KEGG   PATHWAY: cmk00230
Entry
cmk00230                    Pathway                                
Name
Purine metabolism - Callorhinchus milii (elephant shark)
Class
Metabolism; Nucleotide metabolism
Pathway map
cmk00230  Purine metabolism
cmk00230

Module
cmk_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:cmk00230]
cmk_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:cmk00230]
cmk_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:cmk00230]
cmk_M00546  Purine degradation, xanthine => urea [PATH:cmk00230]
cmk_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:cmk00230]
cmk_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:cmk00230]
Other DBs
GO: 0006163 0042278
Organism
Callorhinchus milii (elephant shark) [GN:cmk]
Gene
103175697  adprm; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
103187912  nudt5; ADP-sugar pyrophosphatase isoform X1 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
103188820  pgm1; LOW QUALITY PROTEIN: phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
103175848  pgm2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
103177083  prps1b; ribose-phosphate pyrophosphokinase 1 isoform X1 [KO:K00948] [EC:2.7.6.1]
103177588  ribose-phosphate pyrophosphokinase 2 [KO:K00948] [EC:2.7.6.1]
103178179  ppat; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
103186759  gart; trifunctional purine biosynthetic protein adenosine-3 isoform X3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
103179643  pfas; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
103178180  paics; multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
103176558  atic; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
103175989  aprt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
103177797  snake venom 5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
103174884  cytosolic 5'-nucleotidase 1A-like [KO:K01081] [EC:3.1.3.5]
103175656  5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
103187790  cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
103179629  cytosolic 5'-nucleotidase 1A-like [KO:K01081] [EC:3.1.3.5]
103190706  cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
103183152  cytosolic 5'-nucleotidase 1A-like [KO:K01081] [EC:3.1.3.5]
103183128  cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
103187091  5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
103179254  nt5e; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
103188631  pnp4a; purine nucleoside phosphorylase 4a [KO:K03783] [EC:2.4.2.1]
103191171  pnp6; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
103177523  purine nucleoside phosphorylase LACC1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
103178054  hprt1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
103176703  inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
103190184  inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
103177441  nme7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
103178756  nme4; nucleoside diphosphate kinase, mitochondrial isoform X1 [KO:K00940] [EC:2.7.4.6]
103188966  nucleoside diphosphate kinase-like [KO:K00940] [EC:2.7.4.6]
103173752  nme6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
103186051  nme3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
103178249  ak9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
103181555  ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
103181556  ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
103181557  ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
103182999  ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
103183097  LOW QUALITY PROTEIN: ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
103183098  ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
103189973  entpd1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
103175547  cant1a; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
103188915  ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
103191300  entpd4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
103179204  entpd6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
103186794  entpd5a; ectonucleoside triphosphate diphosphohydrolase 5 isoform X1 [KO:K01511] [EC:3.6.1.6]
103191283  zgc:103759; U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
103180021  itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
103182679  xanthine dehydrogenase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
103187630  xdh; xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
103180986  nudt2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
103176403  gmps; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
103184551  GMP reductase 1 isoform X1 [KO:K00364] [EC:1.7.1.7]
103174276  GMP reductase 2 [KO:K00364] [EC:1.7.1.7]
121848082  GMP reductase 2 [KO:K00364] [EC:1.7.1.7]
103187202  gda; guanine deaminase [KO:K01487] [EC:3.5.4.3]
103188294  guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
103191328  rrm1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
103185624  rrm2; ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:1.17.4.1]
103180951  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
103182308  hddc2; HD domain-containing protein 2 isoform X1 [KO:K07023] [EC:3.1.3.89]
103186473  zgc:110540; deoxynucleoside kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
103191301  deoxycytidine kinase 2 [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
103188503  hddc3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
103187011  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
103183192  adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
103189036  adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
103176081  adcy7; LOW QUALITY PROTEIN: adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
103183440  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
103178726  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
103176565  adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
103185780  gucy1a2; LOW QUALITY PROTEIN: guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
103187183  gucy1a1; LOW QUALITY PROTEIN: guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
103187184  gucy1b1; guanylate cyclase soluble subunit beta-1 isoform X2 [KO:K12319] [EC:4.6.1.2]
103187614  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
121849600  guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
121850339  guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
103172259  heat-stable enterotoxin receptor-like [KO:K12320] [EC:4.6.1.2]
103179559  LOW QUALITY PROTEIN: retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
103186579  gucy2g; guanylate cyclase 2G [KO:K22600] [EC:4.6.1.2]
103181010  atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
103174800  atrial natriuretic peptide receptor 2-like [KO:K12324] [EC:4.6.1.2]
103177390  soluble guanylate cyclase 88E-like [KO:K01769] [EC:4.6.1.2]
103173806  soluble guanylate cyclase 88E-like [KO:K01769] [EC:4.6.1.2]
103183399  pde1ca; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
103176509  pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
103185580  pde3a; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
103174909  pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
103177365  pde5ab; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
103186935  pde6a; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha isoform X1 [KO:K08718] [EC:3.1.4.35]
103187952  rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
103182613  pde6c; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
103175900  pde6d; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
103175521  retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
103180270  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
103180439  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X2 [KO:K13761] [EC:3.1.4.35]
103179193  pde10a; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
103176491  pde11a; LOW QUALITY PROTEIN: dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
103183180  dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A-like [KO:K13298] [EC:3.1.4.17 3.1.4.35]
103175287  adss1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
103181788  adss2; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
103173731  adenylosuccinate synthetase isozyme 2-like [KO:K01939] [EC:6.3.4.4]
103182462  AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
103189725  ampd1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
103189077  ampd3a; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
103181904  adka; adenosine kinase [KO:K00856] [EC:2.7.1.20]
103190689  ada; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
103180762  adenosine deaminase isoform X1 [KO:K01488] [EC:3.5.4.4]
103179367  ada2a; adenosine deaminase 2-A [KO:K19572] [EC:3.5.4.4]
103174728  ak5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
103184649  ak1; adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
103185657  ak2; adenylate kinase 2, mitochondrial [KO:K00939] [EC:2.7.4.3]
103184621  ak8; adenylate kinase 8 isoform X1 [KO:K00939] [EC:2.7.4.3]
103186788  ak7b; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
103182688  ak6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
103191334  ak3; GTP:AMP phosphotransferase AK3, mitochondrial isoform X1 [KO:K00944] [EC:2.7.4.10]
103184645  ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
103179258  ntpcr; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
103182285  venom phosphodiesterase 2 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
103182286  ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
103190210  pde4a; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
103177810  pde4d; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
103182008  cAMP-specific 3',5'-cyclic phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
103172451  pde4ba; cAMP-specific 3',5'-cyclic phosphodiesterase 4B [KO:K13293] [EC:3.1.4.53]
103180728  pde7a; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
103178332  cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
103186390  pde8b; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
103186470  pde8a; LOW QUALITY PROTEIN: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A [KO:K18437] [EC:3.1.4.53]
103179762  fhit; bis(5'-adenosyl)-triphosphatase isoform X3 [KO:K01522] [EC:3.6.1.29]
103184989  enpp4; bis(5'-adenosyl)-triphosphatase enpp4 [KO:K18424] [EC:3.6.1.29]
103180853  papss2b; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2b [KO:K13811] [EC:2.7.7.4 2.7.1.25]
103187958  papss1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
103174706  uox; urate oxidase [KO:K00365] [EC:1.7.3.3]
103175999  uraha; 5-hydroxyisourate hydrolase isoform X1 [KO:K07127] [EC:3.5.2.17]
103183248  urad; 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
103188039  zgc:103559 [KO:K01466] [EC:3.5.2.5]
103185970  allc; allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
cmk00030  Pentose phosphate pathway
cmk00220  Arginine biosynthesis
cmk00250  Alanine, aspartate and glutamate metabolism
cmk00260  Glycine, serine and threonine metabolism
cmk00340  Histidine metabolism
cmk00630  Glyoxylate and dicarboxylate metabolism
cmk00730  Thiamine metabolism
cmk00740  Riboflavin metabolism
cmk00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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