eugenol/chavicol O-methyltransferase [EC:2.1.1.146]
K17059  trans-anol O-methyltransferase [EC:2.1.1.279]
K17649  demethylsterigmatocystin 6-O-methyltransferase [EC:2.1.1.109]
K17650  sterigmatocystin 8-O-methyltransferase [EC:2.1.1.110]
K17712  cytochrome P450 family 2 subfamily D6 [EC:1.14.14.1]
K18280  6-hydroxytryprostatin B O-methyltransferase [EC:2.1.1.293]
K20421  2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase [EC:2.1.1.303]
K21178  O-methyltransferase [EC:2.1.1.-]
K21203  (-)-pluviatolide 4-O-methyltransferase [EC:2.1.1.323]
K21204  5'-demethylyatein 5'-O-methyltransferase [EC:2.1.1.330]
K21255  orsellinic acid C2-O-methyltransferase [EC:2.1.1.-]
K21258  orsellinic acid C3-O-methyltransferase [EC:2.1.1.-]
K21311  norbelladine O-methyltransferase [EC:2.1.1.336]
K21513  (+)-6a-hydroxymaackiain 3-O-methyltransferase [EC:2.1.1.270]
K21550  5-hydroxyfuranocoumarin 5-O-methyltransferase [EC:2.1.1.69]
K21581  desmethylxanthohumol 6'-O-methyltransferase [EC:2.1.1.338]
K21582  xanthohumol 4'-O-methyltransferase [EC:2.1.1.339]
K21786  4-hydroxy-2,2'-bipyrrole-5-carbaldehyde O-methyltransferase [EC:2.1.1.-]
K21895  tabersonine 16-O-methyltransferase [EC:2.1.1.94]
K22088  norreticuline-7-O-methyltransferase [EC:2.1.1.-]
K22091  7'-O-demethylcephaeline/cephaeline O-methyltransferase [EC:2.1.1.395 2.1.1.396 2.1.1.-]
K22440  naringenin 7-O-methyltransferase [EC:2.1.1.232]
K22553  4-methoxybenzoate monooxygenase (O-demethylating) [EC:1.14.99.15]
K22588  acetylserotonin O-methyltransferase, plant [EC:2.1.1.4]
K23053  flavonoid 4'-O-methyltransferase [EC:2.1.1.231]
K23157  3-O-acetyl-4'-O-demethylpapaveroxine 4'-O-methyltransferase subunit OMT2 [EC:2.1.1.352]
K23158  3-O-acetyl-4'-O-demethylpapaveroxine 4'-O-methyltransferase subunit OMT3
K23394  demethylluteothin O-methyltransferase [EC:2.1.1.353]
K23526  aromatic O-demethylase, cytochrome P450 subunit [EC:1.14.14.-]
K23527  aromatic O-demethylase, reductase subunit [EC:1.6.2.-]
K24244  5,5'-dehydrodivanillate O-demethylase ferredoxin subunit
K24245  5,5'-dehydrodivanillate O-demethylase ferredoxin reductase subunit [EC:1.18.1.-]
K25497  5-hydroxybenzimidazole methyltransferase [EC:2.1.1.-]
K25916  methoxylated aromatic compound---corrinoid protein Co-methyltransferase [EC:2.1.1.382]
K27675  4-hydroxy-2,2'-bipyrrole-5-carbaldehyde O-methyltransferase [EC:2.1.1.-]
K27787  hydroxystrychnine O-methyltransferase [EC:2.1.1.397]

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