KEGG   PATHWAY: bbut04820
Entry
bbut04820                   Pathway                                
Name
Cytoskeleton in muscle cells - Buteo buteo (common buzzard)
Class
Cellular Processes; Cell motility
Pathway map
bbut04820  Cytoskeleton in muscle cells
bbut04820

Organism
Buteo buteo (common buzzard) [GN:bbut]
Gene
142025690  SDC4; syndecan-4 isoform X1 [KO:K16338]
142025692  SPTBN2; spectrin beta chain, non-erythrocytic 2 [KO:K23932]
142025810  [KO:K17751]
142025939  [KO:K17751]
142026078  [KO:K12758]
142026188  COL11A2; collagen alpha-2(XI) chain isoform X1 [KO:K19721]
142026533  FBN2; fibrillin-2 [KO:K23342]
142026540  THBS4; thrombospondin-4 [KO:K04659]
142026812  LMNB1; lamin-B1 [KO:K07611]
142027057  COL9A3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
142027115  ITGA2; integrin alpha-2 [KO:K06481]
142027173  SPTBN4; spectrin beta chain, non-erythrocytic 4 [KO:K06115]
142027213  TMOD1; tropomodulin-1 isoform X1 [KO:K10370]
142027272  ITGA1; integrin alpha-1 [KO:K06480]
142027332  TPM2; tropomyosin beta chain isoform X1 [KO:K10374]
142027348  VCAN; versican core protein isoform X1 [KO:K06793]
142027378  TLN1; talin-1 isoform X1 [KO:K06271]
142027385  CKM; creatine kinase M-type [KO:K27382]
142027972  [KO:K17751]
142028426  [KO:K01539] [EC:7.2.2.13]
142028502  TNNC2; troponin C, skeletal muscle [KO:K12042]
142028505  [KO:K24220]
142028956  LAMA1; laminin subunit alpha-1 [KO:K05637]
142028965  MYOM1; myomesin-1 isoform X1 [KO:K24495]
142029013  [KO:K07601]
142029016  DSG2; desmoglein-2 [KO:K07597]
142029026  DTNA; dystrobrevin alpha isoform X1 [KO:K26998]
142029088  TRIM55; tripartite motif-containing protein 55 isoform X1 [KO:K10654]
142029197  SDC2; syndecan-2 [KO:K16336]
142029278  SNTB1; beta-1-syntrophin [KO:K24064]
142029371  PLEC; plectin isoform X1 [KO:K10388]
142029667  FLNC; filamin-C isoform X1 [KO:K27393]
142029848  LMOD2; leiomodin-2 isoform X1 [KO:K22030]
142029929  COL5A3; collagen alpha-3(V) chain isoform X1 [KO:K19721]
142029985  MYPN; myopalladin [KO:K22028]
142030078  ANK3; ankyrin-3 [KO:K09259]
142030089  LDB3; LIM domain-binding protein 3 isoform X1 [KO:K19867]
142030137  VCL; vinculin isoform X1 [KO:K05700]
142030149  SGCB; beta-sarcoglycan [KO:K12566]
142030155  MYOZ1; myozenin-1 isoform X1 [KO:K26050]
142030166  PDLIM1; PDZ and LIM domain protein 1 isoform X1 [KO:K23353]
142030207  C4H10orf71; cardiac-enriched FHL2-interacting protein [KO:K28413]
142030227  ANKRD1; ankyrin repeat domain-containing protein 1 [KO:K21433]
142030363  NRAP; nebulin-related-anchoring protein isoform X1 [KO:K24421]
142030441  SGCZ; zeta-sarcoglycan [KO:K27062]
142030675  ANKRD2; ankyrin repeat domain-containing protein 2 [KO:K21434]
142030862  AGRN; agrin isoform X1 [KO:K06254]
142030870  ENO1; alpha-enolase isoform X1 [KO:K01689] [EC:4.2.1.11]
142030886  PDLIM3; PDZ and LIM domain protein 3 isoform X1 [KO:K23353]
142030956  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
142030978  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X1 [KO:K06255]
142031034  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
142031037  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
142031054  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
142031064  FN1; fibronectin isoform X1 [KO:K05717]
142031073  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
142031088  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
142031098  COL3A1; collagen alpha-1(III) chain [KO:K19720]
142031099  COL5A2; collagen alpha-2(V) chain [KO:K19721]
142031219  ITGA4; LOW QUALITY PROTEIN: integrin alpha-4 [KO:K06483]
142031228  [KO:K12567] [EC:2.7.11.1]
142031271  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
142031328  ITGB6; integrin beta-6 [KO:K06589]
142031340  DES; desmin [KO:K07610]
142031415  ITGB5; integrin beta-5 [KO:K06588]
142031495  NEB; nebulin isoform X1 [KO:K18267]
142031504  FMNL2; formin-like protein 2 isoform X1 [KO:K23957]
142031793  NID2; nidogen-2 [KO:K06826]
142031846  DAAM1; disheveled-associated activator of morphogenesis 1 [KO:K04512]
142031868  SYNE2; nesprin-2 isoform X1 [KO:K19346]
142031893  INF2; inverted formin-2 [KO:K23958]
142031960  SYNE3; nesprin-3 isoform X1 [KO:K21761]
142032138  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
142032157  THBS1; thrombospondin-1 [KO:K16857]
142032235  CAPN3; calpain-3 isoform X1 [KO:K08573] [EC:3.4.22.54]
142032246  SPTBN5; spectrin beta chain, non-erythrocytic 5 [KO:K06115]
142032284  [KO:K19867]
142032288  [KO:K19867]
142032305  MYBPC3; myosin-binding protein C, cardiac-type [KO:K12568]
142032747  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 isoform X1 [KO:K01540]
142032766  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
142032768  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
142032959  ELN; elastin isoform X1 [KO:K14211]
142033553  DMD; dystrophin isoform X1 [KO:K10366]
142033773  MYH15; myosin-15 [KO:K24220]
142033826  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
142033869  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
142033948  ENO2; gamma-enolase isoform X1 [KO:K01689] [EC:4.2.1.11]
142033962  ZYX; zyxin isoform X1 [KO:K06273]
142034316  SPTBN1; spectrin beta chain, non-erythrocytic 1 isoform X1 [KO:K06115]
142034424  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
142034515  SYNE1; nesprin-1 isoform X1 [KO:K19326]
142034617  FMNL1; formin-like protein 1 isoform X1 [KO:K23957]
142034640  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
142034674  COL1A1; collagen alpha-1(I) chain [KO:K06236]
142034677  SGCA; alpha-sarcoglycan isoform X1 [KO:K12565]
142034679  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
142034749  TCAP; telethonin [KO:K19879]
142034780  JUP; junction plakoglobin [KO:K10056]
142035049  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
142035061  [KO:K12750]
142035393  MYOZ2; myozenin-2 [KO:K26050]
142035409  SYNPO2; synaptopodin-2 [KO:K24066]
142035530  ANK2; ankyrin-2 isoform X1 [KO:K09255]
142035639  COMP; cartilage oligomeric matrix protein [KO:K04659]
142035689  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
142035718  FBN3; fibrillin-3 [KO:K23342]
142035802  LMNB2; lamin-B2 isoform X1 [KO:K07611]
142035979  COL11A1; collagen alpha-1(XI) chain [KO:K19721]
142036084  COL24A1; collagen alpha-1(XXIV) chain isoform X1 [KO:K19721]
142036432  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
142036524  SNTB2; beta-2-syntrophin [KO:K24064]
142036907  [KO:K01539] [EC:7.2.2.13]
142036938  TMOD4; tropomodulin-4 [KO:K10370]
142036956  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
142037044  LMNA; lamin [KO:K12641]
142037054  TPM3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
142037072  THBS3; thrombospondin-3 [KO:K04659]
142037645  PDLIM2; PDZ and LIM domain protein 2 [KO:K23353]
142037704  FMN2; formin-2 [KO:K02184]
142037766  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 isoform X1 [KO:K01540]
142037883  LBR; delta(14)-sterol reductase LBR isoform X1 [KO:K19532] [EC:1.3.1.70]
142038005  DAAM2; disheveled-associated activator of morphogenesis 2 [KO:K04512]
142038130  ACTN2; alpha-actinin-2 [KO:K21073]
142038135  NID1; nidogen-1 isoform X1 [KO:K06826]
142038168  ACTA1; actin, alpha skeletal muscle [KO:K10354]
142038192  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
142038260  [KO:K06238]
142038301  MYL3; myosin light chain 3 [KO:K12749]
142038327  ACTG2; actin, gamma-enteric smooth muscle [KO:K12315]
142038366  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
142038541  OBSCN; obscurin isoform X1 [KO:K17531] [EC:2.7.11.1]
142038633  ACTG1; actin, cytoplasmic 2 isoform X1 [KO:K05692]
142038783  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
142038815  XIRP1; xin actin-binding repeat-containing protein 1 [KO:K27381]
142038833  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
142038886  [KO:K24220]
142038887  [KO:K24220]
142038888  [KO:K24220]
142038889  [KO:K24220]
142038890  [KO:K24220]
142038891  [KO:K24220]
142038892  [KO:K24220]
142038893  [KO:K24220]
142038894  [KO:K24220]
142038895  [KO:K24220]
142038896  [KO:K24220]
142038908  MYH10; myosin-10 [KO:K10352]
142039036  [KO:K07611]
142039070  FBN1; fibrillin-1 [KO:K06825]
142039084  [KO:K10370]
142039085  [KO:K10370]
142039163  TLN2; talin-2 isoform X1 [KO:K06271]
142039165  TPM1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
142039227  [KO:K05692]
142039515  DIAPH3; protein diaphanous homolog 3 [KO:K05745]
142039562  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
142039679  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
142040017  FHL3; four and a half LIM domains protein 3 isoform X1 [KO:K24414]
142040058  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
142040119  MYOM3; myomesin-3 [KO:K24495]
142040145  TRIM63; E3 ubiquitin-protein ligase TRIM63 isoform X1 [KO:K10655] [EC:2.3.2.27]
142040194  SDC3; syndecan-3 [KO:K16337]
142040243  NEBL; nebulette isoform X1 [KO:K25865]
142040258  TNNI2; troponin I, fast skeletal muscle [KO:K12043]
142040260  TNNT3; troponin T, fast skeletal muscle isoform X1 [KO:K12046]
142040327  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
142040387  CSRP3; cysteine and glycine-rich protein 3 isoform X1 [KO:K09377]
142040391  VIM; vimentin [KO:K07606]
142040408  [KO:K12314]
142040489  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
142040807  SDC1; syndecan-1 [KO:K06257]
142040894  MYOM2; myomesin-2 isoform X1 [KO:K24495]
142040991  COL1A2; collagen alpha-2(I) chain [KO:K06236]
142040994  FMNL3; formin-like protein 3 isoform X1 [KO:K23957]
142041006  SGCE; LOW QUALITY PROTEIN: epsilon-sarcoglycan [KO:K27061]
142041018  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
142041042  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
142041125  TRIM54; tripartite motif-containing protein 54 [KO:K10653]
142041231  ITGB7; LOW QUALITY PROTEIN: integrin beta-7 [KO:K06590]
142041533  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
142041666  SGCG; gamma-sarcoglycan isoform X1 [KO:K12564]
142041827  PKP2; plakophilin-2 isoform X1 [KO:K12642]
142042014  SUN2; SUN domain-containing protein 2 [KO:K19347]
142042016  MYH9; myosin-9 [KO:K10352]
142042043  SSPN; sarcospan [KO:K22194]
142042045  MYBPC1; myosin-binding protein C, slow-type isoform X1 [KO:K12557]
142042174  FBLN1; fibulin-1 isoform X1 [KO:K17307]
142042203  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
142042270  DSP; desmoplakin isoform X1 [KO:K10381]
142042537  FBLN2; fibulin-2 [KO:K17307]
142042583  TMEM43; transmembrane protein 43 [KO:K27488]
142042648  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
142042799  DAG1; dystroglycan 1 [KO:K06265]
142042877  LMOD3; leiomodin-3 [KO:K22030]
142043022  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
142043023  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
142043075  FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365]
142043106  ITGA9; integrin alpha-9 [KO:K06585]
142043170  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05745]
142043284  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
142043434  COL27A1; collagen alpha-1(XXVII) chain isoform X1 [KO:K19721]
142043653  TNNT2; troponin T, cardiac muscle isoform X1 [KO:K12045]
142043654  TNNI1; troponin I, slow skeletal muscle [KO:K10371]
142043666  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
142043701  CSRP1; cysteine and glycine-rich protein 1 [KO:K09377]
142043788  LMOD1; leiomodin-1 [KO:K22030]
142043860  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
142043953  SPTAN1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
142043956  COL5A1; collagen alpha-1(V) chain isoform X1 [KO:K19721]
142043970  AMPD1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
142044018  [KO:K19721]
142044092  MYBPH; myosin-binding protein H [KO:K24494]
142044131  PDLIM7; PDZ and LIM domain protein 7 [KO:K19867]
142044179  PDLIM4; PDZ and LIM domain protein 4 [KO:K23353]
142044382  MYOZ3; myozenin-3 [KO:K26050]
142044477  SGCD; delta-sarcoglycan isoform X1 [KO:K12563]
142044507  MYOT; myotilin isoform X1 [KO:K19875]
142044770  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
142044771  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
142044790  FHL2; four and a half LIM domains protein 2 [KO:K14380]
142044954  CSRP2; cysteine and glycine-rich protein 2 [KO:K09377]
142045034  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
142045037  DCN; decorin [KO:K04660]
142045109  ACTB; actin, cytoplasmic 1 isoform X1 [KO:K05692]
142045226  SUN1; SUN domain-containing protein 1 isoform X1 [KO:K19347]
142045445  SNTA1; alpha-1-syntrophin [KO:K24063]
142045449  MYH11; myosin-11 isoform X1 [KO:K10352]
142045453  MYH7B; myosin-7B [KO:K24220]
142045535  CAPZA2; F-actin-capping protein subunit alpha-2 isoform X1 [KO:K10364]
Reference
  Authors
Clark KA, McElhinny AS, Beckerle MC, Gregorio CC
  Title
Striated muscle cytoarchitecture: an intricate web of form and function.
  Journal
Annu Rev Cell Dev Biol 18:637-706 (2002)
DOI:10.1146/annurev.cellbio.18.012502.105840
Reference
  Authors
Mukund K, Subramaniam S
  Title
Skeletal muscle: A review of molecular structure and function, in health and disease.
  Journal
Wiley Interdiscip Rev Syst Biol Med 12:e1462 (2020)
DOI:10.1002/wsbm.1462
Reference
  Authors
Stroud MJ, Banerjee I, Veevers J, Chen J
  Title
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
  Journal
Circ Res 114:538-48 (2014)
DOI:10.1161/CIRCRESAHA.114.301236
Reference
  Authors
Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC
  Title
Overview of the Muscle Cytoskeleton.
  Journal
Compr Physiol 7:891-944 (2017)
DOI:10.1002/cphy.c160033
Reference
  Authors
Csapo R, Gumpenberger M, Wessner B
  Title
Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review.
  Journal
Front Physiol 11:253 (2020)
DOI:10.3389/fphys.2020.00253
Reference
  Authors
Pinch M, Guth R, Samanta MP, Chaidez A, Unguez GA
  Title
The myogenic electric organ of Sternopygus macrurus: a non-contractile tissue with a skeletal muscle transcriptome.
  Journal
PeerJ 4:e1828 (2016)
DOI:10.7717/peerj.1828
Reference
  Authors
Sequeira V, Nijenkamp LL, Regan JA, van der Velden J
  Title
The physiological role of cardiac cytoskeleton and its alterations in heart failure.
  Journal
Biochim Biophys Acta 1838:700-22 (2014)
DOI:10.1016/j.bbamem.2013.07.011
Reference
  Authors
Zhang B, Powers JD, McCulloch AD, Chi NC
  Title
Nuclear mechanosignaling in striated muscle diseases.
  Journal
Front Physiol 14:1126111 (2023)
DOI:10.3389/fphys.2023.1126111
Reference
  Authors
Al-Amoudi A, Castano-Diez D, Devos DP, Russell RB, Johnson GT, Frangakis AS
  Title
The three-dimensional molecular structure of the desmosomal plaque.
  Journal
Proc Natl Acad Sci U S A 108:6480-5 (2011)
DOI:10.1073/pnas.1019469108
Reference
  Authors
Sikora M, Ermel UH, Seybold A, Kunz M, Calloni G, Reitz J, Vabulas RM, Hummer G, Frangakis AS
  Title
Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography.
  Journal
Proc Natl Acad Sci U S A 117:27132-27140 (2020)
DOI:10.1073/pnas.2004563117
Reference
  Authors
Xu XP, Kim E, Swift M, Smith JW, Volkmann N, Hanein D
  Title
Three-Dimensional Structures of Full-Length, Membrane-Embedded Human alpha(IIb)beta(3) Integrin Complexes.
  Journal
Biophys J 110:798-809 (2016)
DOI:10.1016/j.bpj.2016.01.016
Reference
  Authors
Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z
  Title
Structural insights into SUN-KASH complexes across the nuclear envelope.
  Journal
Cell Res 22:1440-52 (2012)
DOI:10.1038/cr.2012.126
Reference
  Authors
Sosa BA, Kutay U, Schwartz TU
  Title
Structural insights into LINC complexes.
  Journal
Curr Opin Struct Biol 23:285-91 (2013)
DOI:10.1016/j.sbi.2013.03.005
Reference
  Authors
Cruz VE, Esra Demircioglu F, Schwartz TU
  Title
Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
  Journal
J Mol Biol 432:6028-6041 (2020)
DOI:10.1016/j.jmb.2020.09.019
Reference
  Authors
Schuler SC, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D, Bentzinger CF
  Title
Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.
  Journal
Front Cell Dev Biol 10:1056523 (2022)
DOI:10.3389/fcell.2022.1056523
Reference
  Authors
Brull A, Morales Rodriguez B, Bonne G, Muchir A, Bertrand AT
  Title
The Pathogenesis and Therapies of Striated Muscle Laminopathies.
  Journal
Front Physiol 9:1533 (2018)
DOI:10.3389/fphys.2018.01533
Reference
  Authors
Storey EC, Fuller HR
  Title
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary.
  Journal
Cells 11:cells11244065 (2022)
DOI:10.3390/cells11244065
Related
pathway
bbut04512  ECM-receptor interaction
bbut04814  Motor proteins
KO pathway
ko04820   

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