KEGG   PATHWAY: cbor04514
Entry
cbor04514                   Pathway                                
Name
Cell adhesion molecules - Calonectris borealis (Cory's shearwater)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
cbor04514  Cell adhesion molecules
cbor04514

Other DBs
GO: 0050839
Organism
Calonectris borealis (Cory's shearwater) [GN:cbor]
Gene
142073561  MPZ; myelin protein P0 [KO:K06770]
142073663  NLGN4X; neuroligin-4, X-linked isoform X1 [KO:K07378]
142073741  [KO:K06520]
142074137  [KO:K06751]
142074139  [KO:K06752]
142074140  [KO:K06752]
142074141  [KO:K06752]
142074142  [KO:K06752]
142074143  [KO:K06752]
142074300  L1CAM; neural cell adhesion molecule L1 [KO:K06550]
142074361  CD22; B-cell receptor CD22 [KO:K06467]
142074364  MAG; myelin-associated glycoprotein [KO:K06771]
142074430  CLDN7; claudin-7 [KO:K06087]
142074458  [KO:K07378]
142074489  [KO:K07377]
142075937  PTPRD; receptor-type tyrosine-protein phosphatase delta [KO:K06777] [EC:3.1.3.48]
142075955  VCAN; versican core protein isoform X1 [KO:K06793]
142075986  [KO:K06708]
142075987  [KO:K06745]
142076086  CLDN10; claudin-10 isoform X1 [KO:K06087]
142076134  SLITRK5; SLIT and NTRK-like protein 5 isoform X1 [KO:K25836]
142076495  LRRC4B; leucine-rich repeat-containing protein 4B [KO:K16360]
142077650  [KO:K06590]
142077692  SLITRK6; SLIT and NTRK-like protein 6 [KO:K25837]
142077699  SLITRK1; SLIT and NTRK-like protein 1 [KO:K25832]
142077772  CLDN34; claudin-34 [KO:K06087]
142077873  XG; glycoprotein Xg [KO:K06520]
142078557  LRRC4; leucine-rich repeat-containing protein 4 [KO:K16351]
142078620  SDC2; syndecan-2 [KO:K16336]
142078806  CDH2; cadherin-2 isoform X1 [KO:K06736]
142078858  PTPRM; receptor-type tyrosine-protein phosphatase mu [KO:K05693] [EC:3.1.3.48]
142078899  CD226; CD226 antigen [KO:K06567]
142079183  CNTNAP2; contactin-associated protein-like 2 [KO:K07380]
142079220  ITGA9; integrin alpha-9 [KO:K06585]
142079424  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
142079504  CLDN12; claudin-12 isoform X1 [KO:K06087]
142079518  ITGA8; integrin alpha-8 [KO:K06584]
142079593  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
142080113  SDC1; syndecan-1 [KO:K06257]
142080536  CLDN20; claudin-20 [KO:K06087]
142080980  NRXN1; neurexin-1 isoform X1 [KO:K07377]
142081143  NRCAM; neuronal cell adhesion molecule isoform X1 [KO:K06756]
142081174  CNTN1; contactin-1 [KO:K06759]
142081641  CD8B; LOW QUALITY PROTEIN: T-cell surface glycoprotein CD8 beta chain [KO:K06459]
142081642  CD8A; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
142081917  [KO:K06087]
142082376  SIGLEC1; sialoadhesin [KO:K06548]
142082455  [KO:K06087]
142082472  CLDN23; claudin-23 [KO:K06087]
142082818  [KO:K07377]
142083151  LRRC4C; leucine-rich repeat-containing protein 4C [KO:K07523]
142083600  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
142083643  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
142083659  CD28; T-cell-specific surface glycoprotein CD28 isoform X1 [KO:K06470]
142083660  ICOS; inducible T-cell costimulator [KO:K06713]
142083763  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
142083831  ITGB2; integrin beta-2 [KO:K06464]
142083927  CTLA4; cytotoxic T-lymphocyte protein 4 [KO:K06538]
142084076  VSIR; V-type immunoglobulin domain-containing suppressor of T-cell activation [KO:K23268]
142084679  NEGR1; neuronal growth regulator 1 [KO:K06775]
142084871  PTPRF; receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:3.1.3.48]
142085012  NTNG1; netrin-G1 isoform X1 [KO:K07522]
142085038  PTPRC; receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]
142085071  [KO:K06496]
142085120  [KO:K06494]
142085273  VCAM1; vascular cell adhesion protein 1 [KO:K06527]
142085337  CLDN1; claudin-1 [KO:K06087]
142085440  NLGN1; neuroligin-1 isoform X1 [KO:K07378]
142085553  CLDN18; claudin-18 isoform X1 [KO:K06087]
142085584  CLDN16; claudin-16 [KO:K06087]
142085586  PDCD1; programmed cell death protein 1 [KO:K06744]
142085605  CLDN11; claudin-11 isoform X1 [KO:K06087]
142085607  SLITRK3; SLIT and NTRK-like protein 3 [KO:K25834]
142085777  [KO:K06087]
142086507  NEO1; neogenin [KO:K06766]
142086882  CD276; CD276 antigen [KO:K06746]
142087038  [KO:K06796]
142087133  GLG1; Golgi apparatus protein 1 isoform X1 [KO:K06816]
142087205  CDH15; cadherin-15 [KO:K06809]
142087319  CDH5; cadherin-5 [KO:K06533]
142087418  [KO:K05689]
142087509  CLDN2; claudin-2 [KO:K06087]
142087512  SLITRK4; SLIT and NTRK-like protein 4 [KO:K25835]
142087513  SLITRK2; SLIT and NTRK-like protein 2 [KO:K25833]
142087621  CD40LG; CD40 ligand [KO:K03161]
142087672  NLGN3; neuroligin-3 isoform X1 [KO:K07378]
142087732  CD99L2; CD99 antigen-like protein 2 [KO:K06520]
142088304  CD6; T-cell differentiation antigen CD6 [KO:K06456]
142088898  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
142089342  CD86; T-lymphocyte activation antigen CD86 [KO:K05413]
142089596  VTCN1; V-set domain-containing T-cell activation inhibitor 1 isoform X1 [KO:K06747]
142089690  SDC4; syndecan-4 [KO:K16338]
142089744  CD58; lymphocyte function-associated antigen 3 isoform X1 [KO:K06492]
142089766  CDH4; cadherin-4 [KO:K06797]
142089844  IGSF11; immunoglobulin superfamily member 11 isoform X1 [KO:K06791]
142089896  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
142089974  CLDN5; claudin-5 [KO:K06087]
142090141  SELPLG; P-selectin glycoprotein ligand 1 [KO:K06544]
142090505  ALCAM; CD166 antigen [KO:K06547]
142090683  NECTIN3; nectin-3 isoform X1 [KO:K06592]
142090786  [KO:K06087]
142090787  [KO:K06087]
142090788  [KO:K06087]
142090941  PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
142091098  CD2; T-cell surface antigen CD2 isoform X1 [KO:K06449]
142091120  [KO:K05412]
142091393  NTNG2; netrin-G2 [KO:K16359]
142091394  CXADR; coxsackievirus and adenovirus receptor isoform X1 [KO:K06788]
142091402  NCAM2; neural cell adhesion molecule 2 [KO:K06491]
142091436  JAM2; junctional adhesion molecule B [KO:K06735]
142091804  CNTNAP1; contactin-associated protein 1 [KO:K07379]
142092235  CLDN19; claudin-19 [KO:K06087]
142092236  [KO:K06087]
142092524  NECTIN1; nectin-1 [KO:K06081]
142092540  [KO:K28137]
142092605  CLDN25; claudin-25 [KO:K06087]
142092607  CADM1; cell adhesion molecule 1 isoform X1 [KO:K06781]
142092636  NCAM1; neural cell adhesion molecule 1 isoform X1 [KO:K06491]
142092695  JAM3; junctional adhesion molecule C [KO:K06785]
142092730  ESAM; endothelial cell-selective adhesion molecule [KO:K06787]
142092948  SDC3; syndecan-3 [KO:K16337]
142092959  ICOSLG; ICOS ligand [KO:K06710]
142093066  CD34; hematopoietic progenitor cell antigen CD34 isoform X1 [KO:K06474]
142093091  [KO:K06087]
142093166  [KO:K06087]
142093182  NFASC; neurofascin [KO:K06757]
142093383  CNTN2; contactin-2 [KO:K06760]
142093525  CLDN14; claudin-14 [KO:K06087]
142093691  MADCAM1; mucosal addressin cell adhesion molecule 1 [KO:K06779]
142093934  OCLN; occludin [KO:K06088]
142094011  PTPRS; receptor-type tyrosine-protein phosphatase S isoform X1 [KO:K06778] [EC:3.1.3.48]
142094313  F11R; junctional adhesion molecule A [KO:K06089]
142094319  CADM3; cell adhesion molecule 3 isoform X1 [KO:K06780]
Reference
PMID:14690046
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
PMID:11910893
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
PMID:16034094
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
PMID:12234363
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
PMID:15071551
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
PMID:14519386
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
PMID:10798271
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
PMID:12810109
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
PMID:14519398
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
PMID:15882774
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
PMID:11050419
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
PMID:11860281
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
PMID:10964748
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
PMID:12367625
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
PMID:10664064
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
PMID:14556710
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15115723
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
PMID:15056568
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
PMID:15728677
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
PMID:12500939
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
PMID:15923648
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
cbor04520  Adherens junction
cbor04530  Tight junction
KO pathway
ko04514   

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