KEGG   PATHWAY: cpoo04142
Entry
cpoo04142                   Pathway                                
Name
Lysosome - Crocodylus porosus (Australian saltwater crocodile)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
cpoo04142  Lysosome
cpoo04142

Other DBs
GO: 0005764
Organism
Crocodylus porosus (Australian saltwater crocodile) [GN:cpoo]
Gene
109305553  CTSC; dipeptidyl peptidase 1 [KO:K01275] [EC:3.4.14.1]
109305562  TPP1; tripeptidyl-peptidase 1 [KO:K01279] [EC:3.4.14.9]
109305570  SMPD1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
109306026  AP1S2; AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
109306064  TLR8; toll-like receptor 8 [KO:K10170]
109306065  [KO:K10170]
109306066  TLR7; toll-like receptor 7 [KO:K05404]
109306294  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
109306432  CLN5; ceroid-lipofuscinosis neuronal protein 5 [KO:K12390]
109306861  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
109307050  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
109307334  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
109307336  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
109307345  DNASE2B; deoxyribonuclease-2-beta [KO:K01158] [EC:3.1.22.1]
109307392  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
109307690  HEXB; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
109307718  WDR7; WD repeat-containing protein 7 isoform X1 [KO:K24738]
109307915  SLC38A9; sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
109307999  ARSB; arylsulfatase B isoform X1 [KO:K01135] [EC:3.1.6.12]
109308004  AP3B1; AP-3 complex subunit beta-1 isoform X1 [KO:K12397]
109308473  LAMP3; lysosome-associated membrane glycoprotein 3 [KO:K06562]
109308487  [KO:K12307]
109308504  AP2M1; AP-2 complex subunit mu isoform X1 [KO:K11826]
109308637  AP1S3; AP-1 complex subunit sigma-3 [KO:K12395]
109308792  CLN6; ceroid-lipofuscinosis neuronal protein 6 [KO:K12359]
109308794  SPG11; spatacsin [KO:K19026]
109308831  AP3B2; AP-3 complex subunit beta-2 isoform X1 [KO:K12397]
109308844  HEXA; beta-hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
109308936  VPS13C; vacuolar protein sorting-associated protein 13C isoform X1 [KO:K19525]
109309022  AP4E1; AP-4 complex subunit epsilon-1 isoform X1 [KO:K12400]
109309028  DMXL2; dmX-like protein 2 isoform X1 [KO:K24155]
109309057  BLOC1S6; biogenesis of lysosome-related organelles complex 1 subunit 6 [KO:K20188]
109309243  CTSH; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
109309322  MFSD8; major facilitator superfamily domain-containing protein 8 [KO:K12307]
109309427  HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase isoform X1 [KO:K10532] [EC:2.3.1.78]
109309474  SCARB2; lysosome membrane protein 2 [KO:K12384]
109309699  CTSO; cathepsin O isoform X1 [KO:K01374] [EC:3.4.22.42]
109309774  AGA; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase [KO:K01444] [EC:3.5.1.26]
109309921  [KO:K20463]
109310016  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
109310182  GM2A; ganglioside GM2 activator [KO:K12383]
109310184  [KO:K14209]
109310232  CLTB; clathrin light chain B isoform X1 [KO:K04645]
109310385  PLA2G15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
109310441  [KO:K13289] [EC:3.4.16.5]
109310559  VPS35; vacuolar protein sorting-associated protein 35 [KO:K18468]
109310667  TLDC1; TLD domain-containing protein 1 isoform X1 [KO:K27947]
109310712  GALNS; N-acetylgalactosamine-6-sulfatase isoform X1 [KO:K01132] [EC:3.1.6.4]
109310755  AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
109310928  GLA; alpha-galactosidase A isoform X1 [KO:K01189] [EC:3.2.1.22]
109311152  ARL8B; ADP-ribosylation factor-like protein 8B [KO:K07955]
109311158  SUMF1; sulfatase-modifying factor 1 isoform X1 [KO:K13444] [EC:1.8.3.7]
109311178  MITF; microphthalmia-associated transcription factor isoform X1 [KO:K09455]
109311285  RAB7A; ras-related protein Rab-7a [KO:K07897]
109311615  LAPTM4A; lysosomal-associated transmembrane protein 4A isoform X1 [KO:K12387]
109311648  ATP6V1C2; V-type proton ATPase subunit C 2 [KO:K02148]
109311704  CLN8; protein CLN8 [KO:K12360]
109311705  [KO:K12360]
109311789  [KO:K12309] [EC:3.2.1.23]
109311800  SLC17A5; sialin [KO:K12301]
109311862  RRAGD; ras-related GTP-binding protein D [KO:K16186]
109311925  CD164; sialomucin core protein 24 [KO:K06546]
109311929  FIG4; polyphosphoinositide phosphatase [KO:K22913] [EC:3.1.3.-]
109311993  NCOA7; nuclear receptor coactivator 7 isoform X1 [KO:K25442]
109312056  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
109312137  OSTM1; osteopetrosis-associated transmembrane protein 1 [KO:K23863]
109312333  BORCS8; BLOC-1-related complex subunit 8 [KO:K20822]
109312351  KXD1; kxDL motif-containing protein 1 [KO:K20818]
109312382  AP1M1; AP-1 complex subunit mu-1 [KO:K12393]
109312470  VPS26A; vacuolar protein sorting-associated protein 26A [KO:K18466]
109312483  PSAP; LOW QUALITY PROTEIN: prosaposin [KO:K12382]
109312484  [KO:K12382]
109312536  [KO:K01052] [EC:3.1.1.13]
109312537  [KO:K01052] [EC:3.1.1.13]
109312554  SLC29A3; equilibrative nucleoside transporter 3 [KO:K15014]
109312636  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
109312646  VPS29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
109312697  ABCB9; ATP-binding cassette sub-family B member 9 isoform X1 [KO:K05656]
109312718  ATP6V0A2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
109312737  VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
109312798  SNAP29; synaptosomal-associated protein 29 [KO:K08509]
109312799  CLTCL1; clathrin heavy chain 2 isoform X1 [KO:K04646]
109312937  AP1B1; AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
109312992  SLC15A4; solute carrier family 15 member 4 [KO:K14638]
109313024  TPCN1; two pore calcium channel protein 1 [KO:K16896]
109313107  TTI1; TELO2-interacting protein 1 homolog [KO:K20403]
109313296  CTSA; lysosomal protective protein [KO:K13289] [EC:3.4.16.5]
109313355  ROGDI; protein rogdi homolog [KO:K24628]
109313362  STX17; syntaxin-17 [KO:K08491]
109313390  TELO2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
109313468  CLCN7; H(+)/Cl(-) exchange transporter 7 [KO:K05016]
109313506  LITAF; lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363]
109313532  NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [KO:K01125] [EC:3.1.4.45]
109313533  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
109313575  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
109313625  IDS; iduronate 2-sulfatase isoform X1 [KO:K01136] [EC:3.1.6.13]
109313651  VAMP7; vesicle-associated membrane protein 7 [KO:K08515]
109313669  [KO:K16185]
109313848  ATP6V1G1; V-type proton ATPase subunit G 1 isoform X1 [KO:K02152]
109313986  SLC2A6; solute carrier family 2, facilitated glucose transporter member 6 [KO:K08144]
109314102  ABCA2; ATP-binding cassette sub-family A member 2 [KO:K05642]
109314475  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
109314594  GGA2; ADP-ribosylation factor-binding protein GGA2 [KO:K12404]
109314612  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
109314734  [KO:K12316] [EC:3.2.1.20]
109314813  AP5Z1; AP-5 complex subunit zeta-1 [KO:K19025]
109314896  SGSH; N-sulphoglucosamine sulphohydrolase isoform X1 [KO:K01565] [EC:3.10.1.1]
109314901  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
109314942  ABCA5; ATP-binding cassette sub-family A member 5 [KO:K05648]
109314949  ARSG; arylsulfatase G isoform X1 [KO:K12381] [EC:3.1.6.-]
109315059  GGA3; ADP-ribosylation factor-binding protein GGA3 isoform X1 [KO:K12404]
109315191  GAA; lysosomal alpha-glucosidase [KO:K12316] [EC:3.2.1.20]
109315406  BLOC1S5; biogenesis of lysosome-related organelles complex 1 subunit 5 [KO:K20187]
109315502  [KO:K01382] [EC:3.4.23.34]
109315540  GNS; N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
109315644  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
109315652  [KO:K01197] [EC:3.2.1.35]
109315653  [KO:K01197] [EC:3.2.1.35]
109315654  SPAM1; hyaluronidase PH-20 [KO:K01197] [EC:3.2.1.35]
109315655  [KO:K07955]
109315780  DTNBP1; dysbindin isoform X1 [KO:K20189]
109316231  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
109316311  BORCS5; BLOC-1-related complex subunit 5 [KO:K20819]
109316429  BLOC1S4; biogenesis of lysosome-related organelles complex 1 subunit 4 [KO:K08366]
109316450  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
109316540  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
109316551  GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [KO:K08239] [EC:2.7.8.17]
109316643  GGA1; ADP-ribosylation factor-binding protein GGA1 [KO:K12404]
109316752  NAGA; alpha-N-acetylgalactosaminidase isoform X1 [KO:K01204] [EC:3.2.1.49]
109316989  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
109317061  GUSB; beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
109317174  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
109317206  CTNS; cystinosin [KO:K12386]
109317378  VAMP8; vesicle-associated membrane protein 8 [KO:K08512]
109317393  AP3M2; AP-3 complex subunit mu-2 isoform X1 [KO:K12398]
109317440  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
109317531  LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344]
109317552  SORT1; sortilin isoform X1 [KO:K12388]
109317600  ARL8A; ADP-ribosylation factor-like protein 8A isoform X1 [KO:K07955]
109317695  CTSE; cathepsin E [KO:K01382] [EC:3.4.23.34]
109317782  TFEB; transcription factor EB [KO:K15590]
109317783  [KO:K15590]
109317856  AP4B1; AP-4 complex subunit beta-1 [KO:K12401]
109317930  VPS26B; vacuolar protein sorting-associated protein 26B [KO:K18466]
109318009  NPC1; Niemann-Pick C1 protein [KO:K12385]
109318054  OSBPL1A; oxysterol-binding protein-related protein 1 isoform X1 [KO:K20174]
109318105  VPS11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
109318223  TCIRG1; V-type proton ATPase 116 kDa subunit a [KO:K02154]
109318255  HYAL3; hyaluronidase-3 [KO:K01197] [EC:3.2.1.35]
109318290  HYAL1; hyaluronidase-1 [KO:K01197] [EC:3.2.1.35]
109318293  HYAL2; hyaluronidase-2 [KO:K01197] [EC:3.2.1.35]
109318370  PPT1; palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
109318378  FUCA1; tissue alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
109318589  RRAGC; ras-related GTP-binding protein C [KO:K16186]
109318648  LAPTM5; lysosomal-associated transmembrane protein 5 [KO:K12387]
109318685  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
109318706  CTSZ; cathepsin Z [KO:K08568] [EC:3.4.18.1]
109318820  OSBPL2; oxysterol-binding protein-related protein 2 isoform X1 [KO:K20174]
109318841  [KO:K20402]
109318884  OSBPL7; oxysterol-binding protein-related protein 7 isoform X1 [KO:K20463]
109319030  BLOC1S3; LOW QUALITY PROTEIN: biogenesis of lysosome-related organelles complex 1 subunit 3 [KO:K20186]
109319171  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
109319493  LAMP5; lysosome-associated membrane glycoprotein 5 [KO:K28774]
109319539  [KO:K01444] [EC:3.5.1.26]
109319850  SLC29A1; equilibrative nucleoside transporter 1 [KO:K15014]
109320066  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
109320094  ATP6V0D2; V-type proton ATPase subunit d 2 isoform X1 [KO:K02146]
109320160  FUCA2; plasma alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
109320368  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
109320445  [KO:K01365] [EC:3.4.22.15]
109320466  [KO:K01319] [EC:3.4.21.20]
109320669  AP5M1; AP-5 complex subunit mu-1 isoform X1 [KO:K19023]
109320705  LAPTM4B; lysosomal-associated transmembrane protein 4B [KO:K12387]
109320798  [KO:K11824]
109320799  [KO:K11824]
109320945  AP4S1; AP-4 complex subunit sigma-1 [KO:K12403]
109320951  ACP2; lysosomal acid phosphatase [KO:K14410] [EC:3.1.3.2]
109321023  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
109321081  ZFYVE26; zinc finger FYVE domain-containing protein 26 isoform X1 [KO:K19027]
109321101  TPCN2; two pore calcium channel protein 2 [KO:K14077]
109321156  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
109321190  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
109321290  VPS39; vam6/Vps39-like protein [KO:K20183]
109321331  OSBPL5; oxysterol-binding protein-related protein 5 isoform X1 [KO:K20464]
109321353  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
109321476  NPC2; epididymal secretory protein E1 [KO:K13443]
109321558  DEPTOR; DEP domain-containing mTOR-interacting protein [KO:K20402]
109321658  GALC; galactocerebrosidase isoform X1 [KO:K01202] [EC:3.2.1.46]
109321700  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
109321837  ASAH1; acid ceramidase [KO:K12348] [EC:3.5.1.23]
109321847  [KO:K08512]
109322120  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
109322232  MANBA; beta-mannosidase [KO:K01192] [EC:3.2.1.25]
109322334  TLR3; toll-like receptor 3 isoform X1 [KO:K05401]
109322443  NAGLU; alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
109322504  SLC11A1; natural resistance-associated macrophage protein 1 [KO:K12347]
109322628  GPR155; integral membrane protein GPR155 isoform X1 [KO:K28455]
109322909  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
109323047  PLEKHM1; pleckstrin homology domain-containing family M member 1 [KO:K23282]
109323083  OSBPL6; oxysterol-binding protein-related protein 6 isoform X1 [KO:K20463]
109323209  [KO:K06497]
109323287  AP3S1; AP-3 complex subunit sigma-1 [KO:K12399]
109323405  VPS13A; vacuolar protein sorting-associated protein 13A isoform X1 [KO:K19525]
109323410  IDUA; alpha-L-iduronidase isoform X1 [KO:K01217] [EC:3.2.1.76]
109323420  DMXL1; dmX-like protein 1 isoform X1 [KO:K24155]
109323468  TMEM175; endosomal/lysomomal potassium channel TMEM175 [KO:K24915]
109323661  CLTA; clathrin light chain A isoform X1 [KO:K04644]
109323678  [KO:K01365] [EC:3.4.22.15]
109323743  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
109323821  BORCS7; BLOC-1-related complex subunit 7 [KO:K20821]
109323908  AP3M1; AP-3 complex subunit mu-1 [KO:K12398]
109324008  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
109324285  [KO:K01052] [EC:3.1.1.13]
109324288  BLOC1S2; biogenesis of lysosome-related organelles complex 1 subunit 2 [KO:K16750]
109324298  [KO:K10532] [EC:2.3.1.78]
109324563  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
109324628  OSBP; oxysterol-binding protein 1 [KO:K20456]
109324801  GBA; glucosylceramidase isoform X1 [KO:K01201] [EC:3.2.1.45]
109324822  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
109324918  AP3D1; AP-3 complex subunit delta-1 [KO:K12396]
Compound
C00002  ATP
C00008  ADP
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 22:339-352 (2022)
DOI:10.1038/s41577-021-00626-8
Reference
PMID:19672277
  Authors
Saftig P, Klumperman J
  Title
Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function.
  Journal
Nat Rev Mol Cell Biol 10:623-35 (2009)
DOI:10.1038/nrm2745
Reference
PMID:31611045
  Authors
Savini M, Zhao Q, Wang MC
  Title
Lysosomes: Signaling Hubs for Metabolic Sensing and Longevity.
  Journal
Trends Cell Biol 29:876-887 (2019)
DOI:10.1016/j.tcb.2019.08.008
Reference
PMID:33433692
  Authors
Meyer-Schwesinger C
  Title
Lysosome function in glomerular health and disease.
  Journal
Cell Tissue Res 385:371-392 (2021)
DOI:10.1007/s00441-020-03375-7
Reference
PMID:34345172
  Authors
Allemailem KS, Almatroudi A, Alrumaihi F, Almatroodi SA, Alkurbi MO, Basfar GT, Rahmani AH, Khan AA
  Title
Novel Approaches of Dysregulating Lysosome Functions in Cancer Cells by Specific Drugs and Its Nanoformulations: A Smart Approach of Modern Therapeutics.
  Journal
Int J Nanomedicine 16:5065-5098 (2021)
DOI:10.2147/IJN.S321343
Reference
PMID:36096887
  Authors
Zhang W, Yang X, Li Y, Yu L, Zhang B, Zhang J, Cho WJ, Venkatarangan V, Chen L, Burugula BB, Bui S, Wang Y, Duan C, Kitzman JO, Li M
  Title
GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway.
  Journal
Nat Commun 13:5351 (2022)
DOI:10.1038/s41467-022-33025-1
Reference
PMID:38357444
  Authors
Liu Q, Wang W, Xu L, Zhang Q, Wang H
  Title
The host mannose-6-phosphate pathway and viral infection.
  Journal
Front Cell Infect Microbiol 14:1349221 (2024)
DOI:10.3389/fcimb.2024.1349221
Reference
PMID:38711187
  Authors
He Y, Fan Y, Ahmadpoor X, Wang Y, Li ZA, Zhu W, Lin H
  Title
Targeting lysosomal quality control as a therapeutic strategy against aging and diseases.
  Journal
Med Res Rev 44:2472-2509 (2024)
DOI:10.1002/med.22047
Reference
PMID:40759742
  Authors
Radulovic M, Yang C, Stenmark H
  Title
Lysosomal membrane homeostasis and its importance in physiology and disease.
  Journal
Nat Rev Mol Cell Biol 27:71-87 (2026)
DOI:10.1038/s41580-025-00873-w
Reference
PMID:41214333
  Authors
Watson ET, Wegeng WR, Aravani S, Ernst AM, von Blume J
  Title
Mechanistic insights into cargo sorting and export from the Golgi apparatus.
  Journal
Nat Rev Mol Cell Biol 26:940-956 (2025)
DOI:10.1038/s41580-025-00907-3
Related
pathway
cpoo00511  Other glycan degradation
cpoo00531  Glycosaminoglycan degradation
cpoo04130  SNARE interactions in vesicular transport
cpoo04140  Autophagy - animal
cpoo04144  Endocytosis
cpoo04145  Phagosome
cpoo04150  mTOR signaling pathway
cpoo04620  Toll-like receptor signaling pathway
KO pathway
ko04142   

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